news model
license
| ~ | 3496 (G/A) | 3496 (G/T) | 3496 (G/C) | 3497 (C/T) | 3497 (C/A) | 3497 (C/G) |
|---|---|---|---|---|---|---|
| ~ | 3496 (Gcc/Acc) | 3496 (Gcc/Tcc) | 3496 (Gcc/Ccc) | 3497 (gCc/gTc) | 3497 (gCc/gAc) | 3497 (gCc/gGc) |
| Chr | chrM | chrM | chrM | chrM | chrM | chrM |
| Start | 3496 | 3496 | 3496 | 3497 | 3497 | 3497 |
| End | 3496 | 3496 | 3496 | 3497 | 3497 | 3497 |
| Ref | G | G | G | C | C | C |
| Alt | A | T | C | T | A | G |
| MitImpact id | MI.11153 | MI.11154 | MI.11155 | MI.11156 | MI.11157 | MI.11158 |
| Gene symbol | MT-ND1 | MT-ND1 | MT-ND1 | MT-ND1 | MT-ND1 | MT-ND1 |
| Respiratory Chain complex | I | I | I | I | I | I |
| Ensembl gene id | ENSG00000198888 | ENSG00000198888 | ENSG00000198888 | ENSG00000198888 | ENSG00000198888 | ENSG00000198888 |
| Ensembl protein id | ENSP00000354687 | ENSP00000354687 | ENSP00000354687 | ENSP00000354687 | ENSP00000354687 | ENSP00000354687 |
| Ensembl transcript id | ENST00000361390 | ENST00000361390 | ENST00000361390 | ENST00000361390 | ENST00000361390 | ENST00000361390 |
| Uniprot name | NU1M_HUMAN | NU1M_HUMAN | NU1M_HUMAN | NU1M_HUMAN | NU1M_HUMAN | NU1M_HUMAN |
| Uniprot id | P03886 | P03886 | P03886 | P03886 | P03886 | P03886 |
| Ncbi gene id | 4535 | 4535 | 4535 | 4535 | 4535 | 4535 |
| Ncbi protein id | YP_003024026.1 | YP_003024026.1 | YP_003024026.1 | YP_003024026.1 | YP_003024026.1 | YP_003024026.1 |
| Gene position | 190 | 190 | 190 | 191 | 191 | 191 |
| AA position | 64 | 64 | 64 | 64 | 64 | 64 |
| AA ref | A | A | A | A | A | A |
| AA alt | T | S | P | V | D | G |
| Codon substitution | Gcc/Acc | Gcc/Tcc | Gcc/Ccc | gCc/gTc | gCc/gAc | gCc/gGc |
| PhyloP 100V | -9.89 | -9.89 | -9.89 | -2.08 | -2.08 | -2.08 |
| PhastCons 100V | 0 | 0 | 0 | 0 | 0 | 0 |
| PolyPhen2 | benign | benign | benign | benign | benign | benign |
| PolyPhen2 score | 0 | 0 | 0.11 | 0.01 | 0.06 | 0.04 |
| SIFT | neutral | neutral | neutral | neutral | neutral | neutral |
| SIFT score | 0.72 | 0.81 | 0.35 | 0.49 | 0.61 | 0.47 |
| FatHmm | neutral | neutral | neutral | neutral | neutral | neutral |
| FatHmm score | -0.92 | -0.3 | -2.44 | -2.06 | -1.26 | -1.52 |
| FatHmmW | neutral | neutral | neutral | neutral | neutral | neutral |
| FatHmmW score | 2.71 | 2.79 | 2.65 | 2.71 | 2.7 | 2.67 |
| PROVEAN | neutral | neutral | neutral | neutral | neutral | neutral |
| PROVEAN score | 0.01 | 1.31 | -1.97 | -1.4 | -1.71 | -1.65 |
| MutationAssessor | neutral impact | neutral impact | low impact | low impact | low impact | low impact |
| MutationAssessor score | -0.51 | -0.84 | 1.13 | 1.36 | 1.34 | 1.44 |
| EFIN SP | neutral | neutral | neutral | neutral | neutral | neutral |
| EFIN SP score | 0.76 | 0.68 | 0.67 | 0.75 | 0.73 | 0.68 |
| EFIN HD | neutral | neutral | neutral | neutral | neutral | neutral |
| EFIN HD score | 0.74 | 0.95 | 0.37 | 0.71 | 0.41 | 0.54 |
| CADD | neutral | neutral | neutral | neutral | neutral | neutral |
| CADD score | 0.9 | -1.03 | 0.76 | 1.25 | 1.42 | 0.82 |
| CADD phred | 10.05 | 0.01 | 9.24 | 11.99 | 12.87 | 9.59 |
| VEST pvalue | 0.34 | 0.42 | 0.17 | 0.27 | 0.15 | 0.39 |
| VEST FDR | 0.5 | 0.55 | 0.45 | 0.45 | 0.4 | 0.5 |
| PANTHER | neutral | neutral | neutral | neutral | neutral | neutral |
| PANTHER score | 0.18 | 0.13 | 0.29 | 0.16 | 0.22 | 0.32 |
| PhD-SNP | neutral | neutral | disease | neutral | disease | neutral |
| PhD-SNP score | 0.17 | 0.06 | 0.77 | 0.37 | 0.7 | 0.42 |
| SNAP | neutral | neutral | neutral | neutral | neutral | neutral |
| SNAP score | 0.14 | 0.11 | 0.28 | 0.17 | 0.37 | 0.25 |
| Meta-SNP | neutral | neutral | disease | neutral | neutral | neutral |
| Meta-SNP score | 0.28 | 0.21 | 0.58 | 0.44 | 0.48 | 0.47 |
| Meta-SNP RI | 4 | 6 | 1 | 1 | 0 | 1 |
| CAROL | neutral | neutral | neutral | neutral | neutral | neutral |
| CAROL score | 0.28 | 0.19 | 0.6 | 0.49 | 0.32 | 0.49 |
| Condel | deleterious | deleterious | deleterious | deleterious | deleterious | deleterious |
| Condel score | 0.86 | 0.91 | 0.62 | 0.74 | 0.78 | 0.72 |
| COVEC WMV | neutral | neutral | neutral | neutral | neutral | neutral |
| COVEC WMV score | -6 | -6 | -6 | -6 | -6 | -6 |
| MtoolBox | neutral | neutral | neutral | neutral | neutral | neutral |
| MtoolBox DS | 0.09 | 0.08 | 0.26 | 0.12 | 0.18 | 0.14 |
| PolyPhen2 transf | high impact | high impact | medium impact | medium impact | medium impact | medium impact |
| PolyPhen2 transf score | 2.07 | 2.07 | 0.1 | 1.12 | 0.37 | 0.55 |
| SIFT_transf | medium impact | medium impact | medium impact | medium impact | medium impact | medium impact |
| SIFT transf score | 0.51 | 0.63 | 0.12 | 0.27 | 0.38 | 0.25 |
| MutationAssessor transf | low impact | low impact | medium impact | medium impact | medium impact | medium impact |
| MutationAssessor transf score | -1.63 | -1.92 | -0.2 | 0 | -0.02 | 0.07 |
| CHASM pvalue | 0.55 | 0.39 | 0.37 | 0.47 | 0.17 | 0.52 |
| CHASM FDR | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 |
| APOGEE | Benign | Benign | VUS | Likely-benign | VUS | VUS |
| APOGEE score | 0.0252991649228041 | 0.0300959733751049 | 0.4833255020982564 | 0.125252764204327 | 0.4052798848761242 | 0.2715025084539011 |
| SNPDryad score | 0.34 | 0.07 | 0.74 | 0.45 | 0.54 | 0.49 |
| MutationTaster | polymorphism | polymorphism | polymorphism | polymorphism | polymorphism | polymorphism |
| MutationTaster score | 1 | 1 | 1 | 1 | 1 | 1 |
| DEOGEN2 score | 0.01 | 0 | 0.03 | 0.02 | 0.02 | 0.03 |
| Mitoclass.1 | neutral | neutral | neutral | neutral | neutral | neutral |
| dbSNP 155 id | rs1603218984 | rs1603218984 | . | rs200319905 | . | . |
| ClinVar October2021 Variation id | . | . | . | . | . | . |
| ClinVar October2021 CLNSIG | . | . | . | . | . | . |
| ClinVar October2021 CLNDN | . | . | . | . | . | . |
| ClinVar October2021 CLNDISDB | . | . | . | . | . | . |
| COSMIC 90 | COSM5653110 | . | . | . | . | . |
| MITOMAP Allele | . | G3496T | . | C3497T | . | . |
| MITOMAP Disease Het/Hom | . | +/- | . | +/- | . | . |
| MITOMAP Disease Clinical info | . | LHON | . | LHON | . | . |
| MITOMAP Disease Status | . | Reported / Secondary | . | Reported / Secondary | . | . |
| MITOMAP Disease GenBank Freq | . | 0.000% | . | 0.000% | . | . |
| MITOMAP Disease GenBank Seqs | . | 10 (0) | . | 200 (0) | . | . |
| MITOMAP Disease GenBank Curated refs | . | 3 | . | 6 | . | . |
| MITOMAP General GenBank Freq | 0.014% | 0.018% | . | 0.352% | . | . |
| MITOMAP General GenBank Seqs | 8 | 10 | . | 200 | . | . |
| MITOMAP General Curated refs | 1 | 4 | . | 12 | . | . |
| gnomAD 3.1 filter | PASS | npg | npg | PASS | . | . |
| gnomAD 3.1 AC Homo | 3 | 0 | 0 | 28 | . | . |
| gnomAD 3.1 AC Het | 1 | 0 | 0 | 1 | . | . |
| gnomAD 3.1 AF Hom | 5.3165095e-05 | 0 | 0 | 0.0004961636 | . | . |
| gnomAD 3.1 AF Het | 1.7721699e-05 | 0 | 0 | 1.772013e-05 | . | . |
| gnomAD 3.1 AN | 56428 | 56429 | 56431 | 56433 | . | . |
| HelixMTdb AC Hom | 6 | 16 | . | 238 | . | . |
| HelixMTdb AF Hom | 3.06149e-05 | 8.163974e-05 | . | 0.0012143911 | . | . |
| HelixMTdb AC Het | 1 | 0 | . | 2 | . | . |
| HelixMTdb AF Het | 5.1024836e-06 | 0 | . | 1.0204967e-05 | . | . |
| HelixMTdb mean ARF | 0.86726 | . | . | 0.20944 | . | . | HelixMTdb max ARF | 0.86726 | . | . | 0.28986 | . | . |
| EVmutation | MT-ND1_64A|65T:0.21755;118W:0.097737;183M:0.083952;69T:0.082342;110S:0.082298;305V:0.075737;99N:0.075659;87T:0.074904;302M:0.070495;70L:0.070242;266L:0.066295;247Y:0.065793 | MT-ND1_64A|65T:0.21755;118W:0.097737;183M:0.083952;69T:0.082342;110S:0.082298;305V:0.075737;99N:0.075659;87T:0.074904;302M:0.070495;70L:0.070242;266L:0.066295;247Y:0.065793 | MT-ND1_64A|65T:0.21755;118W:0.097737;183M:0.083952;69T:0.082342;110S:0.082298;305V:0.075737;99N:0.075659;87T:0.074904;302M:0.070495;70L:0.070242;266L:0.066295;247Y:0.065793 | MT-ND1_64A|65T:0.21755;118W:0.097737;183M:0.083952;69T:0.082342;110S:0.082298;305V:0.075737;99N:0.075659;87T:0.074904;302M:0.070495;70L:0.070242;266L:0.066295;247Y:0.065793 | MT-ND1_64A|65T:0.21755;118W:0.097737;183M:0.083952;69T:0.082342;110S:0.082298;305V:0.075737;99N:0.075659;87T:0.074904;302M:0.070495;70L:0.070242;266L:0.066295;247Y:0.065793 | MT-ND1_64A|65T:0.21755;118W:0.097737;183M:0.083952;69T:0.082342;110S:0.082298;305V:0.075737;99N:0.075659;87T:0.074904;302M:0.070495;70L:0.070242;266L:0.066295;247Y:0.065793 |
| Site A InterP | ND1_64 | ND1_64 | ND1_64 | ND1_64 | ND1_64 | ND1_64 |
| Site B InterP | ND4_86;ND5_4;ND6_95;ND2_213;ND2_22;ND2_6;ND2_239;ND2_221;ND2_90;ND2_89;ND2_96;ND2_48;ND3_29;ND3_85;ND3_90;ND3_21;ND3_88;ND3_45;ND3_46;ND3_93;ND3_18;ND3_92;ND3_89;ND4_4;ND4_363;ND4_357;ND4_248;ND4L_19;ND5_420;ND6_86;ND6_150;ND6_165;ND6_142;ND6_139;ND6_102;ND6_140 | ND4_86;ND5_4;ND6_95;ND2_213;ND2_22;ND2_6;ND2_239;ND2_221;ND2_90;ND2_89;ND2_96;ND2_48;ND3_29;ND3_85;ND3_90;ND3_21;ND3_88;ND3_45;ND3_46;ND3_93;ND3_18;ND3_92;ND3_89;ND4_4;ND4_363;ND4_357;ND4_248;ND4L_19;ND5_420;ND6_86;ND6_150;ND6_165;ND6_142;ND6_139;ND6_102;ND6_140 | ND4_86;ND5_4;ND6_95;ND2_213;ND2_22;ND2_6;ND2_239;ND2_221;ND2_90;ND2_89;ND2_96;ND2_48;ND3_29;ND3_85;ND3_90;ND3_21;ND3_88;ND3_45;ND3_46;ND3_93;ND3_18;ND3_92;ND3_89;ND4_4;ND4_363;ND4_357;ND4_248;ND4L_19;ND5_420;ND6_86;ND6_150;ND6_165;ND6_142;ND6_139;ND6_102;ND6_140 | ND4_86;ND5_4;ND6_95;ND2_213;ND2_22;ND2_6;ND2_239;ND2_221;ND2_90;ND2_89;ND2_96;ND2_48;ND3_29;ND3_85;ND3_90;ND3_21;ND3_88;ND3_45;ND3_46;ND3_93;ND3_18;ND3_92;ND3_89;ND4_4;ND4_363;ND4_357;ND4_248;ND4L_19;ND5_420;ND6_86;ND6_150;ND6_165;ND6_142;ND6_139;ND6_102;ND6_140 | ND4_86;ND5_4;ND6_95;ND2_213;ND2_22;ND2_6;ND2_239;ND2_221;ND2_90;ND2_89;ND2_96;ND2_48;ND3_29;ND3_85;ND3_90;ND3_21;ND3_88;ND3_45;ND3_46;ND3_93;ND3_18;ND3_92;ND3_89;ND4_4;ND4_363;ND4_357;ND4_248;ND4L_19;ND5_420;ND6_86;ND6_150;ND6_165;ND6_142;ND6_139;ND6_102;ND6_140 | ND4_86;ND5_4;ND6_95;ND2_213;ND2_22;ND2_6;ND2_239;ND2_221;ND2_90;ND2_89;ND2_96;ND2_48;ND3_29;ND3_85;ND3_90;ND3_21;ND3_88;ND3_45;ND3_46;ND3_93;ND3_18;ND3_92;ND3_89;ND4_4;ND4_363;ND4_357;ND4_248;ND4L_19;ND5_420;ND6_86;ND6_150;ND6_165;ND6_142;ND6_139;ND6_102;ND6_140 |
| Covariation Score InterP | mfDCA_38.19;mfDCA_26.94;mfDCA_22.33;cMI_64.44566;cMI_62.52018;cMI_60.4021;cMI_56.45133;cMI_54.95405;cMI_53.87512;cMI_51.6195;cMI_51.002;cMI_47.62558;cMI_40.80143;cMI_40.31699;cMI_37.82036;cMI_36.19952;cMI_36.09641;cMI_32.72981;cMI_32.51378;cMI_32.15059;cMI_31.94808;cMI_31.65707;cMI_31.37539;cMI_26.4492;cMI_25.59954;cMI_25.42153;cMI_24.47381;cMI_46.40883;cMI_32.71994;cMI_56.91476;cMI_56.31747;cMI_56.27557;cMI_50.7122;cMI_50.43972;cMI_48.25338;cMI_47.30772 | mfDCA_38.19;mfDCA_26.94;mfDCA_22.33;cMI_64.44566;cMI_62.52018;cMI_60.4021;cMI_56.45133;cMI_54.95405;cMI_53.87512;cMI_51.6195;cMI_51.002;cMI_47.62558;cMI_40.80143;cMI_40.31699;cMI_37.82036;cMI_36.19952;cMI_36.09641;cMI_32.72981;cMI_32.51378;cMI_32.15059;cMI_31.94808;cMI_31.65707;cMI_31.37539;cMI_26.4492;cMI_25.59954;cMI_25.42153;cMI_24.47381;cMI_46.40883;cMI_32.71994;cMI_56.91476;cMI_56.31747;cMI_56.27557;cMI_50.7122;cMI_50.43972;cMI_48.25338;cMI_47.30772 | mfDCA_38.19;mfDCA_26.94;mfDCA_22.33;cMI_64.44566;cMI_62.52018;cMI_60.4021;cMI_56.45133;cMI_54.95405;cMI_53.87512;cMI_51.6195;cMI_51.002;cMI_47.62558;cMI_40.80143;cMI_40.31699;cMI_37.82036;cMI_36.19952;cMI_36.09641;cMI_32.72981;cMI_32.51378;cMI_32.15059;cMI_31.94808;cMI_31.65707;cMI_31.37539;cMI_26.4492;cMI_25.59954;cMI_25.42153;cMI_24.47381;cMI_46.40883;cMI_32.71994;cMI_56.91476;cMI_56.31747;cMI_56.27557;cMI_50.7122;cMI_50.43972;cMI_48.25338;cMI_47.30772 | mfDCA_38.19;mfDCA_26.94;mfDCA_22.33;cMI_64.44566;cMI_62.52018;cMI_60.4021;cMI_56.45133;cMI_54.95405;cMI_53.87512;cMI_51.6195;cMI_51.002;cMI_47.62558;cMI_40.80143;cMI_40.31699;cMI_37.82036;cMI_36.19952;cMI_36.09641;cMI_32.72981;cMI_32.51378;cMI_32.15059;cMI_31.94808;cMI_31.65707;cMI_31.37539;cMI_26.4492;cMI_25.59954;cMI_25.42153;cMI_24.47381;cMI_46.40883;cMI_32.71994;cMI_56.91476;cMI_56.31747;cMI_56.27557;cMI_50.7122;cMI_50.43972;cMI_48.25338;cMI_47.30772 | mfDCA_38.19;mfDCA_26.94;mfDCA_22.33;cMI_64.44566;cMI_62.52018;cMI_60.4021;cMI_56.45133;cMI_54.95405;cMI_53.87512;cMI_51.6195;cMI_51.002;cMI_47.62558;cMI_40.80143;cMI_40.31699;cMI_37.82036;cMI_36.19952;cMI_36.09641;cMI_32.72981;cMI_32.51378;cMI_32.15059;cMI_31.94808;cMI_31.65707;cMI_31.37539;cMI_26.4492;cMI_25.59954;cMI_25.42153;cMI_24.47381;cMI_46.40883;cMI_32.71994;cMI_56.91476;cMI_56.31747;cMI_56.27557;cMI_50.7122;cMI_50.43972;cMI_48.25338;cMI_47.30772 | mfDCA_38.19;mfDCA_26.94;mfDCA_22.33;cMI_64.44566;cMI_62.52018;cMI_60.4021;cMI_56.45133;cMI_54.95405;cMI_53.87512;cMI_51.6195;cMI_51.002;cMI_47.62558;cMI_40.80143;cMI_40.31699;cMI_37.82036;cMI_36.19952;cMI_36.09641;cMI_32.72981;cMI_32.51378;cMI_32.15059;cMI_31.94808;cMI_31.65707;cMI_31.37539;cMI_26.4492;cMI_25.59954;cMI_25.42153;cMI_24.47381;cMI_46.40883;cMI_32.71994;cMI_56.91476;cMI_56.31747;cMI_56.27557;cMI_50.7122;cMI_50.43972;cMI_48.25338;cMI_47.30772 |
| Site A IntraP | ND1_64 | ND1_64 | ND1_64 | ND1_64 | ND1_64 | ND1_64 |
| Site B IntraP | ND1_245;ND1_229;ND1_309;ND1_178;ND1_305;ND1_225;ND1_250;ND1_248;ND1_260;ND1_246;ND1_276 | ND1_245;ND1_229;ND1_309;ND1_178;ND1_305;ND1_225;ND1_250;ND1_248;ND1_260;ND1_246;ND1_276 | ND1_245;ND1_229;ND1_309;ND1_178;ND1_305;ND1_225;ND1_250;ND1_248;ND1_260;ND1_246;ND1_276 | ND1_245;ND1_229;ND1_309;ND1_178;ND1_305;ND1_225;ND1_250;ND1_248;ND1_260;ND1_246;ND1_276 | ND1_245;ND1_229;ND1_309;ND1_178;ND1_305;ND1_225;ND1_250;ND1_248;ND1_260;ND1_246;ND1_276 | ND1_245;ND1_229;ND1_309;ND1_178;ND1_305;ND1_225;ND1_250;ND1_248;ND1_260;ND1_246;ND1_276 |
| Covariation Score IntraP | cMI_14.342117;mfDCA_22.8811;mfDCA_22.5193;mfDCA_22.0516;mfDCA_21.8998;mfDCA_21.564;mfDCA_19.5808;mfDCA_19.0999;mfDCA_18.3416;mfDCA_16.1252;mfDCA_14.823 | cMI_14.342117;mfDCA_22.8811;mfDCA_22.5193;mfDCA_22.0516;mfDCA_21.8998;mfDCA_21.564;mfDCA_19.5808;mfDCA_19.0999;mfDCA_18.3416;mfDCA_16.1252;mfDCA_14.823 | cMI_14.342117;mfDCA_22.8811;mfDCA_22.5193;mfDCA_22.0516;mfDCA_21.8998;mfDCA_21.564;mfDCA_19.5808;mfDCA_19.0999;mfDCA_18.3416;mfDCA_16.1252;mfDCA_14.823 | cMI_14.342117;mfDCA_22.8811;mfDCA_22.5193;mfDCA_22.0516;mfDCA_21.8998;mfDCA_21.564;mfDCA_19.5808;mfDCA_19.0999;mfDCA_18.3416;mfDCA_16.1252;mfDCA_14.823 | cMI_14.342117;mfDCA_22.8811;mfDCA_22.5193;mfDCA_22.0516;mfDCA_21.8998;mfDCA_21.564;mfDCA_19.5808;mfDCA_19.0999;mfDCA_18.3416;mfDCA_16.1252;mfDCA_14.823 | cMI_14.342117;mfDCA_22.8811;mfDCA_22.5193;mfDCA_22.0516;mfDCA_21.8998;mfDCA_21.564;mfDCA_19.5808;mfDCA_19.0999;mfDCA_18.3416;mfDCA_16.1252;mfDCA_14.823 |
| CPD AA ref | . | . | . | . | . | . |
| CPD AA alt | . | . | . | . | . | . |
| CPD Aln pos | . | . | . | . | . | . |
| CPD Frequency | . | . | . | . | . | . |
| CPD Species name | . | . | . | . | . | . |
| CPD RefSeq Protein ID | . | . | . | . | . | . |
| CPD Ncbi Taxon id | . | . | . | . | . | . |
| DDG intra | MT-ND1:A64T:T245A:0.276091:0.187811:-0.0212179;MT-ND1:A64T:T245K:2.8503:0.187811:2.88431;MT-ND1:A64T:T245P:-1.77736:0.187811:-2.15484;MT-ND1:A64T:T245M:0.0980715:0.187811:-0.233521;MT-ND1:A64T:T245S:0.801626:0.187811:0.59531;MT-ND1:A64T:T246A:0.579593:0.187811:0.393197;MT-ND1:A64T:T246P:-0.775521:0.187811:-0.949064;MT-ND1:A64T:T246S:0.0648742:0.187811:-0.121189;MT-ND1:A64T:T246M:0.326569:0.187811:0.113932;MT-ND1:A64T:T246K:0.75316:0.187811:0.53622;MT-ND1:A64T:D248H:0.999094:0.187811:0.709978;MT-ND1:A64T:D248Y:0.325915:0.187811:-0.0124181;MT-ND1:A64T:D248G:1.25568:0.187811:1.01568;MT-ND1:A64T:D248A:0.729766:0.187811:0.469864;MT-ND1:A64T:D248E:0.211487:0.187811:-0.0363487;MT-ND1:A64T:D248N:0.480687:0.187811:0.27503;MT-ND1:A64T:D248V:0.786552:0.187811:0.460803;MT-ND1:A64T:L250I:0.606484:0.187811:0.412886;MT-ND1:A64T:L250F:0.218952:0.187811:0.0290031;MT-ND1:A64T:L250V:0.701436:0.187811:0.518854;MT-ND1:A64T:L250P:1.2973:0.187811:1.11168;MT-ND1:A64T:L250H:0.352982:0.187811:0.108448;MT-ND1:A64T:L250R:-0.354091:0.187811:-0.508427;MT-ND1:A64T:A276G:0.571749:0.187811:0.386782;MT-ND1:A64T:A276V:0.816931:0.187811:0.62968;MT-ND1:A64T:A276T:0.897024:0.187811:0.683193;MT-ND1:A64T:A276E:0.241989:0.187811:0.0557187;MT-ND1:A64T:A276P:1.44294:0.187811:1.16054;MT-ND1:A64T:A276S:-0.0237564:0.187811:-0.200186 | MT-ND1:A64S:T245A:0.190663:0.249641:-0.0212179;MT-ND1:A64S:T245P:-1.74279:0.249641:-2.15484;MT-ND1:A64S:T245S:0.824595:0.249641:0.59531;MT-ND1:A64S:T245M:-0.13552:0.249641:-0.233521;MT-ND1:A64S:T245K:2.92241:0.249641:2.88431;MT-ND1:A64S:T246M:0.355215:0.249641:0.113932;MT-ND1:A64S:T246S:0.1281:0.249641:-0.121189;MT-ND1:A64S:T246A:0.642818:0.249641:0.393197;MT-ND1:A64S:T246K:0.817687:0.249641:0.53622;MT-ND1:A64S:T246P:-0.709822:0.249641:-0.949064;MT-ND1:A64S:D248E:0.213008:0.249641:-0.0363487;MT-ND1:A64S:D248G:1.27018:0.249641:1.01568;MT-ND1:A64S:D248V:0.692142:0.249641:0.460803;MT-ND1:A64S:D248A:0.771225:0.249641:0.469864;MT-ND1:A64S:D248H:0.980396:0.249641:0.709978;MT-ND1:A64S:D248Y:0.223799:0.249641:-0.0124181;MT-ND1:A64S:D248N:0.513177:0.249641:0.27503;MT-ND1:A64S:L250F:0.285672:0.249641:0.0290031;MT-ND1:A64S:L250R:-0.27005:0.249641:-0.508427;MT-ND1:A64S:L250V:0.739592:0.249641:0.518854;MT-ND1:A64S:L250I:0.678127:0.249641:0.412886;MT-ND1:A64S:L250P:1.24729:0.249641:1.11168;MT-ND1:A64S:L250H:0.34658:0.249641:0.108448;MT-ND1:A64S:A276G:0.623825:0.249641:0.386782;MT-ND1:A64S:A276E:0.303716:0.249641:0.0557187;MT-ND1:A64S:A276P:1.48856:0.249641:1.16054;MT-ND1:A64S:A276V:0.879093:0.249641:0.62968;MT-ND1:A64S:A276T:0.921644:0.249641:0.683193;MT-ND1:A64S:A276S:0.0497663:0.249641:-0.200186 | MT-ND1:A64P:T245S:-0.801278:-1.39502:0.59531;MT-ND1:A64P:T245K:0.807853:-1.39502:2.88431;MT-ND1:A64P:T245A:-1.35626:-1.39502:-0.0212179;MT-ND1:A64P:T245P:-3.55983:-1.39502:-2.15484;MT-ND1:A64P:T245M:-1.6935:-1.39502:-0.233521;MT-ND1:A64P:T246K:-0.851043:-1.39502:0.53622;MT-ND1:A64P:T246A:-1.00295:-1.39502:0.393197;MT-ND1:A64P:T246S:-1.51726:-1.39502:-0.121189;MT-ND1:A64P:T246M:-1.26842:-1.39502:0.113932;MT-ND1:A64P:T246P:-2.35894:-1.39502:-0.949064;MT-ND1:A64P:D248H:-0.652272:-1.39502:0.709978;MT-ND1:A64P:D248Y:-1.31704:-1.39502:-0.0124181;MT-ND1:A64P:D248N:-1.12795:-1.39502:0.27503;MT-ND1:A64P:D248G:-0.343827:-1.39502:1.01568;MT-ND1:A64P:D248A:-0.892202:-1.39502:0.469864;MT-ND1:A64P:D248V:-0.989584:-1.39502:0.460803;MT-ND1:A64P:D248E:-1.43335:-1.39502:-0.0363487;MT-ND1:A64P:L250R:-1.93156:-1.39502:-0.508427;MT-ND1:A64P:L250V:-0.882259:-1.39502:0.518854;MT-ND1:A64P:L250I:-0.969771:-1.39502:0.412886;MT-ND1:A64P:L250P:-0.416392:-1.39502:1.11168;MT-ND1:A64P:L250H:-1.24722:-1.39502:0.108448;MT-ND1:A64P:L250F:-1.32045:-1.39502:0.0290031;MT-ND1:A64P:A276V:-0.765791:-1.39502:0.62968;MT-ND1:A64P:A276T:-0.717143:-1.39502:0.683193;MT-ND1:A64P:A276G:-1.0173:-1.39502:0.386782;MT-ND1:A64P:A276P:-0.384061:-1.39502:1.16054;MT-ND1:A64P:A276E:-1.33989:-1.39502:0.0557187;MT-ND1:A64P:A276S:-1.60267:-1.39502:-0.200186 | MT-ND1:A64V:T245A:0.282211:0.240076:-0.0212179;MT-ND1:A64V:T245K:2.61657:0.240076:2.88431;MT-ND1:A64V:T245P:-1.75337:0.240076:-2.15484;MT-ND1:A64V:T245S:0.835254:0.240076:0.59531;MT-ND1:A64V:T246P:-0.71974:0.240076:-0.949064;MT-ND1:A64V:T246A:0.634241:0.240076:0.393197;MT-ND1:A64V:T246K:0.79087:0.240076:0.53622;MT-ND1:A64V:T246S:0.118871:0.240076:-0.121189;MT-ND1:A64V:D248G:1.26993:0.240076:1.01568;MT-ND1:A64V:D248A:0.74165:0.240076:0.469864;MT-ND1:A64V:D248H:0.989303:0.240076:0.709978;MT-ND1:A64V:D248N:0.50523:0.240076:0.27503;MT-ND1:A64V:D248Y:0.271555:0.240076:-0.0124181;MT-ND1:A64V:D248E:0.185623:0.240076:-0.0363487;MT-ND1:A64V:L250F:0.278187:0.240076:0.0290031;MT-ND1:A64V:L250P:1.20409:0.240076:1.11168;MT-ND1:A64V:L250V:0.741858:0.240076:0.518854;MT-ND1:A64V:L250H:0.423228:0.240076:0.108448;MT-ND1:A64V:L250I:0.65484:0.240076:0.412886;MT-ND1:A64V:A276V:0.869572:0.240076:0.62968;MT-ND1:A64V:A276G:0.626582:0.240076:0.386782;MT-ND1:A64V:A276S:0.0385583:0.240076:-0.200186;MT-ND1:A64V:A276E:0.295701:0.240076:0.0557187;MT-ND1:A64V:A276P:1.43884:0.240076:1.16054;MT-ND1:A64V:T246M:0.340639:0.240076:0.113932;MT-ND1:A64V:T245M:-0.321748:0.240076:-0.233521;MT-ND1:A64V:D248V:0.648625:0.240076:0.460803;MT-ND1:A64V:L250R:-0.296961:0.240076:-0.508427;MT-ND1:A64V:A276T:0.931218:0.240076:0.683193 | MT-ND1:A64D:T245K:3.1494:0.175529:2.88431;MT-ND1:A64D:T245P:-1.94946:0.175529:-2.15484;MT-ND1:A64D:T245M:-0.211038:0.175529:-0.233521;MT-ND1:A64D:T245A:0.236152:0.175529:-0.0212179;MT-ND1:A64D:T245S:0.755133:0.175529:0.59531;MT-ND1:A64D:T246S:0.0543214:0.175529:-0.121189;MT-ND1:A64D:T246M:0.28801:0.175529:0.113932;MT-ND1:A64D:T246K:0.712343:0.175529:0.53622;MT-ND1:A64D:T246P:-0.774925:0.175529:-0.949064;MT-ND1:A64D:T246A:0.569121:0.175529:0.393197;MT-ND1:A64D:D248V:0.567356:0.175529:0.460803;MT-ND1:A64D:D248E:0.135112:0.175529:-0.0363487;MT-ND1:A64D:D248Y:0.268048:0.175529:-0.0124181;MT-ND1:A64D:D248G:1.14022:0.175529:1.01568;MT-ND1:A64D:D248A:0.712558:0.175529:0.469864;MT-ND1:A64D:D248H:0.857183:0.175529:0.709978;MT-ND1:A64D:D248N:0.436452:0.175529:0.27503;MT-ND1:A64D:L250F:0.20128:0.175529:0.0290031;MT-ND1:A64D:L250H:0.276572:0.175529:0.108448;MT-ND1:A64D:L250R:-0.295136:0.175529:-0.508427;MT-ND1:A64D:L250I:0.589126:0.175529:0.412886;MT-ND1:A64D:L250V:0.678823:0.175529:0.518854;MT-ND1:A64D:L250P:1.17507:0.175529:1.11168;MT-ND1:A64D:A276E:0.231911:0.175529:0.0557187;MT-ND1:A64D:A276V:0.798398:0.175529:0.62968;MT-ND1:A64D:A276T:0.86287:0.175529:0.683193;MT-ND1:A64D:A276G:0.555162:0.175529:0.386782;MT-ND1:A64D:A276S:-0.0185656:0.175529:-0.200186;MT-ND1:A64D:A276P:1.37603:0.175529:1.16054 | MT-ND1:A64G:T245A:0.226187:0.221734:-0.0212179;MT-ND1:A64G:T245S:0.824407:0.221734:0.59531;MT-ND1:A64G:T245P:-1.91837:0.221734:-2.15484;MT-ND1:A64G:T245M:-0.105044:0.221734:-0.233521;MT-ND1:A64G:T245K:3.25376:0.221734:2.88431;MT-ND1:A64G:T246S:0.10026:0.221734:-0.121189;MT-ND1:A64G:T246M:0.342056:0.221734:0.113932;MT-ND1:A64G:T246P:-0.732341:0.221734:-0.949064;MT-ND1:A64G:T246K:0.752018:0.221734:0.53622;MT-ND1:A64G:T246A:0.614539:0.221734:0.393197;MT-ND1:A64G:D248N:0.496277:0.221734:0.27503;MT-ND1:A64G:D248H:0.946212:0.221734:0.709978;MT-ND1:A64G:D248V:0.654698:0.221734:0.460803;MT-ND1:A64G:D248Y:0.254225:0.221734:-0.0124181;MT-ND1:A64G:D248G:1.24184:0.221734:1.01568;MT-ND1:A64G:D248A:0.726488:0.221734:0.469864;MT-ND1:A64G:D248E:0.190584:0.221734:-0.0363487;MT-ND1:A64G:L250I:0.632619:0.221734:0.412886;MT-ND1:A64G:L250F:0.257221:0.221734:0.0290031;MT-ND1:A64G:L250V:0.71142:0.221734:0.518854;MT-ND1:A64G:L250H:0.350236:0.221734:0.108448;MT-ND1:A64G:L250P:1.20007:0.221734:1.11168;MT-ND1:A64G:L250R:-0.291565:0.221734:-0.508427;MT-ND1:A64G:A276G:0.608516:0.221734:0.386782;MT-ND1:A64G:A276E:0.26669:0.221734:0.0557187;MT-ND1:A64G:A276P:1.42061:0.221734:1.16054;MT-ND1:A64G:A276V:0.850426:0.221734:0.62968;MT-ND1:A64G:A276T:0.89468:0.221734:0.683193;MT-ND1:A64G:A276S:0.0132851:0.221734:-0.200186 |
| DDG intra interface | . | . | . | . | . | . |
| DDG inter | MT-ND1:MT-ND3:5lc5:H:A:A64T:S45F:-0.01885:0.20746994:-0.184449762;MT-ND1:MT-ND3:5lc5:H:A:A64T:S45Y:0.03366:0.20746994:-0.209069446;MT-ND1:MT-ND3:5lc5:H:A:A64T:S45A:0.11013:0.20746994:-0.0903697982;MT-ND1:MT-ND3:5lc5:H:A:A64T:S45T:0.38004:0.20746994:0.215980917;MT-ND1:MT-ND3:5lc5:H:A:A64T:S45C:-0.26711:0.20746994:-0.407060623;MT-ND1:MT-ND3:5lc5:H:A:A64T:S45P:-0.9239:0.20746994:-1.09178007;MT-ND1:MT-ND3:5ldw:H:A:A64T:P46A:0.24139:0.10172081:0.124702454;MT-ND1:MT-ND3:5ldw:H:A:A64T:P46S:0.33821:0.10172081:0.256430447;MT-ND1:MT-ND3:5ldw:H:A:A64T:P46T:0.5889:0.10172081:0.476390839;MT-ND1:MT-ND3:5ldw:H:A:A64T:P46R:-0.35933:0.10172081:-0.374820709;MT-ND1:MT-ND3:5ldw:H:A:A64T:P46L:-0.40207:0.10172081:-0.427488327;MT-ND1:MT-ND3:5ldw:H:A:A64T:P46H:-0.01653:0.10172081:-0.123018265;MT-ND1:MT-ND3:5ldw:H:A:A64T:S45F:0.05697:0.10172081:0.122009657;MT-ND1:MT-ND3:5ldw:H:A:A64T:S45Y:0.80886:0.10172081:0.377010345;MT-ND1:MT-ND3:5ldw:H:A:A64T:S45A:0.08599:0.10172081:-0.0156085966;MT-ND1:MT-ND3:5ldw:H:A:A64T:S45T:0.35343:0.10172081:0.170780182;MT-ND1:MT-ND3:5ldw:H:A:A64T:S45C:0.00913:0.10172081:-0.0661293045;MT-ND1:MT-ND3:5ldw:H:A:A64T:S45P:-0.18431:0.10172081:-0.288380057;MT-ND1:MT-ND3:5ldx:H:A:A64T:P46A:0.27275:0.107588194:0.17194137;MT-ND1:MT-ND3:5ldx:H:A:A64T:P46S:0.32556:0.107588194:0.202388763;MT-ND1:MT-ND3:5ldx:H:A:A64T:P46T:0.30775:0.107588194:0.200049967;MT-ND1:MT-ND3:5ldx:H:A:A64T:P46R:-0.37666:0.107588194:-0.366769791;MT-ND1:MT-ND3:5ldx:H:A:A64T:P46L:-0.42001:0.107588194:-0.57003057;MT-ND1:MT-ND3:5ldx:H:A:A64T:P46H:-0.06405:0.107588194:-0.150340647;MT-ND1:MT-ND3:5ldx:H:A:A64T:S45F:0.62142:0.107588194:0.507999063;MT-ND1:MT-ND3:5ldx:H:A:A64T:S45Y:0.61503:0.107588194:0.507420719;MT-ND1:MT-ND3:5ldx:H:A:A64T:S45A:0.65342:0.107588194:0.531179786;MT-ND1:MT-ND3:5ldx:H:A:A64T:S45T:0.48902:0.107588194:0.424250036;MT-ND1:MT-ND3:5ldx:H:A:A64T:S45C:0.6507:0.107588194:0.429790109;MT-ND1:MT-ND3:5ldx:H:A:A64T:S45P:0.88499:0.107588194:0.854759216 | MT-ND1:MT-ND3:5lc5:H:A:A64S:S45A:-0.09243:-0.015329361:-0.0903697982;MT-ND1:MT-ND3:5lc5:H:A:A64S:S45F:-0.23046:-0.015329361:-0.184449762;MT-ND1:MT-ND3:5lc5:H:A:A64S:S45T:0.13552:-0.015329361:0.215980917;MT-ND1:MT-ND3:5lc5:H:A:A64S:S45P:-1.0989:-0.015329361:-1.09178007;MT-ND1:MT-ND3:5lc5:H:A:A64S:S45C:-0.40206:-0.015329361:-0.407060623;MT-ND1:MT-ND3:5lc5:H:A:A64S:S45Y:-0.24798:-0.015329361:-0.209069446;MT-ND1:MT-ND3:5ldw:H:A:A64S:P46T:0.44609:-0.00129890442:0.476390839;MT-ND1:MT-ND3:5ldw:H:A:A64S:P46R:-0.46345:-0.00129890442:-0.374820709;MT-ND1:MT-ND3:5ldw:H:A:A64S:P46L:-0.45383:-0.00129890442:-0.427488327;MT-ND1:MT-ND3:5ldw:H:A:A64S:P46H:-0.09613:-0.00129890442:-0.123018265;MT-ND1:MT-ND3:5ldw:H:A:A64S:P46S:0.22519:-0.00129890442:0.256430447;MT-ND1:MT-ND3:5ldw:H:A:A64S:P46A:0.13265:-0.00129890442:0.124702454;MT-ND1:MT-ND3:5ldw:H:A:A64S:S45A:-0.01984:-0.00129890442:-0.0156085966;MT-ND1:MT-ND3:5ldw:H:A:A64S:S45F:0.01067:-0.00129890442:0.122009657;MT-ND1:MT-ND3:5ldw:H:A:A64S:S45T:0.31238:-0.00129890442:0.170780182;MT-ND1:MT-ND3:5ldw:H:A:A64S:S45P:-0.31463:-0.00129890442:-0.288380057;MT-ND1:MT-ND3:5ldw:H:A:A64S:S45C:-0.32393:-0.00129890442:-0.0661293045;MT-ND1:MT-ND3:5ldw:H:A:A64S:S45Y:0.34543:-0.00129890442:0.377010345;MT-ND1:MT-ND3:5ldx:H:A:A64S:P46T:0.19556:-0.00452117901:0.200049967;MT-ND1:MT-ND3:5ldx:H:A:A64S:P46R:-0.44234:-0.00452117901:-0.366769791;MT-ND1:MT-ND3:5ldx:H:A:A64S:P46L:-0.54013:-0.00452117901:-0.57003057;MT-ND1:MT-ND3:5ldx:H:A:A64S:P46H:-0.18595:-0.00452117901:-0.150340647;MT-ND1:MT-ND3:5ldx:H:A:A64S:P46S:0.19682:-0.00452117901:0.202388763;MT-ND1:MT-ND3:5ldx:H:A:A64S:P46A:0.16036:-0.00452117901:0.17194137;MT-ND1:MT-ND3:5ldx:H:A:A64S:S45A:0.54492:-0.00452117901:0.531179786;MT-ND1:MT-ND3:5ldx:H:A:A64S:S45F:0.50879:-0.00452117901:0.507999063;MT-ND1:MT-ND3:5ldx:H:A:A64S:S45T:0.37223:-0.00452117901:0.424250036;MT-ND1:MT-ND3:5ldx:H:A:A64S:S45P:0.74854:-0.00452117901:0.854759216;MT-ND1:MT-ND3:5ldx:H:A:A64S:S45C:0.49515:-0.00452117901:0.429790109;MT-ND1:MT-ND3:5ldx:H:A:A64S:S45Y:0.50502:-0.00452117901:0.507420719 | 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