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MitImpact 3D

MitImpact is a collection of genomic, clinical and functional annotations for all nucleotide changes that cause non-synonymous substitutions in human mitochondrial protein coding genes

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Latest update

[08-10-2020] MitImpact 3D 3.0.6 released today, with minor fixes to the flat file database version, tooltips that help interpret scores in the result page, and 4 tutorial-like case studies which simulate typical uses of MitImpact.

[03-09-2020] As for our users requests, we have added the possibility to directly search for a variant and then show up its information in the first tab of the result page. We have also provided this function through a restful api, as explained in the Description page. Let's try it typing http://mitimpact.css-mendel.it/search_allele/6253/T>A or http://mitimpact.css-mendel.it/search_allele/6253/T>C in your browser.

[04-08-2020] MitImpact 3D 3.0.5 released today! Minor fixes and some updates to our frequency and phenotype databases (dbSNP 153, ClinVar March 2020, COSMIC 90, MITOMAP February 2020) and to the Description and Output legend pages.

[22-06-2017] PLoS Comput Biol. publishes our paper entitled: High-confidence assessment of functional impact of human mitochondrial non-synonymous genome variations by APOGEE. [link]