General info

Chr
chrM
Start
10191
End
10191
Ref
T
Alt
G
Mitimpact ID
MI.15246
Gene symbol
MT-ND3
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
133
AA pos
45
AA ref
S
AA alt
A
Codon substitution
Tcc/Gcc
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Powered by MitoWheel

Conservation

PhyloP 100v
-0.1 Conservation Score
PhastCons 100v
0.15 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Neutral Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Neutral Score and details of the predictor
Mutation Assessor
Medium impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Neutral Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Neutral Score and details of the predictor
SNAP
Disease Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Neutral Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Neutral Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Medium impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

General info

Chr
chrM
Start
10191
End
10191
Ref
T
Alt
A
Mitimpact ID
MI.15247
Gene symbol
MT-ND3
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
133
AA pos
45
AA ref
S
AA alt
T
Codon substitution
Tcc/Acc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
-0.1 Conservation Score
PhastCons 100v
0.15 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Neutral Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Neutral Score and details of the predictor
Mutation Assessor
Medium impact Score and details of the predictor
EFIN SP
Damaging Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Neutral Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Deleterious Score and details of the predictor
SNAP
Disease Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Neutral Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Neutral Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Medium impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

General info

Chr
chrM
Start
10191
End
10191
Ref
T
Alt
C
Mitimpact ID
MI.15248
Gene symbol
MT-ND3
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
133
AA pos
45
AA ref
S
AA alt
P
Codon substitution
Tcc/Ccc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
-0.1 Conservation Score
PhastCons 100v
0.15 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Neutral Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Deleterious Score and details of the predictor
Mutation Assessor
Medium impact Score and details of the predictor
EFIN SP
Damaging Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Disease Score and details of the predictor
MutationTaster
Disease causing automatic Score and details of the predictor
CADD
Deleterious Score and details of the predictor
SNAP
Disease Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Pathogenic Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Neutral Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Disease Score and details of the meta-predictor
MtoolBox
Deleterious Score and details of the meta-predictor
DEOGEN2
Deleterious Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Medium impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar March2020 ClinSig
Pathogenic
ClinVar March2020 ClnDBN
Leigh syndrome;

mitochondrial complex i deficiency, mitochondrial type 1
ClinVar March2020 ClnAllele ID
24751
ClinVar March2020 ClnDSDB
Medgen:c0023264, omim:256000, orphanet:orpha506, snomed ct:29570005;

medgen:c4746992, omim:500014
MITOMAP Allele
MITOMAP Phenotype
Leigh disease / leigh-like disease / esoc
MITOMAP Homoplasmy
-
MITOMAP Heteroplasmy
+
MITOMAP Status
Cfrm
MITOMAP NRef
25
COSMIC 90
.
dbSNP 153

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

General info

Chr
chrM
Start
10192
End
10192
Ref
C
Alt
G
Mitimpact ID
MI.15249
Gene symbol
MT-ND3
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
134
AA pos
45
AA ref
S
AA alt
C
Codon substitution
tCc/tGc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
3.6 Conservation Score
PhastCons 100v
1 Conservation Score

Pathogenicity predictors

PolyPhen2
Possibly damaging Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Deleterious Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Deleterious Score and details of the predictor
Mutation Assessor
Medium impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Disease Score and details of the predictor
PhD-SNP
Disease Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Deleterious Score and details of the predictor
SNAP
Disease Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Pathogenic Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Neutral Score and details of the meta-predictor
COVEC WMV
. Score and details of the meta-predictor
Meta SNP
Disease Score and details of the meta-predictor
MtoolBox
Deleterious Score and details of the meta-predictor
DEOGEN2
Deleterious Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Low impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

General info

Chr
chrM
Start
10192
End
10192
Ref
C
Alt
A
Mitimpact ID
MI.15250
Gene symbol
MT-ND3
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
134
AA pos
45
AA ref
S
AA alt
Y
Codon substitution
tCc/tAc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
3.6 Conservation Score
PhastCons 100v
1 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Neutral Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Deleterious Score and details of the predictor
Mutation Assessor
Medium impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Disease Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Deleterious Score and details of the predictor
SNAP
Disease Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Pathogenic Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Disease Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Deleterious Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Medium impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

General info

Chr
chrM
Start
10192
End
10192
Ref
C
Alt
T
Mitimpact ID
MI.15251
Gene symbol
MT-ND3
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
134
AA pos
45
AA ref
S
AA alt
F
Codon substitution
tCc/tTc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
3.6 Conservation Score
PhastCons 100v
1 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Deleterious Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Deleterious Score and details of the predictor
Mutation Assessor
Medium impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Disease Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Deleterious Score and details of the predictor
SNAP
Disease Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Pathogenic Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Disease Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Deleterious Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Medium impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar March2020 ClinSig
Benign
ClinVar March2020 ClnDBN
Leigh syndrome
ClinVar March2020 ClnAllele ID
680161
ClinVar March2020 ClnDSDB
Medgen:c0023264, omim:256000, orphanet:orpha506, snomed ct:29570005
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.
~ 10191 (T/G) 10191 (T/A) 10191 (T/C) 10192 (C/G) 10192 (C/A) 10192 (C/T)
~ 10191 (Tcc/Gcc) 10191 (Tcc/Acc) 10191 (Tcc/Ccc) 10192 (tCc/tGc) 10192 (tCc/tAc) 10192 (tCc/tTc)
Chr chrM chrM chrM chrM chrM chrM
Start 10191 10191 10191 10192 10192 10192
End 10191 10191 10191 10192 10192 10192
Ref T T T C C C
Alt G A C G A T
MitImpact id MI.15246 MI.15247 MI.15248 MI.15249 MI.15250 MI.15251
Gene symbol MT-ND3 MT-ND3 MT-ND3 MT-ND3 MT-ND3 MT-ND3
Respiratory Chain complex I I I I I I
Ensembl gene id ENSG00000198840 ENSG00000198840 ENSG00000198840 ENSG00000198840 ENSG00000198840 ENSG00000198840
Ensembl protein id ENSP00000355206 ENSP00000355206 ENSP00000355206 ENSP00000355206 ENSP00000355206 ENSP00000355206
Ensembl transcript id ENST00000361227 ENST00000361227 ENST00000361227 ENST00000361227 ENST00000361227 ENST00000361227
Uniprot name NU3M_HUMAN NU3M_HUMAN NU3M_HUMAN NU3M_HUMAN NU3M_HUMAN NU3M_HUMAN
Uniprot id P03897 P03897 P03897 P03897 P03897 P03897
Ncbi gene id 4537 4537 4537 4537 4537 4537
Ncbi protein id YP_003024033.1 YP_003024033.1 YP_003024033.1 YP_003024033.1 YP_003024033.1 YP_003024033.1
Gene position 133 133 133 134 134 134
AA position 45 45 45 45 45 45
AA ref S S S S S S
AA alt A T P C Y F
Codon substitution Tcc/Gcc Tcc/Acc Tcc/Ccc tCc/tGc tCc/tAc tCc/tTc
PhyloP 100V -0.1 -0.1 -0.1 3.6 3.6 3.6
PhastCons 100V 0.15 0.15 0.15 1 1 1
PolyPhen2 benign benign benign possibly_damaging benign benign
PolyPhen2 score 0.09 0.09 0.43 0.71 0 0
SIFT neutral neutral neutral neutral neutral neutral
SIFT score 0.79 0.6 0.3 0.08 0.17 0.14
FatHmm neutral neutral neutral deleterious neutral deleterious
FatHmm score -0.27 -0.75 -1.41 -4.12 -2.73 -3.14
FatHmmW neutral neutral neutral neutral neutral neutral
FatHmmW score 0.91 0.9 0.85 0.82 0.84 0.84
PROVEAN neutral neutral deleterious deleterious deleterious deleterious
PROVEAN score -0.84 -1.76 -2.51 -3.36 -3.39 -3.55
MutationAssessor medium impact medium impact medium impact medium impact medium impact medium impact
MutationAssessor score 2.38 2.13 2.88 3.23 2.54 2.6
EFIN SP neutral damaging damaging neutral neutral neutral
EFIN SP score 0.76 0.6 0.17 0.69 0.7 0.62
EFIN HD neutral neutral neutral neutral neutral neutral
EFIN HD score 0.81 0.65 0.35 0.43 0.58 0.54
CADD neutral deleterious deleterious deleterious deleterious deleterious
CADD score 1.74 1.82 2.31 3.22 2.2 2.24
CADD phred 14.63 15.08 18.21 22.7 17.48 17.75
VEST pvalue 0.3 0.33 0.12 0.11 0.09 0.11
VEST FDR 0.45 0.5 0.4 0.4 0.35 0.4
PANTHER neutral neutral neutral disease neutral neutral
PANTHER score 0.21 0.25 0.44 0.63 0.43 0.44
PhD-SNP neutral neutral disease disease disease disease
PhD-SNP score 0.31 0.35 0.76 0.6 0.59 0.65
SNAP disease disease disease disease disease disease
SNAP score 0.56 0.6 0.6 0.54 0.64 0.62
Meta-SNP neutral neutral disease disease disease disease
Meta-SNP score 0.4 0.42 0.69 0.66 0.69 0.7
Meta-SNP RI 2 2 4 3 4 4
CAROL neutral neutral neutral neutral neutral neutral
CAROL score 0.11 0.31 0.66 0.93 0.83 0.86
Condel deleterious deleterious neutral neutral deleterious deleterious
Condel score 0.85 0.76 0.44 0.19 0.59 0.57
COVEC WMV neutral neutral neutral . neutral neutral
COVEC WMV score -3 -3 -3 0 -3 -3
MtoolBox neutral neutral deleterious deleterious neutral neutral
MtoolBox DS 0.15 0.16 0.57 0.62 0.19 0.21
PolyPhen2 transf medium impact medium impact medium impact low impact medium impact medium impact
PolyPhen2 transf score 0.19 0.19 -0.61 -1.07 1.99 1.99
SIFT_transf medium impact medium impact medium impact medium impact medium impact medium impact
SIFT transf score 0.51 0.29 -0.01 -0.4 -0.19 -0.25
MutationAssessor transf medium impact medium impact medium impact medium impact medium impact medium impact
MutationAssessor transf score 1.07 0.84 1.53 1.85 1.22 1.28
CHASM pvalue 0.35 0.48 0.22 0.27 0.2 0.09
CHASM FDR 0.8 0.8 0.8 0.8 0.8 0.8
APOGEE Neutral Neutral Pathogenic Pathogenic Pathogenic Pathogenic
APOGEE score 0.35 0.4 0.95 0.6 0.53 0.55
SNPDryad score 0.1 0.13 0.6 0.56 0.06 0.54
MutationTaster polymorphism polymorphism disease_causing_automatic polymorphism polymorphism polymorphism
MutationTaster score 1 1 0 1 1 1
DEOGEN2 score 0.33 0.37 0.55 0.68 0.56 0.63
Mitoclass.1 neutral neutral neutral neutral neutral neutral
dbSNP 153 id . . rs267606890 . . rs1556423776
ClinVar March2020 ClinSig . . Pathogenic . . Benign
ClinVar March2020 ClnDBN . . Leigh_syndrome|MITOCHONDRIAL_COMPLEX_I_DEFICIENCY,_MITOCHONDRIAL_TYPE_1 . . Leigh_syndrome
ClinVar March2020 ClnAllele id . . 24751 . . 680161
ClinVar March2020 ClnDSDB . . MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C4746992,OMIM:500014 . . MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005
COSMIC 90 . . . . . .
CPD Frequency . . . . . .
MITOMAP Allele . . T10191C . . .
MITOMAP Phenotype . . Leigh Disease / Leigh-like Disease / ESOC . . .
MITOMAP Homoplasmy . . - . . .
MITOMAP Heteroplasmy . . + . . .
MITOMAP Status . . Cfrm . . .
MITOMAP NRef . . 25 . . .
EVmutation MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759 MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759 MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759 MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759 MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759 MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759
Site A InterP ND3_45 ND3_45 ND3_45 ND3_45 ND3_45 ND3_45
Site B InterP ND1_231;ND1_128;ND1_46;ND1_156;ND2_4;ND2_60;ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND1_248;ND1_67;ND1_126;ND1_71;ND1_93;ND1_76;ND1_27;ND1_84;ND1_276;ND1_249;ND1_163;ND1_229;ND1_85;ND1_62;ND1_301;ND1_64;ND1_251;ND1_79;ND2_166;ND2_6;ND2_89;ND2_265;ND2_241;ND2_239;ND2_276;ND2_78;ND2_10;ND2_76;ND2_94;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5 ND1_231;ND1_128;ND1_46;ND1_156;ND2_4;ND2_60;ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND1_248;ND1_67;ND1_126;ND1_71;ND1_93;ND1_76;ND1_27;ND1_84;ND1_276;ND1_249;ND1_163;ND1_229;ND1_85;ND1_62;ND1_301;ND1_64;ND1_251;ND1_79;ND2_166;ND2_6;ND2_89;ND2_265;ND2_241;ND2_239;ND2_276;ND2_78;ND2_10;ND2_76;ND2_94;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5 ND1_231;ND1_128;ND1_46;ND1_156;ND2_4;ND2_60;ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND1_248;ND1_67;ND1_126;ND1_71;ND1_93;ND1_76;ND1_27;ND1_84;ND1_276;ND1_249;ND1_163;ND1_229;ND1_85;ND1_62;ND1_301;ND1_64;ND1_251;ND1_79;ND2_166;ND2_6;ND2_89;ND2_265;ND2_241;ND2_239;ND2_276;ND2_78;ND2_10;ND2_76;ND2_94;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5 ND1_231;ND1_128;ND1_46;ND1_156;ND2_4;ND2_60;ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND1_248;ND1_67;ND1_126;ND1_71;ND1_93;ND1_76;ND1_27;ND1_84;ND1_276;ND1_249;ND1_163;ND1_229;ND1_85;ND1_62;ND1_301;ND1_64;ND1_251;ND1_79;ND2_166;ND2_6;ND2_89;ND2_265;ND2_241;ND2_239;ND2_276;ND2_78;ND2_10;ND2_76;ND2_94;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5 ND1_231;ND1_128;ND1_46;ND1_156;ND2_4;ND2_60;ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND1_248;ND1_67;ND1_126;ND1_71;ND1_93;ND1_76;ND1_27;ND1_84;ND1_276;ND1_249;ND1_163;ND1_229;ND1_85;ND1_62;ND1_301;ND1_64;ND1_251;ND1_79;ND2_166;ND2_6;ND2_89;ND2_265;ND2_241;ND2_239;ND2_276;ND2_78;ND2_10;ND2_76;ND2_94;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5 ND1_231;ND1_128;ND1_46;ND1_156;ND2_4;ND2_60;ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND1_248;ND1_67;ND1_126;ND1_71;ND1_93;ND1_76;ND1_27;ND1_84;ND1_276;ND1_249;ND1_163;ND1_229;ND1_85;ND1_62;ND1_301;ND1_64;ND1_251;ND1_79;ND2_166;ND2_6;ND2_89;ND2_265;ND2_241;ND2_239;ND2_276;ND2_78;ND2_10;ND2_76;ND2_94;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5
Covariation Score InterP mfDCA_43.06;mfDCA_38.66;mfDCA_33.28;mfDCA_32.98;mfDCA_37.45;mfDCA_27.97;mfDCA_37.96;mfDCA_22.41;mfDCA_21.64;cMI_14.42049;mfDCA_34.27;mfDCA_26.86;mfDCA_79.1;mfDCA_31.92;cMI_49.89251;cMI_42.92984;cMI_41.72575;cMI_41.35901;cMI_39.83745;cMI_39.80877;cMI_39.28621;cMI_39.25341;cMI_38.90435;cMI_37.23441;cMI_37.10332;cMI_35.91475;cMI_35.72486;cMI_34.76365;cMI_34.26473;cMI_32.72981;cMI_31.32613;cMI_30.89244;cMI_22.94652;cMI_22.92951;cMI_22.78181;cMI_22.0794;cMI_21.36701;cMI_21.16552;cMI_19.74607;cMI_19.27132;cMI_18.72378;cMI_18.45074;cMI_18.01385;cMI_45.83789;cMI_44.22917;cMI_36.96359;cMI_36.7885;cMI_36.36468;cMI_34.82834;cMI_34.44059;cMI_34.16881;cMI_34.00615;cMI_33.7583;cMI_32.86419;cMI_32.3116;cMI_32.27547;cMI_31.86143;cMI_31.70077;cMI_30.23993;cMI_22.23638;cMI_19.73961;cMI_19.16892;cMI_15.51931;cMI_14.42049;cMI_12.72224;cMI_12.48772;cMI_45.56686;cMI_39.36692;cMI_39.2702;cMI_39.21392;cMI_37.50221;cMI_37.33206;cMI_37.03395;cMI_36.14669;cMI_36.0487;cMI_36.01114;cMI_35.29195;cMI_33.17587;cMI_32.8188;cMI_31.61218;cMI_19.13398;cMI_17.85636;cMI_17.52418;cMI_16.19448;cMI_14.52225;cMI_13.83411;cMI_13.57866 mfDCA_43.06;mfDCA_38.66;mfDCA_33.28;mfDCA_32.98;mfDCA_37.45;mfDCA_27.97;mfDCA_37.96;mfDCA_22.41;mfDCA_21.64;cMI_14.42049;mfDCA_34.27;mfDCA_26.86;mfDCA_79.1;mfDCA_31.92;cMI_49.89251;cMI_42.92984;cMI_41.72575;cMI_41.35901;cMI_39.83745;cMI_39.80877;cMI_39.28621;cMI_39.25341;cMI_38.90435;cMI_37.23441;cMI_37.10332;cMI_35.91475;cMI_35.72486;cMI_34.76365;cMI_34.26473;cMI_32.72981;cMI_31.32613;cMI_30.89244;cMI_22.94652;cMI_22.92951;cMI_22.78181;cMI_22.0794;cMI_21.36701;cMI_21.16552;cMI_19.74607;cMI_19.27132;cMI_18.72378;cMI_18.45074;cMI_18.01385;cMI_45.83789;cMI_44.22917;cMI_36.96359;cMI_36.7885;cMI_36.36468;cMI_34.82834;cMI_34.44059;cMI_34.16881;cMI_34.00615;cMI_33.7583;cMI_32.86419;cMI_32.3116;cMI_32.27547;cMI_31.86143;cMI_31.70077;cMI_30.23993;cMI_22.23638;cMI_19.73961;cMI_19.16892;cMI_15.51931;cMI_14.42049;cMI_12.72224;cMI_12.48772;cMI_45.56686;cMI_39.36692;cMI_39.2702;cMI_39.21392;cMI_37.50221;cMI_37.33206;cMI_37.03395;cMI_36.14669;cMI_36.0487;cMI_36.01114;cMI_35.29195;cMI_33.17587;cMI_32.8188;cMI_31.61218;cMI_19.13398;cMI_17.85636;cMI_17.52418;cMI_16.19448;cMI_14.52225;cMI_13.83411;cMI_13.57866 mfDCA_43.06;mfDCA_38.66;mfDCA_33.28;mfDCA_32.98;mfDCA_37.45;mfDCA_27.97;mfDCA_37.96;mfDCA_22.41;mfDCA_21.64;cMI_14.42049;mfDCA_34.27;mfDCA_26.86;mfDCA_79.1;mfDCA_31.92;cMI_49.89251;cMI_42.92984;cMI_41.72575;cMI_41.35901;cMI_39.83745;cMI_39.80877;cMI_39.28621;cMI_39.25341;cMI_38.90435;cMI_37.23441;cMI_37.10332;cMI_35.91475;cMI_35.72486;cMI_34.76365;cMI_34.26473;cMI_32.72981;cMI_31.32613;cMI_30.89244;cMI_22.94652;cMI_22.92951;cMI_22.78181;cMI_22.0794;cMI_21.36701;cMI_21.16552;cMI_19.74607;cMI_19.27132;cMI_18.72378;cMI_18.45074;cMI_18.01385;cMI_45.83789;cMI_44.22917;cMI_36.96359;cMI_36.7885;cMI_36.36468;cMI_34.82834;cMI_34.44059;cMI_34.16881;cMI_34.00615;cMI_33.7583;cMI_32.86419;cMI_32.3116;cMI_32.27547;cMI_31.86143;cMI_31.70077;cMI_30.23993;cMI_22.23638;cMI_19.73961;cMI_19.16892;cMI_15.51931;cMI_14.42049;cMI_12.72224;cMI_12.48772;cMI_45.56686;cMI_39.36692;cMI_39.2702;cMI_39.21392;cMI_37.50221;cMI_37.33206;cMI_37.03395;cMI_36.14669;cMI_36.0487;cMI_36.01114;cMI_35.29195;cMI_33.17587;cMI_32.8188;cMI_31.61218;cMI_19.13398;cMI_17.85636;cMI_17.52418;cMI_16.19448;cMI_14.52225;cMI_13.83411;cMI_13.57866 mfDCA_43.06;mfDCA_38.66;mfDCA_33.28;mfDCA_32.98;mfDCA_37.45;mfDCA_27.97;mfDCA_37.96;mfDCA_22.41;mfDCA_21.64;cMI_14.42049;mfDCA_34.27;mfDCA_26.86;mfDCA_79.1;mfDCA_31.92;cMI_49.89251;cMI_42.92984;cMI_41.72575;cMI_41.35901;cMI_39.83745;cMI_39.80877;cMI_39.28621;cMI_39.25341;cMI_38.90435;cMI_37.23441;cMI_37.10332;cMI_35.91475;cMI_35.72486;cMI_34.76365;cMI_34.26473;cMI_32.72981;cMI_31.32613;cMI_30.89244;cMI_22.94652;cMI_22.92951;cMI_22.78181;cMI_22.0794;cMI_21.36701;cMI_21.16552;cMI_19.74607;cMI_19.27132;cMI_18.72378;cMI_18.45074;cMI_18.01385;cMI_45.83789;cMI_44.22917;cMI_36.96359;cMI_36.7885;cMI_36.36468;cMI_34.82834;cMI_34.44059;cMI_34.16881;cMI_34.00615;cMI_33.7583;cMI_32.86419;cMI_32.3116;cMI_32.27547;cMI_31.86143;cMI_31.70077;cMI_30.23993;cMI_22.23638;cMI_19.73961;cMI_19.16892;cMI_15.51931;cMI_14.42049;cMI_12.72224;cMI_12.48772;cMI_45.56686;cMI_39.36692;cMI_39.2702;cMI_39.21392;cMI_37.50221;cMI_37.33206;cMI_37.03395;cMI_36.14669;cMI_36.0487;cMI_36.01114;cMI_35.29195;cMI_33.17587;cMI_32.8188;cMI_31.61218;cMI_19.13398;cMI_17.85636;cMI_17.52418;cMI_16.19448;cMI_14.52225;cMI_13.83411;cMI_13.57866 mfDCA_43.06;mfDCA_38.66;mfDCA_33.28;mfDCA_32.98;mfDCA_37.45;mfDCA_27.97;mfDCA_37.96;mfDCA_22.41;mfDCA_21.64;cMI_14.42049;mfDCA_34.27;mfDCA_26.86;mfDCA_79.1;mfDCA_31.92;cMI_49.89251;cMI_42.92984;cMI_41.72575;cMI_41.35901;cMI_39.83745;cMI_39.80877;cMI_39.28621;cMI_39.25341;cMI_38.90435;cMI_37.23441;cMI_37.10332;cMI_35.91475;cMI_35.72486;cMI_34.76365;cMI_34.26473;cMI_32.72981;cMI_31.32613;cMI_30.89244;cMI_22.94652;cMI_22.92951;cMI_22.78181;cMI_22.0794;cMI_21.36701;cMI_21.16552;cMI_19.74607;cMI_19.27132;cMI_18.72378;cMI_18.45074;cMI_18.01385;cMI_45.83789;cMI_44.22917;cMI_36.96359;cMI_36.7885;cMI_36.36468;cMI_34.82834;cMI_34.44059;cMI_34.16881;cMI_34.00615;cMI_33.7583;cMI_32.86419;cMI_32.3116;cMI_32.27547;cMI_31.86143;cMI_31.70077;cMI_30.23993;cMI_22.23638;cMI_19.73961;cMI_19.16892;cMI_15.51931;cMI_14.42049;cMI_12.72224;cMI_12.48772;cMI_45.56686;cMI_39.36692;cMI_39.2702;cMI_39.21392;cMI_37.50221;cMI_37.33206;cMI_37.03395;cMI_36.14669;cMI_36.0487;cMI_36.01114;cMI_35.29195;cMI_33.17587;cMI_32.8188;cMI_31.61218;cMI_19.13398;cMI_17.85636;cMI_17.52418;cMI_16.19448;cMI_14.52225;cMI_13.83411;cMI_13.57866 mfDCA_43.06;mfDCA_38.66;mfDCA_33.28;mfDCA_32.98;mfDCA_37.45;mfDCA_27.97;mfDCA_37.96;mfDCA_22.41;mfDCA_21.64;cMI_14.42049;mfDCA_34.27;mfDCA_26.86;mfDCA_79.1;mfDCA_31.92;cMI_49.89251;cMI_42.92984;cMI_41.72575;cMI_41.35901;cMI_39.83745;cMI_39.80877;cMI_39.28621;cMI_39.25341;cMI_38.90435;cMI_37.23441;cMI_37.10332;cMI_35.91475;cMI_35.72486;cMI_34.76365;cMI_34.26473;cMI_32.72981;cMI_31.32613;cMI_30.89244;cMI_22.94652;cMI_22.92951;cMI_22.78181;cMI_22.0794;cMI_21.36701;cMI_21.16552;cMI_19.74607;cMI_19.27132;cMI_18.72378;cMI_18.45074;cMI_18.01385;cMI_45.83789;cMI_44.22917;cMI_36.96359;cMI_36.7885;cMI_36.36468;cMI_34.82834;cMI_34.44059;cMI_34.16881;cMI_34.00615;cMI_33.7583;cMI_32.86419;cMI_32.3116;cMI_32.27547;cMI_31.86143;cMI_31.70077;cMI_30.23993;cMI_22.23638;cMI_19.73961;cMI_19.16892;cMI_15.51931;cMI_14.42049;cMI_12.72224;cMI_12.48772;cMI_45.56686;cMI_39.36692;cMI_39.2702;cMI_39.21392;cMI_37.50221;cMI_37.33206;cMI_37.03395;cMI_36.14669;cMI_36.0487;cMI_36.01114;cMI_35.29195;cMI_33.17587;cMI_32.8188;cMI_31.61218;cMI_19.13398;cMI_17.85636;cMI_17.52418;cMI_16.19448;cMI_14.52225;cMI_13.83411;cMI_13.57866
Site A IntraP ND3_45 ND3_45 ND3_45 ND3_45 ND3_45 ND3_45
Site B IntraP ND3_35;ND3_18;ND3_88;ND3_8;ND3_97;ND3_89;ND3_4;ND3_49;ND3_21;ND3_79;ND3_29;ND3_19;ND3_44;ND3_15;ND3_112;ND3_91;ND3_35;ND3_88;ND3_89;ND3_19;ND3_44;ND3_21;ND3_107 ND3_35;ND3_18;ND3_88;ND3_8;ND3_97;ND3_89;ND3_4;ND3_49;ND3_21;ND3_79;ND3_29;ND3_19;ND3_44;ND3_15;ND3_112;ND3_91;ND3_35;ND3_88;ND3_89;ND3_19;ND3_44;ND3_21;ND3_107 ND3_35;ND3_18;ND3_88;ND3_8;ND3_97;ND3_89;ND3_4;ND3_49;ND3_21;ND3_79;ND3_29;ND3_19;ND3_44;ND3_15;ND3_112;ND3_91;ND3_35;ND3_88;ND3_89;ND3_19;ND3_44;ND3_21;ND3_107 ND3_35;ND3_18;ND3_88;ND3_8;ND3_97;ND3_89;ND3_4;ND3_49;ND3_21;ND3_79;ND3_29;ND3_19;ND3_44;ND3_15;ND3_112;ND3_91;ND3_35;ND3_88;ND3_89;ND3_19;ND3_44;ND3_21;ND3_107 ND3_35;ND3_18;ND3_88;ND3_8;ND3_97;ND3_89;ND3_4;ND3_49;ND3_21;ND3_79;ND3_29;ND3_19;ND3_44;ND3_15;ND3_112;ND3_91;ND3_35;ND3_88;ND3_89;ND3_19;ND3_44;ND3_21;ND3_107 ND3_35;ND3_18;ND3_88;ND3_8;ND3_97;ND3_89;ND3_4;ND3_49;ND3_21;ND3_79;ND3_29;ND3_19;ND3_44;ND3_15;ND3_112;ND3_91;ND3_35;ND3_88;ND3_89;ND3_19;ND3_44;ND3_21;ND3_107
Covariation Score IntraP mfDCA_24.6929;cMI_18.130184;mfDCA_22.1031;cMI_15.679218;cMI_15.674643;mfDCA_18.5493;cMI_15.140093;cMI_12.779061;mfDCA_16.7255;cMI_12.428753;cMI_12.024128;mfDCA_18.0094;mfDCA_17.102;cMI_10.232872;cMI_10.168221;cMI_9.709738;mfDCA_24.6929;mfDCA_22.1031;mfDCA_18.5493;mfDCA_18.0094;mfDCA_17.102;mfDCA_16.7255;mfDCA_15.438 mfDCA_24.6929;cMI_18.130184;mfDCA_22.1031;cMI_15.679218;cMI_15.674643;mfDCA_18.5493;cMI_15.140093;cMI_12.779061;mfDCA_16.7255;cMI_12.428753;cMI_12.024128;mfDCA_18.0094;mfDCA_17.102;cMI_10.232872;cMI_10.168221;cMI_9.709738;mfDCA_24.6929;mfDCA_22.1031;mfDCA_18.5493;mfDCA_18.0094;mfDCA_17.102;mfDCA_16.7255;mfDCA_15.438 mfDCA_24.6929;cMI_18.130184;mfDCA_22.1031;cMI_15.679218;cMI_15.674643;mfDCA_18.5493;cMI_15.140093;cMI_12.779061;mfDCA_16.7255;cMI_12.428753;cMI_12.024128;mfDCA_18.0094;mfDCA_17.102;cMI_10.232872;cMI_10.168221;cMI_9.709738;mfDCA_24.6929;mfDCA_22.1031;mfDCA_18.5493;mfDCA_18.0094;mfDCA_17.102;mfDCA_16.7255;mfDCA_15.438 mfDCA_24.6929;cMI_18.130184;mfDCA_22.1031;cMI_15.679218;cMI_15.674643;mfDCA_18.5493;cMI_15.140093;cMI_12.779061;mfDCA_16.7255;cMI_12.428753;cMI_12.024128;mfDCA_18.0094;mfDCA_17.102;cMI_10.232872;cMI_10.168221;cMI_9.709738;mfDCA_24.6929;mfDCA_22.1031;mfDCA_18.5493;mfDCA_18.0094;mfDCA_17.102;mfDCA_16.7255;mfDCA_15.438 mfDCA_24.6929;cMI_18.130184;mfDCA_22.1031;cMI_15.679218;cMI_15.674643;mfDCA_18.5493;cMI_15.140093;cMI_12.779061;mfDCA_16.7255;cMI_12.428753;cMI_12.024128;mfDCA_18.0094;mfDCA_17.102;cMI_10.232872;cMI_10.168221;cMI_9.709738;mfDCA_24.6929;mfDCA_22.1031;mfDCA_18.5493;mfDCA_18.0094;mfDCA_17.102;mfDCA_16.7255;mfDCA_15.438 mfDCA_24.6929;cMI_18.130184;mfDCA_22.1031;cMI_15.679218;cMI_15.674643;mfDCA_18.5493;cMI_15.140093;cMI_12.779061;mfDCA_16.7255;cMI_12.428753;cMI_12.024128;mfDCA_18.0094;mfDCA_17.102;cMI_10.232872;cMI_10.168221;cMI_9.709738;mfDCA_24.6929;mfDCA_22.1031;mfDCA_18.5493;mfDCA_18.0094;mfDCA_17.102;mfDCA_16.7255;mfDCA_15.438
CPD AA ref . . . . . .
CPD AA alt . . . . . .
CPD Aln pos . . . . . .
CPD Species name . . . . . .
CPD RefSeq Protein ID . . . . . .
CPD Ncbi Taxon id . . . . . .
DDG intra MT-ND3:S45A:L107Q:1.86944:0.898719:0.964638;MT-ND3:S45A:L107V:2.4996:0.898719:1.58272;MT-ND3:S45A:L107M:0.715066:0.898719:-0.186263;MT-ND3:S45A:L107P:5.69195:0.898719:4.56316;MT-ND3:S45A:L107R:1.54806:0.898719:0.654602;MT-ND3:S45A:D112N:0.927985:0.898719:-0.0131052;MT-ND3:S45A:D112Y:0.523376:0.898719:-0.433469;MT-ND3:S45A:D112A:0.520717:0.898719:-0.418179;MT-ND3:S45A:D112G:1.3301:0.898719:0.414236;MT-ND3:S45A:D112E:0.712251:0.898719:-0.258161;MT-ND3:S45A:D112H:1.01463:0.898719:0.0340833;MT-ND3:S45A:D112V:1.12683:0.898719:0.179616;MT-ND3:S45A:V49G:1.91344:0.898719:0.888794;MT-ND3:S45A:V49A:1.18917:0.898719:0.193963;MT-ND3:S45A:V49I:1.04652:0.898719:-0.482548;MT-ND3:S45A:V49D:0.361223:0.898719:-0.607087;MT-ND3:S45A:V49F:0.363601:0.898719:-0.639481;MT-ND3:S45A:V49L:0.656181:0.898719:-0.289594;MT-ND3:S45A:L79Q:1.61103:0.898719:0.615227;MT-ND3:S45A:L79M:0.765146:0.898719:-0.174798;MT-ND3:S45A:L79P:4.64388:0.898719:3.64483;MT-ND3:S45A:L79V:2.59329:0.898719:1.69291;MT-ND3:S45A:L79R:1.91579:0.898719:1.00907;MT-ND3:S45A:G29R:1.02808:0.898719:0.0789448;MT-ND3:S45A:G29S:0.984365:0.898719:0.061955;MT-ND3:S45A:G29C:1.2321:0.898719:0.290877;MT-ND3:S45A:G29D:1.16518:0.898719:0.254493;MT-ND3:S45A:G29V:1.44128:0.898719:0.518345;MT-ND3:S45A:G29A:1.08002:0.898719:0.171581;MT-ND3:S45A:T35I:0.400209:0.898719:-0.515883;MT-ND3:S45A:T35P:1.37802:0.898719:0.442305;MT-ND3:S45A:T35S:1.32111:0.898719:0.233842;MT-ND3:S45A:T35N:1.22877:0.898719:0.309927;MT-ND3:S45A:T35A:1.00227:0.898719:0.0855016;MT-ND3:S45A:M44L:1.1635:0.898719:0.360285;MT-ND3:S45A:M44I:1.172:0.898719:0.322536;MT-ND3:S45A:M44K:1.1209:0.898719:0.331748;MT-ND3:S45A:M44V:1.30387:0.898719:0.489564;MT-ND3:S45A:M44T:1.30656:0.898719:0.4131;MT-ND3:S45A:A4D:1.05147:0.898719:0.190562;MT-ND3:S45A:A4P:-0.509629:0.898719:-1.526;MT-ND3:S45A:A4G:2.00368:0.898719:1.08914;MT-ND3:S45A:A4S:1.82332:0.898719:0.901348;MT-ND3:S45A:A4V:1.29706:0.898719:0.176529;MT-ND3:S45A:A4T:2.66952:0.898719:1.29799 MT-ND3:S45T:L107M:-0.381736:-0.193334:-0.186263;MT-ND3:S45T:L107R:0.471732:-0.193334:0.654602;MT-ND3:S45T:L107P:4.50682:-0.193334:4.56316;MT-ND3:S45T:L107V:1.38096:-0.193334:1.58272;MT-ND3:S45T:L107Q:0.786723:-0.193334:0.964638;MT-ND3:S45T:D112V:-0.0198059:-0.193334:0.179616;MT-ND3:S45T:D112E:-0.445382:-0.193334:-0.258161;MT-ND3:S45T:D112G:0.202581:-0.193334:0.414236;MT-ND3:S45T:D112A:-0.626307:-0.193334:-0.418179;MT-ND3:S45T:D112Y:-0.636864:-0.193334:-0.433469;MT-ND3:S45T:D112N:-0.201313:-0.193334:-0.0131052;MT-ND3:S45T:D112H:-0.145536:-0.193334:0.0340833;MT-ND3:S45T:V49F:-0.827647:-0.193334:-0.639481;MT-ND3:S45T:V49D:-0.82733:-0.193334:-0.607087;MT-ND3:S45T:V49L:-0.356219:-0.193334:-0.289594;MT-ND3:S45T:V49G:0.795547:-0.193334:0.888794;MT-ND3:S45T:V49I:-0.547249:-0.193334:-0.482548;MT-ND3:S45T:V49A:0.303211:-0.193334:0.193963;MT-ND3:S45T:L79P:3.45752:-0.193334:3.64483;MT-ND3:S45T:L79M:-0.355915:-0.193334:-0.174798;MT-ND3:S45T:L79Q:0.443294:-0.193334:0.615227;MT-ND3:S45T:L79V:1.49783:-0.193334:1.69291;MT-ND3:S45T:L79R:0.819644:-0.193334:1.00907;MT-ND3:S45T:G29C:0.100006:-0.193334:0.290877;MT-ND3:S45T:G29D:0.0640916:-0.193334:0.254493;MT-ND3:S45T:G29S:-0.130535:-0.193334:0.061955;MT-ND3:S45T:G29A:-0.0189741:-0.193334:0.171581;MT-ND3:S45T:G29R:-0.103894:-0.193334:0.0789448;MT-ND3:S45T:G29V:0.325636:-0.193334:0.518345;MT-ND3:S45T:T35A:-0.102041:-0.193334:0.0855016;MT-ND3:S45T:T35S:0.0445892:-0.193334:0.233842;MT-ND3:S45T:T35N:0.146617:-0.193334:0.309927;MT-ND3:S45T:T35P:0.248048:-0.193334:0.442305;MT-ND3:S45T:T35I:-0.708227:-0.193334:-0.515883;MT-ND3:S45T:M44K:0.114574:-0.193334:0.331748;MT-ND3:S45T:M44T:0.268254:-0.193334:0.4131;MT-ND3:S45T:M44V:0.340112:-0.193334:0.489564;MT-ND3:S45T:M44I:0.140842:-0.193334:0.322536;MT-ND3:S45T:M44L:0.0106605:-0.193334:0.360285;MT-ND3:S45T:A4S:0.708495:-0.193334:0.901348;MT-ND3:S45T:A4G:0.900125:-0.193334:1.08914;MT-ND3:S45T:A4P:-1.64918:-0.193334:-1.526;MT-ND3:S45T:A4D:0.0231006:-0.193334:0.190562;MT-ND3:S45T:A4V:-0.0981623:-0.193334:0.176529;MT-ND3:S45T:A4T:1.44737:-0.193334:1.29799 MT-ND3:S45P:L107Q:5.1219:4.1339:0.964638;MT-ND3:S45P:L107R:4.80834:4.1339:0.654602;MT-ND3:S45P:L107P:8.85061:4.1339:4.56316;MT-ND3:S45P:L107V:5.75541:4.1339:1.58272;MT-ND3:S45P:L107M:3.93827:4.1339:-0.186263;MT-ND3:S45P:D112H:4.20228:4.1339:0.0340833;MT-ND3:S45P:D112Y:3.77103:4.1339:-0.433469;MT-ND3:S45P:D112N:4.16016:4.1339:-0.0131052;MT-ND3:S45P:D112E:3.96989:4.1339:-0.258161;MT-ND3:S45P:D112G:4.55127:4.1339:0.414236;MT-ND3:S45P:D112V:4.3272:4.1339:0.179616;MT-ND3:S45P:D112A:3.66153:4.1339:-0.418179;MT-ND3:S45P:V49G:5.06697:4.1339:0.888794;MT-ND3:S45P:V49A:4.39278:4.1339:0.193963;MT-ND3:S45P:V49L:3.81485:4.1339:-0.289594;MT-ND3:S45P:V49D:3.5169:4.1339:-0.607087;MT-ND3:S45P:V49F:3.48098:4.1339:-0.639481;MT-ND3:S45P:V49I:4.28611:4.1339:-0.482548;MT-ND3:S45P:L79Q:4.85566:4.1339:0.615227;MT-ND3:S45P:L79R:5.1586:4.1339:1.00907;MT-ND3:S45P:L79M:3.98456:4.1339:-0.174798;MT-ND3:S45P:L79V:5.84676:4.1339:1.69291;MT-ND3:S45P:L79P:7.80779:4.1339:3.64483;MT-ND3:S45P:G29D:4.40541:4.1339:0.254493;MT-ND3:S45P:G29A:4.25797:4.1339:0.171581;MT-ND3:S45P:G29C:4.43954:4.1339:0.290877;MT-ND3:S45P:G29S:4.20152:4.1339:0.061955;MT-ND3:S45P:G29V:4.69077:4.1339:0.518345;MT-ND3:S45P:G29R:4.21889:4.1339:0.0789448;MT-ND3:S45P:T35A:4.19861:4.1339:0.0855016;MT-ND3:S45P:T35N:4.46139:4.1339:0.309927;MT-ND3:S45P:T35S:4.57446:4.1339:0.233842;MT-ND3:S45P:T35P:4.57535:4.1339:0.442305;MT-ND3:S45P:T35I:3.60392:4.1339:-0.515883;MT-ND3:S45P:M44T:4.71464:4.1339:0.4131;MT-ND3:S45P:M44K:4.25508:4.1339:0.331748;MT-ND3:S45P:M44I:4.34348:4.1339:0.322536;MT-ND3:S45P:M44V:4.66005:4.1339:0.489564;MT-ND3:S45P:M44L:4.29145:4.1339:0.360285;MT-ND3:S45P:A4P:2.705:4.1339:-1.526;MT-ND3:S45P:A4S:5.07628:4.1339:0.901348;MT-ND3:S45P:A4G:5.18293:4.1339:1.08914;MT-ND3:S45P:A4V:4.28057:4.1339:0.176529;MT-ND3:S45P:A4D:4.33837:4.1339:0.190562;MT-ND3:S45P:A4T:5.51494:4.1339:1.29799 MT-ND3:S45C:L107P:5.50999:0.826151:4.56316;MT-ND3:S45C:L107M:0.6183:0.826151:-0.186263;MT-ND3:S45C:L107V:2.39813:0.826151:1.58272;MT-ND3:S45C:L107R:1.48454:0.826151:0.654602;MT-ND3:S45C:L107Q:1.73148:0.826151:0.964638;MT-ND3:S45C:D112Y:0.398607:0.826151:-0.433469;MT-ND3:S45C:D112E:0.546487:0.826151:-0.258161;MT-ND3:S45C:D112G:1.22005:0.826151:0.414236;MT-ND3:S45C:D112N:0.783482:0.826151:-0.0131052;MT-ND3:S45C:D112H:0.866113:0.826151:0.0340833;MT-ND3:S45C:D112A:0.3159:0.826151:-0.418179;MT-ND3:S45C:D112V:1.01008:0.826151:0.179616;MT-ND3:S45C:V49D:0.313673:0.826151:-0.607087;MT-ND3:S45C:V49G:1.84501:0.826151:0.888794;MT-ND3:S45C:V49A:1.14598:0.826151:0.193963;MT-ND3:S45C:V49L:0.552329:0.826151:-0.289594;MT-ND3:S45C:V49F:0.324433:0.826151:-0.639481;MT-ND3:S45C:V49I:0.920002:0.826151:-0.482548;MT-ND3:S45C:L79V:2.50222:0.826151:1.69291;MT-ND3:S45C:L79R:1.70268:0.826151:1.00907;MT-ND3:S45C:L79P:4.53785:0.826151:3.64483;MT-ND3:S45C:L79M:0.653034:0.826151:-0.174798;MT-ND3:S45C:L79Q:1.46177:0.826151:0.615227;MT-ND3:S45C:G29D:1.01752:0.826151:0.254493;MT-ND3:S45C:G29S:0.916085:0.826151:0.061955;MT-ND3:S45C:G29C:1.13128:0.826151:0.290877;MT-ND3:S45C:G29A:0.98033:0.826151:0.171581;MT-ND3:S45C:G29R:0.789326:0.826151:0.0789448;MT-ND3:S45C:G29V:1.34477:0.826151:0.518345;MT-ND3:S45C:T35S:1.25284:0.826151:0.233842;MT-ND3:S45C:T35P:1.29424:0.826151:0.442305;MT-ND3:S45C:T35N:1.15791:0.826151:0.309927;MT-ND3:S45C:T35A:0.893042:0.826151:0.0855016;MT-ND3:S45C:T35I:0.284032:0.826151:-0.515883;MT-ND3:S45C:M44T:1.22718:0.826151:0.4131;MT-ND3:S45C:M44L:1.00458:0.826151:0.360285;MT-ND3:S45C:M44K:1.03591:0.826151:0.331748;MT-ND3:S45C:M44I:0.999161:0.826151:0.322536;MT-ND3:S45C:M44V:1.22112:0.826151:0.489564;MT-ND3:S45C:A4G:1.86863:0.826151:1.08914;MT-ND3:S45C:A4D:0.997836:0.826151:0.190562;MT-ND3:S45C:A4S:1.7267:0.826151:0.901348;MT-ND3:S45C:A4T:2.06432:0.826151:1.29799;MT-ND3:S45C:A4V:1.26122:0.826151:0.176529;MT-ND3:S45C:A4P:-0.505855:0.826151:-1.526 MT-ND3:S45Y:L107V:2.32591:0.6055:1.58272;MT-ND3:S45Y:L107P:5.40646:0.6055:4.56316;MT-ND3:S45Y:L107M:0.50254:0.6055:-0.186263;MT-ND3:S45Y:L107Q:1.68566:0.6055:0.964638;MT-ND3:S45Y:D112G:0.975755:0.6055:0.414236;MT-ND3:S45Y:D112A:0.227884:0.6055:-0.418179;MT-ND3:S45Y:D112H:0.669175:0.6055:0.0340833;MT-ND3:S45Y:D112E:0.459912:0.6055:-0.258161;MT-ND3:S45Y:D112N:0.62202:0.6055:-0.0131052;MT-ND3:S45Y:D112V:0.84797:0.6055:0.179616;MT-ND3:S45Y:V49L:0.396099:0.6055:-0.289594;MT-ND3:S45Y:V49F:0.056688:0.6055:-0.639481;MT-ND3:S45Y:V49D:0.062921:0.6055:-0.607087;MT-ND3:S45Y:V49I:0.872843:0.6055:-0.482548;MT-ND3:S45Y:V49G:1.62741:0.6055:0.888794;MT-ND3:S45Y:L79V:2.3271:0.6055:1.69291;MT-ND3:S45Y:L79M:0.571163:0.6055:-0.174798;MT-ND3:S45Y:L79R:1.5776:0.6055:1.00907;MT-ND3:S45Y:L79P:4.30922:0.6055:3.64483;MT-ND3:S45Y:D112Y:0.270734:0.6055:-0.433469;MT-ND3:S45Y:L79Q:1.29823:0.6055:0.615227;MT-ND3:S45Y:V49A:0.9252:0.6055:0.193963;MT-ND3:S45Y:L107R:1.29055:0.6055:0.654602;MT-ND3:S45Y:G29R:0.719265:0.6055:0.0789448;MT-ND3:S45Y:G29A:0.82546:0.6055:0.171581;MT-ND3:S45Y:G29S:0.697066:0.6055:0.061955;MT-ND3:S45Y:G29V:1.14448:0.6055:0.518345;MT-ND3:S45Y:G29D:0.87644:0.6055:0.254493;MT-ND3:S45Y:T35I:0.142279:0.6055:-0.515883;MT-ND3:S45Y:T35N:0.927255:0.6055:0.309927;MT-ND3:S45Y:T35S:1.02729:0.6055:0.233842;MT-ND3:S45Y:T35P:1.00572:0.6055:0.442305;MT-ND3:S45Y:M44T:1.12536:0.6055:0.4131;MT-ND3:S45Y:M44L:0.776645:0.6055:0.360285;MT-ND3:S45Y:M44V:0.89617:0.6055:0.489564;MT-ND3:S45Y:M44K:0.808765:0.6055:0.331748;MT-ND3:S45Y:A4V:1.06032:0.6055:0.176529;MT-ND3:S45Y:A4T:1.82082:0.6055:1.29799;MT-ND3:S45Y:A4P:-0.809287:0.6055:-1.526;MT-ND3:S45Y:A4S:1.52907:0.6055:0.901348;MT-ND3:S45Y:A4G:1.76796:0.6055:1.08914;MT-ND3:S45Y:T35A:0.755983:0.6055:0.0855016;MT-ND3:S45Y:M44I:0.480335:0.6055:0.322536;MT-ND3:S45Y:A4D:0.788075:0.6055:0.190562;MT-ND3:S45Y:G29C:0.904387:0.6055:0.290877 MT-ND3:S45F:L107Q:1.49813:0.503661:0.964638;MT-ND3:S45F:L107V:2.17291:0.503661:1.58272;MT-ND3:S45F:L107M:0.271432:0.503661:-0.186263;MT-ND3:S45F:L107P:5.1301:0.503661:4.56316;MT-ND3:S45F:L107R:1.17674:0.503661:0.654602;MT-ND3:S45F:D112H:0.556441:0.503661:0.0340833;MT-ND3:S45F:D112N:0.492885:0.503661:-0.0131052;MT-ND3:S45F:D112A:0.0979919:0.503661:-0.418179;MT-ND3:S45F:D112Y:0.117732:0.503661:-0.433469;MT-ND3:S45F:D112G:0.813154:0.503661:0.414236;MT-ND3:S45F:D112E:0.348247:0.503661:-0.258161;MT-ND3:S45F:D112V:0.694058:0.503661:0.179616;MT-ND3:S45F:V49D:-0.0898759:0.503661:-0.607087;MT-ND3:S45F:V49F:-0.105163:0.503661:-0.639481;MT-ND3:S45F:V49A:0.791301:0.503661:0.193963;MT-ND3:S45F:V49I:0.785048:0.503661:-0.482548;MT-ND3:S45F:V49G:1.48081:0.503661:0.888794;MT-ND3:S45F:V49L:0.209412:0.503661:-0.289594;MT-ND3:S45F:L79V:2.08106:0.503661:1.69291;MT-ND3:S45F:L79M:0.39727:0.503661:-0.174798;MT-ND3:S45F:L79P:4.19811:0.503661:3.64483;MT-ND3:S45F:L79R:1.58043:0.503661:1.00907;MT-ND3:S45F:L79Q:1.15178:0.503661:0.615227;MT-ND3:S45F:G29D:0.777833:0.503661:0.254493;MT-ND3:S45F:G29V:0.893807:0.503661:0.518345;MT-ND3:S45F:G29S:0.558952:0.503661:0.061955;MT-ND3:S45F:G29A:0.710058:0.503661:0.171581;MT-ND3:S45F:G29R:0.637593:0.503661:0.0789448;MT-ND3:S45F:G29C:0.780297:0.503661:0.290877;MT-ND3:S45F:T35N:0.804215:0.503661:0.309927;MT-ND3:S45F:T35P:0.896665:0.503661:0.442305;MT-ND3:S45F:T35A:0.547631:0.503661:0.0855016;MT-ND3:S45F:T35I:-0.0204942:0.503661:-0.515883;MT-ND3:S45F:T35S:0.78972:0.503661:0.233842;MT-ND3:S45F:M44L:0.347368:0.503661:0.360285;MT-ND3:S45F:M44V:0.554149:0.503661:0.489564;MT-ND3:S45F:M44T:0.994677:0.503661:0.4131;MT-ND3:S45F:M44I:0.374943:0.503661:0.322536;MT-ND3:S45F:M44K:0.695619:0.503661:0.331748;MT-ND3:S45F:A4V:0.658189:0.503661:0.176529;MT-ND3:S45F:A4P:-0.934704:0.503661:-1.526;MT-ND3:S45F:A4G:1.57964:0.503661:1.08914;MT-ND3:S45F:A4T:1.65751:0.503661:1.29799;MT-ND3:S45F:A4D:0.708873:0.503661:0.190562;MT-ND3:S45F:A4S:1.27838:0.503661:0.901348
DDG intra interface MT-ND3:NDUFS2:5lc5:A:D:S45A:V49A:0.113256:-0.06109:0.155824;MT-ND3:NDUFS2:5lc5:A:D:S45A:V49D:-0.092071:-0.06109:-0.028075;MT-ND3:NDUFS2:5lc5:A:D:S45A:V49F:0.110306:-0.06109:0.166614;MT-ND3:NDUFS2:5lc5:A:D:S45A:V49G:0.078517:-0.06109:0.140612;MT-ND3:NDUFS2:5lc5:A:D:S45A:V49I:0.005306:-0.06109:0.109823;MT-ND3:NDUFS2:5lc5:A:D:S45A:V49L:0.141731:-0.06109:0.185479;MT-ND3:MT-ND1:5lc5:A:H:S45A:L15F:0.49613:-0.08371:0.77833;MT-ND3:MT-ND1:5lc5:A:H:S45A:L15M:0.03655:-0.08371:0.1131;MT-ND3:MT-ND1:5lc5:A:H:S45A:L15S:1.2181:-0.08371:1.28246;MT-ND3:MT-ND1:5lc5:A:H:S45A:L15V:0.90226:-0.08371:1.06051;MT-ND3:MT-ND1:5lc5:A:H:S45A:L15W:-0.401:-0.08371:-0.4324;MT-ND3:MT-ND1:5lc5:A:H:S45A:M18I:0.69331:-0.08376:0.66938;MT-ND3:MT-ND1:5lc5:A:H:S45A:M18K:2.4746:-0.08376:2.49572;MT-ND3:MT-ND1:5lc5:A:H:S45A:M18L:0.52276:-0.08376:0.5324;MT-ND3:MT-ND1:5lc5:A:H:S45A:M18T:2.425:-0.08376:2.4593;MT-ND3:MT-ND1:5lc5:A:H:S45A:M18V:1.27582:-0.08376:1.36914;MT-ND3:MT-ND1:5lc5:A:H:S45A:T35A:-0.10865:-0.08374:0.14765;MT-ND3:MT-ND1:5lc5:A:H:S45A:T35I:-0.16491:-0.08374:-0.06767;MT-ND3:MT-ND1:5lc5:A:H:S45A:T35N:-0.01276:-0.08374:0.1598;MT-ND3:MT-ND1:5lc5:A:H:S45A:T35P:-0.24694:-0.08374:-0.18368;MT-ND3:MT-ND1:5lc5:A:H:S45A:T35S:-0.18944:-0.08374:-0.12436;MT-ND3:MT-ND1:5lc5:A:H:S45A:M44I:-0.3684:-0.08361:-0.26598;MT-ND3:MT-ND1:5lc5:A:H:S45A:M44K:-0.36506:-0.08361:-0.29543;MT-ND3:MT-ND1:5lc5:A:H:S45A:M44L:-0.25903:-0.08361:-0.25651;MT-ND3:MT-ND1:5lc5:A:H:S45A:M44T:0.02853:-0.08361:0.06186;MT-ND3:MT-ND1:5lc5:A:H:S45A:M44V:-0.23875:-0.08361:-0.15183;MT-ND3:MT-ND1:5ldw:A:H:S45A:L15F:0.39165:-0.01562:0.16768;MT-ND3:MT-ND1:5ldw:A:H:S45A:L15M:-0.2597:-0.01562:-0.22176;MT-ND3:MT-ND1:5ldw:A:H:S45A:L15S:0.59796:-0.01562:0.71124;MT-ND3:MT-ND1:5ldw:A:H:S45A:L15V:0.31813:-0.01562:0.32203;MT-ND3:MT-ND1:5ldw:A:H:S45A:L15W:-0.1989:-0.01562:-0.12821;MT-ND3:MT-ND1:5ldw:A:H:S45A:M18I:0.57096:-0.01562:0.6076;MT-ND3:MT-ND1:5ldw:A:H:S45A:M18K:0.90714:-0.01562:1.03939;MT-ND3:MT-ND1:5ldw:A:H:S45A:M18L:0.14282:-0.01562:0.23679;MT-ND3:MT-ND1:5ldw:A:H:S45A:M18T:1.86075:-0.01562:1.85929;MT-ND3:MT-ND1:5ldw:A:H:S45A:M18V:1.04238:-0.01562:1.04567;MT-ND3:MT-ND1:5ldw:A:H:S45A:T35A:-0.37972:-0.01562:-0.39186;MT-ND3:MT-ND1:5ldw:A:H:S45A:T35I:-0.54754:-0.01562:-0.53034;MT-ND3:MT-ND1:5ldw:A:H:S45A:T35N:-0.22507:-0.01562:-0.30034;MT-ND3:MT-ND1:5ldw:A:H:S45A:T35P:-0.82443:-0.01562:-0.80325;MT-ND3:MT-ND1:5ldw:A:H:S45A:T35S:-0.3899:-0.01562:-0.19208;MT-ND3:MT-ND1:5ldw:A:H:S45A:M44I:-0.0235:-0.01562:0.00493000000002;MT-ND3:MT-ND1:5ldw:A:H:S45A:M44K:-0.0206:-0.01562:-0.10369;MT-ND3:MT-ND1:5ldw:A:H:S45A:M44L:0.3833:-0.01562:-0.10361;MT-ND3:MT-ND1:5ldw:A:H:S45A:M44T:0.00764000000001:-0.01562:0.01395;MT-ND3:MT-ND1:5ldw:A:H:S45A:M44V:0.005:-0.01562:0.0288;MT-ND3:MT-ND1:5ldx:A:H:S45A:L15F:1.09525:0.55252:0.54581;MT-ND3:MT-ND1:5ldx:A:H:S45A:L15M:0.32118:0.55252:-0.21274;MT-ND3:MT-ND1:5ldx:A:H:S45A:L15S:1.19836:0.55252:0.64412;MT-ND3:MT-ND1:5ldx:A:H:S45A:L15V:1.03343:0.55252:0.48811;MT-ND3:MT-ND1:5ldx:A:H:S45A:L15W:0.29914:0.55252:-0.23467;MT-ND3:MT-ND1:5ldx:A:H:S45A:M18I:1.27372:0.55324:0.65117;MT-ND3:MT-ND1:5ldx:A:H:S45A:M18K:1.72475:0.55324:1.20633;MT-ND3:MT-ND1:5ldx:A:H:S45A:M18L:0.91957:0.55324:0.49592;MT-ND3:MT-ND1:5ldx:A:H:S45A:M18T:2.35463:0.55324:1.70221;MT-ND3:MT-ND1:5ldx:A:H:S45A:M18V:1.61699:0.55324:1.12518;MT-ND3:MT-ND1:5ldx:A:H:S45A:T35A:0.24389:0.54952:-0.28604;MT-ND3:MT-ND1:5ldx:A:H:S45A:T35I:0.02464:0.54952:-0.5748;MT-ND3:MT-ND1:5ldx:A:H:S45A:T35N:0.32055:0.54952:-0.12195;MT-ND3:MT-ND1:5ldx:A:H:S45A:T35P:-0.32351:0.54952:-0.88659;MT-ND3:MT-ND1:5ldx:A:H:S45A:T35S:0.31074:0.54952:-0.18413;MT-ND3:MT-ND1:5ldx:A:H:S45A:M44I:0.79949:0.55324:-0.03478;MT-ND3:MT-ND1:5ldx:A:H:S45A:M44K:0.58783:0.55324:-0.07642;MT-ND3:MT-ND1:5ldx:A:H:S45A:M44L:0.92142:0.55324:-0.07877;MT-ND3:MT-ND1:5ldx:A:H:S45A:M44T:0.62619:0.55324:0.03867;MT-ND3:MT-ND1:5ldx:A:H:S45A:M44V:0.94888:0.55324:0.04435 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MT-ND3:NDUFS2:5lc5:A:D:S45F:V49A:-1.2844962:-1.1369547:0.155824;MT-ND3:NDUFS2:5lc5:A:D:S45F:V49D:-1.5460474:-1.1369547:-0.028075;MT-ND3:NDUFS2:5lc5:A:D:S45F:V49F:-1.2483167:-1.1369547:0.166614;MT-ND3:NDUFS2:5lc5:A:D:S45F:V49G:-1.0306:-1.1369547:0.140612;MT-ND3:NDUFS2:5lc5:A:D:S45F:V49I:-1.4003141:-1.1369547:0.109823;MT-ND3:NDUFS2:5lc5:A:D:S45F:V49L:-1.2673499:-1.1369547:0.185479;MT-ND3:MT-ND1:5lc5:A:H:S45F:L15F:0.36638:-0.27181:0.77833;MT-ND3:MT-ND1:5lc5:A:H:S45F:L15M:-0.18265:-0.27181:0.1131;MT-ND3:MT-ND1:5lc5:A:H:S45F:L15S:1.11228:-0.27181:1.28246;MT-ND3:MT-ND1:5lc5:A:H:S45F:L15V:0.77572:-0.27181:1.06051;MT-ND3:MT-ND1:5lc5:A:H:S45F:L15W:-0.50368:-0.27181:-0.4324;MT-ND3:MT-ND1:5lc5:A:H:S45F:M18I:0.49106:-0.27178:0.66938;MT-ND3:MT-ND1:5lc5:A:H:S45F:M18K:2.2519:-0.27178:2.49572;MT-ND3:MT-ND1:5lc5:A:H:S45F:M18L:0.31462:-0.27178:0.5324;MT-ND3:MT-ND1:5lc5:A:H:S45F:M18T:2.24102:-0.27178:2.4593;MT-ND3:MT-ND1:5lc5:A:H:S45F:M18V:1.10345:-0.27178:1.36914;MT-ND3:MT-ND1:5lc5:A:H:S45F:T35A:-0.12098:-0.27365:0.14765;MT-ND3:MT-ND1:5lc5:A:H:S45F:T35I:-0.25428:-0.27365:-0.06767;MT-ND3:MT-ND1:5lc5:A:H:S45F:T35N:-0.04763:-0.27365:0.1598;MT-ND3:MT-ND1:5lc5:A:H:S45F:T35P:-0.42:-0.27365:-0.18368;MT-ND3:MT-ND1:5lc5:A:H:S45F:T35S:-0.37544:-0.27365:-0.12436;MT-ND3:MT-ND1:5lc5:A:H:S45F:M44I:-0.4842:-0.26155:-0.26598;MT-ND3:MT-ND1:5lc5:A:H:S45F:M44K:-0.39465:-0.26155:-0.29543;MT-ND3:MT-ND1:5lc5:A:H:S45F:M44L:-0.34863:-0.26155:-0.25651;MT-ND3:MT-ND1:5lc5:A:H:S45F:M44T:-0.11156:-0.26155:0.06186;MT-ND3:MT-ND1:5lc5:A:H:S45F:M44V:-0.30967:-0.26155:-0.15183;MT-ND3:MT-ND1:5ldw:A:H:S45F:L15F:0.49933:0.01284:0.16768;MT-ND3:MT-ND1:5ldw:A:H:S45F:L15M:-0.32746:0.01284:-0.22176;MT-ND3:MT-ND1:5ldw:A:H:S45F:L15S:0.66074:0.01284:0.71124;MT-ND3:MT-ND1:5ldw:A:H:S45F:L15V:0.36578:0.01284:0.32203;MT-ND3:MT-ND1:5ldw:A:H:S45F:L15W:-0.09059:0.01284:-0.12821;MT-ND3:MT-ND1:5ldw:A:H:S45F:M18I:0.85928:0.01343:0.6076;MT-ND3:MT-ND1:5ldw:A:H:S45F:M18K:0.73576:0.01343:1.03939;MT-ND3:MT-ND1:5ldw:A:H:S45F:M18L:0.43312:0.01343:0.23679;MT-ND3:MT-ND1:5ldw:A:H:S45F:M18T:1.96731:0.01343:1.85929;MT-ND3:MT-ND1:5ldw:A:H:S45F:M18V:1.24718:0.01343:1.04567;MT-ND3:MT-ND1:5ldw:A:H:S45F:T35A:-0.39977:0.10391:-0.39186;MT-ND3:MT-ND1:5ldw:A:H:S45F:T35I:-0.50429:0.10391:-0.53034;MT-ND3:MT-ND1:5ldw:A:H:S45F:T35N:-0.30707:0.10391:-0.30034;MT-ND3:MT-ND1:5ldw:A:H:S45F:T35P:-0.93427:0.10391:-0.80325;MT-ND3:MT-ND1:5ldw:A:H:S45F:T35S:-0.36963:0.10391:-0.19208;MT-ND3:MT-ND1:5ldw:A:H:S45F:M44I:-0.1464:0.07069:0.00493000000002;MT-ND3:MT-ND1:5ldw:A:H:S45F:M44K:0.08844:0.07069:-0.10369;MT-ND3:MT-ND1:5ldw:A:H:S45F:M44L:0.11065:0.07069:-0.10361;MT-ND3:MT-ND1:5ldw:A:H:S45F:M44T:0.29087:0.07069:0.01395;MT-ND3:MT-ND1:5ldw:A:H:S45F:M44V:-0.15865:0.07069:0.0288;MT-ND3:MT-ND1:5ldx:A:H:S45F:L15F:1.05745:0.50513:0.54581;MT-ND3:MT-ND1:5ldx:A:H:S45F:L15M:0.22456:0.50513:-0.21274;MT-ND3:MT-ND1:5ldx:A:H:S45F:L15S:1.1544:0.50513:0.64412;MT-ND3:MT-ND1:5ldx:A:H:S45F:L15V:0.99582:0.50513:0.48811;MT-ND3:MT-ND1:5ldx:A:H:S45F:L15W:0.27385:0.50513:-0.23467;MT-ND3:MT-ND1:5ldx:A:H:S45F:M18I:1.16602:0.50899:0.65117;MT-ND3:MT-ND1:5ldx:A:H:S45F:M18K:1.70963:0.50899:1.20633;MT-ND3:MT-ND1:5ldx:A:H:S45F:M18L:0.91289:0.50899:0.49592;MT-ND3:MT-ND1:5ldx:A:H:S45F:M18T:2.30901:0.50899:1.70221;MT-ND3:MT-ND1:5ldx:A:H:S45F:M18V:1.52245:0.50899:1.12518;MT-ND3:MT-ND1:5ldx:A:H:S45F:T35A:0.20521:0.50768:-0.28604;MT-ND3:MT-ND1:5ldx:A:H:S45F:T35I:-0.0618:0.50768:-0.5748;MT-ND3:MT-ND1:5ldx:A:H:S45F:T35N:0.27494:0.50768:-0.12195;MT-ND3:MT-ND1:5ldx:A:H:S45F:T35P:-0.35732:0.50768:-0.88659;MT-ND3:MT-ND1:5ldx:A:H:S45F:T35S:0.26535:0.50768:-0.18413;MT-ND3:MT-ND1:5ldx:A:H:S45F:M44I:0.85083:0.5088:-0.03478;MT-ND3:MT-ND1:5ldx:A:H:S45F:M44K:0.51116:0.5088:-0.07642;MT-ND3:MT-ND1:5ldx:A:H:S45F:M44L:0.87592:0.5088:-0.07877;MT-ND3:MT-ND1:5ldx:A:H:S45F:M44T:0.58676:0.5088:0.03867;MT-ND3:MT-ND1:5ldx:A:H:S45F:M44V:0.90803:0.5088:0.04435
DDG inter 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MT-ND3:MT-ND1:5lc5:A:H:S45F:A64V:-0.02833:-0.184449762:0.204209521;MT-ND3:MT-ND1:5lc5:A:H:S45F:A64D:-0.24595:-0.184449762:0.00521049509;MT-ND3:MT-ND1:5lc5:A:H:S45F:A64T:-0.01885:-0.184449762:0.20746994;MT-ND3:MT-ND1:5lc5:A:H:S45F:A64S:-0.23046:-0.184449762:-0.015329361;MT-ND3:MT-ND1:5lc5:A:H:S45F:A64G:-0.51142:-0.184449762:-0.339129269;MT-ND3:MT-ND1:5lc5:A:H:S45F:A64P:3.22824:-0.184449762:3.39117956;MT-ND3:MT-ND1:5lc5:A:H:S45F:K62E:0.35208:-0.184449762:0.412649542;MT-ND3:MT-ND1:5lc5:A:H:S45F:K62Q:-0.52595:-0.184449762:-0.241339117;MT-ND3:MT-ND1:5lc5:A:H:S45F:K62N:0.5255:-0.184449762:0.846379876;MT-ND3:MT-ND1:5lc5:A:H:S45F:K62M:-0.40484:-0.184449762:-0.217529684;MT-ND3:MT-ND1:5lc5:A:H:S45F:K62T:0.4885:-0.184449762:0.832580209;MT-ND3:MT-ND1:5lc5:A:H:S45F:N126K:0.31403:-0.184449762:0.553079605;MT-ND3:MT-ND1:5lc5:A:H:S45F:N126H:0.77368:-0.184449762:0.694760144;MT-ND3:MT-ND1:5lc5:A:H:S45F:N126I:0.09066:-0.184449762:0.053360749;MT-ND3:MT-ND1:5lc5:A:H:S45F:N126T:0.80873:-0.184449762:0.124269105;MT-ND3:MT-ND1:5lc5:A:H:S45F:N126Y:0.74714:-0.184449762:0.641970038;MT-ND3:MT-ND1:5lc5:A:H:S45F:N126S:0.27624:-0.184449762:0.245739743;MT-ND3:MT-ND1:5lc5:A:H:S45F:N126D:1.72617:-0.184449762:1.59534991;MT-ND3:MT-ND1:5ldw:A:H:S45F:A64V:0.27776:0.122009657:0.0742809325;MT-ND3:MT-ND1:5ldw:A:H:S45F:A64D:-0.10511:0.122009657:0.016371537;MT-ND3:MT-ND1:5ldw:A:H:S45F:A64T:0.05697:0.122009657:0.10172081;MT-ND3:MT-ND1:5ldw:A:H:S45F:A64S:0.01067:0.122009657:-0.00129890442;MT-ND3:MT-ND1:5ldw:A:H:S45F:A64G:-0.1581:0.122009657:-0.290697873;MT-ND3:MT-ND1:5ldw:A:H:S45F:A64P:2.22822:0.122009657:1.89254951;MT-ND3:MT-ND1:5ldw:A:H:S45F:K62E:0.36466:0.122009657:0.301341236;MT-ND3:MT-ND1:5ldw:A:H:S45F:K62Q:-0.08954:0.122009657:-0.0290084835;MT-ND3:MT-ND1:5ldw:A:H:S45F:K62N:0.64931:0.122009657:0.465351105;MT-ND3:MT-ND1:5ldw:A:H:S45F:K62M:0.10054:0.122009657:-0.012728882;MT-ND3:MT-ND1:5ldw:A:H:S45F:K62T:0.56165:0.122009657:0.183251187;MT-ND3:MT-ND1:5ldw:A:H:S45F:N126K:0.68767:0.122009657:-0.182450861;MT-ND3:MT-ND1:5ldw:A:H:S45F:N126H:0.33766:0.122009657:0.233639911;MT-ND3:MT-ND1:5ldw:A:H:S45F:N126I:0.37357:0.122009657:0.457019031;MT-ND3:MT-ND1:5ldw:A:H:S45F:N126T:-0.2508:0.122009657:-0.612128854;MT-ND3:MT-ND1:5ldw:A:H:S45F:N126Y:0.15736:0.122009657:0.15291062;MT-ND3:MT-ND1:5ldw:A:H:S45F:N126S:-0.11969:0.122009657:-0.494969934;MT-ND3:MT-ND1:5ldw:A:H:S45F:N126D:1.20761:0.122009657:0.906030297;MT-ND3:MT-ND1:5ldx:A:H:S45F:A64V:0.50438:0.507999063:-0.00509109488;MT-ND3:MT-ND1:5ldx:A:H:S45F:A64D:0.49689:0.507999063:-0.0113109592;MT-ND3:MT-ND1:5ldx:A:H:S45F:A64T:0.62142:0.507999063:0.107588194;MT-ND3:MT-ND1:5ldx:A:H:S45F:A64S:0.50879:0.507999063:-0.00452117901;MT-ND3:MT-ND1:5ldx:A:H:S45F:A64G:0.18506:0.507999063:-0.325099945;MT-ND3:MT-ND1:5ldx:A:H:S45F:A64P:3.71931:0.507999063:3.81227994;MT-ND3:MT-ND1:5ldx:A:H:S45F:K62E:1.10355:0.507999063:0.575948715;MT-ND3:MT-ND1:5ldx:A:H:S45F:K62Q:0.54544:0.507999063:0.0151092531;MT-ND3:MT-ND1:5ldx:A:H:S45F:K62N:0.97663:0.507999063:0.452788532;MT-ND3:MT-ND1:5ldx:A:H:S45F:K62M:0.58069:0.507999063:0.0504192337;MT-ND3:MT-ND1:5ldx:A:H:S45F:K62T:0.42017:0.507999063:0.109650038;MT-ND3:MT-ND1:5ldx:A:H:S45F:N126K:1.08193:0.507999063:0.152239606;MT-ND3:MT-ND1:5ldx:A:H:S45F:N126H:1.21576:0.507999063:0.557869315;MT-ND3:MT-ND1:5ldx:A:H:S45F:N126I:0.9564:0.507999063:0.753100991;MT-ND3:MT-ND1:5ldx:A:H:S45F:N126T:0.32723:0.507999063:-0.200669855;MT-ND3:MT-ND1:5ldx:A:H:S45F:N126Y:0.16075:0.507999063:0.512129188;MT-ND3:MT-ND1:5ldx:A:H:S45F:N126S:0.43571:0.507999063:-0.153670117;MT-ND3:MT-ND1:5ldx:A:H:S45F:N126D:1.80101:0.507999063:1.31459963
For more info, please check the output legend.
ΔΔG values >±0.61 Kcal/mol are indicative of disrupting variants.
ΔΔG values close to zero (<±0.1 Kcal/mol) are indicative of possibly
compensating double mutants.
For more info, please check the output legend.
ΔΔG values >±0.61 Kcal/mol are indicative of disrupting variants.
ΔΔG values close to zero (<±0.1 Kcal/mol) are indicative of possibly
compensating double mutants.
For more info, please check the output legend.
ΔΔG values >±0.61 Kcal/mol are indicative of disrupting variants.
ΔΔG values close to zero (<±0.1 Kcal/mol) are indicative of possibly
compensating double mutants.
For more info, please check the output legend.
For more info, please check the output legend.
Score:  
0
  [min -20, max 10]
  • Predicted accelerated evolution:  score <= 0
  • Conserved:  score > 0
Score:  
0
  [min 0, max 1]
  • Non-conserved:  score <= 0.9
  • Conserved:  score > 0.9 (soft threshold)
Score:  
0
  [min 0, max 1]
  • Neutral:  score <= 0.15
  • Possibly damaging:  0.15 < score <= 0.85
  • Probably damaging:  score > 0.85
Score:  
0
  [min 0, max 1]
  • Neutral:  score > 0.05
  • Deleterious:  score <= 0.05
Score:  
0
  [min -15, max 10]
  • Neutral:  score > -3
  • Deleterious:  score <= -3
Score:  
0
  [min -3, max 6]
  • Neutral:  score > -1.5
  • Deleterious:  score <= -1.5
Score:  
0
  [min -14, max 14]
  • Neutral:  score > -2.5
  • Deleterious:  score <= -2.5 (soft threshold)
Score:  
0
  [min -6, max 6]
  • Neutral:  score <= 0.8
  • Low impact:  0.8 < score <= 1.9
  • Medium impact:  1.9 < score <= 3.5
  • High impact:  score > 3.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score > 0.6
  • Damaging:  score <= 0.6
Score:  
0
  [min 0, max 1]
  • Neutral:  score > 0.28
  • Damaging:  score <= 0.28
Phred score:  
0
  [min 0, max 35]
  • Neutral:  score < 20 (soft threshold)
  • Deleterious:  score >= 20
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Polymorphism:  score < 0.5
  • Disease causing:  score >= 0.5
P-value:  
0
  [min 0, max 1]
  • Neutral:  p-value > 0.05
  • Pathogenic:  p-value <= 0.05
Score:  
0
  [min 0, max 1]
No hard-thresholds were indicated by authors (ref). Indicatively:
  • Neutral:  score < 0.9
  • Pathogenic:  score >= 0.9
No score. Categorical only
Please refer to Additional File 14: Table S10 for further details.
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.98
  • Deleterious:  score >= 0.98
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Deleterious:  score >= 0.5
Score:  
0
  [min -6, max 6]
  • Neutral:  score < 0
  • Deleterious:  score > 0
  • Inaccurate prediction:  score = 0
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Deleterious:  score >= 0.5
DS score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.43
  • Deleterious:  score >= 0.43
Score:  
0
  [min 0, max 1]
  • Neutral:  score <= 0.5
  • Pathogenic:  score > 0.5
Score:  
0
  [min -5, max 5]
  • Low impact:  score <= -1 (soft threshold)
  • Medium impact:  -1 < score < 1.5 (soft threshold)
  • High impact:  score >= 1.5 (soft threshold)
Score:  
0
  [min -5, max 5]
  • Low impact:  score <= -1
  • Medium impact:  -1 < score < 2 (soft threshold)
  • High impact:  score >= 2 (soft threshold)
Score:  
0
  [min -5, max 5]
  • Low impact:  score <= -1
  • Medium impact:  -1 < score < 2 (soft threshold)
  • High impact:  score >= 2 (soft threshold)
P-value:  
0
  [min 0, max 1]
  • Neutral:  FDR > 0.2
  • Driver:  FDR <= 0.2
The frequency of a CPD variant is proportional to the
number of aligned orthologous sequences that
carry a specific human pathogenic variant as
wild-type amino acid on the total number of aligned
sequences.

For more info, please check the output legend