General info

Chr
chrM
Start
10191
End
10191
Ref
T
Alt
C
Mitimpact ID
MI.15248
Gene symbol
MT-ND3
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
133
AA pos
45
AA ref
S
AA alt
P
Codon substitution
Tcc/Ccc
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Conservation

PhyloP 100v
-0.1 Conservation Score
PhastCons 100v
0.15 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Neutral Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Deleterious Score and details of the predictor
Mutation Assessor
Medium impact Score and details of the predictor
EFIN SP
Damaging Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Disease Score and details of the predictor
MutationTaster
Disease causing automatic Score and details of the predictor
CADD
Deleterious Score and details of the predictor
SNAP
Disease Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Pathogenic Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Neutral Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Disease Score and details of the meta-predictor
MtoolBox
Deleterious Score and details of the meta-predictor
DEOGEN2
Deleterious Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Medium impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar October2021 CLNSIG
Pathogenic
ClinVar October2021 CLNDN
Leigh syndrome;

mitochondrial complex 1 deficiency, mitochondrial type 1;

mitochondrial complex i deficiency
ClinVar October2021 Variation ID
ClinVar October2021 CLNDISDB
Mondo:mondo:0009723, medgen:c0023264, omim:256000, orphanet:orpha506, snomed ct:29570005;

mondo:mondo:0027068, medgen:c4746992, omim:500014;

mondo:mondo:0100133, medgen:c1838979, orphanet:orpha2609
MITOMAP Allele
MITOMAP Disease Het/Hom
-/+
MITOMAP Disease Clinical info
Leigh disease / leigh-like disease / esoc
MITOMAP Disease Status
Cfrm
MITOMAP Disease GenBank Freq
0.000%
MITOMAP Disease GenBank Seqs
0 (0)
MITOMAP Disease GenBank Curated refs
27
MITOMAP General GenBank Freq
.
MITOMAP General GenBank Seqs
.
MITOMAP General GenBank Curated refs
.
Gnomad31 filter
Npg
Gnomad31 AC hom
0
Gnomad31 AC het
0
Gnomad31 AF hom
0
Gnomad31 AF het
0
Gnomad31 AN
56433
COSMIC 90
.
dbSNP 155

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

General info

Chr
chrM
Start
10191
End
10191
Ref
T
Alt
A
Mitimpact ID
MI.15247
Gene symbol
MT-ND3
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
133
AA pos
45
AA ref
S
AA alt
T
Codon substitution
Tcc/Acc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
-0.1 Conservation Score
PhastCons 100v
0.15 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Neutral Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Neutral Score and details of the predictor
Mutation Assessor
Medium impact Score and details of the predictor
EFIN SP
Damaging Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Neutral Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Deleterious Score and details of the predictor
SNAP
Disease Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Neutral Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Neutral Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Medium impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar October2021 CLNSIG
.
ClinVar October2021 CLNDN
.
ClinVar October2021 Variation ID
ClinVar October2021 CLNDISDB
.
MITOMAP Allele
.
MITOMAP Disease Het/Hom
.
MITOMAP Disease Clinical info
.
MITOMAP Disease Status
.
MITOMAP Disease GenBank Freq
.
MITOMAP Disease GenBank Seqs
.
MITOMAP Disease GenBank Curated refs
.
MITOMAP General GenBank Freq
.
MITOMAP General GenBank Seqs
.
MITOMAP General GenBank Curated refs
.
Gnomad31 filter
Pass
Gnomad31 AC hom
1
Gnomad31 AC het
0
Gnomad31 AF hom
1.7719814e-05
Gnomad31 AF het
0
Gnomad31 AN
56434
COSMIC 90
.
dbSNP 155

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

General info

Chr
chrM
Start
10191
End
10191
Ref
T
Alt
G
Mitimpact ID
MI.15246
Gene symbol
MT-ND3
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
133
AA pos
45
AA ref
S
AA alt
A
Codon substitution
Tcc/Gcc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
-0.1 Conservation Score
PhastCons 100v
0.15 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Neutral Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Neutral Score and details of the predictor
Mutation Assessor
Medium impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Neutral Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Neutral Score and details of the predictor
SNAP
Disease Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Neutral Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Neutral Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Medium impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar October2021 CLNSIG
.
ClinVar October2021 CLNDN
.
ClinVar October2021 Variation ID
ClinVar October2021 CLNDISDB
.
MITOMAP Allele
.
MITOMAP Disease Het/Hom
.
MITOMAP Disease Clinical info
.
MITOMAP Disease Status
.
MITOMAP Disease GenBank Freq
.
MITOMAP Disease GenBank Seqs
.
MITOMAP Disease GenBank Curated refs
.
MITOMAP General GenBank Freq
0.000%
MITOMAP General GenBank Seqs
0
MITOMAP General GenBank Curated refs
1
Gnomad31 filter
Pass
Gnomad31 AC hom
2
Gnomad31 AC het
0
Gnomad31 AF hom
3.543963e-05
Gnomad31 AF het
0
Gnomad31 AN
56434
COSMIC 90
.
dbSNP 155

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.
~ 10191 (T/C) 10191 (T/A) 10191 (T/G)
~ 10191 (Tcc/Ccc) 10191 (Tcc/Acc) 10191 (Tcc/Gcc)
Chr chrM chrM chrM
Start 10191 10191 10191
End 10191 10191 10191
Ref T T T
Alt C A G
MitImpact id MI.15248 MI.15247 MI.15246
Gene symbol MT-ND3 MT-ND3 MT-ND3
Respiratory Chain complex I I I
Ensembl gene id ENSG00000198840 ENSG00000198840 ENSG00000198840
Ensembl protein id ENSP00000355206 ENSP00000355206 ENSP00000355206
Ensembl transcript id ENST00000361227 ENST00000361227 ENST00000361227
Uniprot name NU3M_HUMAN NU3M_HUMAN NU3M_HUMAN
Uniprot id P03897 P03897 P03897
Ncbi gene id 4537 4537 4537
Ncbi protein id YP_003024033.1 YP_003024033.1 YP_003024033.1
Gene position 133 133 133
AA position 45 45 45
AA ref S S S
AA alt P T A
Codon substitution Tcc/Ccc Tcc/Acc Tcc/Gcc
PhyloP 100V -0.1 -0.1 -0.1
PhastCons 100V 0.15 0.15 0.15
PolyPhen2 benign benign benign
PolyPhen2 score 0.43 0.09 0.09
SIFT neutral neutral neutral
SIFT score 0.3 0.6 0.79
FatHmm neutral neutral neutral
FatHmm score -1.41 -0.75 -0.27
FatHmmW neutral neutral neutral
FatHmmW score 0.85 0.9 0.91
PROVEAN deleterious neutral neutral
PROVEAN score -2.51 -1.76 -0.84
MutationAssessor medium impact medium impact medium impact
MutationAssessor score 2.88 2.13 2.38
EFIN SP damaging damaging neutral
EFIN SP score 0.17 0.6 0.76
EFIN HD neutral neutral neutral
EFIN HD score 0.35 0.65 0.81
CADD deleterious deleterious neutral
CADD score 2.31 1.82 1.74
CADD phred 18.21 15.08 14.63
VEST pvalue 0.12 0.33 0.3
VEST FDR 0.4 0.5 0.45
PANTHER neutral neutral neutral
PANTHER score 0.44 0.25 0.21
PhD-SNP disease neutral neutral
PhD-SNP score 0.76 0.35 0.31
SNAP disease disease disease
SNAP score 0.6 0.6 0.56
Meta-SNP disease neutral neutral
Meta-SNP score 0.69 0.42 0.4
Meta-SNP RI 4 2 2
CAROL neutral neutral neutral
CAROL score 0.66 0.31 0.11
Condel neutral deleterious deleterious
Condel score 0.44 0.76 0.85
COVEC WMV neutral neutral neutral
COVEC WMV score -3 -3 -3
MtoolBox deleterious neutral neutral
MtoolBox DS 0.57 0.16 0.15
PolyPhen2 transf medium impact medium impact medium impact
PolyPhen2 transf score -0.61 0.19 0.19
SIFT_transf medium impact medium impact medium impact
SIFT transf score -0.01 0.29 0.51
MutationAssessor transf medium impact medium impact medium impact
MutationAssessor transf score 1.53 0.84 1.07
CHASM pvalue 0.22 0.48 0.35
CHASM FDR 0.8 0.8 0.8
APOGEE Pathogenic Neutral Neutral
APOGEE score 0.95 0.4 0.35
SNPDryad score 0.6 0.13 0.1
MutationTaster disease_causing_automatic polymorphism polymorphism
MutationTaster score 0 1 1
DEOGEN2 score 0.55 0.37 0.33
Mitoclass.1 neutral neutral neutral
dbSNP 155 id rs267606890 . .
ClinVar October2021 Variation id 9712 . .
ClinVar October2021 CLNSIG Pathogenic . .
ClinVar October2021 CLNDN Leigh_syndrome|Mitochondrial_complex_1_deficiency,_mitochondrial_type_1|Mitochondrial_complex_I_deficiency . .
ClinVar October2021 CLNDISDB MONDO:MONDO:0009723,MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MONDO:MONDO:0027068,MedGen:C4746992,OMIM:500014|MONDO:MONDO:0100133,MedGen:C1838979,Orphanet:ORPHA2609 . .
COSMIC 90 . . .
MITOMAP Allele T10191C . .
MITOMAP Disease Het/Hom -/+ . .
MITOMAP Disease Clinical info Leigh Disease / Leigh-like Disease / ESOC . .
MITOMAP Disease Status Cfrm . .
MITOMAP Disease GenBank Freq 0.000% . .
MITOMAP Disease GenBank Seqs 0 (0) . .
MITOMAP Disease GenBank Curated refs 27 . .
MITOMAP General GenBank Freq . . 0.000%
MITOMAP General GenBank Seqs . . 0
MITOMAP General Curated refs . . 1
gnomAD 3.1 filter npg PASS PASS
gnomAD 3.1 AC Homo 0 1 2
gnomAD 3.1 AC Het 0 0 0
gnomAD 3.1 AF Hom 0 1.7719814e-05 3.543963e-05
gnomAD 3.1 AF Het 0 0 0
gnomAD 3.1 AN 56433 56434 56434
EVmutation MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759 MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759 MT-ND3_45S|47A:0.28422;53M:0.197548;77W:0.189385;67L:0.153054;46P:0.148367;63L:0.140246;49V:0.127445;70A:0.110601;69I:0.089183;99A:0.088252;106W:0.080069;83N:0.078717;89M:0.071885;97I:0.069759
Site A InterP ND3_45 ND3_45 ND3_45
Site B InterP ND1_231;ND1_128;ND1_46;ND1_156;ND2_4;ND2_60;ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND1_248;ND1_67;ND1_126;ND1_71;ND1_93;ND1_76;ND1_27;ND1_84;ND1_276;ND1_249;ND1_163;ND1_229;ND1_85;ND1_62;ND1_301;ND1_64;ND1_251;ND1_79;ND2_166;ND2_6;ND2_89;ND2_265;ND2_241;ND2_239;ND2_276;ND2_78;ND2_10;ND2_76;ND2_94;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5 ND1_231;ND1_128;ND1_46;ND1_156;ND2_4;ND2_60;ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND1_248;ND1_67;ND1_126;ND1_71;ND1_93;ND1_76;ND1_27;ND1_84;ND1_276;ND1_249;ND1_163;ND1_229;ND1_85;ND1_62;ND1_301;ND1_64;ND1_251;ND1_79;ND2_166;ND2_6;ND2_89;ND2_265;ND2_241;ND2_239;ND2_276;ND2_78;ND2_10;ND2_76;ND2_94;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5 ND1_231;ND1_128;ND1_46;ND1_156;ND2_4;ND2_60;ND4_198;ND4_202;ND4_416;ND4L_57;ND4L_67;ND4L_27;ND5_497;ND5_414;ND1_248;ND1_67;ND1_126;ND1_71;ND1_93;ND1_76;ND1_27;ND1_84;ND1_276;ND1_249;ND1_163;ND1_229;ND1_85;ND1_62;ND1_301;ND1_64;ND1_251;ND1_79;ND2_166;ND2_6;ND2_89;ND2_265;ND2_241;ND2_239;ND2_276;ND2_78;ND2_10;ND2_76;ND2_94;ND4_442;ND4_411;ND4_49;ND4_248;ND4_38;ND4_4;ND4_438;ND4_426;ND4_85;ND4_56;ND4_140;ND4_27;ND4_54;ND4_99;ND4_444;ND4L_80;ND4L_54;ND4L_48;ND4L_91;ND4L_58;ND4L_57;ND4L_28;ND4L_38;ND5_193;ND5_572;ND5_480;ND5_202;ND5_160;ND5_518;ND5_428;ND5_41;ND5_75;ND5_420;ND5_492;ND5_583;ND5_169;ND5_426;ND6_41;ND6_17;ND6_87;ND6_135;ND6_21;ND6_86;ND6_5
Covariation Score InterP mfDCA_43.06;mfDCA_38.66;mfDCA_33.28;mfDCA_32.98;mfDCA_37.45;mfDCA_27.97;mfDCA_37.96;mfDCA_22.41;mfDCA_21.64;cMI_14.42049;mfDCA_34.27;mfDCA_26.86;mfDCA_79.1;mfDCA_31.92;cMI_49.89251;cMI_42.92984;cMI_41.72575;cMI_41.35901;cMI_39.83745;cMI_39.80877;cMI_39.28621;cMI_39.25341;cMI_38.90435;cMI_37.23441;cMI_37.10332;cMI_35.91475;cMI_35.72486;cMI_34.76365;cMI_34.26473;cMI_32.72981;cMI_31.32613;cMI_30.89244;cMI_22.94652;cMI_22.92951;cMI_22.78181;cMI_22.0794;cMI_21.36701;cMI_21.16552;cMI_19.74607;cMI_19.27132;cMI_18.72378;cMI_18.45074;cMI_18.01385;cMI_45.83789;cMI_44.22917;cMI_36.96359;cMI_36.7885;cMI_36.36468;cMI_34.82834;cMI_34.44059;cMI_34.16881;cMI_34.00615;cMI_33.7583;cMI_32.86419;cMI_32.3116;cMI_32.27547;cMI_31.86143;cMI_31.70077;cMI_30.23993;cMI_22.23638;cMI_19.73961;cMI_19.16892;cMI_15.51931;cMI_14.42049;cMI_12.72224;cMI_12.48772;cMI_45.56686;cMI_39.36692;cMI_39.2702;cMI_39.21392;cMI_37.50221;cMI_37.33206;cMI_37.03395;cMI_36.14669;cMI_36.0487;cMI_36.01114;cMI_35.29195;cMI_33.17587;cMI_32.8188;cMI_31.61218;cMI_19.13398;cMI_17.85636;cMI_17.52418;cMI_16.19448;cMI_14.52225;cMI_13.83411;cMI_13.57866 mfDCA_43.06;mfDCA_38.66;mfDCA_33.28;mfDCA_32.98;mfDCA_37.45;mfDCA_27.97;mfDCA_37.96;mfDCA_22.41;mfDCA_21.64;cMI_14.42049;mfDCA_34.27;mfDCA_26.86;mfDCA_79.1;mfDCA_31.92;cMI_49.89251;cMI_42.92984;cMI_41.72575;cMI_41.35901;cMI_39.83745;cMI_39.80877;cMI_39.28621;cMI_39.25341;cMI_38.90435;cMI_37.23441;cMI_37.10332;cMI_35.91475;cMI_35.72486;cMI_34.76365;cMI_34.26473;cMI_32.72981;cMI_31.32613;cMI_30.89244;cMI_22.94652;cMI_22.92951;cMI_22.78181;cMI_22.0794;cMI_21.36701;cMI_21.16552;cMI_19.74607;cMI_19.27132;cMI_18.72378;cMI_18.45074;cMI_18.01385;cMI_45.83789;cMI_44.22917;cMI_36.96359;cMI_36.7885;cMI_36.36468;cMI_34.82834;cMI_34.44059;cMI_34.16881;cMI_34.00615;cMI_33.7583;cMI_32.86419;cMI_32.3116;cMI_32.27547;cMI_31.86143;cMI_31.70077;cMI_30.23993;cMI_22.23638;cMI_19.73961;cMI_19.16892;cMI_15.51931;cMI_14.42049;cMI_12.72224;cMI_12.48772;cMI_45.56686;cMI_39.36692;cMI_39.2702;cMI_39.21392;cMI_37.50221;cMI_37.33206;cMI_37.03395;cMI_36.14669;cMI_36.0487;cMI_36.01114;cMI_35.29195;cMI_33.17587;cMI_32.8188;cMI_31.61218;cMI_19.13398;cMI_17.85636;cMI_17.52418;cMI_16.19448;cMI_14.52225;cMI_13.83411;cMI_13.57866 mfDCA_43.06;mfDCA_38.66;mfDCA_33.28;mfDCA_32.98;mfDCA_37.45;mfDCA_27.97;mfDCA_37.96;mfDCA_22.41;mfDCA_21.64;cMI_14.42049;mfDCA_34.27;mfDCA_26.86;mfDCA_79.1;mfDCA_31.92;cMI_49.89251;cMI_42.92984;cMI_41.72575;cMI_41.35901;cMI_39.83745;cMI_39.80877;cMI_39.28621;cMI_39.25341;cMI_38.90435;cMI_37.23441;cMI_37.10332;cMI_35.91475;cMI_35.72486;cMI_34.76365;cMI_34.26473;cMI_32.72981;cMI_31.32613;cMI_30.89244;cMI_22.94652;cMI_22.92951;cMI_22.78181;cMI_22.0794;cMI_21.36701;cMI_21.16552;cMI_19.74607;cMI_19.27132;cMI_18.72378;cMI_18.45074;cMI_18.01385;cMI_45.83789;cMI_44.22917;cMI_36.96359;cMI_36.7885;cMI_36.36468;cMI_34.82834;cMI_34.44059;cMI_34.16881;cMI_34.00615;cMI_33.7583;cMI_32.86419;cMI_32.3116;cMI_32.27547;cMI_31.86143;cMI_31.70077;cMI_30.23993;cMI_22.23638;cMI_19.73961;cMI_19.16892;cMI_15.51931;cMI_14.42049;cMI_12.72224;cMI_12.48772;cMI_45.56686;cMI_39.36692;cMI_39.2702;cMI_39.21392;cMI_37.50221;cMI_37.33206;cMI_37.03395;cMI_36.14669;cMI_36.0487;cMI_36.01114;cMI_35.29195;cMI_33.17587;cMI_32.8188;cMI_31.61218;cMI_19.13398;cMI_17.85636;cMI_17.52418;cMI_16.19448;cMI_14.52225;cMI_13.83411;cMI_13.57866
Site A IntraP ND3_45 ND3_45 ND3_45
Site B IntraP ND3_35;ND3_18;ND3_88;ND3_8;ND3_97;ND3_89;ND3_4;ND3_49;ND3_21;ND3_79;ND3_29;ND3_19;ND3_44;ND3_15;ND3_112;ND3_91;ND3_35;ND3_88;ND3_89;ND3_19;ND3_44;ND3_21;ND3_107 ND3_35;ND3_18;ND3_88;ND3_8;ND3_97;ND3_89;ND3_4;ND3_49;ND3_21;ND3_79;ND3_29;ND3_19;ND3_44;ND3_15;ND3_112;ND3_91;ND3_35;ND3_88;ND3_89;ND3_19;ND3_44;ND3_21;ND3_107 ND3_35;ND3_18;ND3_88;ND3_8;ND3_97;ND3_89;ND3_4;ND3_49;ND3_21;ND3_79;ND3_29;ND3_19;ND3_44;ND3_15;ND3_112;ND3_91;ND3_35;ND3_88;ND3_89;ND3_19;ND3_44;ND3_21;ND3_107
Covariation Score IntraP mfDCA_24.6929;cMI_18.130184;mfDCA_22.1031;cMI_15.679218;cMI_15.674643;mfDCA_18.5493;cMI_15.140093;cMI_12.779061;mfDCA_16.7255;cMI_12.428753;cMI_12.024128;mfDCA_18.0094;mfDCA_17.102;cMI_10.232872;cMI_10.168221;cMI_9.709738;mfDCA_24.6929;mfDCA_22.1031;mfDCA_18.5493;mfDCA_18.0094;mfDCA_17.102;mfDCA_16.7255;mfDCA_15.438 mfDCA_24.6929;cMI_18.130184;mfDCA_22.1031;cMI_15.679218;cMI_15.674643;mfDCA_18.5493;cMI_15.140093;cMI_12.779061;mfDCA_16.7255;cMI_12.428753;cMI_12.024128;mfDCA_18.0094;mfDCA_17.102;cMI_10.232872;cMI_10.168221;cMI_9.709738;mfDCA_24.6929;mfDCA_22.1031;mfDCA_18.5493;mfDCA_18.0094;mfDCA_17.102;mfDCA_16.7255;mfDCA_15.438 mfDCA_24.6929;cMI_18.130184;mfDCA_22.1031;cMI_15.679218;cMI_15.674643;mfDCA_18.5493;cMI_15.140093;cMI_12.779061;mfDCA_16.7255;cMI_12.428753;cMI_12.024128;mfDCA_18.0094;mfDCA_17.102;cMI_10.232872;cMI_10.168221;cMI_9.709738;mfDCA_24.6929;mfDCA_22.1031;mfDCA_18.5493;mfDCA_18.0094;mfDCA_17.102;mfDCA_16.7255;mfDCA_15.438
CPD AA ref . . .
CPD AA alt . . .
CPD Aln pos . . .
CPD Frequency . . .
CPD Species name . . .
CPD RefSeq Protein ID . . .
CPD Ncbi Taxon id . . .
DDG intra MT-ND3:S45P:L107Q:5.1219:4.1339:0.964638;MT-ND3:S45P:L107R:4.80834:4.1339:0.654602;MT-ND3:S45P:L107P:8.85061:4.1339:4.56316;MT-ND3:S45P:L107V:5.75541:4.1339:1.58272;MT-ND3:S45P:L107M:3.93827:4.1339:-0.186263;MT-ND3:S45P:D112H:4.20228:4.1339:0.0340833;MT-ND3:S45P:D112Y:3.77103:4.1339:-0.433469;MT-ND3:S45P:D112N:4.16016:4.1339:-0.0131052;MT-ND3:S45P:D112E:3.96989:4.1339:-0.258161;MT-ND3:S45P:D112G:4.55127:4.1339:0.414236;MT-ND3:S45P:D112V:4.3272:4.1339:0.179616;MT-ND3:S45P:D112A:3.66153:4.1339:-0.418179;MT-ND3:S45P:V49G:5.06697:4.1339:0.888794;MT-ND3:S45P:V49A:4.39278:4.1339:0.193963;MT-ND3:S45P:V49L:3.81485:4.1339:-0.289594;MT-ND3:S45P:V49D:3.5169:4.1339:-0.607087;MT-ND3:S45P:V49F:3.48098:4.1339:-0.639481;MT-ND3:S45P:V49I:4.28611:4.1339:-0.482548;MT-ND3:S45P:L79Q:4.85566:4.1339:0.615227;MT-ND3:S45P:L79R:5.1586:4.1339:1.00907;MT-ND3:S45P:L79M:3.98456:4.1339:-0.174798;MT-ND3:S45P:L79V:5.84676:4.1339:1.69291;MT-ND3:S45P:L79P:7.80779:4.1339:3.64483;MT-ND3:S45P:G29D:4.40541:4.1339:0.254493;MT-ND3:S45P:G29A:4.25797:4.1339:0.171581;MT-ND3:S45P:G29C:4.43954:4.1339:0.290877;MT-ND3:S45P:G29S:4.20152:4.1339:0.061955;MT-ND3:S45P:G29V:4.69077:4.1339:0.518345;MT-ND3:S45P:G29R:4.21889:4.1339:0.0789448;MT-ND3:S45P:T35A:4.19861:4.1339:0.0855016;MT-ND3:S45P:T35N:4.46139:4.1339:0.309927;MT-ND3:S45P:T35S:4.57446:4.1339:0.233842;MT-ND3:S45P:T35P:4.57535:4.1339:0.442305;MT-ND3:S45P:T35I:3.60392:4.1339:-0.515883;MT-ND3:S45P:M44T:4.71464:4.1339:0.4131;MT-ND3:S45P:M44K:4.25508:4.1339:0.331748;MT-ND3:S45P:M44I:4.34348:4.1339:0.322536;MT-ND3:S45P:M44V:4.66005:4.1339:0.489564;MT-ND3:S45P:M44L:4.29145:4.1339:0.360285;MT-ND3:S45P:A4P:2.705:4.1339:-1.526;MT-ND3:S45P:A4S:5.07628:4.1339:0.901348;MT-ND3:S45P:A4G:5.18293:4.1339:1.08914;MT-ND3:S45P:A4V:4.28057:4.1339:0.176529;MT-ND3:S45P:A4D:4.33837:4.1339:0.190562;MT-ND3:S45P:A4T:5.51494:4.1339:1.29799 MT-ND3:S45T:L107M:-0.381736:-0.193334:-0.186263;MT-ND3:S45T:L107R:0.471732:-0.193334:0.654602;MT-ND3:S45T:L107P:4.50682:-0.193334:4.56316;MT-ND3:S45T:L107V:1.38096:-0.193334:1.58272;MT-ND3:S45T:L107Q:0.786723:-0.193334:0.964638;MT-ND3:S45T:D112V:-0.0198059:-0.193334:0.179616;MT-ND3:S45T:D112E:-0.445382:-0.193334:-0.258161;MT-ND3:S45T:D112G:0.202581:-0.193334:0.414236;MT-ND3:S45T:D112A:-0.626307:-0.193334:-0.418179;MT-ND3:S45T:D112Y:-0.636864:-0.193334:-0.433469;MT-ND3:S45T:D112N:-0.201313:-0.193334:-0.0131052;MT-ND3:S45T:D112H:-0.145536:-0.193334:0.0340833;MT-ND3:S45T:V49F:-0.827647:-0.193334:-0.639481;MT-ND3:S45T:V49D:-0.82733:-0.193334:-0.607087;MT-ND3:S45T:V49L:-0.356219:-0.193334:-0.289594;MT-ND3:S45T:V49G:0.795547:-0.193334:0.888794;MT-ND3:S45T:V49I:-0.547249:-0.193334:-0.482548;MT-ND3:S45T:V49A:0.303211:-0.193334:0.193963;MT-ND3:S45T:L79P:3.45752:-0.193334:3.64483;MT-ND3:S45T:L79M:-0.355915:-0.193334:-0.174798;MT-ND3:S45T:L79Q:0.443294:-0.193334:0.615227;MT-ND3:S45T:L79V:1.49783:-0.193334:1.69291;MT-ND3:S45T:L79R:0.819644:-0.193334:1.00907;MT-ND3:S45T:G29C:0.100006:-0.193334:0.290877;MT-ND3:S45T:G29D:0.0640916:-0.193334:0.254493;MT-ND3:S45T:G29S:-0.130535:-0.193334:0.061955;MT-ND3:S45T:G29A:-0.0189741:-0.193334:0.171581;MT-ND3:S45T:G29R:-0.103894:-0.193334:0.0789448;MT-ND3:S45T:G29V:0.325636:-0.193334:0.518345;MT-ND3:S45T:T35A:-0.102041:-0.193334:0.0855016;MT-ND3:S45T:T35S:0.0445892:-0.193334:0.233842;MT-ND3:S45T:T35N:0.146617:-0.193334:0.309927;MT-ND3:S45T:T35P:0.248048:-0.193334:0.442305;MT-ND3:S45T:T35I:-0.708227:-0.193334:-0.515883;MT-ND3:S45T:M44K:0.114574:-0.193334:0.331748;MT-ND3:S45T:M44T:0.268254:-0.193334:0.4131;MT-ND3:S45T:M44V:0.340112:-0.193334:0.489564;MT-ND3:S45T:M44I:0.140842:-0.193334:0.322536;MT-ND3:S45T:M44L:0.0106605:-0.193334:0.360285;MT-ND3:S45T:A4S:0.708495:-0.193334:0.901348;MT-ND3:S45T:A4G:0.900125:-0.193334:1.08914;MT-ND3:S45T:A4P:-1.64918:-0.193334:-1.526;MT-ND3:S45T:A4D:0.0231006:-0.193334:0.190562;MT-ND3:S45T:A4V:-0.0981623:-0.193334:0.176529;MT-ND3:S45T:A4T:1.44737:-0.193334:1.29799 MT-ND3:S45A:L107Q:1.86944:0.898719:0.964638;MT-ND3:S45A:L107V:2.4996:0.898719:1.58272;MT-ND3:S45A:L107M:0.715066:0.898719:-0.186263;MT-ND3:S45A:L107P:5.69195:0.898719:4.56316;MT-ND3:S45A:L107R:1.54806:0.898719:0.654602;MT-ND3:S45A:D112N:0.927985:0.898719:-0.0131052;MT-ND3:S45A:D112Y:0.523376:0.898719:-0.433469;MT-ND3:S45A:D112A:0.520717:0.898719:-0.418179;MT-ND3:S45A:D112G:1.3301:0.898719:0.414236;MT-ND3:S45A:D112E:0.712251:0.898719:-0.258161;MT-ND3:S45A:D112H:1.01463:0.898719:0.0340833;MT-ND3:S45A:D112V:1.12683:0.898719:0.179616;MT-ND3:S45A:V49G:1.91344:0.898719:0.888794;MT-ND3:S45A:V49A:1.18917:0.898719:0.193963;MT-ND3:S45A:V49I:1.04652:0.898719:-0.482548;MT-ND3:S45A:V49D:0.361223:0.898719:-0.607087;MT-ND3:S45A:V49F:0.363601:0.898719:-0.639481;MT-ND3:S45A:V49L:0.656181:0.898719:-0.289594;MT-ND3:S45A:L79Q:1.61103:0.898719:0.615227;MT-ND3:S45A:L79M:0.765146:0.898719:-0.174798;MT-ND3:S45A:L79P:4.64388:0.898719:3.64483;MT-ND3:S45A:L79V:2.59329:0.898719:1.69291;MT-ND3:S45A:L79R:1.91579:0.898719:1.00907;MT-ND3:S45A:G29R:1.02808:0.898719:0.0789448;MT-ND3:S45A:G29S:0.984365:0.898719:0.061955;MT-ND3:S45A:G29C:1.2321:0.898719:0.290877;MT-ND3:S45A:G29D:1.16518:0.898719:0.254493;MT-ND3:S45A:G29V:1.44128:0.898719:0.518345;MT-ND3:S45A:G29A:1.08002:0.898719:0.171581;MT-ND3:S45A:T35I:0.400209:0.898719:-0.515883;MT-ND3:S45A:T35P:1.37802:0.898719:0.442305;MT-ND3:S45A:T35S:1.32111:0.898719:0.233842;MT-ND3:S45A:T35N:1.22877:0.898719:0.309927;MT-ND3:S45A:T35A:1.00227:0.898719:0.0855016;MT-ND3:S45A:M44L:1.1635:0.898719:0.360285;MT-ND3:S45A:M44I:1.172:0.898719:0.322536;MT-ND3:S45A:M44K:1.1209:0.898719:0.331748;MT-ND3:S45A:M44V:1.30387:0.898719:0.489564;MT-ND3:S45A:M44T:1.30656:0.898719:0.4131;MT-ND3:S45A:A4D:1.05147:0.898719:0.190562;MT-ND3:S45A:A4P:-0.509629:0.898719:-1.526;MT-ND3:S45A:A4G:2.00368:0.898719:1.08914;MT-ND3:S45A:A4S:1.82332:0.898719:0.901348;MT-ND3:S45A:A4V:1.29706:0.898719:0.176529;MT-ND3:S45A:A4T:2.66952:0.898719:1.29799
DDG intra interface MT-ND3:NDUFS2:5lc5:A:D:S45P:V49A:-0.062485:-0.18296:0.155824;MT-ND3:NDUFS2:5lc5:A:D:S45P:V49D:-0.205783:-0.18296:-0.028075;MT-ND3:NDUFS2:5lc5:A:D:S45P:V49F:-0.021177:-0.18296:0.166614;MT-ND3:NDUFS2:5lc5:A:D:S45P:V49G:0.054543:-0.18296:0.140612;MT-ND3:NDUFS2:5lc5:A:D:S45P:V49I:-0.111426:-0.18296:0.109823;MT-ND3:NDUFS2:5lc5:A:D:S45P:V49L:0.018407:-0.18296:0.185479;MT-ND3:MT-ND1:5lc5:A:H:S45P:L15F:-0.4552:-1.07436:0.77833;MT-ND3:MT-ND1:5lc5:A:H:S45P:L15M:-0.98575:-1.07436:0.1131;MT-ND3:MT-ND1:5lc5:A:H:S45P:L15S:0.19336:-1.07436:1.28246;MT-ND3:MT-ND1:5lc5:A:H:S45P:L15V:0.01304:-1.07436:1.06051;MT-ND3:MT-ND1:5lc5:A:H:S45P:L15W:-1.25689:-1.07436:-0.4324;MT-ND3:MT-ND1:5lc5:A:H:S45P:M18I:-0.32891:-1.07545:0.66938;MT-ND3:MT-ND1:5lc5:A:H:S45P:M18K:1.43117:-1.07545:2.49572;MT-ND3:MT-ND1:5lc5:A:H:S45P:M18L:-0.47669:-1.07545:0.5324;MT-ND3:MT-ND1:5lc5:A:H:S45P:M18T:1.38096:-1.07545:2.4593;MT-ND3:MT-ND1:5lc5:A:H:S45P:M18V:0.36122:-1.07545:1.36914;MT-ND3:MT-ND1:5lc5:A:H:S45P:T35A:-0.96405:-1.0707:0.14765;MT-ND3:MT-ND1:5lc5:A:H:S45P:T35I:-1.02652:-1.0707:-0.06767;MT-ND3:MT-ND1:5lc5:A:H:S45P:T35N:-0.91461:-1.0707:0.1598;MT-ND3:MT-ND1:5lc5:A:H:S45P:T35P:-1.24854:-1.0707:-0.18368;MT-ND3:MT-ND1:5lc5:A:H:S45P:T35S:-1.2019:-1.0707:-0.12436;MT-ND3:MT-ND1:5lc5:A:H:S45P:M44I:-1.03341:-1.09531:-0.26598;MT-ND3:MT-ND1:5lc5:A:H:S45P:M44K:-0.9639:-1.09531:-0.29543;MT-ND3:MT-ND1:5lc5:A:H:S45P:M44L:-0.82817:-1.09531:-0.25651;MT-ND3:MT-ND1:5lc5:A:H:S45P:M44T:-1.12326:-1.09531:0.06186;MT-ND3:MT-ND1:5lc5:A:H:S45P:M44V:-1.04836:-1.09531:-0.15183;MT-ND3:MT-ND1:5ldw:A:H:S45P:L15F:0.05373:-0.30532:0.16768;MT-ND3:MT-ND1:5ldw:A:H:S45P:L15M:-0.48584:-0.30532:-0.22176;MT-ND3:MT-ND1:5ldw:A:H:S45P:L15S:0.34378:-0.30532:0.71124;MT-ND3:MT-ND1:5ldw:A:H:S45P:L15V:0.04199:-0.30532:0.32203;MT-ND3:MT-ND1:5ldw:A:H:S45P:L15W:-0.42049:-0.30532:-0.12821;MT-ND3:MT-ND1:5ldw:A:H:S45P:M18I:0.53185:-0.30211:0.6076;MT-ND3:MT-ND1:5ldw:A:H:S45P:M18K:0.68297:-0.30211:1.03939;MT-ND3:MT-ND1:5ldw:A:H:S45P:M18L:0.04092:-0.30211:0.23679;MT-ND3:MT-ND1:5ldw:A:H:S45P:M18T:1.48991:-0.30211:1.85929;MT-ND3:MT-ND1:5ldw:A:H:S45P:M18V:0.87111:-0.30211:1.04567;MT-ND3:MT-ND1:5ldw:A:H:S45P:T35A:-0.70703:-0.30095:-0.39186;MT-ND3:MT-ND1:5ldw:A:H:S45P:T35I:-0.80929:-0.30095:-0.53034;MT-ND3:MT-ND1:5ldw:A:H:S45P:T35N:-0.5271:-0.30095:-0.30034;MT-ND3:MT-ND1:5ldw:A:H:S45P:T35P:-1.05072:-0.30095:-0.80325;MT-ND3:MT-ND1:5ldw:A:H:S45P:T35S:-0.71497:-0.30095:-0.19208;MT-ND3:MT-ND1:5ldw:A:H:S45P:M44I:-0.15653:-0.29889:0.00493000000002;MT-ND3:MT-ND1:5ldw:A:H:S45P:M44K:-0.46416:-0.29889:-0.10369;MT-ND3:MT-ND1:5ldw:A:H:S45P:M44L:0.76673:-0.29889:-0.10361;MT-ND3:MT-ND1:5ldw:A:H:S45P:M44T:-0.38545:-0.29889:0.01395;MT-ND3:MT-ND1:5ldw:A:H:S45P:M44V:-0.06756:-0.29889:0.0288;MT-ND3:MT-ND1:5ldx:A:H:S45P:L15F:1.28211:0.71647:0.54581;MT-ND3:MT-ND1:5ldx:A:H:S45P:L15M:0.52987:0.71647:-0.21274;MT-ND3:MT-ND1:5ldx:A:H:S45P:L15S:1.41922:0.71647:0.64412;MT-ND3:MT-ND1:5ldx:A:H:S45P:L15V:1.2856:0.71647:0.48811;MT-ND3:MT-ND1:5ldx:A:H:S45P:L15W:0.44199:0.71647:-0.23467;MT-ND3:MT-ND1:5ldx:A:H:S45P:M18I:1.24941:0.76551:0.65117;MT-ND3:MT-ND1:5ldx:A:H:S45P:M18K:2.05655:0.76551:1.20633;MT-ND3:MT-ND1:5ldx:A:H:S45P:M18L:1.12669:0.76551:0.49592;MT-ND3:MT-ND1:5ldx:A:H:S45P:M18T:2.50408:0.76551:1.70221;MT-ND3:MT-ND1:5ldx:A:H:S45P:M18V:1.83828:0.76551:1.12518;MT-ND3:MT-ND1:5ldx:A:H:S45P:T35A:0.47221:0.70384:-0.28604;MT-ND3:MT-ND1:5ldx:A:H:S45P:T35I:0.03252:0.70384:-0.5748;MT-ND3:MT-ND1:5ldx:A:H:S45P:T35N:0.55116:0.70384:-0.12195;MT-ND3:MT-ND1:5ldx:A:H:S45P:T35P:-0.14447:0.70384:-0.88659;MT-ND3:MT-ND1:5ldx:A:H:S45P:T35S:0.479:0.70384:-0.18413;MT-ND3:MT-ND1:5ldx:A:H:S45P:M44I:0.70082:0.75603:-0.03478;MT-ND3:MT-ND1:5ldx:A:H:S45P:M44K:0.63693:0.75603:-0.07642;MT-ND3:MT-ND1:5ldx:A:H:S45P:M44L:0.98361:0.75603:-0.07877;MT-ND3:MT-ND1:5ldx:A:H:S45P:M44T:0.66629:0.75603:0.03867;MT-ND3:MT-ND1:5ldx:A:H:S45P:M44V:0.87723:0.75603:0.04435 MT-ND3:NDUFS2:5lc5:A:D:S45T:V49A:-0.142604:-0.269482:0.155824;MT-ND3:NDUFS2:5lc5:A:D:S45T:V49D:-0.319611:-0.269482:-0.028075;MT-ND3:NDUFS2:5lc5:A:D:S45T:V49F:-0.067598:-0.269482:0.166614;MT-ND3:NDUFS2:5lc5:A:D:S45T:V49G:-0.075341:-0.269482:0.140612;MT-ND3:NDUFS2:5lc5:A:D:S45T:V49I:-0.166487:-0.269482:0.109823;MT-ND3:NDUFS2:5lc5:A:D:S45T:V49L:-0.079242:-0.269482:0.185479;MT-ND3:MT-ND1:5lc5:A:H:S45T:L15F:0.94416:0.17377:0.77833;MT-ND3:MT-ND1:5lc5:A:H:S45T:L15M:0.29817:0.17377:0.1131;MT-ND3:MT-ND1:5lc5:A:H:S45T:L15S:1.38279:0.17377:1.28246;MT-ND3:MT-ND1:5lc5:A:H:S45T:L15V:1.32736:0.17377:1.06051;MT-ND3:MT-ND1:5lc5:A:H:S45T:L15W:-0.04049:0.17377:-0.4324;MT-ND3:MT-ND1:5lc5:A:H:S45T:M18I:0.83376:0.18219:0.66938;MT-ND3:MT-ND1:5lc5:A:H:S45T:M18K:2.68883:0.18219:2.49572;MT-ND3:MT-ND1:5lc5:A:H:S45T:M18L:0.70329:0.18219:0.5324;MT-ND3:MT-ND1:5lc5:A:H:S45T:M18T:2.69571:0.18219:2.4593;MT-ND3:MT-ND1:5lc5:A:H:S45T:M18V:1.64915:0.18219:1.36914;MT-ND3:MT-ND1:5lc5:A:H:S45T:T35A:0.42612:0.23364:0.14765;MT-ND3:MT-ND1:5lc5:A:H:S45T:T35I:0.10237:0.23364:-0.06767;MT-ND3:MT-ND1:5lc5:A:H:S45T:T35N:0.37601:0.23364:0.1598;MT-ND3:MT-ND1:5lc5:A:H:S45T:T35P:0.05681:0.23364:-0.18368;MT-ND3:MT-ND1:5lc5:A:H:S45T:T35S:0.07405:0.23364:-0.12436;MT-ND3:MT-ND1:5lc5:A:H:S45T:M44I:-1.24444:0.15893:-0.26598;MT-ND3:MT-ND1:5lc5:A:H:S45T:M44K:-1.21321:0.15893:-0.29543;MT-ND3:MT-ND1:5lc5:A:H:S45T:M44L:-0.76774:0.15893:-0.25651;MT-ND3:MT-ND1:5lc5:A:H:S45T:M44T:-0.64524:0.15893:0.06186;MT-ND3:MT-ND1:5lc5:A:H:S45T:M44V:-0.94635:0.15893:-0.15183;MT-ND3:MT-ND1:5ldw:A:H:S45T:L15F:0.53777:0.20131:0.16768;MT-ND3:MT-ND1:5ldw:A:H:S45T:L15M:-0.02397:0.20131:-0.22176;MT-ND3:MT-ND1:5ldw:A:H:S45T:L15S:0.9421:0.20131:0.71124;MT-ND3:MT-ND1:5ldw:A:H:S45T:L15V:0.56955:0.20131:0.32203;MT-ND3:MT-ND1:5ldw:A:H:S45T:L15W:-0.01047:0.20131:-0.12821;MT-ND3:MT-ND1:5ldw:A:H:S45T:M18I:0.466:0.18825:0.6076;MT-ND3:MT-ND1:5ldw:A:H:S45T:M18K:1.13309:0.18825:1.03939;MT-ND3:MT-ND1:5ldw:A:H:S45T:M18L:0.23677:0.18825:0.23679;MT-ND3:MT-ND1:5ldw:A:H:S45T:M18T:2.02409:0.18825:1.85929;MT-ND3:MT-ND1:5ldw:A:H:S45T:M18V:1.14142:0.18825:1.04567;MT-ND3:MT-ND1:5ldw:A:H:S45T:T35A:-0.76025:0.16123:-0.39186;MT-ND3:MT-ND1:5ldw:A:H:S45T:T35I:-0.27091:0.16123:-0.53034;MT-ND3:MT-ND1:5ldw:A:H:S45T:T35N:0.0535:0.16123:-0.30034;MT-ND3:MT-ND1:5ldw:A:H:S45T:T35P:-1.03145:0.16123:-0.80325;MT-ND3:MT-ND1:5ldw:A:H:S45T:T35S:-0.48439:0.16123:-0.19208;MT-ND3:MT-ND1:5ldw:A:H:S45T:M44I:-0.08871:0.1834:0.00493000000002;MT-ND3:MT-ND1:5ldw:A:H:S45T:M44K:0.03738:0.1834:-0.10369;MT-ND3:MT-ND1:5ldw:A:H:S45T:M44L:0.51183:0.1834:-0.10361;MT-ND3:MT-ND1:5ldw:A:H:S45T:M44T:-0.08413:0.1834:0.01395;MT-ND3:MT-ND1:5ldw:A:H:S45T:M44V:0.01719:0.1834:0.0288;MT-ND3:MT-ND1:5ldx:A:H:S45T:L15F:1.15263:0.5621:0.54581;MT-ND3:MT-ND1:5ldx:A:H:S45T:L15M:0.32143:0.5621:-0.21274;MT-ND3:MT-ND1:5ldx:A:H:S45T:L15S:1.06309:0.5621:0.64412;MT-ND3:MT-ND1:5ldx:A:H:S45T:L15V:1.04289:0.5621:0.48811;MT-ND3:MT-ND1:5ldx:A:H:S45T:L15W:0.18279:0.5621:-0.23467;MT-ND3:MT-ND1:5ldx:A:H:S45T:M18I:1.35605:0.53533:0.65117;MT-ND3:MT-ND1:5ldx:A:H:S45T:M18K:1.86029:0.53533:1.20633;MT-ND3:MT-ND1:5ldx:A:H:S45T:M18L:0.56567:0.53533:0.49592;MT-ND3:MT-ND1:5ldx:A:H:S45T:M18T:2.37079:0.53533:1.70221;MT-ND3:MT-ND1:5ldx:A:H:S45T:M18V:1.60746:0.53533:1.12518;MT-ND3:MT-ND1:5ldx:A:H:S45T:T35A:0.47212:0.53239:-0.28604;MT-ND3:MT-ND1:5ldx:A:H:S45T:T35I:0.22983:0.53239:-0.5748;MT-ND3:MT-ND1:5ldx:A:H:S45T:T35N:0.45945:0.53239:-0.12195;MT-ND3:MT-ND1:5ldx:A:H:S45T:T35P:-0.17436:0.53239:-0.88659;MT-ND3:MT-ND1:5ldx:A:H:S45T:T35S:0.48873:0.53239:-0.18413;MT-ND3:MT-ND1:5ldx:A:H:S45T:M44I:0.44152:0.55968:-0.03478;MT-ND3:MT-ND1:5ldx:A:H:S45T:M44K:0.60991:0.55968:-0.07642;MT-ND3:MT-ND1:5ldx:A:H:S45T:M44L:0.50732:0.55968:-0.07877;MT-ND3:MT-ND1:5ldx:A:H:S45T:M44T:0.68112:0.55968:0.03867;MT-ND3:MT-ND1:5ldx:A:H:S45T:M44V:0.56757:0.55968:0.04435 MT-ND3:NDUFS2:5lc5:A:D:S45A:V49A:0.113256:-0.06109:0.155824;MT-ND3:NDUFS2:5lc5:A:D:S45A:V49D:-0.092071:-0.06109:-0.028075;MT-ND3:NDUFS2:5lc5:A:D:S45A:V49F:0.110306:-0.06109:0.166614;MT-ND3:NDUFS2:5lc5:A:D:S45A:V49G:0.078517:-0.06109:0.140612;MT-ND3:NDUFS2:5lc5:A:D:S45A:V49I:0.005306:-0.06109:0.109823;MT-ND3:NDUFS2:5lc5:A:D:S45A:V49L:0.141731:-0.06109:0.185479;MT-ND3:MT-ND1:5lc5:A:H:S45A:L15F:0.49613:-0.08371:0.77833;MT-ND3:MT-ND1:5lc5:A:H:S45A:L15M:0.03655:-0.08371:0.1131;MT-ND3:MT-ND1:5lc5:A:H:S45A:L15S:1.2181:-0.08371:1.28246;MT-ND3:MT-ND1:5lc5:A:H:S45A:L15V:0.90226:-0.08371:1.06051;MT-ND3:MT-ND1:5lc5:A:H:S45A:L15W:-0.401:-0.08371:-0.4324;MT-ND3:MT-ND1:5lc5:A:H:S45A:M18I:0.69331:-0.08376:0.66938;MT-ND3:MT-ND1:5lc5:A:H:S45A:M18K:2.4746:-0.08376:2.49572;MT-ND3:MT-ND1:5lc5:A:H:S45A:M18L:0.52276:-0.08376:0.5324;MT-ND3:MT-ND1:5lc5:A:H:S45A:M18T:2.425:-0.08376:2.4593;MT-ND3:MT-ND1:5lc5:A:H:S45A:M18V:1.27582:-0.08376:1.36914;MT-ND3:MT-ND1:5lc5:A:H:S45A:T35A:-0.10865:-0.08374:0.14765;MT-ND3:MT-ND1:5lc5:A:H:S45A:T35I:-0.16491:-0.08374:-0.06767;MT-ND3:MT-ND1:5lc5:A:H:S45A:T35N:-0.01276:-0.08374:0.1598;MT-ND3:MT-ND1:5lc5:A:H:S45A:T35P:-0.24694:-0.08374:-0.18368;MT-ND3:MT-ND1:5lc5:A:H:S45A:T35S:-0.18944:-0.08374:-0.12436;MT-ND3:MT-ND1:5lc5:A:H:S45A:M44I:-0.3684:-0.08361:-0.26598;MT-ND3:MT-ND1:5lc5:A:H:S45A:M44K:-0.36506:-0.08361:-0.29543;MT-ND3:MT-ND1:5lc5:A:H:S45A:M44L:-0.25903:-0.08361:-0.25651;MT-ND3:MT-ND1:5lc5:A:H:S45A:M44T:0.02853:-0.08361:0.06186;MT-ND3:MT-ND1:5lc5:A:H:S45A:M44V:-0.23875:-0.08361:-0.15183;MT-ND3:MT-ND1:5ldw:A:H:S45A:L15F:0.39165:-0.01562:0.16768;MT-ND3:MT-ND1:5ldw:A:H:S45A:L15M:-0.2597:-0.01562:-0.22176;MT-ND3:MT-ND1:5ldw:A:H:S45A:L15S:0.59796:-0.01562:0.71124;MT-ND3:MT-ND1:5ldw:A:H:S45A:L15V:0.31813:-0.01562:0.32203;MT-ND3:MT-ND1:5ldw:A:H:S45A:L15W:-0.1989:-0.01562:-0.12821;MT-ND3:MT-ND1:5ldw:A:H:S45A:M18I:0.57096:-0.01562:0.6076;MT-ND3:MT-ND1:5ldw:A:H:S45A:M18K:0.90714:-0.01562:1.03939;MT-ND3:MT-ND1:5ldw:A:H:S45A:M18L:0.14282:-0.01562:0.23679;MT-ND3:MT-ND1:5ldw:A:H:S45A:M18T:1.86075:-0.01562:1.85929;MT-ND3:MT-ND1:5ldw:A:H:S45A:M18V:1.04238:-0.01562:1.04567;MT-ND3:MT-ND1:5ldw:A:H:S45A:T35A:-0.37972:-0.01562:-0.39186;MT-ND3:MT-ND1:5ldw:A:H:S45A:T35I:-0.54754:-0.01562:-0.53034;MT-ND3:MT-ND1:5ldw:A:H:S45A:T35N:-0.22507:-0.01562:-0.30034;MT-ND3:MT-ND1:5ldw:A:H:S45A:T35P:-0.82443:-0.01562:-0.80325;MT-ND3:MT-ND1:5ldw:A:H:S45A:T35S:-0.3899:-0.01562:-0.19208;MT-ND3:MT-ND1:5ldw:A:H:S45A:M44I:-0.0235:-0.01562:0.00493000000002;MT-ND3:MT-ND1:5ldw:A:H:S45A:M44K:-0.0206:-0.01562:-0.10369;MT-ND3:MT-ND1:5ldw:A:H:S45A:M44L:0.3833:-0.01562:-0.10361;MT-ND3:MT-ND1:5ldw:A:H:S45A:M44T:0.00764000000001:-0.01562:0.01395;MT-ND3:MT-ND1:5ldw:A:H:S45A:M44V:0.005:-0.01562:0.0288;MT-ND3:MT-ND1:5ldx:A:H:S45A:L15F:1.09525:0.55252:0.54581;MT-ND3:MT-ND1:5ldx:A:H:S45A:L15M:0.32118:0.55252:-0.21274;MT-ND3:MT-ND1:5ldx:A:H:S45A:L15S:1.19836:0.55252:0.64412;MT-ND3:MT-ND1:5ldx:A:H:S45A:L15V:1.03343:0.55252:0.48811;MT-ND3:MT-ND1:5ldx:A:H:S45A:L15W:0.29914:0.55252:-0.23467;MT-ND3:MT-ND1:5ldx:A:H:S45A:M18I:1.27372:0.55324:0.65117;MT-ND3:MT-ND1:5ldx:A:H:S45A:M18K:1.72475:0.55324:1.20633;MT-ND3:MT-ND1:5ldx:A:H:S45A:M18L:0.91957:0.55324:0.49592;MT-ND3:MT-ND1:5ldx:A:H:S45A:M18T:2.35463:0.55324:1.70221;MT-ND3:MT-ND1:5ldx:A:H:S45A:M18V:1.61699:0.55324:1.12518;MT-ND3:MT-ND1:5ldx:A:H:S45A:T35A:0.24389:0.54952:-0.28604;MT-ND3:MT-ND1:5ldx:A:H:S45A:T35I:0.02464:0.54952:-0.5748;MT-ND3:MT-ND1:5ldx:A:H:S45A:T35N:0.32055:0.54952:-0.12195;MT-ND3:MT-ND1:5ldx:A:H:S45A:T35P:-0.32351:0.54952:-0.88659;MT-ND3:MT-ND1:5ldx:A:H:S45A:T35S:0.31074:0.54952:-0.18413;MT-ND3:MT-ND1:5ldx:A:H:S45A:M44I:0.79949:0.55324:-0.03478;MT-ND3:MT-ND1:5ldx:A:H:S45A:M44K:0.58783:0.55324:-0.07642;MT-ND3:MT-ND1:5ldx:A:H:S45A:M44L:0.92142:0.55324:-0.07877;MT-ND3:MT-ND1:5ldx:A:H:S45A:M44T:0.62619:0.55324:0.03867;MT-ND3:MT-ND1:5ldx:A:H:S45A:M44V:0.94888:0.55324:0.04435
DDG inter MT-ND3:MT-ND1:5lc5:A:H:S45P:A64P:2.34015:-1.09178007:3.39117956;MT-ND3:MT-ND1:5lc5:A:H:S45P:A64D:-1.07176:-1.09178007:0.00521049509;MT-ND3:MT-ND1:5lc5:A:H:S45P:A64G:-1.41027:-1.09178007:-0.339129269;MT-ND3:MT-ND1:5lc5:A:H:S45P:A64V:-0.87059:-1.09178007:0.204209521;MT-ND3:MT-ND1:5lc5:A:H:S45P:A64S:-1.0989:-1.09178007:-0.015329361;MT-ND3:MT-ND1:5lc5:A:H:S45P:A64T:-0.9239:-1.09178007:0.20746994;MT-ND3:MT-ND1:5lc5:A:H:S45P:K62Q:-1.35861:-1.09178007:-0.241339117;MT-ND3:MT-ND1:5lc5:A:H:S45P:K62T:-0.34137:-1.09178007:0.832580209;MT-ND3:MT-ND1:5lc5:A:H:S45P:K62M:-1.30943:-1.09178007:-0.217529684;MT-ND3:MT-ND1:5lc5:A:H:S45P:K62E:-0.63057:-1.09178007:0.412649542;MT-ND3:MT-ND1:5lc5:A:H:S45P:K62N:-0.31288:-1.09178007:0.846379876;MT-ND3:MT-ND1:5lc5:A:H:S45P:N126K:-0.06355:-1.09178007:0.553079605;MT-ND3:MT-ND1:5lc5:A:H:S45P:N126D:1.60729:-1.09178007:1.59534991;MT-ND3:MT-ND1:5lc5:A:H:S45P:N126I:-1.12513:-1.09178007:0.053360749;MT-ND3:MT-ND1:5lc5:A:H:S45P:N126Y:0.03113:-1.09178007:0.641970038;MT-ND3:MT-ND1:5lc5:A:H:S45P:N126T:0.12937:-1.09178007:0.124269105;MT-ND3:MT-ND1:5lc5:A:H:S45P:N126S:0.09708:-1.09178007:0.245739743;MT-ND3:MT-ND1:5lc5:A:H:S45P:N126H:0.48746:-1.09178007:0.694760144;MT-ND3:MT-ND1:5ldw:A:H:S45P:A64P:1.51753:-0.288380057:1.89254951;MT-ND3:MT-ND1:5ldw:A:H:S45P:A64D:-0.28629:-0.288380057:0.016371537;MT-ND3:MT-ND1:5ldw:A:H:S45P:A64G:-0.58631:-0.288380057:-0.290697873;MT-ND3:MT-ND1:5ldw:A:H:S45P:A64V:-0.20191:-0.288380057:0.0742809325;MT-ND3:MT-ND1:5ldw:A:H:S45P:A64S:-0.31463:-0.288380057:-0.00129890442;MT-ND3:MT-ND1:5ldw:A:H:S45P:A64T:-0.18431:-0.288380057:0.10172081;MT-ND3:MT-ND1:5ldw:A:H:S45P:K62Q:-0.30247:-0.288380057:-0.0290084835;MT-ND3:MT-ND1:5ldw:A:H:S45P:K62T:-0.15744:-0.288380057:0.183251187;MT-ND3:MT-ND1:5ldw:A:H:S45P:K62M:-0.29642:-0.288380057:-0.012728882;MT-ND3:MT-ND1:5ldw:A:H:S45P:K62E:0.03594:-0.288380057:0.301341236;MT-ND3:MT-ND1:5ldw:A:H:S45P:K62N:0.17598:-0.288380057:0.465351105;MT-ND3:MT-ND1:5ldw:A:H:S45P:N126K:-0.13148:-0.288380057:-0.182450861;MT-ND3:MT-ND1:5ldw:A:H:S45P:N126D:0.96061:-0.288380057:0.906030297;MT-ND3:MT-ND1:5ldw:A:H:S45P:N126I:-0.79158:-0.288380057:0.457019031;MT-ND3:MT-ND1:5ldw:A:H:S45P:N126Y:-0.18661:-0.288380057:0.15291062;MT-ND3:MT-ND1:5ldw:A:H:S45P:N126T:-0.68483:-0.288380057:-0.612128854;MT-ND3:MT-ND1:5ldw:A:H:S45P:N126S:-0.47956:-0.288380057:-0.494969934;MT-ND3:MT-ND1:5ldw:A:H:S45P:N126H:0.11291:-0.288380057:0.233639911;MT-ND3:MT-ND1:5ldx:A:H:S45P:A64P:4.03637:0.854759216:3.81227994;MT-ND3:MT-ND1:5ldx:A:H:S45P:A64D:0.68501:0.854759216:-0.0113109592;MT-ND3:MT-ND1:5ldx:A:H:S45P:A64G:0.44228:0.854759216:-0.325099945;MT-ND3:MT-ND1:5ldx:A:H:S45P:A64V:0.60377:0.854759216:-0.00509109488;MT-ND3:MT-ND1:5ldx:A:H:S45P:A64S:0.74854:0.854759216:-0.00452117901;MT-ND3:MT-ND1:5ldx:A:H:S45P:A64T:0.88499:0.854759216:0.107588194;MT-ND3:MT-ND1:5ldx:A:H:S45P:K62Q:0.70032:0.854759216:0.0151092531;MT-ND3:MT-ND1:5ldx:A:H:S45P:K62T:0.63491:0.854759216:0.109650038;MT-ND3:MT-ND1:5ldx:A:H:S45P:K62M:0.68073:0.854759216:0.0504192337;MT-ND3:MT-ND1:5ldx:A:H:S45P:K62E:1.13652:0.854759216:0.575948715;MT-ND3:MT-ND1:5ldx:A:H:S45P:K62N:1.25505:0.854759216:0.452788532;MT-ND3:MT-ND1:5ldx:A:H:S45P:N126K:0.51943:0.854759216:0.152239606;MT-ND3:MT-ND1:5ldx:A:H:S45P:N126D:1.80929:0.854759216:1.31459963;MT-ND3:MT-ND1:5ldx:A:H:S45P:N126I:0.20322:0.854759216:0.753100991;MT-ND3:MT-ND1:5ldx:A:H:S45P:N126Y:0.86675:0.854759216:0.512129188;MT-ND3:MT-ND1:5ldx:A:H:S45P:N126T:0.13397:0.854759216:-0.200669855;MT-ND3:MT-ND1:5ldx:A:H:S45P:N126S:0.43315:0.854759216:-0.153670117;MT-ND3:MT-ND1:5ldx:A:H:S45P:N126H:1.07917:0.854759216:0.557869315 MT-ND3:MT-ND1:5lc5:A:H:S45T:A64P:3.61842:0.215980917:3.39117956;MT-ND3:MT-ND1:5lc5:A:H:S45T:A64S:0.13552:0.215980917:-0.015329361;MT-ND3:MT-ND1:5lc5:A:H:S45T:A64T:0.38004:0.215980917:0.20746994;MT-ND3:MT-ND1:5lc5:A:H:S45T:A64D:0.20795:0.215980917:0.00521049509;MT-ND3:MT-ND1:5lc5:A:H:S45T:A64V:0.40023:0.215980917:0.204209521;MT-ND3:MT-ND1:5lc5:A:H:S45T:A64G:-0.12843:0.215980917:-0.339129269;MT-ND3:MT-ND1:5lc5:A:H:S45T:K62Q:-0.06226:0.215980917:-0.241339117;MT-ND3:MT-ND1:5lc5:A:H:S45T:K62N:0.92636:0.215980917:0.846379876;MT-ND3:MT-ND1:5lc5:A:H:S45T:K62T:0.92303:0.215980917:0.832580209;MT-ND3:MT-ND1:5lc5:A:H:S45T:K62E:0.10504:0.215980917:0.412649542;MT-ND3:MT-ND1:5lc5:A:H:S45T:K62M:0.16331:0.215980917:-0.217529684;MT-ND3:MT-ND1:5lc5:A:H:S45T:N126H:0.69791:0.215980917:0.694760144;MT-ND3:MT-ND1:5lc5:A:H:S45T:N126T:0.0173:0.215980917:0.124269105;MT-ND3:MT-ND1:5lc5:A:H:S45T:N126K:0.29244:0.215980917:0.553079605;MT-ND3:MT-ND1:5lc5:A:H:S45T:N126I:-0.41481:0.215980917:0.053360749;MT-ND3:MT-ND1:5lc5:A:H:S45T:N126S:0.28193:0.215980917:0.245739743;MT-ND3:MT-ND1:5lc5:A:H:S45T:N126Y:0.44212:0.215980917:0.641970038;MT-ND3:MT-ND1:5lc5:A:H:S45T:N126D:1.67779:0.215980917:1.59534991;MT-ND3:MT-ND1:5ldw:A:H:S45T:A64P:2.16184:0.170780182:1.89254951;MT-ND3:MT-ND1:5ldw:A:H:S45T:A64S:0.31238:0.170780182:-0.00129890442;MT-ND3:MT-ND1:5ldw:A:H:S45T:A64T:0.35343:0.170780182:0.10172081;MT-ND3:MT-ND1:5ldw:A:H:S45T:A64D:0.09323:0.170780182:0.016371537;MT-ND3:MT-ND1:5ldw:A:H:S45T:A64V:0.33199:0.170780182:0.0742809325;MT-ND3:MT-ND1:5ldw:A:H:S45T:A64G:-0.03498:0.170780182:-0.290697873;MT-ND3:MT-ND1:5ldw:A:H:S45T:K62Q:0.1782:0.170780182:-0.0290084835;MT-ND3:MT-ND1:5ldw:A:H:S45T:K62N:0.60346:0.170780182:0.465351105;MT-ND3:MT-ND1:5ldw:A:H:S45T:K62T:0.1089:0.170780182:0.183251187;MT-ND3:MT-ND1:5ldw:A:H:S45T:K62E:0.55431:0.170780182:0.301341236;MT-ND3:MT-ND1:5ldw:A:H:S45T:K62M:0.2066:0.170780182:-0.012728882;MT-ND3:MT-ND1:5ldw:A:H:S45T:N126H:0.14252:0.170780182:0.233639911;MT-ND3:MT-ND1:5ldw:A:H:S45T:N126T:-0.20638:0.170780182:-0.612128854;MT-ND3:MT-ND1:5ldw:A:H:S45T:N126K:-0.14316:0.170780182:-0.182450861;MT-ND3:MT-ND1:5ldw:A:H:S45T:N126I:0.31568:0.170780182:0.457019031;MT-ND3:MT-ND1:5ldw:A:H:S45T:N126S:-0.29264:0.170780182:-0.494969934;MT-ND3:MT-ND1:5ldw:A:H:S45T:N126Y:0.28745:0.170780182:0.15291062;MT-ND3:MT-ND1:5ldw:A:H:S45T:N126D:0.92759:0.170780182:0.906030297;MT-ND3:MT-ND1:5ldx:A:H:S45T:A64P:3.51497:0.424250036:3.81227994;MT-ND3:MT-ND1:5ldx:A:H:S45T:A64S:0.37223:0.424250036:-0.00452117901;MT-ND3:MT-ND1:5ldx:A:H:S45T:A64T:0.48902:0.424250036:0.107588194;MT-ND3:MT-ND1:5ldx:A:H:S45T:A64D:0.2769:0.424250036:-0.0113109592;MT-ND3:MT-ND1:5ldx:A:H:S45T:A64V:0.45066:0.424250036:-0.00509109488;MT-ND3:MT-ND1:5ldx:A:H:S45T:A64G:0.27749:0.424250036:-0.325099945;MT-ND3:MT-ND1:5ldx:A:H:S45T:K62Q:0.27175:0.424250036:0.0151092531;MT-ND3:MT-ND1:5ldx:A:H:S45T:K62N:1.04835:0.424250036:0.452788532;MT-ND3:MT-ND1:5ldx:A:H:S45T:K62T:0.66071:0.424250036:0.109650038;MT-ND3:MT-ND1:5ldx:A:H:S45T:K62E:0.90794:0.424250036:0.575948715;MT-ND3:MT-ND1:5ldx:A:H:S45T:K62M:0.57074:0.424250036:0.0504192337;MT-ND3:MT-ND1:5ldx:A:H:S45T:N126H:0.56323:0.424250036:0.557869315;MT-ND3:MT-ND1:5ldx:A:H:S45T:N126T:-0.24798:0.424250036:-0.200669855;MT-ND3:MT-ND1:5ldx:A:H:S45T:N126K:0.06326:0.424250036:0.152239606;MT-ND3:MT-ND1:5ldx:A:H:S45T:N126I:0.50186:0.424250036:0.753100991;MT-ND3:MT-ND1:5ldx:A:H:S45T:N126S:-0.04869:0.424250036:-0.153670117;MT-ND3:MT-ND1:5ldx:A:H:S45T:N126Y:0.4601:0.424250036:0.512129188;MT-ND3:MT-ND1:5ldx:A:H:S45T:N126D:1.42456:0.424250036:1.31459963 MT-ND3:MT-ND1:5lc5:A:H:S45A:A64V:0.11566:-0.0903697982:0.204209521;MT-ND3:MT-ND1:5lc5:A:H:S45A:A64S:-0.09243:-0.0903697982:-0.015329361;MT-ND3:MT-ND1:5lc5:A:H:S45A:A64D:-0.06206:-0.0903697982:0.00521049509;MT-ND3:MT-ND1:5lc5:A:H:S45A:A64T:0.11013:-0.0903697982:0.20746994;MT-ND3:MT-ND1:5lc5:A:H:S45A:A64P:3.33631:-0.0903697982:3.39117956;MT-ND3:MT-ND1:5lc5:A:H:S45A:A64G:-0.44291:-0.0903697982:-0.339129269;MT-ND3:MT-ND1:5lc5:A:H:S45A:K62Q:-0.4992:-0.0903697982:-0.241339117;MT-ND3:MT-ND1:5lc5:A:H:S45A:K62T:0.65075:-0.0903697982:0.832580209;MT-ND3:MT-ND1:5lc5:A:H:S45A:K62E:0.6052:-0.0903697982:0.412649542;MT-ND3:MT-ND1:5lc5:A:H:S45A:K62M:-0.43482:-0.0903697982:-0.217529684;MT-ND3:MT-ND1:5lc5:A:H:S45A:K62N:0.80299:-0.0903697982:0.846379876;MT-ND3:MT-ND1:5lc5:A:H:S45A:N126Y:0.5488:-0.0903697982:0.641970038;MT-ND3:MT-ND1:5lc5:A:H:S45A:N126T:0.63612:-0.0903697982:0.124269105;MT-ND3:MT-ND1:5lc5:A:H:S45A:N126K:0.47411:-0.0903697982:0.553079605;MT-ND3:MT-ND1:5lc5:A:H:S45A:N126D:1.74469:-0.0903697982:1.59534991;MT-ND3:MT-ND1:5lc5:A:H:S45A:N126I:0.08452:-0.0903697982:0.053360749;MT-ND3:MT-ND1:5lc5:A:H:S45A:N126H:0.88892:-0.0903697982:0.694760144;MT-ND3:MT-ND1:5lc5:A:H:S45A:N126S:0.42511:-0.0903697982:0.245739743;MT-ND3:MT-ND1:5ldw:A:H:S45A:A64V:0.05852:-0.0156085966:0.0742809325;MT-ND3:MT-ND1:5ldw:A:H:S45A:A64S:-0.01984:-0.0156085966:-0.00129890442;MT-ND3:MT-ND1:5ldw:A:H:S45A:A64D:0.00147:-0.0156085966:0.016371537;MT-ND3:MT-ND1:5ldw:A:H:S45A:A64T:0.08599:-0.0156085966:0.10172081;MT-ND3:MT-ND1:5ldw:A:H:S45A:A64P:1.82161:-0.0156085966:1.89254951;MT-ND3:MT-ND1:5ldw:A:H:S45A:A64G:-0.30644:-0.0156085966:-0.290697873;MT-ND3:MT-ND1:5ldw:A:H:S45A:K62Q:-0.03384:-0.0156085966:-0.0290084835;MT-ND3:MT-ND1:5ldw:A:H:S45A:K62T:0.0492:-0.0156085966:0.183251187;MT-ND3:MT-ND1:5ldw:A:H:S45A:K62E:0.47682:-0.0156085966:0.301341236;MT-ND3:MT-ND1:5ldw:A:H:S45A:K62M:-0.02866:-0.0156085966:-0.012728882;MT-ND3:MT-ND1:5ldw:A:H:S45A:K62N:0.44287:-0.0156085966:0.465351105;MT-ND3:MT-ND1:5ldw:A:H:S45A:N126Y:0.1214:-0.0156085966:0.15291062;MT-ND3:MT-ND1:5ldw:A:H:S45A:N126T:-0.53775:-0.0156085966:-0.612128854;MT-ND3:MT-ND1:5ldw:A:H:S45A:N126K:0.05685:-0.0156085966:-0.182450861;MT-ND3:MT-ND1:5ldw:A:H:S45A:N126D:0.89838:-0.0156085966:0.906030297;MT-ND3:MT-ND1:5ldw:A:H:S45A:N126I:0.33655:-0.0156085966:0.457019031;MT-ND3:MT-ND1:5ldw:A:H:S45A:N126H:0.19473:-0.0156085966:0.233639911;MT-ND3:MT-ND1:5ldw:A:H:S45A:N126S:-0.37587:-0.0156085966:-0.494969934;MT-ND3:MT-ND1:5ldx:A:H:S45A:A64V:0.55233:0.531179786:-0.00509109488;MT-ND3:MT-ND1:5ldx:A:H:S45A:A64S:0.54492:0.531179786:-0.00452117901;MT-ND3:MT-ND1:5ldx:A:H:S45A:A64D:0.53624:0.531179786:-0.0113109592;MT-ND3:MT-ND1:5ldx:A:H:S45A:A64T:0.65342:0.531179786:0.107588194;MT-ND3:MT-ND1:5ldx:A:H:S45A:A64P:3.25567:0.531179786:3.81227994;MT-ND3:MT-ND1:5ldx:A:H:S45A:A64G:0.22381:0.531179786:-0.325099945;MT-ND3:MT-ND1:5ldx:A:H:S45A:K62Q:0.53665:0.531179786:0.0151092531;MT-ND3:MT-ND1:5ldx:A:H:S45A:K62T:0.59559:0.531179786:0.109650038;MT-ND3:MT-ND1:5ldx:A:H:S45A:K62E:1.20875:0.531179786:0.575948715;MT-ND3:MT-ND1:5ldx:A:H:S45A:K62M:0.60852:0.531179786:0.0504192337;MT-ND3:MT-ND1:5ldx:A:H:S45A:K62N:1.01432:0.531179786:0.452788532;MT-ND3:MT-ND1:5ldx:A:H:S45A:N126Y:1.09013:0.531179786:0.512129188;MT-ND3:MT-ND1:5ldx:A:H:S45A:N126T:0.31946:0.531179786:-0.200669855;MT-ND3:MT-ND1:5ldx:A:H:S45A:N126K:0.98402:0.531179786:0.152239606;MT-ND3:MT-ND1:5ldx:A:H:S45A:N126D:1.85508:0.531179786:1.31459963;MT-ND3:MT-ND1:5ldx:A:H:S45A:N126I:1.30795:0.531179786:0.753100991;MT-ND3:MT-ND1:5ldx:A:H:S45A:N126H:1.24743:0.531179786:0.557869315;MT-ND3:MT-ND1:5ldx:A:H:S45A:N126S:0.4613:0.531179786:-0.153670117
For more info, please check the output legend.
ΔΔG values >±0.61 Kcal/mol are indicative of disrupting variants.
ΔΔG values close to zero (<±0.1 Kcal/mol) are indicative of possibly
compensating double mutants.
For more info, please check the output legend.
ΔΔG values >±0.61 Kcal/mol are indicative of disrupting variants.
ΔΔG values close to zero (<±0.1 Kcal/mol) are indicative of possibly
compensating double mutants.
For more info, please check the output legend.
ΔΔG values >±0.61 Kcal/mol are indicative of disrupting variants.
ΔΔG values close to zero (<±0.1 Kcal/mol) are indicative of possibly
compensating double mutants.
For more info, please check the output legend.
For more info, please check the output legend.
Score:  
0
  [min -20, max 10]
  • Predicted accelerated evolution:  score <= 0
  • Conserved:  score > 0
Score:  
0
  [min 0, max 1]
  • Non-conserved:  score <= 0.9
  • Conserved:  score > 0.9 (soft threshold)
Score:  
0
  [min 0, max 1]
  • Neutral:  score <= 0.15
  • Possibly damaging:  0.15 < score <= 0.85
  • Probably damaging:  score > 0.85
Score:  
0
  [min 0, max 1]
  • Neutral:  score > 0.05
  • Deleterious:  score <= 0.05
Score:  
0
  [min -15, max 10]
  • Neutral:  score > -3
  • Deleterious:  score <= -3
Score:  
0
  [min -3, max 6]
  • Neutral:  score > -1.5
  • Deleterious:  score <= -1.5
Score:  
0
  [min -14, max 14]
  • Neutral:  score > -2.5
  • Deleterious:  score <= -2.5 (soft threshold)
Score:  
0
  [min -6, max 6]
  • Neutral:  score <= 0.8
  • Low impact:  0.8 < score <= 1.9
  • Medium impact:  1.9 < score <= 3.5
  • High impact:  score > 3.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score > 0.6
  • Damaging:  score <= 0.6
Score:  
0
  [min 0, max 1]
  • Neutral:  score > 0.28
  • Damaging:  score <= 0.28
Phred score:  
0
  [min 0, max 35]
  • Neutral:  score < 20 (soft threshold)
  • Deleterious:  score >= 20
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Polymorphism:  score < 0.5
  • Disease causing:  score >= 0.5
P-value:  
0
  [min 0, max 1]
  • Neutral:  p-value > 0.05
  • Pathogenic:  p-value <= 0.05
Score:  
0
  [min 0, max 1]
No hard-thresholds were indicated by authors (ref). Indicatively:
  • Neutral:  score < 0.9
  • Pathogenic:  score >= 0.9
No score. Categorical only
Please refer to Additional File 14: Table S10 for further details.
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.98
  • Deleterious:  score >= 0.98
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Deleterious:  score >= 0.5
Score:  
0
  [min -6, max 6]
  • Neutral:  score < 0
  • Deleterious:  score > 0
  • Inaccurate prediction:  score = 0
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Deleterious:  score >= 0.5
DS score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.43
  • Deleterious:  score >= 0.43
Score:  
0
  [min 0, max 1]
  • Neutral:  score <= 0.5
  • Pathogenic:  score > 0.5
Score:  
0
  [min -5, max 5]
  • Low impact:  score <= -1 (soft threshold)
  • Medium impact:  -1 < score < 1.5 (soft threshold)
  • High impact:  score >= 1.5 (soft threshold)
Score:  
0
  [min -5, max 5]
  • Low impact:  score <= -1
  • Medium impact:  -1 < score < 2 (soft threshold)
  • High impact:  score >= 2 (soft threshold)
Score:  
0
  [min -5, max 5]
  • Low impact:  score <= -1
  • Medium impact:  -1 < score < 2 (soft threshold)
  • High impact:  score >= 2 (soft threshold)
P-value:  
0
  [min 0, max 1]
  • Neutral:  FDR > 0.2
  • Driver:  FDR <= 0.2
The frequency of a CPD variant is proportional to the
number of aligned orthologous sequences that
carry a specific human pathogenic variant as
wild-type amino acid on the total number of aligned
sequences.

For more info, please check the output legend