3496 (G > A)

General info

Chr
chrM
Start
3496
End
3496
Ref
G
Alt
A
Mitimpact ID
MI.11153
Gene symbol
MT-ND1
Oxphos complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
190
AA position
64
AA ref
A
AA alt
T
Codon substitution
Gcc/Acc
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Conservation

PhyloP 100v
-9.89
PhastCons 100v
0

Pathogenicity predictors

PolyPhen2
Benign
PolyPhen2 score
0
SIFT
Neutral
SIFT score
0.72
FatHmm
Neutral
FatHmm score
-0.92
FatHMMW
Neutral
FatHMMW score
2.71
PROVEAN
Neutral
PROVEAN score
0.01
Mutation Assessor
Neutral impact
Mutation Assessor score
-0.51
EFIN SP
Neutral
EFIN SP score
0.76
EFIN HD
Neutral
EFIN HD score
0.74
VEST p-value
0.34
VEST FDR
0.5
PANTHER
Neutral
PANTHER score
0.18
PhD-SNP
Neutral
PhD-SNP score
0.17
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Neutral
CADD score
0.9
CADD phred
10.05
SNAP
Neutral
SNAP score
0.14
MitoClass 1
Neutral
SNPDryad score
0.34

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.28
Condel
Deleterious
Condel score
0.86
COVEC WMV
Neutral
COVEC WMV score
-6
Meta SNP
Neutral
Meta SNP score
0.28
Meta SNP RI
4
MtoolBox
Neutral
MtoolBox DS
0.09
APOGEE consensus
N
APOGEE mean p
0.46
DEOGEN score
0.01

Cancer-specific predictors

PolyPhen2 transf
High impact
PolyPhen2 transf score
2.07
SIFT transf
Medium impact
SIFT transf score
0.51
MutationAssessor transf
Low impact
MutationAssessor transf score
-1.63
CHASM p-value
0.55
CHASM FDR
0.8

Residue interaction

EV Mutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Frequency & Phenotype DBs

ClinVar June2018 ClinSig
.
ClinVar June2018 ClnDBN
.
ClinVar June2018 ClnAllele ID
.
ClinVar June2018 ClnDSDB
.
Mitomap Allele
.
Mitomap Phenotype
.
Mitomap Homoplasmy
.
Mitomap Heteroplasmy
.
Mitomap Status
.
Mitomap NRef
.
COSMIC 87
Cosm5653110
Classification Clinvar
.
Classification Mitomap
.
Classification global
.
dbSNP 151 ID

Pathogenic variants, CPD

CPD candidate
.
CPD frequency
.
CPD AA ref
.
CPD AA alt
.
CPD aln pos
.
CPD RefSeq Protein ID
.
CPD Species name
.
CPD Ncbi Taxon ID
.

General info

Chr
chrM
Start
3496
End
3496
Ref
G
Alt
T
Mitimpact ID
MI.11154
Gene symbol
MT-ND1
Oxphos complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
190
AA position
64
AA ref
A
AA alt
S
Codon substitution
Gcc/Tcc
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Conservation

PhyloP 100v
-9.89
PhastCons 100v
0

Pathogenicity predictors

PolyPhen2
Benign
PolyPhen2 score
0
SIFT
Neutral
SIFT score
0.81
FatHmm
Neutral
FatHmm score
-0.3
FatHMMW
Neutral
FatHMMW score
2.79
PROVEAN
Neutral
PROVEAN score
1.31
Mutation Assessor
Neutral impact
Mutation Assessor score
-0.84
EFIN SP
Neutral
EFIN SP score
0.68
EFIN HD
Neutral
EFIN HD score
0.95
VEST p-value
0.42
VEST FDR
0.55
PANTHER
Neutral
PANTHER score
0.13
PhD-SNP
Neutral
PhD-SNP score
0.06
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Neutral
CADD score
-1.03
CADD phred
0.01
SNAP
Neutral
SNAP score
0.11
MitoClass 1
Neutral
SNPDryad score
0.07

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.19
Condel
Deleterious
Condel score
0.91
COVEC WMV
Neutral
COVEC WMV score
-6
Meta SNP
Neutral
Meta SNP score
0.21
Meta SNP RI
6
MtoolBox
Neutral
MtoolBox DS
0.08
APOGEE consensus
N
APOGEE mean p
0.44
DEOGEN score
0

Cancer-specific predictors

PolyPhen2 transf
High impact
PolyPhen2 transf score
2.07
SIFT transf
Medium impact
SIFT transf score
0.63
MutationAssessor transf
Low impact
MutationAssessor transf score
-1.92
CHASM p-value
0.39
CHASM FDR
0.8

Residue interaction

EV Mutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Frequency & Phenotype DBs

ClinVar June2018 ClinSig
.
ClinVar June2018 ClnDBN
.
ClinVar June2018 ClnAllele ID
.
ClinVar June2018 ClnDSDB
.
Mitomap Allele
G3496t
Mitomap Phenotype
Lhon
Mitomap Homoplasmy
+
Mitomap Heteroplasmy
-
Mitomap Status
Reported / secondary
Mitomap NRef
2
COSMIC 87
.
Classification Clinvar
.
Classification Mitomap
N
Classification global
N
dbSNP 151 ID

Pathogenic variants, CPD

CPD candidate
.
CPD frequency
.
CPD AA ref
.
CPD AA alt
.
CPD aln pos
.
CPD RefSeq Protein ID
.
CPD Species name
.
CPD Ncbi Taxon ID
.

3496 (G > C)

General info

Chr
chrM
Start
3496
End
3496
Ref
G
Alt
C
Mitimpact ID
MI.11155
Gene symbol
MT-ND1
Oxphos complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
190
AA position
64
AA ref
A
AA alt
P
Codon substitution
Gcc/Ccc
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Conservation

PhyloP 100v
-9.89
PhastCons 100v
0

Pathogenicity predictors

PolyPhen2
Benign
PolyPhen2 score
0.11
SIFT
Neutral
SIFT score
0.35
FatHmm
Neutral
FatHmm score
-2.44
FatHMMW
Neutral
FatHMMW score
2.65
PROVEAN
Neutral
PROVEAN score
-1.97
Mutation Assessor
Low impact
Mutation Assessor score
1.13
EFIN SP
Neutral
EFIN SP score
0.67
EFIN HD
Neutral
EFIN HD score
0.37
VEST p-value
0.17
VEST FDR
0.45
PANTHER
Neutral
PANTHER score
0.29
PhD-SNP
Disease
PhD-SNP score
0.77
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Neutral
CADD score
0.76
CADD phred
9.24
SNAP
Neutral
SNAP score
0.28
MitoClass 1
Neutral
SNPDryad score
0.74

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.6
Condel
Deleterious
Condel score
0.62
COVEC WMV
Neutral
COVEC WMV score
-6
Meta SNP
Disease
Meta SNP score
0.58
Meta SNP RI
1
MtoolBox
Neutral
MtoolBox DS
0.26
APOGEE consensus
N
APOGEE mean p
0.38
DEOGEN score
0.03

Cancer-specific predictors

PolyPhen2 transf
Medium impact
PolyPhen2 transf score
0.1
SIFT transf
Medium impact
SIFT transf score
0.12
MutationAssessor transf
Medium impact
MutationAssessor transf score
-0.2
CHASM p-value
0.37
CHASM FDR
0.8

Residue interaction

EV Mutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Frequency & Phenotype DBs

ClinVar June2018 ClinSig
.
ClinVar June2018 ClnDBN
.
ClinVar June2018 ClnAllele ID
.
ClinVar June2018 ClnDSDB
.
Mitomap Allele
.
Mitomap Phenotype
.
Mitomap Homoplasmy
.
Mitomap Heteroplasmy
.
Mitomap Status
.
Mitomap NRef
.
COSMIC 87
.
Classification Clinvar
.
Classification Mitomap
.
Classification global
.
dbSNP 151 ID

Pathogenic variants, CPD

CPD candidate
.
CPD frequency
.
CPD AA ref
.
CPD AA alt
.
CPD aln pos
.
CPD RefSeq Protein ID
.
CPD Species name
.
CPD Ncbi Taxon ID
.

General info

Chr
chrM
Start
3497
End
3497
Ref
C
Alt
T
Mitimpact ID
MI.11156
Gene symbol
MT-ND1
Oxphos complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
191
AA position
64
AA ref
A
AA alt
V
Codon substitution
gCc/gTc
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Conservation

PhyloP 100v
-2.08
PhastCons 100v
0

Pathogenicity predictors

PolyPhen2
Benign
PolyPhen2 score
0.01
SIFT
Neutral
SIFT score
0.49
FatHmm
Neutral
FatHmm score
-2.06
FatHMMW
Neutral
FatHMMW score
2.71
PROVEAN
Neutral
PROVEAN score
-1.4
Mutation Assessor
Low impact
Mutation Assessor score
1.36
EFIN SP
Neutral
EFIN SP score
0.75
EFIN HD
Neutral
EFIN HD score
0.71
VEST p-value
0.27
VEST FDR
0.45
PANTHER
Neutral
PANTHER score
0.16
PhD-SNP
Neutral
PhD-SNP score
0.37
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Neutral
CADD score
1.25
CADD phred
11.99
SNAP
Neutral
SNAP score
0.17
MitoClass 1
Neutral
SNPDryad score
0.45

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.49
Condel
Deleterious
Condel score
0.74
COVEC WMV
Neutral
COVEC WMV score
-6
Meta SNP
Neutral
Meta SNP score
0.44
Meta SNP RI
1
MtoolBox
Neutral
MtoolBox DS
0.12
APOGEE consensus
N
APOGEE mean p
0.44
DEOGEN score
0.02

Cancer-specific predictors

PolyPhen2 transf
Medium impact
PolyPhen2 transf score
1.12
SIFT transf
Medium impact
SIFT transf score
0.27
MutationAssessor transf
Medium impact
MutationAssessor transf score
0
CHASM p-value
0.47
CHASM FDR
0.8

Residue interaction

EV Mutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Frequency & Phenotype DBs

ClinVar June2018 ClinSig
.
ClinVar June2018 ClnDBN
.
ClinVar June2018 ClnAllele ID
.
ClinVar June2018 ClnDSDB
.
Mitomap Allele
C3497t
Mitomap Phenotype
Lhon
Mitomap Homoplasmy
+
Mitomap Heteroplasmy
-
Mitomap Status
Reported / secondary
Mitomap NRef
3
COSMIC 87
.
Classification Clinvar
N
Classification Mitomap
N
Classification global
N
dbSNP 151 ID

Pathogenic variants, CPD

CPD candidate
.
CPD frequency
.
CPD AA ref
.
CPD AA alt
.
CPD aln pos
.
CPD RefSeq Protein ID
.
CPD Species name
.
CPD Ncbi Taxon ID
.

3497 (C > A)

General info

Chr
chrM
Start
3497
End
3497
Ref
C
Alt
A
Mitimpact ID
MI.11157
Gene symbol
MT-ND1
Oxphos complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
191
AA position
64
AA ref
A
AA alt
D
Codon substitution
gCc/gAc
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Conservation

PhyloP 100v
-2.08
PhastCons 100v
0

Pathogenicity predictors

PolyPhen2
Benign
PolyPhen2 score
0.06
SIFT
Neutral
SIFT score
0.61
FatHmm
Neutral
FatHmm score
-1.26
FatHMMW
Neutral
FatHMMW score
2.7
PROVEAN
Neutral
PROVEAN score
-1.71
Mutation Assessor
Low impact
Mutation Assessor score
1.34
EFIN SP
Neutral
EFIN SP score
0.73
EFIN HD
Neutral
EFIN HD score
0.41
VEST p-value
0.15
VEST FDR
0.4
PANTHER
Neutral
PANTHER score
0.22
PhD-SNP
Disease
PhD-SNP score
0.7
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Neutral
CADD score
1.42
CADD phred
12.87
SNAP
Neutral
SNAP score
0.37
MitoClass 1
Neutral
SNPDryad score
0.54

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.32
Condel
Deleterious
Condel score
0.78
COVEC WMV
Neutral
COVEC WMV score
-6
Meta SNP
Neutral
Meta SNP score
0.48
Meta SNP RI
0
MtoolBox
Neutral
MtoolBox DS
0.18
APOGEE consensus
N
APOGEE mean p
0.29
DEOGEN score
0.02

Cancer-specific predictors

PolyPhen2 transf
Medium impact
PolyPhen2 transf score
0.37
SIFT transf
Medium impact
SIFT transf score
0.38
MutationAssessor transf
Medium impact
MutationAssessor transf score
-0.02
CHASM p-value
0.17
CHASM FDR
0.8

Residue interaction

EV Mutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Frequency & Phenotype DBs

ClinVar June2018 ClinSig
.
ClinVar June2018 ClnDBN
.
ClinVar June2018 ClnAllele ID
.
ClinVar June2018 ClnDSDB
.
Mitomap Allele
.
Mitomap Phenotype
.
Mitomap Homoplasmy
.
Mitomap Heteroplasmy
.
Mitomap Status
.
Mitomap NRef
.
COSMIC 87
.
Classification Clinvar
.
Classification Mitomap
.
Classification global
.
dbSNP 151 ID

Pathogenic variants, CPD

CPD candidate
.
CPD frequency
.
CPD AA ref
.
CPD AA alt
.
CPD aln pos
.
CPD RefSeq Protein ID
.
CPD Species name
.
CPD Ncbi Taxon ID
.

3497 (C > G)

General info

Chr
chrM
Start
3497
End
3497
Ref
C
Alt
G
Mitimpact ID
MI.11158
Gene symbol
MT-ND1
Oxphos complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
191
AA position
64
AA ref
A
AA alt
G
Codon substitution
gCc/gGc
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Conservation

PhyloP 100v
-2.08
PhastCons 100v
0

Pathogenicity predictors

PolyPhen2
Benign
PolyPhen2 score
0.04
SIFT
Neutral
SIFT score
0.47
FatHmm
Neutral
FatHmm score
-1.52
FatHMMW
Neutral
FatHMMW score
2.67
PROVEAN
Neutral
PROVEAN score
-1.65
Mutation Assessor
Low impact
Mutation Assessor score
1.44
EFIN SP
Neutral
EFIN SP score
0.68
EFIN HD
Neutral
EFIN HD score
0.54
VEST p-value
0.39
VEST FDR
0.5
PANTHER
Neutral
PANTHER score
0.32
PhD-SNP
Neutral
PhD-SNP score
0.42
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Neutral
CADD score
0.82
CADD phred
9.59
SNAP
Neutral
SNAP score
0.25
MitoClass 1
Neutral
SNPDryad score
0.49

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.49
Condel
Deleterious
Condel score
0.72
COVEC WMV
Neutral
COVEC WMV score
-6
Meta SNP
Neutral
Meta SNP score
0.47
Meta SNP RI
1
MtoolBox
Neutral
MtoolBox DS
0.14
APOGEE consensus
N
APOGEE mean p
0.44
DEOGEN score
0.03

Cancer-specific predictors

PolyPhen2 transf
Medium impact
PolyPhen2 transf score
0.55
SIFT transf
Medium impact
SIFT transf score
0.25
MutationAssessor transf
Medium impact
MutationAssessor transf score
0.07
CHASM p-value
0.52
CHASM FDR
0.8

Residue interaction

EV Mutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Frequency & Phenotype DBs

ClinVar June2018 ClinSig
.
ClinVar June2018 ClnDBN
.
ClinVar June2018 ClnAllele ID
.
ClinVar June2018 ClnDSDB
.
Mitomap Allele
.
Mitomap Phenotype
.
Mitomap Homoplasmy
.
Mitomap Heteroplasmy
.
Mitomap Status
.
Mitomap NRef
.
COSMIC 87
.
Classification Clinvar
.
Classification Mitomap
.
Classification global
.
dbSNP 151 ID

Pathogenic variants, CPD

CPD candidate
.
CPD frequency
.
CPD AA ref
.
CPD AA alt
.
CPD aln pos
.
CPD RefSeq Protein ID
.
CPD Species name
.
CPD Ncbi Taxon ID
.
~ 3496 (G/A) 3496 (G/T) 3496 (G/C) 3497 (C/T) 3497 (C/A) 3497 (C/G)
~ 3496 (Gcc/Acc) 3496 (Gcc/Tcc) 3496 (Gcc/Ccc) 3497 (gCc/gTc) 3497 (gCc/gAc) 3497 (gCc/gGc)
Chr chrM chrM chrM chrM chrM chrM
Start 3496 3496 3496 3497 3497 3497
End 3496 3496 3496 3497 3497 3497
Ref G G G C C C
Alt A T C T A G
MitImpact id MI.11153 MI.11154 MI.11155 MI.11156 MI.11157 MI.11158
Gene symbol MT-ND1 MT-ND1 MT-ND1 MT-ND1 MT-ND1 MT-ND1
OXPHOS complex I I I I I I
Ensembl gene id ENSG00000198888 ENSG00000198888 ENSG00000198888 ENSG00000198888 ENSG00000198888 ENSG00000198888
Ensembl protein id ENSP00000354687 ENSP00000354687 ENSP00000354687 ENSP00000354687 ENSP00000354687 ENSP00000354687
Ensembl transcript id ENST00000361390 ENST00000361390 ENST00000361390 ENST00000361390 ENST00000361390 ENST00000361390
Uniprot name NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN
Uniprot id P03886 P03886 P03886 P03886 P03886 P03886
Ncbi gene id 4535 4535 4535 4535 4535 4535
Ncbi protein id YP_003024026.1 YP_003024026.1 YP_003024026.1 YP_003024026.1 YP_003024026.1 YP_003024026.1
Gene position 190 190 190 191 191 191
AA position 64 64 64 64 64 64
AA ref A A A A A A
AA alt T S P V D G
Codon substitution Gcc/Acc Gcc/Tcc Gcc/Ccc gCc/gTc gCc/gAc gCc/gGc
PhyloP 100V -9.89 -9.89 -9.89 -2.08 -2.08 -2.08
PhastCons 100V 0 0 0 0 0 0
PolyPhen2 benign benign benign benign benign benign
PolyPhen2 score 0 0 0.11 0.01 0.06 0.04
SIFT neutral neutral neutral neutral neutral neutral
SIFT score 0.72 0.81 0.35 0.49 0.61 0.47
FatHmm neutral neutral neutral neutral neutral neutral
FatHmm score -0.92 -0.3 -2.44 -2.06 -1.26 -1.52
FatHmmW neutral neutral neutral neutral neutral neutral
FatHmmW score 2.71 2.79 2.65 2.71 2.7 2.67
PROVEAN neutral neutral neutral neutral neutral neutral
PROVEAN score 0.01 1.31 -1.97 -1.4 -1.71 -1.65
MutationAssessor neutral impact neutral impact low impact low impact low impact low impact
MutationAssessor score -0.51 -0.84 1.13 1.36 1.34 1.44
EFIN SP neutral neutral neutral neutral neutral neutral
EFIN SP score 0.76 0.68 0.67 0.75 0.73 0.68
EFIN HD neutral neutral neutral neutral neutral neutral
EFIN HD score 0.74 0.95 0.37 0.71 0.41 0.54
CADD neutral neutral neutral neutral neutral neutral
CADD score 0.9 -1.03 0.76 1.25 1.42 0.82
CADD phred 10.05 0.01 9.24 11.99 12.87 9.59
VEST pvalue 0.34 0.42 0.17 0.27 0.15 0.39
VEST FDR 0.5 0.55 0.45 0.45 0.4 0.5
PANTHER neutral neutral neutral neutral neutral neutral
PANTHER score 0.18 0.13 0.29 0.16 0.22 0.32
PhD-SNP neutral neutral disease neutral disease neutral
PhD-SNP score 0.17 0.06 0.77 0.37 0.7 0.42
SNAP neutral neutral neutral neutral neutral neutral
SNAP score 0.14 0.11 0.28 0.17 0.37 0.25
Meta-SNP neutral neutral disease neutral neutral neutral
Meta-SNP score 0.28 0.21 0.58 0.44 0.48 0.47
Meta-SNP RI 4 6 1 1 0 1
CAROL neutral neutral neutral neutral neutral neutral
CAROL score 0.28 0.19 0.6 0.49 0.32 0.49
Condel deleterious deleterious deleterious deleterious deleterious deleterious
Condel score 0.86 0.91 0.62 0.74 0.78 0.72
COVEC WMV neutral neutral neutral neutral neutral neutral
COVEC WMV score -6 -6 -6 -6 -6 -6
MtoolBox neutral neutral neutral neutral neutral neutral
MtoolBox DS 0.09 0.08 0.26 0.12 0.18 0.14
PolyPhen2 transf high impact high impact medium impact medium impact medium impact medium impact
PolyPhen2 transf score 2.07 2.07 0.1 1.12 0.37 0.55
SIFT_transf medium impact medium impact medium impact medium impact medium impact medium impact
SIFT transf score 0.51 0.63 0.12 0.27 0.38 0.25
MutationAssessor transf low impact low impact medium impact medium impact medium impact medium impact
MutationAssessor transf score -1.63 -1.92 -0.2 0 -0.02 0.07
CHASM pvalue 0.55 0.39 0.37 0.47 0.17 0.52
CHASM FDR 0.8 0.8 0.8 0.8 0.8 0.8
APOGEE bootstrap consensus N N N N N N
APOGEE bootstrap mean probability (mp) 0.46 0.44 0.38 0.44 0.29 0.44
SNPDryad score 0.34 0.07 0.74 0.45 0.54 0.49
MutationTaster polymorphism polymorphism polymorphism polymorphism polymorphism polymorphism
MutationTaster score 1 1 1 1 1 1
DEOGEN score 0.01 0 0.03 0.02 0.02 0.03
Mitoclass.1 neutral neutral neutral neutral neutral neutral
dbSNP 151 id . . . rs200319905 . .
ClinVar June2018 ClinSig . . . . . .
ClinVar June2018 ClnDBN . . . . . .
ClinVar June2018 ClnAllele id . . . . . .
ClinVar June2018 ClnDSDB . . . . . .
COSMIC 87 COSM5653110 . . . . .
CPD candidate . . . . . .
CPD frequency . . . . . .
Mitomap Allele . G3496T . C3497T . .
Mitomap Phenotype . LHON . LHON . .
Mitomap Homoplasmy . + . + . .
Mitomap Heteroplasmy . - . - . .
Mitomap Status . Reported / Secondary . Reported / Secondary . .
Mitomap NRef . 2 . 3 . .
Classification Clinvar . . . N . .
Classification Mitomap . N . N . .
Classification Global . N . N . .
Classification Global . N . N . .
EV Mutation MT-ND1_64A|65T:0.21755;118W:0.097737;183M:0.083952;69T:0.082342;110S:0.082298;305V:0.075737;99N:0.075659;87T:0.074904;302M:0.070495;70L:0.070242;266L:0.066295;247Y:0.065793 MT-ND1_64A|65T:0.21755;118W:0.097737;183M:0.083952;69T:0.082342;110S:0.082298;305V:0.075737;99N:0.075659;87T:0.074904;302M:0.070495;70L:0.070242;266L:0.066295;247Y:0.065793 MT-ND1_64A|65T:0.21755;118W:0.097737;183M:0.083952;69T:0.082342;110S:0.082298;305V:0.075737;99N:0.075659;87T:0.074904;302M:0.070495;70L:0.070242;266L:0.066295;247Y:0.065793 MT-ND1_64A|65T:0.21755;118W:0.097737;183M:0.083952;69T:0.082342;110S:0.082298;305V:0.075737;99N:0.075659;87T:0.074904;302M:0.070495;70L:0.070242;266L:0.066295;247Y:0.065793 MT-ND1_64A|65T:0.21755;118W:0.097737;183M:0.083952;69T:0.082342;110S:0.082298;305V:0.075737;99N:0.075659;87T:0.074904;302M:0.070495;70L:0.070242;266L:0.066295;247Y:0.065793 MT-ND1_64A|65T:0.21755;118W:0.097737;183M:0.083952;69T:0.082342;110S:0.082298;305V:0.075737;99N:0.075659;87T:0.074904;302M:0.070495;70L:0.070242;266L:0.066295;247Y:0.065793
Site A InterP ND1_64 ND1_64 ND1_64 ND1_64 ND1_64 ND1_64
Site B InterP ND4_86;ND5_4;ND6_95;ND2_213;ND2_22;ND2_6;ND2_239;ND2_221;ND2_90;ND2_89;ND2_96;ND2_48;ND3_29;ND3_85;ND3_90;ND3_21;ND3_88;ND3_45;ND3_46;ND3_93;ND3_18;ND3_92;ND3_89;ND4_4;ND4_363;ND4_357;ND4_248;ND4L_19;ND5_420;ND6_86;ND6_150;ND6_165;ND6_142;ND6_139;ND6_102;ND6_140 ND4_86;ND5_4;ND6_95;ND2_213;ND2_22;ND2_6;ND2_239;ND2_221;ND2_90;ND2_89;ND2_96;ND2_48;ND3_29;ND3_85;ND3_90;ND3_21;ND3_88;ND3_45;ND3_46;ND3_93;ND3_18;ND3_92;ND3_89;ND4_4;ND4_363;ND4_357;ND4_248;ND4L_19;ND5_420;ND6_86;ND6_150;ND6_165;ND6_142;ND6_139;ND6_102;ND6_140 ND4_86;ND5_4;ND6_95;ND2_213;ND2_22;ND2_6;ND2_239;ND2_221;ND2_90;ND2_89;ND2_96;ND2_48;ND3_29;ND3_85;ND3_90;ND3_21;ND3_88;ND3_45;ND3_46;ND3_93;ND3_18;ND3_92;ND3_89;ND4_4;ND4_363;ND4_357;ND4_248;ND4L_19;ND5_420;ND6_86;ND6_150;ND6_165;ND6_142;ND6_139;ND6_102;ND6_140 ND4_86;ND5_4;ND6_95;ND2_213;ND2_22;ND2_6;ND2_239;ND2_221;ND2_90;ND2_89;ND2_96;ND2_48;ND3_29;ND3_85;ND3_90;ND3_21;ND3_88;ND3_45;ND3_46;ND3_93;ND3_18;ND3_92;ND3_89;ND4_4;ND4_363;ND4_357;ND4_248;ND4L_19;ND5_420;ND6_86;ND6_150;ND6_165;ND6_142;ND6_139;ND6_102;ND6_140 ND4_86;ND5_4;ND6_95;ND2_213;ND2_22;ND2_6;ND2_239;ND2_221;ND2_90;ND2_89;ND2_96;ND2_48;ND3_29;ND3_85;ND3_90;ND3_21;ND3_88;ND3_45;ND3_46;ND3_93;ND3_18;ND3_92;ND3_89;ND4_4;ND4_363;ND4_357;ND4_248;ND4L_19;ND5_420;ND6_86;ND6_150;ND6_165;ND6_142;ND6_139;ND6_102;ND6_140 ND4_86;ND5_4;ND6_95;ND2_213;ND2_22;ND2_6;ND2_239;ND2_221;ND2_90;ND2_89;ND2_96;ND2_48;ND3_29;ND3_85;ND3_90;ND3_21;ND3_88;ND3_45;ND3_46;ND3_93;ND3_18;ND3_92;ND3_89;ND4_4;ND4_363;ND4_357;ND4_248;ND4L_19;ND5_420;ND6_86;ND6_150;ND6_165;ND6_142;ND6_139;ND6_102;ND6_140
Covariation Score InterP mfDCA:38.1853;mfDCA:26.9377;mfDCA:22.3338;cMI:64.445656;cMI:62.520184;cMI:60.4021;cMI:56.451332;cMI:54.954052;cMI:53.875118;cMI:51.619503;cMI:51.002003;cMI:47.62558;cMI:40.801426;cMI:40.316986;cMI:37.820358;cMI:36.199524;cMI:36.096405;cMI:32.729809;cMI:32.513779;cMI:32.150593;cMI:31.948084;cMI:31.65707;cMI:31.375387;cMI:26.449203;cMI:25.599543;cMI:25.42153;cMI:24.47381;cMI:46.408833;cMI:32.719944;cMI:56.914764;cMI:56.317474;cMI:56.275574;cMI:50.712196;cMI:50.43972;cMI:48.25338;cMI:47.307716 mfDCA:38.1853;mfDCA:26.9377;mfDCA:22.3338;cMI:64.445656;cMI:62.520184;cMI:60.4021;cMI:56.451332;cMI:54.954052;cMI:53.875118;cMI:51.619503;cMI:51.002003;cMI:47.62558;cMI:40.801426;cMI:40.316986;cMI:37.820358;cMI:36.199524;cMI:36.096405;cMI:32.729809;cMI:32.513779;cMI:32.150593;cMI:31.948084;cMI:31.65707;cMI:31.375387;cMI:26.449203;cMI:25.599543;cMI:25.42153;cMI:24.47381;cMI:46.408833;cMI:32.719944;cMI:56.914764;cMI:56.317474;cMI:56.275574;cMI:50.712196;cMI:50.43972;cMI:48.25338;cMI:47.307716 mfDCA:38.1853;mfDCA:26.9377;mfDCA:22.3338;cMI:64.445656;cMI:62.520184;cMI:60.4021;cMI:56.451332;cMI:54.954052;cMI:53.875118;cMI:51.619503;cMI:51.002003;cMI:47.62558;cMI:40.801426;cMI:40.316986;cMI:37.820358;cMI:36.199524;cMI:36.096405;cMI:32.729809;cMI:32.513779;cMI:32.150593;cMI:31.948084;cMI:31.65707;cMI:31.375387;cMI:26.449203;cMI:25.599543;cMI:25.42153;cMI:24.47381;cMI:46.408833;cMI:32.719944;cMI:56.914764;cMI:56.317474;cMI:56.275574;cMI:50.712196;cMI:50.43972;cMI:48.25338;cMI:47.307716 mfDCA:38.1853;mfDCA:26.9377;mfDCA:22.3338;cMI:64.445656;cMI:62.520184;cMI:60.4021;cMI:56.451332;cMI:54.954052;cMI:53.875118;cMI:51.619503;cMI:51.002003;cMI:47.62558;cMI:40.801426;cMI:40.316986;cMI:37.820358;cMI:36.199524;cMI:36.096405;cMI:32.729809;cMI:32.513779;cMI:32.150593;cMI:31.948084;cMI:31.65707;cMI:31.375387;cMI:26.449203;cMI:25.599543;cMI:25.42153;cMI:24.47381;cMI:46.408833;cMI:32.719944;cMI:56.914764;cMI:56.317474;cMI:56.275574;cMI:50.712196;cMI:50.43972;cMI:48.25338;cMI:47.307716 mfDCA:38.1853;mfDCA:26.9377;mfDCA:22.3338;cMI:64.445656;cMI:62.520184;cMI:60.4021;cMI:56.451332;cMI:54.954052;cMI:53.875118;cMI:51.619503;cMI:51.002003;cMI:47.62558;cMI:40.801426;cMI:40.316986;cMI:37.820358;cMI:36.199524;cMI:36.096405;cMI:32.729809;cMI:32.513779;cMI:32.150593;cMI:31.948084;cMI:31.65707;cMI:31.375387;cMI:26.449203;cMI:25.599543;cMI:25.42153;cMI:24.47381;cMI:46.408833;cMI:32.719944;cMI:56.914764;cMI:56.317474;cMI:56.275574;cMI:50.712196;cMI:50.43972;cMI:48.25338;cMI:47.307716 mfDCA:38.1853;mfDCA:26.9377;mfDCA:22.3338;cMI:64.445656;cMI:62.520184;cMI:60.4021;cMI:56.451332;cMI:54.954052;cMI:53.875118;cMI:51.619503;cMI:51.002003;cMI:47.62558;cMI:40.801426;cMI:40.316986;cMI:37.820358;cMI:36.199524;cMI:36.096405;cMI:32.729809;cMI:32.513779;cMI:32.150593;cMI:31.948084;cMI:31.65707;cMI:31.375387;cMI:26.449203;cMI:25.599543;cMI:25.42153;cMI:24.47381;cMI:46.408833;cMI:32.719944;cMI:56.914764;cMI:56.317474;cMI:56.275574;cMI:50.712196;cMI:50.43972;cMI:48.25338;cMI:47.307716
Site A IntraP ND1_64 ND1_64 ND1_64 ND1_64 ND1_64 ND1_64
Site B IntraP ND1_245;ND1_229;ND1_309;ND1_178;ND1_305;ND1_225;ND1_250;ND1_248;ND1_260;ND1_246;ND1_276 ND1_245;ND1_229;ND1_309;ND1_178;ND1_305;ND1_225;ND1_250;ND1_248;ND1_260;ND1_246;ND1_276 ND1_245;ND1_229;ND1_309;ND1_178;ND1_305;ND1_225;ND1_250;ND1_248;ND1_260;ND1_246;ND1_276 ND1_245;ND1_229;ND1_309;ND1_178;ND1_305;ND1_225;ND1_250;ND1_248;ND1_260;ND1_246;ND1_276 ND1_245;ND1_229;ND1_309;ND1_178;ND1_305;ND1_225;ND1_250;ND1_248;ND1_260;ND1_246;ND1_276 ND1_245;ND1_229;ND1_309;ND1_178;ND1_305;ND1_225;ND1_250;ND1_248;ND1_260;ND1_246;ND1_276
Covariation Score IntraP cMI:14.342117;mfDCA:22.8811;mfDCA:22.5193;mfDCA:22.0516;mfDCA:21.8998;mfDCA:21.564;mfDCA:19.5808;mfDCA:19.0999;mfDCA:18.3416;mfDCA:16.1252;mfDCA:14.823 cMI:14.342117;mfDCA:22.8811;mfDCA:22.5193;mfDCA:22.0516;mfDCA:21.8998;mfDCA:21.564;mfDCA:19.5808;mfDCA:19.0999;mfDCA:18.3416;mfDCA:16.1252;mfDCA:14.823 cMI:14.342117;mfDCA:22.8811;mfDCA:22.5193;mfDCA:22.0516;mfDCA:21.8998;mfDCA:21.564;mfDCA:19.5808;mfDCA:19.0999;mfDCA:18.3416;mfDCA:16.1252;mfDCA:14.823 cMI:14.342117;mfDCA:22.8811;mfDCA:22.5193;mfDCA:22.0516;mfDCA:21.8998;mfDCA:21.564;mfDCA:19.5808;mfDCA:19.0999;mfDCA:18.3416;mfDCA:16.1252;mfDCA:14.823 cMI:14.342117;mfDCA:22.8811;mfDCA:22.5193;mfDCA:22.0516;mfDCA:21.8998;mfDCA:21.564;mfDCA:19.5808;mfDCA:19.0999;mfDCA:18.3416;mfDCA:16.1252;mfDCA:14.823 cMI:14.342117;mfDCA:22.8811;mfDCA:22.5193;mfDCA:22.0516;mfDCA:21.8998;mfDCA:21.564;mfDCA:19.5808;mfDCA:19.0999;mfDCA:18.3416;mfDCA:16.1252;mfDCA:14.823
CPD AA ref . . . . . .
CPD AA alt . . . . . .
CPD aln pos . . . . . .
CPD Species name . . . . . .
CPD RefSeq Protein ID . . . . . .
CPD Ncbi Taxon ID . . . . . .
DDG intra MT-ND1:A64T:T245A:0.276091:0.187811:-0.0212179;MT-ND1:A64T:T245K:2.8503:0.187811:2.88431;MT-ND1:A64T:T245P:-1.77736:0.187811:-2.15484;MT-ND1:A64T:T245M:0.0980715:0.187811:-0.233521;MT-ND1:A64T:T245S:0.801626:0.187811:0.59531;MT-ND1:A64T:T246A:0.579593:0.187811:0.393197;MT-ND1:A64T:T246P:-0.775521:0.187811:-0.949064;MT-ND1:A64T:T246S:0.0648742:0.187811:-0.121189;MT-ND1:A64T:T246M:0.326569:0.187811:0.113932;MT-ND1:A64T:T246K:0.75316:0.187811:0.53622;MT-ND1:A64T:D248H:0.999094:0.187811:0.709978;MT-ND1:A64T:D248Y:0.325915:0.187811:-0.0124181;MT-ND1:A64T:D248G:1.25568:0.187811:1.01568;MT-ND1:A64T:D248A:0.729766:0.187811:0.469864;MT-ND1:A64T:D248E:0.211487:0.187811:-0.0363487;MT-ND1:A64T:D248N:0.480687:0.187811:0.27503;MT-ND1:A64T:D248V:0.786552:0.187811:0.460803;MT-ND1:A64T:L250I:0.606484:0.187811:0.412886;MT-ND1:A64T:L250F:0.218952:0.187811:0.0290031;MT-ND1:A64T:L250V:0.701436:0.187811:0.518854;MT-ND1:A64T:L250P:1.2973:0.187811:1.11168;MT-ND1:A64T:L250H:0.352982:0.187811:0.108448;MT-ND1:A64T:L250R:-0.354091:0.187811:-0.508427;MT-ND1:A64T:A276G:0.571749:0.187811:0.386782;MT-ND1:A64T:A276V:0.816931:0.187811:0.62968;MT-ND1:A64T:A276T:0.897024:0.187811:0.683193;MT-ND1:A64T:A276E:0.241989:0.187811:0.0557187;MT-ND1:A64T:A276P:1.44294:0.187811:1.16054;MT-ND1:A64T:A276S:-0.0237564:0.187811:-0.200186 MT-ND1:A64S:T245A:0.190663:0.249641:-0.0212179;MT-ND1:A64S:T245P:-1.74279:0.249641:-2.15484;MT-ND1:A64S:T245S:0.824595:0.249641:0.59531;MT-ND1:A64S:T245M:-0.13552:0.249641:-0.233521;MT-ND1:A64S:T245K:2.92241:0.249641:2.88431;MT-ND1:A64S:T246M:0.355215:0.249641:0.113932;MT-ND1:A64S:T246S:0.1281:0.249641:-0.121189;MT-ND1:A64S:T246A:0.642818:0.249641:0.393197;MT-ND1:A64S:T246K:0.817687:0.249641:0.53622;MT-ND1:A64S:T246P:-0.709822:0.249641:-0.949064;MT-ND1:A64S:D248E:0.213008:0.249641:-0.0363487;MT-ND1:A64S:D248G:1.27018:0.249641:1.01568;MT-ND1:A64S:D248V:0.692142:0.249641:0.460803;MT-ND1:A64S:D248A:0.771225:0.249641:0.469864;MT-ND1:A64S:D248H:0.980396:0.249641:0.709978;MT-ND1:A64S:D248Y:0.223799:0.249641:-0.0124181;MT-ND1:A64S:D248N:0.513177:0.249641:0.27503;MT-ND1:A64S:L250F:0.285672:0.249641:0.0290031;MT-ND1:A64S:L250R:-0.27005:0.249641:-0.508427;MT-ND1:A64S:L250V:0.739592:0.249641:0.518854;MT-ND1:A64S:L250I:0.678127:0.249641:0.412886;MT-ND1:A64S:L250P:1.24729:0.249641:1.11168;MT-ND1:A64S:L250H:0.34658:0.249641:0.108448;MT-ND1:A64S:A276G:0.623825:0.249641:0.386782;MT-ND1:A64S:A276E:0.303716:0.249641:0.0557187;MT-ND1:A64S:A276P:1.48856:0.249641:1.16054;MT-ND1:A64S:A276V:0.879093:0.249641:0.62968;MT-ND1:A64S:A276T:0.921644:0.249641:0.683193;MT-ND1:A64S:A276S:0.0497663:0.249641:-0.200186 MT-ND1:A64P:T245S:-0.801278:-1.39502:0.59531;MT-ND1:A64P:T245K:0.807853:-1.39502:2.88431;MT-ND1:A64P:T245A:-1.35626:-1.39502:-0.0212179;MT-ND1:A64P:T245P:-3.55983:-1.39502:-2.15484;MT-ND1:A64P:T245M:-1.6935:-1.39502:-0.233521;MT-ND1:A64P:T246K:-0.851043:-1.39502:0.53622;MT-ND1:A64P:T246A:-1.00295:-1.39502:0.393197;MT-ND1:A64P:T246S:-1.51726:-1.39502:-0.121189;MT-ND1:A64P:T246M:-1.26842:-1.39502:0.113932;MT-ND1:A64P:T246P:-2.35894:-1.39502:-0.949064;MT-ND1:A64P:D248H:-0.652272:-1.39502:0.709978;MT-ND1:A64P:D248Y:-1.31704:-1.39502:-0.0124181;MT-ND1:A64P:D248N:-1.12795:-1.39502:0.27503;MT-ND1:A64P:D248G:-0.343827:-1.39502:1.01568;MT-ND1:A64P:D248A:-0.892202:-1.39502:0.469864;MT-ND1:A64P:D248V:-0.989584:-1.39502:0.460803;MT-ND1:A64P:D248E:-1.43335:-1.39502:-0.0363487;MT-ND1:A64P:L250R:-1.93156:-1.39502:-0.508427;MT-ND1:A64P:L250V:-0.882259:-1.39502:0.518854;MT-ND1:A64P:L250I:-0.969771:-1.39502:0.412886;MT-ND1:A64P:L250P:-0.416392:-1.39502:1.11168;MT-ND1:A64P:L250H:-1.24722:-1.39502:0.108448;MT-ND1:A64P:L250F:-1.32045:-1.39502:0.0290031;MT-ND1:A64P:A276V:-0.765791:-1.39502:0.62968;MT-ND1:A64P:A276T:-0.717143:-1.39502:0.683193;MT-ND1:A64P:A276G:-1.0173:-1.39502:0.386782;MT-ND1:A64P:A276P:-0.384061:-1.39502:1.16054;MT-ND1:A64P:A276E:-1.33989:-1.39502:0.0557187;MT-ND1:A64P:A276S:-1.60267:-1.39502:-0.200186 MT-ND1:A64V:T245A:0.282211:0.240076:-0.0212179;MT-ND1:A64V:T245K:2.61657:0.240076:2.88431;MT-ND1:A64V:T245P:-1.75337:0.240076:-2.15484;MT-ND1:A64V:T245S:0.835254:0.240076:0.59531;MT-ND1:A64V:T246P:-0.71974:0.240076:-0.949064;MT-ND1:A64V:T246A:0.634241:0.240076:0.393197;MT-ND1:A64V:T246K:0.79087:0.240076:0.53622;MT-ND1:A64V:T246S:0.118871:0.240076:-0.121189;MT-ND1:A64V:D248G:1.26993:0.240076:1.01568;MT-ND1:A64V:D248A:0.74165:0.240076:0.469864;MT-ND1:A64V:D248H:0.989303:0.240076:0.709978;MT-ND1:A64V:D248N:0.50523:0.240076:0.27503;MT-ND1:A64V:D248Y:0.271555:0.240076:-0.0124181;MT-ND1:A64V:D248E:0.185623:0.240076:-0.0363487;MT-ND1:A64V:L250F:0.278187:0.240076:0.0290031;MT-ND1:A64V:L250P:1.20409:0.240076:1.11168;MT-ND1:A64V:L250V:0.741858:0.240076:0.518854;MT-ND1:A64V:L250H:0.423228:0.240076:0.108448;MT-ND1:A64V:L250I:0.65484:0.240076:0.412886;MT-ND1:A64V:A276V:0.869572:0.240076:0.62968;MT-ND1:A64V:A276G:0.626582:0.240076:0.386782;MT-ND1:A64V:A276S:0.0385583:0.240076:-0.200186;MT-ND1:A64V:A276E:0.295701:0.240076:0.0557187;MT-ND1:A64V:A276P:1.43884:0.240076:1.16054;MT-ND1:A64V:T246M:0.340639:0.240076:0.113932;MT-ND1:A64V:T245M:-0.321748:0.240076:-0.233521;MT-ND1:A64V:D248V:0.648625:0.240076:0.460803;MT-ND1:A64V:L250R:-0.296961:0.240076:-0.508427;MT-ND1:A64V:A276T:0.931218:0.240076:0.683193 MT-ND1:A64D:T245K:3.1494:0.175529:2.88431;MT-ND1:A64D:T245P:-1.94946:0.175529:-2.15484;MT-ND1:A64D:T245M:-0.211038:0.175529:-0.233521;MT-ND1:A64D:T245A:0.236152:0.175529:-0.0212179;MT-ND1:A64D:T245S:0.755133:0.175529:0.59531;MT-ND1:A64D:T246S:0.0543214:0.175529:-0.121189;MT-ND1:A64D:T246M:0.28801:0.175529:0.113932;MT-ND1:A64D:T246K:0.712343:0.175529:0.53622;MT-ND1:A64D:T246P:-0.774925:0.175529:-0.949064;MT-ND1:A64D:T246A:0.569121:0.175529:0.393197;MT-ND1:A64D:D248V:0.567356:0.175529:0.460803;MT-ND1:A64D:D248E:0.135112:0.175529:-0.0363487;MT-ND1:A64D:D248Y:0.268048:0.175529:-0.0124181;MT-ND1:A64D:D248G:1.14022:0.175529:1.01568;MT-ND1:A64D:D248A:0.712558:0.175529:0.469864;MT-ND1:A64D:D248H:0.857183:0.175529:0.709978;MT-ND1:A64D:D248N:0.436452:0.175529:0.27503;MT-ND1:A64D:L250F:0.20128:0.175529:0.0290031;MT-ND1:A64D:L250H:0.276572:0.175529:0.108448;MT-ND1:A64D:L250R:-0.295136:0.175529:-0.508427;MT-ND1:A64D:L250I:0.589126:0.175529:0.412886;MT-ND1:A64D:L250V:0.678823:0.175529:0.518854;MT-ND1:A64D:L250P:1.17507:0.175529:1.11168;MT-ND1:A64D:A276E:0.231911:0.175529:0.0557187;MT-ND1:A64D:A276V:0.798398:0.175529:0.62968;MT-ND1:A64D:A276T:0.86287:0.175529:0.683193;MT-ND1:A64D:A276G:0.555162:0.175529:0.386782;MT-ND1:A64D:A276S:-0.0185656:0.175529:-0.200186;MT-ND1:A64D:A276P:1.37603:0.175529:1.16054 MT-ND1:A64G:T245A:0.226187:0.221734:-0.0212179;MT-ND1:A64G:T245S:0.824407:0.221734:0.59531;MT-ND1:A64G:T245P:-1.91837:0.221734:-2.15484;MT-ND1:A64G:T245M:-0.105044:0.221734:-0.233521;MT-ND1:A64G:T245K:3.25376:0.221734:2.88431;MT-ND1:A64G:T246S:0.10026:0.221734:-0.121189;MT-ND1:A64G:T246M:0.342056:0.221734:0.113932;MT-ND1:A64G:T246P:-0.732341:0.221734:-0.949064;MT-ND1:A64G:T246K:0.752018:0.221734:0.53622;MT-ND1:A64G:T246A:0.614539:0.221734:0.393197;MT-ND1:A64G:D248N:0.496277:0.221734:0.27503;MT-ND1:A64G:D248H:0.946212:0.221734:0.709978;MT-ND1:A64G:D248V:0.654698:0.221734:0.460803;MT-ND1:A64G:D248Y:0.254225:0.221734:-0.0124181;MT-ND1:A64G:D248G:1.24184:0.221734:1.01568;MT-ND1:A64G:D248A:0.726488:0.221734:0.469864;MT-ND1:A64G:D248E:0.190584:0.221734:-0.0363487;MT-ND1:A64G:L250I:0.632619:0.221734:0.412886;MT-ND1:A64G:L250F:0.257221:0.221734:0.0290031;MT-ND1:A64G:L250V:0.71142:0.221734:0.518854;MT-ND1:A64G:L250H:0.350236:0.221734:0.108448;MT-ND1:A64G:L250P:1.20007:0.221734:1.11168;MT-ND1:A64G:L250R:-0.291565:0.221734:-0.508427;MT-ND1:A64G:A276G:0.608516:0.221734:0.386782;MT-ND1:A64G:A276E:0.26669:0.221734:0.0557187;MT-ND1:A64G:A276P:1.42061:0.221734:1.16054;MT-ND1:A64G:A276V:0.850426:0.221734:0.62968;MT-ND1:A64G:A276T:0.89468:0.221734:0.683193;MT-ND1:A64G:A276S:0.0132851:0.221734:-0.200186
DDG intra interface . . . . . .
DDG inter MT-ND1:MT-ND3:5lc5:H:A:A64T:S45F:-0.01885:0.20746994:-0.184449762;MT-ND1:MT-ND3:5lc5:H:A:A64T:S45Y:0.03366:0.20746994:-0.209069446;MT-ND1:MT-ND3:5lc5:H:A:A64T:S45A:0.11013:0.20746994:-0.0903697982;MT-ND1:MT-ND3:5lc5:H:A:A64T:S45T:0.38004:0.20746994:0.215980917;MT-ND1:MT-ND3:5lc5:H:A:A64T:S45C:-0.26711:0.20746994:-0.407060623;MT-ND1:MT-ND3:5lc5:H:A:A64T:S45P:-0.9239:0.20746994:-1.09178007;MT-ND1:MT-ND3:5ldw:H:A:A64T:P46A:0.24139:0.10172081:0.124702454;MT-ND1:MT-ND3:5ldw:H:A:A64T:P46S:0.33821:0.10172081:0.256430447;MT-ND1:MT-ND3:5ldw:H:A:A64T:P46T:0.5889:0.10172081:0.476390839;MT-ND1:MT-ND3:5ldw:H:A:A64T:P46R:-0.35933:0.10172081:-0.374820709;MT-ND1:MT-ND3:5ldw:H:A:A64T:P46L:-0.40207:0.10172081:-0.427488327;MT-ND1:MT-ND3:5ldw:H:A:A64T:P46H:-0.01653:0.10172081:-0.123018265;MT-ND1:MT-ND3:5ldw:H:A:A64T:S45F:0.05697:0.10172081:0.122009657;MT-ND1:MT-ND3:5ldw:H:A:A64T:S45Y:0.80886:0.10172081:0.377010345;MT-ND1:MT-ND3:5ldw:H:A:A64T:S45A:0.08599:0.10172081:-0.0156085966;MT-ND1:MT-ND3:5ldw:H:A:A64T:S45T:0.35343:0.10172081:0.170780182;MT-ND1:MT-ND3:5ldw:H:A:A64T:S45C:0.00913:0.10172081:-0.0661293045;MT-ND1:MT-ND3:5ldw:H:A:A64T:S45P:-0.18431:0.10172081:-0.288380057;MT-ND1:MT-ND3:5ldx:H:A:A64T:P46A:0.27275:0.107588194:0.17194137;MT-ND1:MT-ND3:5ldx:H:A:A64T:P46S:0.32556:0.107588194:0.202388763;MT-ND1:MT-ND3:5ldx:H:A:A64T:P46T:0.30775:0.107588194:0.200049967;MT-ND1:MT-ND3:5ldx:H:A:A64T:P46R:-0.37666:0.107588194:-0.366769791;MT-ND1:MT-ND3:5ldx:H:A:A64T:P46L:-0.42001:0.107588194:-0.57003057;MT-ND1:MT-ND3:5ldx:H:A:A64T:P46H:-0.06405:0.107588194:-0.150340647;MT-ND1:MT-ND3:5ldx:H:A:A64T:S45F:0.62142:0.107588194:0.507999063;MT-ND1:MT-ND3:5ldx:H:A:A64T:S45Y:0.61503:0.107588194:0.507420719;MT-ND1:MT-ND3:5ldx:H:A:A64T:S45A:0.65342:0.107588194:0.531179786;MT-ND1:MT-ND3:5ldx:H:A:A64T:S45T:0.48902:0.107588194:0.424250036;MT-ND1:MT-ND3:5ldx:H:A:A64T:S45C:0.6507:0.107588194:0.429790109;MT-ND1:MT-ND3:5ldx:H:A:A64T:S45P:0.88499:0.107588194:0.854759216 MT-ND1:MT-ND3:5lc5:H:A:A64S:S45A:-0.09243:-0.015329361:-0.0903697982;MT-ND1:MT-ND3:5lc5:H:A:A64S:S45F:-0.23046:-0.015329361:-0.184449762;MT-ND1:MT-ND3:5lc5:H:A:A64S:S45T:0.13552:-0.015329361:0.215980917;MT-ND1:MT-ND3:5lc5:H:A:A64S:S45P:-1.0989:-0.015329361:-1.09178007;MT-ND1:MT-ND3:5lc5:H:A:A64S:S45C:-0.40206:-0.015329361:-0.407060623;MT-ND1:MT-ND3:5lc5:H:A:A64S:S45Y:-0.24798:-0.015329361:-0.209069446;MT-ND1:MT-ND3:5ldw:H:A:A64S:P46T:0.44609:-0.00129890442:0.476390839;MT-ND1:MT-ND3:5ldw:H:A:A64S:P46R:-0.46345:-0.00129890442:-0.374820709;MT-ND1:MT-ND3:5ldw:H:A:A64S:P46L:-0.45383:-0.00129890442:-0.427488327;MT-ND1:MT-ND3:5ldw:H:A:A64S:P46H:-0.09613:-0.00129890442:-0.123018265;MT-ND1:MT-ND3:5ldw:H:A:A64S:P46S:0.22519:-0.00129890442:0.256430447;MT-ND1:MT-ND3:5ldw:H:A:A64S:P46A:0.13265:-0.00129890442:0.124702454;MT-ND1:MT-ND3:5ldw:H:A:A64S:S45A:-0.01984:-0.00129890442:-0.0156085966;MT-ND1:MT-ND3:5ldw:H:A:A64S:S45F:0.01067:-0.00129890442:0.122009657;MT-ND1:MT-ND3:5ldw:H:A:A64S:S45T:0.31238:-0.00129890442:0.170780182;MT-ND1:MT-ND3:5ldw:H:A:A64S:S45P:-0.31463:-0.00129890442:-0.288380057;MT-ND1:MT-ND3:5ldw:H:A:A64S:S45C:-0.32393:-0.00129890442:-0.0661293045;MT-ND1:MT-ND3:5ldw:H:A:A64S:S45Y:0.34543:-0.00129890442:0.377010345;MT-ND1:MT-ND3:5ldx:H:A:A64S:P46T:0.19556:-0.00452117901:0.200049967;MT-ND1:MT-ND3:5ldx:H:A:A64S:P46R:-0.44234:-0.00452117901:-0.366769791;MT-ND1:MT-ND3:5ldx:H:A:A64S:P46L:-0.54013:-0.00452117901:-0.57003057;MT-ND1:MT-ND3:5ldx:H:A:A64S:P46H:-0.18595:-0.00452117901:-0.150340647;MT-ND1:MT-ND3:5ldx:H:A:A64S:P46S:0.19682:-0.00452117901:0.202388763;MT-ND1:MT-ND3:5ldx:H:A:A64S:P46A:0.16036:-0.00452117901:0.17194137;MT-ND1:MT-ND3:5ldx:H:A:A64S:S45A:0.54492:-0.00452117901:0.531179786;MT-ND1:MT-ND3:5ldx:H:A:A64S:S45F:0.50879:-0.00452117901:0.507999063;MT-ND1:MT-ND3:5ldx:H:A:A64S:S45T:0.37223:-0.00452117901:0.424250036;MT-ND1:MT-ND3:5ldx:H:A:A64S:S45P:0.74854:-0.00452117901:0.854759216;MT-ND1:MT-ND3:5ldx:H:A:A64S:S45C:0.49515:-0.00452117901:0.429790109;MT-ND1:MT-ND3:5ldx:H:A:A64S:S45Y:0.50502:-0.00452117901:0.507420719 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For more info, please check the output legend.
For more info, please check the output legend.
For more info, please check the output legend.
For more info, please check the output legend.
For more info, please check the output legend.