General info

Chr
chrM
Start
10191
End
10191
Ref
T
Alt
G
Mitimpact ID
MI.15246
Gene symbol
MT-ND3
Oxphos complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
133
AA position
45
AA ref
S
AA alt
A
Codon substitution
Tcc/Gcc
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Conservation

PhyloP 100v
-0.1
PhastCons 100v
0.15

Pathogenicity predictors

PolyPhen2
Benign
PolyPhen2 score
0.09
SIFT
Neutral
SIFT score
0.79
FatHmm
Neutral
FatHmm score
-0.27
FatHMMW
Neutral
FatHMMW score
0.91
PROVEAN
Neutral
PROVEAN score
-0.84
Mutation Assessor
Medium impact
Mutation Assessor score
2.38
EFIN SP
Neutral
EFIN SP score
0.76
EFIN HD
Neutral
EFIN HD score
0.81
VEST p-value
0.3
VEST FDR
0.45
PANTHER
Neutral
PANTHER score
0.21
PhD-SNP
Neutral
PhD-SNP score
0.31
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Neutral
CADD score
1.74
CADD phred
14.63
SNAP
Disease
SNAP score
0.56
MitoClass 1
Neutral
SNPDryad score
0.1

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.11
Condel
Deleterious
Condel score
0.85
COVEC WMV
Neutral
COVEC WMV score
-3
Meta SNP
Neutral
Meta SNP score
0.4
Meta SNP RI
2
MtoolBox
Neutral
MtoolBox DS
0.15
APOGEE consensus
N
APOGEE mean p
0.35
DEOGEN score
0.33

Cancer-specific predictors

PolyPhen2 transf
Medium impact
PolyPhen2 transf score
0.19
SIFT transf
Medium impact
SIFT transf score
0.51
MutationAssessor transf
Medium impact
MutationAssessor transf score
1.07
CHASM p-value
0.35
CHASM FDR
0.8

Residue interaction

EV Mutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Frequency & Phenotype DBs

ClinVar June2018 ClinSig
.
ClinVar June2018 ClnDBN
.
ClinVar June2018 ClnAllele ID
.
ClinVar June2018 ClnDSDB
.
Mitomap Allele
.
Mitomap Phenotype
.
Mitomap Homoplasmy
.
Mitomap Heteroplasmy
.
Mitomap Status
.
Mitomap NRef
.
COSMIC 87
.
Classification Clinvar
.
Classification Mitomap
.
Classification global
.
dbSNP 151 ID

Pathogenic variants, CPD

CPD candidate
.
CPD frequency
.
CPD AA ref
.
CPD AA alt
.
CPD aln pos
.
CPD RefSeq Protein ID
.
CPD Species name
.
CPD Ncbi Taxon ID
.

General info

Chr
chrM
Start
10191
End
10191
Ref
T
Alt
A
Mitimpact ID
MI.15247
Gene symbol
MT-ND3
Oxphos complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
133
AA position
45
AA ref
S
AA alt
T
Codon substitution
Tcc/Acc
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Conservation

PhyloP 100v
-0.1
PhastCons 100v
0.15

Pathogenicity predictors

PolyPhen2
Benign
PolyPhen2 score
0.09
SIFT
Neutral
SIFT score
0.6
FatHmm
Neutral
FatHmm score
-0.75
FatHMMW
Neutral
FatHMMW score
0.9
PROVEAN
Neutral
PROVEAN score
-1.76
Mutation Assessor
Medium impact
Mutation Assessor score
2.13
EFIN SP
Damaging
EFIN SP score
0.6
EFIN HD
Neutral
EFIN HD score
0.65
VEST p-value
0.33
VEST FDR
0.5
PANTHER
Neutral
PANTHER score
0.25
PhD-SNP
Neutral
PhD-SNP score
0.35
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Deleterious
CADD score
1.82
CADD phred
15.08
SNAP
Disease
SNAP score
0.6
MitoClass 1
Neutral
SNPDryad score
0.13

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.31
Condel
Deleterious
Condel score
0.76
COVEC WMV
Neutral
COVEC WMV score
-3
Meta SNP
Neutral
Meta SNP score
0.42
Meta SNP RI
2
MtoolBox
Neutral
MtoolBox DS
0.16
APOGEE consensus
N
APOGEE mean p
0.4
DEOGEN score
0.37

Cancer-specific predictors

PolyPhen2 transf
Medium impact
PolyPhen2 transf score
0.19
SIFT transf
Medium impact
SIFT transf score
0.29
MutationAssessor transf
Medium impact
MutationAssessor transf score
0.84
CHASM p-value
0.48
CHASM FDR
0.8

Residue interaction

EV Mutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Frequency & Phenotype DBs

ClinVar June2018 ClinSig
.
ClinVar June2018 ClnDBN
.
ClinVar June2018 ClnAllele ID
.
ClinVar June2018 ClnDSDB
.
Mitomap Allele
.
Mitomap Phenotype
.
Mitomap Homoplasmy
.
Mitomap Heteroplasmy
.
Mitomap Status
.
Mitomap NRef
.
COSMIC 87
.
Classification Clinvar
.
Classification Mitomap
.
Classification global
.
dbSNP 151 ID

Pathogenic variants, CPD

CPD candidate
.
CPD frequency
.
CPD AA ref
.
CPD AA alt
.
CPD aln pos
.
CPD RefSeq Protein ID
.
CPD Species name
.
CPD Ncbi Taxon ID
.

General info

Chr
chrM
Start
10191
End
10191
Ref
T
Alt
C
Mitimpact ID
MI.15248
Gene symbol
MT-ND3
Oxphos complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
133
AA position
45
AA ref
S
AA alt
P
Codon substitution
Tcc/Ccc
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Conservation

PhyloP 100v
-0.1
PhastCons 100v
0.15

Pathogenicity predictors

PolyPhen2
Benign
PolyPhen2 score
0.43
SIFT
Neutral
SIFT score
0.3
FatHmm
Neutral
FatHmm score
-1.41
FatHMMW
Neutral
FatHMMW score
0.85
PROVEAN
Deleterious
PROVEAN score
-2.51
Mutation Assessor
Medium impact
Mutation Assessor score
2.88
EFIN SP
Damaging
EFIN SP score
0.17
EFIN HD
Neutral
EFIN HD score
0.35
VEST p-value
0.12
VEST FDR
0.4
PANTHER
Neutral
PANTHER score
0.44
PhD-SNP
Disease
PhD-SNP score
0.76
MutationTaster
Disease causing automatic
MutationTaster score
0
CADD
Deleterious
CADD score
2.31
CADD phred
18.21
SNAP
Disease
SNAP score
0.6
MitoClass 1
Neutral
SNPDryad score
0.6

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.66
Condel
Neutral
Condel score
0.44
COVEC WMV
Neutral
COVEC WMV score
-3
Meta SNP
Disease
Meta SNP score
0.69
Meta SNP RI
4
MtoolBox
Deleterious
MtoolBox DS
0.57
APOGEE consensus
P
APOGEE mean p
0.95
DEOGEN score
0.55

Cancer-specific predictors

PolyPhen2 transf
Medium impact
PolyPhen2 transf score
-0.61
SIFT transf
Medium impact
SIFT transf score
-0.01
MutationAssessor transf
Medium impact
MutationAssessor transf score
1.53
CHASM p-value
0.22
CHASM FDR
0.8

Residue interaction

EV Mutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Frequency & Phenotype DBs

ClinVar June2018 ClinSig
Pathogenic
ClinVar June2018 ClnDBN
Leigh syndrome;

mitochondrial complex i deficiency
ClinVar June2018 ClnAllele ID
24751
ClinVar June2018 ClnDSDB
Medgen:c0023264, omim:256000, orphanet:orpha506, snomed ct:29570005;

medgen:c1838979, omim:252010
Mitomap Allele
T10191c
Mitomap Phenotype
Leigh disease / leigh-like disease / esoc
Mitomap Homoplasmy
-
Mitomap Heteroplasmy
+
Mitomap Status
Cfrm
Mitomap NRef
21
COSMIC 87
.
Classification Clinvar
P
Classification Mitomap
P
Classification global
P
dbSNP 151 ID

Pathogenic variants, CPD

CPD candidate
.
CPD frequency
.
CPD AA ref
.
CPD AA alt
.
CPD aln pos
.
CPD RefSeq Protein ID
.
CPD Species name
.
CPD Ncbi Taxon ID
.

General info

Chr
chrM
Start
10192
End
10192
Ref
C
Alt
G
Mitimpact ID
MI.15249
Gene symbol
MT-ND3
Oxphos complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
134
AA position
45
AA ref
S
AA alt
C
Codon substitution
tCc/tGc
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Conservation

PhyloP 100v
3.6
PhastCons 100v
1

Pathogenicity predictors

PolyPhen2
Possibly damaging
PolyPhen2 score
0.71
SIFT
Neutral
SIFT score
0.08
FatHmm
Deleterious
FatHmm score
-4.12
FatHMMW
Neutral
FatHMMW score
0.82
PROVEAN
Deleterious
PROVEAN score
-3.36
Mutation Assessor
Medium impact
Mutation Assessor score
3.23
EFIN SP
Neutral
EFIN SP score
0.69
EFIN HD
Neutral
EFIN HD score
0.43
VEST p-value
0.11
VEST FDR
0.4
PANTHER
Disease
PANTHER score
0.63
PhD-SNP
Disease
PhD-SNP score
0.6
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Deleterious
CADD score
3.22
CADD phred
22.7
SNAP
Disease
SNAP score
0.54
MitoClass 1
Neutral
SNPDryad score
0.56

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.93
Condel
Neutral
Condel score
0.19
COVEC WMV
.
COVEC WMV score
0
Meta SNP
Disease
Meta SNP score
0.66
Meta SNP RI
3
MtoolBox
Deleterious
MtoolBox DS
0.62
APOGEE consensus
P
APOGEE mean p
0.6
DEOGEN score
0.68

Cancer-specific predictors

PolyPhen2 transf
Low impact
PolyPhen2 transf score
-1.07
SIFT transf
Medium impact
SIFT transf score
-0.4
MutationAssessor transf
Medium impact
MutationAssessor transf score
1.85
CHASM p-value
0.27
CHASM FDR
0.8

Residue interaction

EV Mutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Frequency & Phenotype DBs

ClinVar June2018 ClinSig
.
ClinVar June2018 ClnDBN
.
ClinVar June2018 ClnAllele ID
.
ClinVar June2018 ClnDSDB
.
Mitomap Allele
.
Mitomap Phenotype
.
Mitomap Homoplasmy
.
Mitomap Heteroplasmy
.
Mitomap Status
.
Mitomap NRef
.
COSMIC 87
.
Classification Clinvar
.
Classification Mitomap
.
Classification global
.
dbSNP 151 ID

Pathogenic variants, CPD

CPD candidate
.
CPD frequency
.
CPD AA ref
.
CPD AA alt
.
CPD aln pos
.
CPD RefSeq Protein ID
.
CPD Species name
.
CPD Ncbi Taxon ID
.

General info

Chr
chrM
Start
10192
End
10192
Ref
C
Alt
A
Mitimpact ID
MI.15250
Gene symbol
MT-ND3
Oxphos complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
134
AA position
45
AA ref
S
AA alt
Y
Codon substitution
tCc/tAc
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Conservation

PhyloP 100v
3.6
PhastCons 100v
1

Pathogenicity predictors

PolyPhen2
Benign
PolyPhen2 score
0
SIFT
Neutral
SIFT score
0.17
FatHmm
Neutral
FatHmm score
-2.73
FatHMMW
Neutral
FatHMMW score
0.84
PROVEAN
Deleterious
PROVEAN score
-3.39
Mutation Assessor
Medium impact
Mutation Assessor score
2.54
EFIN SP
Neutral
EFIN SP score
0.7
EFIN HD
Neutral
EFIN HD score
0.58
VEST p-value
0.09
VEST FDR
0.35
PANTHER
Neutral
PANTHER score
0.43
PhD-SNP
Disease
PhD-SNP score
0.59
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Deleterious
CADD score
2.2
CADD phred
17.48
SNAP
Disease
SNAP score
0.64
MitoClass 1
Neutral
SNPDryad score
0.06

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.83
Condel
Deleterious
Condel score
0.59
COVEC WMV
Neutral
COVEC WMV score
-3
Meta SNP
Disease
Meta SNP score
0.69
Meta SNP RI
4
MtoolBox
Neutral
MtoolBox DS
0.19
APOGEE consensus
N
APOGEE mean p
0.53
DEOGEN score
0.56

Cancer-specific predictors

PolyPhen2 transf
Medium impact
PolyPhen2 transf score
1.99
SIFT transf
Medium impact
SIFT transf score
-0.19
MutationAssessor transf
Medium impact
MutationAssessor transf score
1.22
CHASM p-value
0.2
CHASM FDR
0.8

Residue interaction

EV Mutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Frequency & Phenotype DBs

ClinVar June2018 ClinSig
.
ClinVar June2018 ClnDBN
.
ClinVar June2018 ClnAllele ID
.
ClinVar June2018 ClnDSDB
.
Mitomap Allele
.
Mitomap Phenotype
.
Mitomap Homoplasmy
.
Mitomap Heteroplasmy
.
Mitomap Status
.
Mitomap NRef
.
COSMIC 87
.
Classification Clinvar
.
Classification Mitomap
.
Classification global
.
dbSNP 151 ID

Pathogenic variants, CPD

CPD candidate
.
CPD frequency
.
CPD AA ref
.
CPD AA alt
.
CPD aln pos
.
CPD RefSeq Protein ID
.
CPD Species name
.
CPD Ncbi Taxon ID
.

General info

Chr
chrM
Start
10192
End
10192
Ref
C
Alt
T
Mitimpact ID
MI.15251
Gene symbol
MT-ND3
Oxphos complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
134
AA position
45
AA ref
S
AA alt
F
Codon substitution
tCc/tTc
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Conservation

PhyloP 100v
3.6
PhastCons 100v
1

Pathogenicity predictors

PolyPhen2
Benign
PolyPhen2 score
0
SIFT
Neutral
SIFT score
0.14
FatHmm
Deleterious
FatHmm score
-3.14
FatHMMW
Neutral
FatHMMW score
0.84
PROVEAN
Deleterious
PROVEAN score
-3.55
Mutation Assessor
Medium impact
Mutation Assessor score
2.6
EFIN SP
Neutral
EFIN SP score
0.62
EFIN HD
Neutral
EFIN HD score
0.54
VEST p-value
0.11
VEST FDR
0.4
PANTHER
Neutral
PANTHER score
0.44
PhD-SNP
Disease
PhD-SNP score
0.65
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Deleterious
CADD score
2.24
CADD phred
17.75
SNAP
Disease
SNAP score
0.62
MitoClass 1
Neutral
SNPDryad score
0.54

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.86
Condel
Deleterious
Condel score
0.57
COVEC WMV
Neutral
COVEC WMV score
-3
Meta SNP
Disease
Meta SNP score
0.7
Meta SNP RI
4
MtoolBox
Neutral
MtoolBox DS
0.21
APOGEE consensus
P
APOGEE mean p
0.55
DEOGEN score
0.63

Cancer-specific predictors

PolyPhen2 transf
Medium impact
PolyPhen2 transf score
1.99
SIFT transf
Medium impact
SIFT transf score
-0.25
MutationAssessor transf
Medium impact
MutationAssessor transf score
1.28
CHASM p-value
0.09
CHASM FDR
0.8

Residue interaction

EV Mutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Frequency & Phenotype DBs

ClinVar June2018 ClinSig
.
ClinVar June2018 ClnDBN
.
ClinVar June2018 ClnAllele ID
.
ClinVar June2018 ClnDSDB
.
Mitomap Allele
.
Mitomap Phenotype
.
Mitomap Homoplasmy
.
Mitomap Heteroplasmy
.
Mitomap Status
.
Mitomap NRef
.
COSMIC 87
.
Classification Clinvar
.
Classification Mitomap
.
Classification global
.
dbSNP 151 ID

Pathogenic variants, CPD

CPD candidate
.
CPD frequency
.
CPD AA ref
.
CPD AA alt
.
CPD aln pos
.
CPD RefSeq Protein ID
.
CPD Species name
.
CPD Ncbi Taxon ID
.
~ 10191 (T/G) 10191 (T/A) 10191 (T/C) 10192 (C/G) 10192 (C/A) 10192 (C/T)
~ 10191 (Tcc/Gcc) 10191 (Tcc/Acc) 10191 (Tcc/Ccc) 10192 (tCc/tGc) 10192 (tCc/tAc) 10192 (tCc/tTc)
Chr chrM chrM chrM chrM chrM chrM
Start 10191 10191 10191 10192 10192 10192
End 10191 10191 10191 10192 10192 10192
Ref T T T C C C
Alt G A C G A T
MitImpact id MI.15246 MI.15247 MI.15248 MI.15249 MI.15250 MI.15251
Gene symbol MT-ND3 MT-ND3 MT-ND3 MT-ND3 MT-ND3 MT-ND3
OXPHOS complex I I I I I I
Ensembl gene id ENSG00000198840 ENSG00000198840 ENSG00000198840 ENSG00000198840 ENSG00000198840 ENSG00000198840
Ensembl protein id ENSP00000355206 ENSP00000355206 ENSP00000355206 ENSP00000355206 ENSP00000355206 ENSP00000355206
Ensembl transcript id ENST00000361227 ENST00000361227 ENST00000361227 ENST00000361227 ENST00000361227 ENST00000361227
Uniprot name NU3M_HUMAN NU3M_HUMAN NU3M_HUMAN NU3M_HUMAN NU3M_HUMAN NU3M_HUMAN
Uniprot id P03897 P03897 P03897 P03897 P03897 P03897
Ncbi gene id 4537 4537 4537 4537 4537 4537
Ncbi protein id YP_003024033.1 YP_003024033.1 YP_003024033.1 YP_003024033.1 YP_003024033.1 YP_003024033.1
Gene position 133 133 133 134 134 134
AA position 45 45 45 45 45 45
AA ref S S S S S S
AA alt A T P C Y F
Codon substitution Tcc/Gcc Tcc/Acc Tcc/Ccc tCc/tGc tCc/tAc tCc/tTc
PhyloP 100V -0.1 -0.1 -0.1 3.6 3.6 3.6
PhastCons 100V 0.15 0.15 0.15 1 1 1
PolyPhen2 benign benign benign possibly_damaging benign benign
PolyPhen2 score 0.09 0.09 0.43 0.71 0 0
SIFT neutral neutral neutral neutral neutral neutral
SIFT score 0.79 0.6 0.3 0.08 0.17 0.14
FatHmm neutral neutral neutral deleterious neutral deleterious
FatHmm score -0.27 -0.75 -1.41 -4.12 -2.73 -3.14
FatHmmW neutral neutral neutral neutral neutral neutral
FatHmmW score 0.91 0.9 0.85 0.82 0.84 0.84
PROVEAN neutral neutral deleterious deleterious deleterious deleterious
PROVEAN score -0.84 -1.76 -2.51 -3.36 -3.39 -3.55
MutationAssessor medium impact medium impact medium impact medium impact medium impact medium impact
MutationAssessor score 2.38 2.13 2.88 3.23 2.54 2.6
EFIN SP neutral damaging damaging neutral neutral neutral
EFIN SP score 0.76 0.6 0.17 0.69 0.7 0.62
EFIN HD neutral neutral neutral neutral neutral neutral
EFIN HD score 0.81 0.65 0.35 0.43 0.58 0.54
CADD neutral deleterious deleterious deleterious deleterious deleterious
CADD score 1.74 1.82 2.31 3.22 2.2 2.24
CADD phred 14.63 15.08 18.21 22.7 17.48 17.75
VEST pvalue 0.3 0.33 0.12 0.11 0.09 0.11
VEST FDR 0.45 0.5 0.4 0.4 0.35 0.4
PANTHER neutral neutral neutral disease neutral neutral
PANTHER score 0.21 0.25 0.44 0.63 0.43 0.44
PhD-SNP neutral neutral disease disease disease disease
PhD-SNP score 0.31 0.35 0.76 0.6 0.59 0.65
SNAP disease disease disease disease disease disease
SNAP score 0.56 0.6 0.6 0.54 0.64 0.62
Meta-SNP neutral neutral disease disease disease disease
Meta-SNP score 0.4 0.42 0.69 0.66 0.69 0.7
Meta-SNP RI 2 2 4 3 4 4
CAROL neutral neutral neutral neutral neutral neutral
CAROL score 0.11 0.31 0.66 0.93 0.83 0.86
Condel deleterious deleterious neutral neutral deleterious deleterious
Condel score 0.85 0.76 0.44 0.19 0.59 0.57
COVEC WMV neutral neutral neutral . neutral neutral
COVEC WMV score -3 -3 -3 0 -3 -3
MtoolBox neutral neutral deleterious deleterious neutral neutral
MtoolBox DS 0.15 0.16 0.57 0.62 0.19 0.21
PolyPhen2 transf medium impact medium impact medium impact low impact medium impact medium impact
PolyPhen2 transf score 0.19 0.19 -0.61 -1.07 1.99 1.99
SIFT_transf medium impact medium impact medium impact medium impact medium impact medium impact
SIFT transf score 0.51 0.29 -0.01 -0.4 -0.19 -0.25
MutationAssessor transf medium impact medium impact medium impact medium impact medium impact medium impact
MutationAssessor transf score 1.07 0.84 1.53 1.85 1.22 1.28
CHASM pvalue 0.35 0.48 0.22 0.27 0.2 0.09
CHASM FDR 0.8 0.8 0.8 0.8 0.8 0.8
APOGEE bootstrap consensus N N P P N P
APOGEE bootstrap mean probability (mp) 0.35 0.4 0.95 0.6 0.53 0.55
SNPDryad score 0.1 0.13 0.6 0.56 0.06 0.54
MutationTaster polymorphism polymorphism disease_causing_automatic polymorphism polymorphism polymorphism
MutationTaster score 1 1 0 1 1 1
DEOGEN score 0.33 0.37 0.55 0.68 0.56 0.63
Mitoclass.1 neutral neutral neutral neutral neutral neutral
dbSNP 151 id . . rs267606890 . . .
ClinVar June2018 ClinSig . . Pathogenic . . .
ClinVar June2018 ClnDBN . . Leigh_syndrome|Mitochondrial_complex_I_deficiency . . .
ClinVar June2018 ClnAllele id . . 24751 . . .
ClinVar June2018 ClnDSDB . . MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:C1838979,OMIM:252010 . . .
COSMIC 87 . . . . . .
CPD candidate . . . . . .
CPD frequency . . . . . .
Mitomap Allele . . T10191C . . .
Mitomap Phenotype . . Leigh Disease / Leigh-like Disease / ESOC . . .
Mitomap Homoplasmy . . - . . .
Mitomap Heteroplasmy . . + . . .
Mitomap Status . . Cfrm . . .
Mitomap NRef . . 21 . . .
Classification Clinvar . . P . . .
Classification Mitomap . . P . . .
Classification Global . . P . . .
Classification Global . . P . . .
EV Mutation MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759 MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759 MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759 MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759 MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759 MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759
Site A InterP ND3_45 ND3_45 ND3_45 ND3_45 ND3_45 ND3_45
Site B InterP ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5 ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5 ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5 ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5 ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5 ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5
Covariation Score InterP mfDCA:37.957;mfDCA:22.4133;mfDCA:21.6351;mfDCA:37.1592;mfDCA:34.2687;mfDCA:26.8643;mfDCA:79.0956;mfDCA:31.9178;cMI:45.837894;cMI:44.229172;cMI:36.963593;cMI:36.788498;cMI:36.364681;cMI:34.828339;cMI:34.440586;cMI:34.168812;cMI:34.006149;cMI:33.758301;cMI:32.864185;cMI:32.3116;cMI:32.275471;cMI:31.861425;cMI:31.700768;cMI:30.239931;cMI:22.236382;cMI:19.739613;cMI:19.168917;cMI:15.519309;cMI:14.420492;cMI:12.722235;cMI:12.487722;cMI:45.566856;cMI:39.366917;cMI:39.270199;cMI:39.213924;cMI:37.502209;cMI:37.332058;cMI:37.033947;cMI:36.146694;cMI:36.048695;cMI:36.011139;cMI:35.29195;cMI:33.175873;cMI:32.818802;cMI:31.612175;cMI:19.133984;cMI:17.856361;cMI:17.524183;cMI:16.194481;cMI:14.522247;cMI:13.834105;cMI:13.578656 mfDCA:37.957;mfDCA:22.4133;mfDCA:21.6351;mfDCA:37.1592;mfDCA:34.2687;mfDCA:26.8643;mfDCA:79.0956;mfDCA:31.9178;cMI:45.837894;cMI:44.229172;cMI:36.963593;cMI:36.788498;cMI:36.364681;cMI:34.828339;cMI:34.440586;cMI:34.168812;cMI:34.006149;cMI:33.758301;cMI:32.864185;cMI:32.3116;cMI:32.275471;cMI:31.861425;cMI:31.700768;cMI:30.239931;cMI:22.236382;cMI:19.739613;cMI:19.168917;cMI:15.519309;cMI:14.420492;cMI:12.722235;cMI:12.487722;cMI:45.566856;cMI:39.366917;cMI:39.270199;cMI:39.213924;cMI:37.502209;cMI:37.332058;cMI:37.033947;cMI:36.146694;cMI:36.048695;cMI:36.011139;cMI:35.29195;cMI:33.175873;cMI:32.818802;cMI:31.612175;cMI:19.133984;cMI:17.856361;cMI:17.524183;cMI:16.194481;cMI:14.522247;cMI:13.834105;cMI:13.578656 mfDCA:37.957;mfDCA:22.4133;mfDCA:21.6351;mfDCA:37.1592;mfDCA:34.2687;mfDCA:26.8643;mfDCA:79.0956;mfDCA:31.9178;cMI:45.837894;cMI:44.229172;cMI:36.963593;cMI:36.788498;cMI:36.364681;cMI:34.828339;cMI:34.440586;cMI:34.168812;cMI:34.006149;cMI:33.758301;cMI:32.864185;cMI:32.3116;cMI:32.275471;cMI:31.861425;cMI:31.700768;cMI:30.239931;cMI:22.236382;cMI:19.739613;cMI:19.168917;cMI:15.519309;cMI:14.420492;cMI:12.722235;cMI:12.487722;cMI:45.566856;cMI:39.366917;cMI:39.270199;cMI:39.213924;cMI:37.502209;cMI:37.332058;cMI:37.033947;cMI:36.146694;cMI:36.048695;cMI:36.011139;cMI:35.29195;cMI:33.175873;cMI:32.818802;cMI:31.612175;cMI:19.133984;cMI:17.856361;cMI:17.524183;cMI:16.194481;cMI:14.522247;cMI:13.834105;cMI:13.578656 mfDCA:37.957;mfDCA:22.4133;mfDCA:21.6351;mfDCA:37.1592;mfDCA:34.2687;mfDCA:26.8643;mfDCA:79.0956;mfDCA:31.9178;cMI:45.837894;cMI:44.229172;cMI:36.963593;cMI:36.788498;cMI:36.364681;cMI:34.828339;cMI:34.440586;cMI:34.168812;cMI:34.006149;cMI:33.758301;cMI:32.864185;cMI:32.3116;cMI:32.275471;cMI:31.861425;cMI:31.700768;cMI:30.239931;cMI:22.236382;cMI:19.739613;cMI:19.168917;cMI:15.519309;cMI:14.420492;cMI:12.722235;cMI:12.487722;cMI:45.566856;cMI:39.366917;cMI:39.270199;cMI:39.213924;cMI:37.502209;cMI:37.332058;cMI:37.033947;cMI:36.146694;cMI:36.048695;cMI:36.011139;cMI:35.29195;cMI:33.175873;cMI:32.818802;cMI:31.612175;cMI:19.133984;cMI:17.856361;cMI:17.524183;cMI:16.194481;cMI:14.522247;cMI:13.834105;cMI:13.578656 mfDCA:37.957;mfDCA:22.4133;mfDCA:21.6351;mfDCA:37.1592;mfDCA:34.2687;mfDCA:26.8643;mfDCA:79.0956;mfDCA:31.9178;cMI:45.837894;cMI:44.229172;cMI:36.963593;cMI:36.788498;cMI:36.364681;cMI:34.828339;cMI:34.440586;cMI:34.168812;cMI:34.006149;cMI:33.758301;cMI:32.864185;cMI:32.3116;cMI:32.275471;cMI:31.861425;cMI:31.700768;cMI:30.239931;cMI:22.236382;cMI:19.739613;cMI:19.168917;cMI:15.519309;cMI:14.420492;cMI:12.722235;cMI:12.487722;cMI:45.566856;cMI:39.366917;cMI:39.270199;cMI:39.213924;cMI:37.502209;cMI:37.332058;cMI:37.033947;cMI:36.146694;cMI:36.048695;cMI:36.011139;cMI:35.29195;cMI:33.175873;cMI:32.818802;cMI:31.612175;cMI:19.133984;cMI:17.856361;cMI:17.524183;cMI:16.194481;cMI:14.522247;cMI:13.834105;cMI:13.578656 mfDCA:37.957;mfDCA:22.4133;mfDCA:21.6351;mfDCA:37.1592;mfDCA:34.2687;mfDCA:26.8643;mfDCA:79.0956;mfDCA:31.9178;cMI:45.837894;cMI:44.229172;cMI:36.963593;cMI:36.788498;cMI:36.364681;cMI:34.828339;cMI:34.440586;cMI:34.168812;cMI:34.006149;cMI:33.758301;cMI:32.864185;cMI:32.3116;cMI:32.275471;cMI:31.861425;cMI:31.700768;cMI:30.239931;cMI:22.236382;cMI:19.739613;cMI:19.168917;cMI:15.519309;cMI:14.420492;cMI:12.722235;cMI:12.487722;cMI:45.566856;cMI:39.366917;cMI:39.270199;cMI:39.213924;cMI:37.502209;cMI:37.332058;cMI:37.033947;cMI:36.146694;cMI:36.048695;cMI:36.011139;cMI:35.29195;cMI:33.175873;cMI:32.818802;cMI:31.612175;cMI:19.133984;cMI:17.856361;cMI:17.524183;cMI:16.194481;cMI:14.522247;cMI:13.834105;cMI:13.578656
Site A IntraP ND3_45 ND3_45 ND3_45 ND3_45 ND3_45 ND3_45
Site B IntraP ND3_88;ND3_97;ND3_89;ND3_49;ND3_79;ND3_112;ND3_91;ND3_88;ND3_89;ND3_107 ND3_88;ND3_97;ND3_89;ND3_49;ND3_79;ND3_112;ND3_91;ND3_88;ND3_89;ND3_107 ND3_88;ND3_97;ND3_89;ND3_49;ND3_79;ND3_112;ND3_91;ND3_88;ND3_89;ND3_107 ND3_88;ND3_97;ND3_89;ND3_49;ND3_79;ND3_112;ND3_91;ND3_88;ND3_89;ND3_107 ND3_88;ND3_97;ND3_89;ND3_49;ND3_79;ND3_112;ND3_91;ND3_88;ND3_89;ND3_107 ND3_88;ND3_97;ND3_89;ND3_49;ND3_79;ND3_112;ND3_91;ND3_88;ND3_89;ND3_107
Covariation Score IntraP cMI:16.100534;cMI:15.674643;cMI:15.464886;cMI:12.779061;cMI:12.428753;cMI:10.168221;cMI:9.709738;mfDCA:22.1031;mfDCA:18.5493;mfDCA:15.438 cMI:16.100534;cMI:15.674643;cMI:15.464886;cMI:12.779061;cMI:12.428753;cMI:10.168221;cMI:9.709738;mfDCA:22.1031;mfDCA:18.5493;mfDCA:15.438 cMI:16.100534;cMI:15.674643;cMI:15.464886;cMI:12.779061;cMI:12.428753;cMI:10.168221;cMI:9.709738;mfDCA:22.1031;mfDCA:18.5493;mfDCA:15.438 cMI:16.100534;cMI:15.674643;cMI:15.464886;cMI:12.779061;cMI:12.428753;cMI:10.168221;cMI:9.709738;mfDCA:22.1031;mfDCA:18.5493;mfDCA:15.438 cMI:16.100534;cMI:15.674643;cMI:15.464886;cMI:12.779061;cMI:12.428753;cMI:10.168221;cMI:9.709738;mfDCA:22.1031;mfDCA:18.5493;mfDCA:15.438 cMI:16.100534;cMI:15.674643;cMI:15.464886;cMI:12.779061;cMI:12.428753;cMI:10.168221;cMI:9.709738;mfDCA:22.1031;mfDCA:18.5493;mfDCA:15.438
CPD AA ref . . . . . .
CPD AA alt . . . . . .
CPD aln pos . . . . . .
CPD Species name . . . . . .
CPD RefSeq Protein ID . . . . . .
CPD Ncbi Taxon ID . . . . . .
DDG intra MT-ND3:S45A:L107Q:1.86944:0.898719:0.964638;MT-ND3:S45A:L107V:2.4996:0.898719:1.58272;MT-ND3:S45A:L107M:0.715066:0.898719:-0.186263;MT-ND3:S45A:L107P:5.69195:0.898719:4.56316;MT-ND3:S45A:L107R:1.54806:0.898719:0.654602;MT-ND3:S45A:D112N:0.927985:0.898719:-0.0131052;MT-ND3:S45A:D112Y:0.523376:0.898719:-0.433469;MT-ND3:S45A:D112A:0.520717:0.898719:-0.418179;MT-ND3:S45A:D112G:1.3301:0.898719:0.414236;MT-ND3:S45A:D112E:0.712251:0.898719:-0.258161;MT-ND3:S45A:D112H:1.01463:0.898719:0.0340833;MT-ND3:S45A:D112V:1.12683:0.898719:0.179616;MT-ND3:S45A:V49G:1.91344:0.898719:0.888794;MT-ND3:S45A:V49A:1.18917:0.898719:0.193963;MT-ND3:S45A:V49I:1.04652:0.898719:-0.482548;MT-ND3:S45A:V49D:0.361223:0.898719:-0.607087;MT-ND3:S45A:V49F:0.363601:0.898719:-0.639481;MT-ND3:S45A:V49L:0.656181:0.898719:-0.289594;MT-ND3:S45A:L79Q:1.61103:0.898719:0.615227;MT-ND3:S45A:L79M:0.765146:0.898719:-0.174798;MT-ND3:S45A:L79P:4.64388:0.898719:3.64483;MT-ND3:S45A:L79V:2.59329:0.898719:1.69291;MT-ND3:S45A:L79R:1.91579:0.898719:1.00907;MT-ND3:S45A:G29R:1.02808:0.898719:0.0789448;MT-ND3:S45A:G29S:0.984365:0.898719:0.061955;MT-ND3:S45A:G29C:1.2321:0.898719:0.290877;MT-ND3:S45A:G29D:1.16518:0.898719:0.254493;MT-ND3:S45A:G29V:1.44128:0.898719:0.518345;MT-ND3:S45A:G29A:1.08002:0.898719:0.171581;MT-ND3:S45A:T35I:0.400209:0.898719:-0.515883;MT-ND3:S45A:T35P:1.37802:0.898719:0.442305;MT-ND3:S45A:T35S:1.32111:0.898719:0.233842;MT-ND3:S45A:T35N:1.22877:0.898719:0.309927;MT-ND3:S45A:T35A:1.00227:0.898719:0.0855016;MT-ND3:S45A:M44L:1.1635:0.898719:0.360285;MT-ND3:S45A:M44I:1.172:0.898719:0.322536;MT-ND3:S45A:M44K:1.1209:0.898719:0.331748;MT-ND3:S45A:M44V:1.30387:0.898719:0.489564;MT-ND3:S45A:M44T:1.30656:0.898719:0.4131;MT-ND3:S45A:A4D:1.05147:0.898719:0.190562;MT-ND3:S45A:A4P:-0.509629:0.898719:-1.526;MT-ND3:S45A:A4G:2.00368:0.898719:1.08914;MT-ND3:S45A:A4S:1.82332:0.898719:0.901348;MT-ND3:S45A:A4V:1.29706:0.898719:0.176529;MT-ND3:S45A:A4T:2.66952:0.898719:1.29799 MT-ND3:S45T:L107M:-0.381736:-0.193334:-0.186263;MT-ND3:S45T:L107R:0.471732:-0.193334:0.654602;MT-ND3:S45T:L107P:4.50682:-0.193334:4.56316;MT-ND3:S45T:L107V:1.38096:-0.193334:1.58272;MT-ND3:S45T:L107Q:0.786723:-0.193334:0.964638;MT-ND3:S45T:D112V:-0.0198059:-0.193334:0.179616;MT-ND3:S45T:D112E:-0.445382:-0.193334:-0.258161;MT-ND3:S45T:D112G:0.202581:-0.193334:0.414236;MT-ND3:S45T:D112A:-0.626307:-0.193334:-0.418179;MT-ND3:S45T:D112Y:-0.636864:-0.193334:-0.433469;MT-ND3:S45T:D112N:-0.201313:-0.193334:-0.0131052;MT-ND3:S45T:D112H:-0.145536:-0.193334:0.0340833;MT-ND3:S45T:V49F:-0.827647:-0.193334:-0.639481;MT-ND3:S45T:V49D:-0.82733:-0.193334:-0.607087;MT-ND3:S45T:V49L:-0.356219:-0.193334:-0.289594;MT-ND3:S45T:V49G:0.795547:-0.193334:0.888794;MT-ND3:S45T:V49I:-0.547249:-0.193334:-0.482548;MT-ND3:S45T:V49A:0.303211:-0.193334:0.193963;MT-ND3:S45T:L79P:3.45752:-0.193334:3.64483;MT-ND3:S45T:L79M:-0.355915:-0.193334:-0.174798;MT-ND3:S45T:L79Q:0.443294:-0.193334:0.615227;MT-ND3:S45T:L79V:1.49783:-0.193334:1.69291;MT-ND3:S45T:L79R:0.819644:-0.193334:1.00907;MT-ND3:S45T:G29C:0.100006:-0.193334:0.290877;MT-ND3:S45T:G29D:0.0640916:-0.193334:0.254493;MT-ND3:S45T:G29S:-0.130535:-0.193334:0.061955;MT-ND3:S45T:G29A:-0.0189741:-0.193334:0.171581;MT-ND3:S45T:G29R:-0.103894:-0.193334:0.0789448;MT-ND3:S45T:G29V:0.325636:-0.193334:0.518345;MT-ND3:S45T:T35A:-0.102041:-0.193334:0.0855016;MT-ND3:S45T:T35S:0.0445892:-0.193334:0.233842;MT-ND3:S45T:T35N:0.146617:-0.193334:0.309927;MT-ND3:S45T:T35P:0.248048:-0.193334:0.442305;MT-ND3:S45T:T35I:-0.708227:-0.193334:-0.515883;MT-ND3:S45T:M44K:0.114574:-0.193334:0.331748;MT-ND3:S45T:M44T:0.268254:-0.193334:0.4131;MT-ND3:S45T:M44V:0.340112:-0.193334:0.489564;MT-ND3:S45T:M44I:0.140842:-0.193334:0.322536;MT-ND3:S45T:M44L:0.0106605:-0.193334:0.360285;MT-ND3:S45T:A4S:0.708495:-0.193334:0.901348;MT-ND3:S45T:A4G:0.900125:-0.193334:1.08914;MT-ND3:S45T:A4P:-1.64918:-0.193334:-1.526;MT-ND3:S45T:A4D:0.0231006:-0.193334:0.190562;MT-ND3:S45T:A4V:-0.0981623:-0.193334:0.176529;MT-ND3:S45T:A4T:1.44737:-0.193334:1.29799 MT-ND3:S45P:L107Q:5.1219:4.1339:0.964638;MT-ND3:S45P:L107R:4.80834:4.1339:0.654602;MT-ND3:S45P:L107P:8.85061:4.1339:4.56316;MT-ND3:S45P:L107V:5.75541:4.1339:1.58272;MT-ND3:S45P:L107M:3.93827:4.1339:-0.186263;MT-ND3:S45P:D112H:4.20228:4.1339:0.0340833;MT-ND3:S45P:D112Y:3.77103:4.1339:-0.433469;MT-ND3:S45P:D112N:4.16016:4.1339:-0.0131052;MT-ND3:S45P:D112E:3.96989:4.1339:-0.258161;MT-ND3:S45P:D112G:4.55127:4.1339:0.414236;MT-ND3:S45P:D112V:4.3272:4.1339:0.179616;MT-ND3:S45P:D112A:3.66153:4.1339:-0.418179;MT-ND3:S45P:V49G:5.06697:4.1339:0.888794;MT-ND3:S45P:V49A:4.39278:4.1339:0.193963;MT-ND3:S45P:V49L:3.81485:4.1339:-0.289594;MT-ND3:S45P:V49D:3.5169:4.1339:-0.607087;MT-ND3:S45P:V49F:3.48098:4.1339:-0.639481;MT-ND3:S45P:V49I:4.28611:4.1339:-0.482548;MT-ND3:S45P:L79Q:4.85566:4.1339:0.615227;MT-ND3:S45P:L79R:5.1586:4.1339:1.00907;MT-ND3:S45P:L79M:3.98456:4.1339:-0.174798;MT-ND3:S45P:L79V:5.84676:4.1339:1.69291;MT-ND3:S45P:L79P:7.80779:4.1339:3.64483;MT-ND3:S45P:G29D:4.40541:4.1339:0.254493;MT-ND3:S45P:G29A:4.25797:4.1339:0.171581;MT-ND3:S45P:G29C:4.43954:4.1339:0.290877;MT-ND3:S45P:G29S:4.20152:4.1339:0.061955;MT-ND3:S45P:G29V:4.69077:4.1339:0.518345;MT-ND3:S45P:G29R:4.21889:4.1339:0.0789448;MT-ND3:S45P:T35A:4.19861:4.1339:0.0855016;MT-ND3:S45P:T35N:4.46139:4.1339:0.309927;MT-ND3:S45P:T35S:4.57446:4.1339:0.233842;MT-ND3:S45P:T35P:4.57535:4.1339:0.442305;MT-ND3:S45P:T35I:3.60392:4.1339:-0.515883;MT-ND3:S45P:M44T:4.71464:4.1339:0.4131;MT-ND3:S45P:M44K:4.25508:4.1339:0.331748;MT-ND3:S45P:M44I:4.34348:4.1339:0.322536;MT-ND3:S45P:M44V:4.66005:4.1339:0.489564;MT-ND3:S45P:M44L:4.29145:4.1339:0.360285;MT-ND3:S45P:A4P:2.705:4.1339:-1.526;MT-ND3:S45P:A4S:5.07628:4.1339:0.901348;MT-ND3:S45P:A4G:5.18293:4.1339:1.08914;MT-ND3:S45P:A4V:4.28057:4.1339:0.176529;MT-ND3:S45P:A4D:4.33837:4.1339:0.190562;MT-ND3:S45P:A4T:5.51494:4.1339:1.29799 MT-ND3:S45C:L107P:5.50999:0.826151:4.56316;MT-ND3:S45C:L107M:0.6183:0.826151:-0.186263;MT-ND3:S45C:L107V:2.39813:0.826151:1.58272;MT-ND3:S45C:L107R:1.48454:0.826151:0.654602;MT-ND3:S45C:L107Q:1.73148:0.826151:0.964638;MT-ND3:S45C:D112Y:0.398607:0.826151:-0.433469;MT-ND3:S45C:D112E:0.546487:0.826151:-0.258161;MT-ND3:S45C:D112G:1.22005:0.826151:0.414236;MT-ND3:S45C:D112N:0.783482:0.826151:-0.0131052;MT-ND3:S45C:D112H:0.866113:0.826151:0.0340833;MT-ND3:S45C:D112A:0.3159:0.826151:-0.418179;MT-ND3:S45C:D112V:1.01008:0.826151:0.179616;MT-ND3:S45C:V49D:0.313673:0.826151:-0.607087;MT-ND3:S45C:V49G:1.84501:0.826151:0.888794;MT-ND3:S45C:V49A:1.14598:0.826151:0.193963;MT-ND3:S45C:V49L:0.552329:0.826151:-0.289594;MT-ND3:S45C:V49F:0.324433:0.826151:-0.639481;MT-ND3:S45C:V49I:0.920002:0.826151:-0.482548;MT-ND3:S45C:L79V:2.50222:0.826151:1.69291;MT-ND3:S45C:L79R:1.70268:0.826151:1.00907;MT-ND3:S45C:L79P:4.53785:0.826151:3.64483;MT-ND3:S45C:L79M:0.653034:0.826151:-0.174798;MT-ND3:S45C:L79Q:1.46177:0.826151:0.615227;MT-ND3:S45C:G29D:1.01752:0.826151:0.254493;MT-ND3:S45C:G29S:0.916085:0.826151:0.061955;MT-ND3:S45C:G29C:1.13128:0.826151:0.290877;MT-ND3:S45C:G29A:0.98033:0.826151:0.171581;MT-ND3:S45C:G29R:0.789326:0.826151:0.0789448;MT-ND3:S45C:G29V:1.34477:0.826151:0.518345;MT-ND3:S45C:T35S:1.25284:0.826151:0.233842;MT-ND3:S45C:T35P:1.29424:0.826151:0.442305;MT-ND3:S45C:T35N:1.15791:0.826151:0.309927;MT-ND3:S45C:T35A:0.893042:0.826151:0.0855016;MT-ND3:S45C:T35I:0.284032:0.826151:-0.515883;MT-ND3:S45C:M44T:1.22718:0.826151:0.4131;MT-ND3:S45C:M44L:1.00458:0.826151:0.360285;MT-ND3:S45C:M44K:1.03591:0.826151:0.331748;MT-ND3:S45C:M44I:0.999161:0.826151:0.322536;MT-ND3:S45C:M44V:1.22112:0.826151:0.489564;MT-ND3:S45C:A4G:1.86863:0.826151:1.08914;MT-ND3:S45C:A4D:0.997836:0.826151:0.190562;MT-ND3:S45C:A4S:1.7267:0.826151:0.901348;MT-ND3:S45C:A4T:2.06432:0.826151:1.29799;MT-ND3:S45C:A4V:1.26122:0.826151:0.176529;MT-ND3:S45C:A4P:-0.505855:0.826151:-1.526 MT-ND3:S45Y:L107V:2.32591:0.6055:1.58272;MT-ND3:S45Y:L107P:5.40646:0.6055:4.56316;MT-ND3:S45Y:L107M:0.50254:0.6055:-0.186263;MT-ND3:S45Y:L107Q:1.68566:0.6055:0.964638;MT-ND3:S45Y:D112G:0.975755:0.6055:0.414236;MT-ND3:S45Y:D112A:0.227884:0.6055:-0.418179;MT-ND3:S45Y:D112H:0.669175:0.6055:0.0340833;MT-ND3:S45Y:D112E:0.459912:0.6055:-0.258161;MT-ND3:S45Y:D112N:0.62202:0.6055:-0.0131052;MT-ND3:S45Y:D112V:0.84797:0.6055:0.179616;MT-ND3:S45Y:V49L:0.396099:0.6055:-0.289594;MT-ND3:S45Y:V49F:0.056688:0.6055:-0.639481;MT-ND3:S45Y:V49D:0.062921:0.6055:-0.607087;MT-ND3:S45Y:V49I:0.872843:0.6055:-0.482548;MT-ND3:S45Y:V49G:1.62741:0.6055:0.888794;MT-ND3:S45Y:L79V:2.3271:0.6055:1.69291;MT-ND3:S45Y:L79M:0.571163:0.6055:-0.174798;MT-ND3:S45Y:L79R:1.5776:0.6055:1.00907;MT-ND3:S45Y:L79P:4.30922:0.6055:3.64483;MT-ND3:S45Y:D112Y:0.270734:0.6055:-0.433469;MT-ND3:S45Y:L79Q:1.29823:0.6055:0.615227;MT-ND3:S45Y:V49A:0.9252:0.6055:0.193963;MT-ND3:S45Y:L107R:1.29055:0.6055:0.654602;MT-ND3:S45Y:G29R:0.719265:0.6055:0.0789448;MT-ND3:S45Y:G29A:0.82546:0.6055:0.171581;MT-ND3:S45Y:G29S:0.697066:0.6055:0.061955;MT-ND3:S45Y:G29V:1.14448:0.6055:0.518345;MT-ND3:S45Y:G29D:0.87644:0.6055:0.254493;MT-ND3:S45Y:T35I:0.142279:0.6055:-0.515883;MT-ND3:S45Y:T35N:0.927255:0.6055:0.309927;MT-ND3:S45Y:T35S:1.02729:0.6055:0.233842;MT-ND3:S45Y:T35P:1.00572:0.6055:0.442305;MT-ND3:S45Y:M44T:1.12536:0.6055:0.4131;MT-ND3:S45Y:M44L:0.776645:0.6055:0.360285;MT-ND3:S45Y:M44V:0.89617:0.6055:0.489564;MT-ND3:S45Y:M44K:0.808765:0.6055:0.331748;MT-ND3:S45Y:A4V:1.06032:0.6055:0.176529;MT-ND3:S45Y:A4T:1.82082:0.6055:1.29799;MT-ND3:S45Y:A4P:-0.809287:0.6055:-1.526;MT-ND3:S45Y:A4S:1.52907:0.6055:0.901348;MT-ND3:S45Y:A4G:1.76796:0.6055:1.08914;MT-ND3:S45Y:T35A:0.755983:0.6055:0.0855016;MT-ND3:S45Y:M44I:0.480335:0.6055:0.322536;MT-ND3:S45Y:A4D:0.788075:0.6055:0.190562;MT-ND3:S45Y:G29C:0.904387:0.6055:0.290877 MT-ND3:S45F:L107Q:1.49813:0.503661:0.964638;MT-ND3:S45F:L107V:2.17291:0.503661:1.58272;MT-ND3:S45F:L107M:0.271432:0.503661:-0.186263;MT-ND3:S45F:L107P:5.1301:0.503661:4.56316;MT-ND3:S45F:L107R:1.17674:0.503661:0.654602;MT-ND3:S45F:D112H:0.556441:0.503661:0.0340833;MT-ND3:S45F:D112N:0.492885:0.503661:-0.0131052;MT-ND3:S45F:D112A:0.0979919:0.503661:-0.418179;MT-ND3:S45F:D112Y:0.117732:0.503661:-0.433469;MT-ND3:S45F:D112G:0.813154:0.503661:0.414236;MT-ND3:S45F:D112E:0.348247:0.503661:-0.258161;MT-ND3:S45F:D112V:0.694058:0.503661:0.179616;MT-ND3:S45F:V49D:-0.0898759:0.503661:-0.607087;MT-ND3:S45F:V49F:-0.105163:0.503661:-0.639481;MT-ND3:S45F:V49A:0.791301:0.503661:0.193963;MT-ND3:S45F:V49I:0.785048:0.503661:-0.482548;MT-ND3:S45F:V49G:1.48081:0.503661:0.888794;MT-ND3:S45F:V49L:0.209412:0.503661:-0.289594;MT-ND3:S45F:L79V:2.08106:0.503661:1.69291;MT-ND3:S45F:L79M:0.39727:0.503661:-0.174798;MT-ND3:S45F:L79P:4.19811:0.503661:3.64483;MT-ND3:S45F:L79R:1.58043:0.503661:1.00907;MT-ND3:S45F:L79Q:1.15178:0.503661:0.615227;MT-ND3:S45F:G29D:0.777833:0.503661:0.254493;MT-ND3:S45F:G29V:0.893807:0.503661:0.518345;MT-ND3:S45F:G29S:0.558952:0.503661:0.061955;MT-ND3:S45F:G29A:0.710058:0.503661:0.171581;MT-ND3:S45F:G29R:0.637593:0.503661:0.0789448;MT-ND3:S45F:G29C:0.780297:0.503661:0.290877;MT-ND3:S45F:T35N:0.804215:0.503661:0.309927;MT-ND3:S45F:T35P:0.896665:0.503661:0.442305;MT-ND3:S45F:T35A:0.547631:0.503661:0.0855016;MT-ND3:S45F:T35I:-0.0204942:0.503661:-0.515883;MT-ND3:S45F:T35S:0.78972:0.503661:0.233842;MT-ND3:S45F:M44L:0.347368:0.503661:0.360285;MT-ND3:S45F:M44V:0.554149:0.503661:0.489564;MT-ND3:S45F:M44T:0.994677:0.503661:0.4131;MT-ND3:S45F:M44I:0.374943:0.503661:0.322536;MT-ND3:S45F:M44K:0.695619:0.503661:0.331748;MT-ND3:S45F:A4V:0.658189:0.503661:0.176529;MT-ND3:S45F:A4P:-0.934704:0.503661:-1.526;MT-ND3:S45F:A4G:1.57964:0.503661:1.08914;MT-ND3:S45F:A4T:1.65751:0.503661:1.29799;MT-ND3:S45F:A4D:0.708873:0.503661:0.190562;MT-ND3:S45F:A4S:1.27838:0.503661:0.901348
DDG intra interface 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MT-ND3:NDUFS2:5lc5:A:D:S45F:V49A:-1.2844962:-1.1369547:0.155824;MT-ND3:NDUFS2:5lc5:A:D:S45F:V49D:-1.5460474:-1.1369547:-0.028075;MT-ND3:NDUFS2:5lc5:A:D:S45F:V49F:-1.2483167:-1.1369547:0.166614;MT-ND3:NDUFS2:5lc5:A:D:S45F:V49G:-1.0306:-1.1369547:0.140612;MT-ND3:NDUFS2:5lc5:A:D:S45F:V49I:-1.4003141:-1.1369547:0.109823;MT-ND3:NDUFS2:5lc5:A:D:S45F:V49L:-1.2673499:-1.1369547:0.185479;MT-ND3:MT-ND1:5lc5:A:H:S45F:L15F:0.36638:-0.27181:0.77833;MT-ND3:MT-ND1:5lc5:A:H:S45F:L15M:-0.18265:-0.27181:0.1131;MT-ND3:MT-ND1:5lc5:A:H:S45F:L15S:1.11228:-0.27181:1.28246;MT-ND3:MT-ND1:5lc5:A:H:S45F:L15V:0.77572:-0.27181:1.06051;MT-ND3:MT-ND1:5lc5:A:H:S45F:L15W:-0.50368:-0.27181:-0.4324;MT-ND3:MT-ND1:5lc5:A:H:S45F:M18I:0.49106:-0.27178:0.66938;MT-ND3:MT-ND1:5lc5:A:H:S45F:M18K:2.2519:-0.27178:2.49572;MT-ND3:MT-ND1:5lc5:A:H:S45F:M18L:0.31462:-0.27178:0.5324;MT-ND3:MT-ND1:5lc5:A:H:S45F:M18T:2.24102:-0.27178:2.4593;MT-ND3:MT-ND1:5lc5:A:H:S45F:M18V:1.10345:-0.27178:1.36914;MT-ND3:MT-ND1:5lc5:A:H:S45F:T35A:-0.12098:-0.27365:0.14765;MT-ND3:MT-ND1:5lc5:A:H:S45F:T35I:-0.25428:-0.27365:-0.06767;MT-ND3:MT-ND1:5lc5:A:H:S45F:T35N:-0.04763:-0.27365:0.1598;MT-ND3:MT-ND1:5lc5:A:H:S45F:T35P:-0.42:-0.27365:-0.18368;MT-ND3:MT-ND1:5lc5:A:H:S45F:T35S:-0.37544:-0.27365:-0.12436;MT-ND3:MT-ND1:5lc5:A:H:S45F:M44I:-0.4842:-0.26155:-0.26598;MT-ND3:MT-ND1:5lc5:A:H:S45F:M44K:-0.39465:-0.26155:-0.29543;MT-ND3:MT-ND1:5lc5:A:H:S45F:M44L:-0.34863:-0.26155:-0.25651;MT-ND3:MT-ND1:5lc5:A:H:S45F:M44T:-0.11156:-0.26155:0.06186;MT-ND3:MT-ND1:5lc5:A:H:S45F:M44V:-0.30967:-0.26155:-0.15183;MT-ND3:MT-ND1:5ldw:A:H:S45F:L15F:0.49933:0.01284:0.16768;MT-ND3:MT-ND1:5ldw:A:H:S45F:L15M:-0.32746:0.01284:-0.22176;MT-ND3:MT-ND1:5ldw:A:H:S45F:L15S:0.66074:0.01284:0.71124;MT-ND3:MT-ND1:5ldw:A:H:S45F:L15V:0.36578:0.01284:0.32203;MT-ND3:MT-ND1:5ldw:A:H:S45F:L15W:-0.09059:0.01284:-0.12821;MT-ND3:MT-ND1:5ldw:A:H:S45F:M18I:0.85928:0.01343:0.6076;MT-ND3:MT-ND1:5ldw:A:H:S45F:M18K:0.73576:0.01343:1.03939;MT-ND3:MT-ND1:5ldw:A:H:S45F:M18L:0.43312:0.01343:0.23679;MT-ND3:MT-ND1:5ldw:A:H:S45F:M18T:1.96731:0.01343:1.85929;MT-ND3:MT-ND1:5ldw:A:H:S45F:M18V:1.24718:0.01343:1.04567;MT-ND3:MT-ND1:5ldw:A:H:S45F:T35A:-0.39977:0.10391:-0.39186;MT-ND3:MT-ND1:5ldw:A:H:S45F:T35I:-0.50429:0.10391:-0.53034;MT-ND3:MT-ND1:5ldw:A:H:S45F:T35N:-0.30707:0.10391:-0.30034;MT-ND3:MT-ND1:5ldw:A:H:S45F:T35P:-0.93427:0.10391:-0.80325;MT-ND3:MT-ND1:5ldw:A:H:S45F:T35S:-0.36963:0.10391:-0.19208;MT-ND3:MT-ND1:5ldw:A:H:S45F:M44I:-0.1464:0.07069:0.00493000000002;MT-ND3:MT-ND1:5ldw:A:H:S45F:M44K:0.08844:0.07069:-0.10369;MT-ND3:MT-ND1:5ldw:A:H:S45F:M44L:0.11065:0.07069:-0.10361;MT-ND3:MT-ND1:5ldw:A:H:S45F:M44T:0.29087:0.07069:0.01395;MT-ND3:MT-ND1:5ldw:A:H:S45F:M44V:-0.15865:0.07069:0.0288;MT-ND3:MT-ND1:5ldx:A:H:S45F:L15F:1.05745:0.50513:0.54581;MT-ND3:MT-ND1:5ldx:A:H:S45F:L15M:0.22456:0.50513:-0.21274;MT-ND3:MT-ND1:5ldx:A:H:S45F:L15S:1.1544:0.50513:0.64412;MT-ND3:MT-ND1:5ldx:A:H:S45F:L15V:0.99582:0.50513:0.48811;MT-ND3:MT-ND1:5ldx:A:H:S45F:L15W:0.27385:0.50513:-0.23467;MT-ND3:MT-ND1:5ldx:A:H:S45F:M18I:1.16602:0.50899:0.65117;MT-ND3:MT-ND1:5ldx:A:H:S45F:M18K:1.70963:0.50899:1.20633;MT-ND3:MT-ND1:5ldx:A:H:S45F:M18L:0.91289:0.50899:0.49592;MT-ND3:MT-ND1:5ldx:A:H:S45F:M18T:2.30901:0.50899:1.70221;MT-ND3:MT-ND1:5ldx:A:H:S45F:M18V:1.52245:0.50899:1.12518;MT-ND3:MT-ND1:5ldx:A:H:S45F:T35A:0.20521:0.50768:-0.28604;MT-ND3:MT-ND1:5ldx:A:H:S45F:T35I:-0.0618:0.50768:-0.5748;MT-ND3:MT-ND1:5ldx:A:H:S45F:T35N:0.27494:0.50768:-0.12195;MT-ND3:MT-ND1:5ldx:A:H:S45F:T35P:-0.35732:0.50768:-0.88659;MT-ND3:MT-ND1:5ldx:A:H:S45F:T35S:0.26535:0.50768:-0.18413;MT-ND3:MT-ND1:5ldx:A:H:S45F:M44I:0.85083:0.5088:-0.03478;MT-ND3:MT-ND1:5ldx:A:H:S45F:M44K:0.51116:0.5088:-0.07642;MT-ND3:MT-ND1:5ldx:A:H:S45F:M44L:0.87592:0.5088:-0.07877;MT-ND3:MT-ND1:5ldx:A:H:S45F:M44T:0.58676:0.5088:0.03867;MT-ND3:MT-ND1:5ldx:A:H:S45F:M44V:0.90803:0.5088:0.04435
DDG inter 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For more info, please check the output legend.
For more info, please check the output legend.
For more info, please check the output legend.
For more info, please check the output legend.
For more info, please check the output legend.