4219 (G > C)

General info

Chr
chrM
Start
4219
End
4219
Ref
G
Alt
C
Mitimpact ID
MI.12659
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
913
AA pos
305
AA ref
V
AA alt
L
Codon substitution
Gtc/Ctc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
0.0332598 Conservation Score
PhastCons 100v
0 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
SIFT4G
Tolerated Score and details of the predictor
FatHmm
Neutral Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Neutral Score and details of the predictor
Mutation Assessor
Neutral impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Neutral Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Neutral Score and details of the predictor
SNAP
Neutral Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE1
Neutral Score and details of the meta-predictor
APOGEE2
Likely-benign Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Neutral Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
High impact Score and details of the cancer-specific predictor
SIFT transf
High impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar July2022 CLNSIG
.
ClinVar July2022 CLNDN
.
ClinVar July2022 Variation ID
ClinVar July2022 CLNDISDB
.
MITOMAP Allele
.
MITOMAP Disease Het/Hom
.
MITOMAP Disease Clinical info
.
MITOMAP Disease Status
.
MITOMAP Disease GenBank Freq
.
MITOMAP Disease GenBank Seqs
.
MITOMAP Disease GenBank Curated refs
.
MITOMAP General GenBank Freq
0
MITOMAP General GenBank Seqs
0
MITOMAP General GenBank Curated refs
1
Gnomad31 filter
Npg
Gnomad31 AC hom
0
Gnomad31 AC het
0
Gnomad31 AF hom
0
Gnomad31 AF het
0
Gnomad31 AN
56431
HelixMTdb AC hom
0.0
HelixMTdb AF hom
0.0
HelixMTdb AC het
2.0
HelixMTdb AF het
1.0204967e-05
HelixMTdb mean ARF
0.23311
HelixMTdb max ARF
0.3375
COSMIC 90
.
dbSNP 155

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

4219 (G > A)

General info

Chr
chrM
Start
4219
End
4219
Ref
G
Alt
A
Mitimpact ID
MI.12660
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
913
AA pos
305
AA ref
V
AA alt
I
Codon substitution
Gtc/Atc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
0.0332598 Conservation Score
PhastCons 100v
0 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
SIFT4G
Tolerated Score and details of the predictor
FatHmm
Neutral Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Neutral Score and details of the predictor
Mutation Assessor
Neutral impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Neutral Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Neutral Score and details of the predictor
SNAP
Neutral Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE1
Neutral Score and details of the meta-predictor
APOGEE2
Benign Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Neutral Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
High impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Low impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar July2022 CLNSIG
.
ClinVar July2022 CLNDN
.
ClinVar July2022 Variation ID
ClinVar July2022 CLNDISDB
.
MITOMAP Allele
.
MITOMAP Disease Het/Hom
.
MITOMAP Disease Clinical info
.
MITOMAP Disease Status
.
MITOMAP Disease GenBank Freq
.
MITOMAP Disease GenBank Seqs
.
MITOMAP Disease GenBank Curated refs
.
MITOMAP General GenBank Freq
0.00081
MITOMAP General GenBank Seqs
48
MITOMAP General GenBank Curated refs
3
Gnomad31 filter
Pass
Gnomad31 AC hom
57
Gnomad31 AC het
3
Gnomad31 AF hom
0.0010103517
Gnomad31 AF het
0.000053176405
Gnomad31 AN
56416
HelixMTdb AC hom
59.0
HelixMTdb AF hom
0.00030104653
HelixMTdb AC het
16.0
HelixMTdb AF het
8.163974e-05
HelixMTdb mean ARF
0.40884
HelixMTdb max ARF
0.97368
COSMIC 90
.
dbSNP 155

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

4219 (G > T)

General info

Chr
chrM
Start
4219
End
4219
Ref
G
Alt
T
Mitimpact ID
MI.12658
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
913
AA pos
305
AA ref
V
AA alt
F
Codon substitution
Gtc/Ttc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
0.0332598 Conservation Score
PhastCons 100v
0 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
SIFT4G
Damaging Score and details of the predictor
FatHmm
Deleterious Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Neutral Score and details of the predictor
Mutation Assessor
Neutral impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Disease Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Deleterious Score and details of the predictor
SNAP
Neutral Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE1
Neutral Score and details of the meta-predictor
APOGEE2
Likely-benign Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Neutral Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Medium impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar July2022 CLNSIG
.
ClinVar July2022 CLNDN
.
ClinVar July2022 Variation ID
ClinVar July2022 CLNDISDB
.
MITOMAP Allele
.
MITOMAP Disease Het/Hom
.
MITOMAP Disease Clinical info
.
MITOMAP Disease Status
.
MITOMAP Disease GenBank Freq
.
MITOMAP Disease GenBank Seqs
.
MITOMAP Disease GenBank Curated refs
.
MITOMAP General GenBank Freq
.
MITOMAP General GenBank Seqs
.
MITOMAP General GenBank Curated refs
.
Gnomad31 filter
.
Gnomad31 AC hom
.
Gnomad31 AC het
.
Gnomad31 AF hom
.
Gnomad31 AF het
.
Gnomad31 AN
.
HelixMTdb AC hom
.
HelixMTdb AF hom
.
HelixMTdb AC het
.
HelixMTdb AF het
.
HelixMTdb mean ARF
.
HelixMTdb max ARF
.
COSMIC 90
.
dbSNP 155

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

4220 (T > G)

General info

Chr
chrM
Start
4220
End
4220
Ref
T
Alt
G
Mitimpact ID
MI.12662
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
914
AA pos
305
AA ref
V
AA alt
G
Codon substitution
gTc/gGc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
0.0332598 Conservation Score
PhastCons 100v
0 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
SIFT4G
Damaging Score and details of the predictor
FatHmm
Deleterious Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Deleterious Score and details of the predictor
Mutation Assessor
Neutral impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Pathogenic Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Disease Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Deleterious Score and details of the predictor
SNAP
Neutral Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE1
Neutral Score and details of the meta-predictor
APOGEE2
Vus- Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Neutral Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Medium impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Low impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar July2022 CLNSIG
.
ClinVar July2022 CLNDN
.
ClinVar July2022 Variation ID
ClinVar July2022 CLNDISDB
.
MITOMAP Allele
.
MITOMAP Disease Het/Hom
.
MITOMAP Disease Clinical info
.
MITOMAP Disease Status
.
MITOMAP Disease GenBank Freq
.
MITOMAP Disease GenBank Seqs
.
MITOMAP Disease GenBank Curated refs
.
MITOMAP General GenBank Freq
.
MITOMAP General GenBank Seqs
.
MITOMAP General GenBank Curated refs
.
Gnomad31 filter
.
Gnomad31 AC hom
.
Gnomad31 AC het
.
Gnomad31 AF hom
.
Gnomad31 AF het
.
Gnomad31 AN
.
HelixMTdb AC hom
.
HelixMTdb AF hom
.
HelixMTdb AC het
.
HelixMTdb AF het
.
HelixMTdb mean ARF
.
HelixMTdb max ARF
.
COSMIC 90
.
dbSNP 155

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

4220 (T > A)

General info

Chr
chrM
Start
4220
End
4220
Ref
T
Alt
A
Mitimpact ID
MI.12661
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
914
AA pos
305
AA ref
V
AA alt
D
Codon substitution
gTc/gAc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
0.0332598 Conservation Score
PhastCons 100v
0 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
SIFT4G
Damaging Score and details of the predictor
FatHmm
Deleterious Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Deleterious Score and details of the predictor
Mutation Assessor
Medium impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Pathogenic Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Disease Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Deleterious Score and details of the predictor
SNAP
Disease Score and details of the predictor
MitoClass 1
Damaging Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE1
Neutral Score and details of the meta-predictor
APOGEE2
Vus Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Neutral Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Disease Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Medium impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar July2022 CLNSIG
.
ClinVar July2022 CLNDN
.
ClinVar July2022 Variation ID
ClinVar July2022 CLNDISDB
.
MITOMAP Allele
.
MITOMAP Disease Het/Hom
.
MITOMAP Disease Clinical info
.
MITOMAP Disease Status
.
MITOMAP Disease GenBank Freq
.
MITOMAP Disease GenBank Seqs
.
MITOMAP Disease GenBank Curated refs
.
MITOMAP General GenBank Freq
.
MITOMAP General GenBank Seqs
.
MITOMAP General GenBank Curated refs
.
Gnomad31 filter
.
Gnomad31 AC hom
.
Gnomad31 AC het
.
Gnomad31 AF hom
.
Gnomad31 AF het
.
Gnomad31 AN
.
HelixMTdb AC hom
.
HelixMTdb AF hom
.
HelixMTdb AC het
.
HelixMTdb AF het
.
HelixMTdb mean ARF
.
HelixMTdb max ARF
.
COSMIC 90
.
dbSNP 155

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

4220 (T > C)

General info

Chr
chrM
Start
4220
End
4220
Ref
T
Alt
C
Mitimpact ID
MI.12663
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
914
AA pos
305
AA ref
V
AA alt
A
Codon substitution
gTc/gCc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
0.0332598 Conservation Score
PhastCons 100v
0 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
SIFT4G
Tolerated Score and details of the predictor
FatHmm
Neutral Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Neutral Score and details of the predictor
Mutation Assessor
Neutral impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Neutral Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Neutral Score and details of the predictor
SNAP
Neutral Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE1
Neutral Score and details of the meta-predictor
APOGEE2
Benign Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Neutral Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
High impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Low impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar July2022 CLNSIG
.
ClinVar July2022 CLNDN
.
ClinVar July2022 Variation ID
ClinVar July2022 CLNDISDB
.
MITOMAP Allele
.
MITOMAP Disease Het/Hom
.
MITOMAP Disease Clinical info
.
MITOMAP Disease Status
.
MITOMAP Disease GenBank Freq
.
MITOMAP Disease GenBank Seqs
.
MITOMAP Disease GenBank Curated refs
.
MITOMAP General GenBank Freq
.
MITOMAP General GenBank Seqs
.
MITOMAP General GenBank Curated refs
.
Gnomad31 filter
Pass
Gnomad31 AC hom
0
Gnomad31 AC het
2
Gnomad31 AF hom
0
Gnomad31 AF het
0.000035440884
Gnomad31 AN
56432
HelixMTdb AC hom
.
HelixMTdb AF hom
.
HelixMTdb AC het
.
HelixMTdb AF het
.
HelixMTdb mean ARF
.
HelixMTdb max ARF
.
COSMIC 90
.
dbSNP 155

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.
~ 4219 (G/C) 4219 (G/A) 4219 (G/T) 4220 (T/G) 4220 (T/A) 4220 (T/C)
~ 4219 (Gtc/Ctc) 4219 (Gtc/Atc) 4219 (Gtc/Ttc) 4220 (gTc/gGc) 4220 (gTc/gAc) 4220 (gTc/gCc)
Chr chrM chrM chrM chrM chrM chrM
Start 4219 4219 4219 4220 4220 4220
End 4219 4219 4219 4220 4220 4220
Ref G G G T T T
Alt C A T G A C
MitImpact id MI.12659 MI.12660 MI.12658 MI.12662 MI.12661 MI.12663
Gene symbol MT-ND1 MT-ND1 MT-ND1 MT-ND1 MT-ND1 MT-ND1
Respiratory Chain complex I I I I I I
Ensembl gene id ENSG00000198888 ENSG00000198888 ENSG00000198888 ENSG00000198888 ENSG00000198888 ENSG00000198888
Ensembl protein id ENSP00000354687 ENSP00000354687 ENSP00000354687 ENSP00000354687 ENSP00000354687 ENSP00000354687
Ensembl transcript id ENST00000361390 ENST00000361390 ENST00000361390 ENST00000361390 ENST00000361390 ENST00000361390
Uniprot name NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN
Uniprot id P03886 P03886 P03886 P03886 P03886 P03886
Ncbi gene id 4535 4535 4535 4535 4535 4535
Ncbi protein id YP_003024026.1 YP_003024026.1 YP_003024026.1 YP_003024026.1 YP_003024026.1 YP_003024026.1
Gene position 913 913 913 914 914 914
AA position 305 305 305 305 305 305
AA ref V V V V V V
AA alt L I F G D A
Codon substitution Gtc/Ctc Gtc/Atc Gtc/Ttc gTc/gGc gTc/gAc gTc/gCc
PhyloP 100V 0.0332598 0.0332598 0.0332598 0.0332598 0.0332598 0.0332598
PhastCons 100V 0 0 0 0 0 0
PolyPhen2 benign benign benign benign benign benign
PolyPhen2 score 0.0 0.0 0.16 0.1 0.21 0.0
SIFT neutral neutral neutral neutral neutral neutral
SIFT score 1.0 0.48 0.43 0.16 0.06 0.51
SIFT4G Tolerated Tolerated Damaging Damaging Damaging Tolerated
SIFT4G score 0.665 1 0.011 0.001 0.001 0.065
FatHmm neutral neutral deleterious deleterious deleterious neutral
FatHmm score -1.49 -0.42 -3.0 -3.26 -4.11 -1.35
FatHmmW neutral neutral neutral neutral neutral neutral
FatHmmW score 2.77 2.81 2.7 2.7 2.7 2.88
PROVEAN neutral neutral neutral deleterious deleterious neutral
PROVEAN score 0.01 0.24 -1.95 -4.34 -3.92 -2.01
MutationAssessor neutral impact neutral impact neutral impact neutral impact medium impact neutral impact
MutationAssessor score 0.38 -1.02 0.65 0.14 2.21 -0.3
EFIN SP neutral neutral neutral neutral neutral neutral
EFIN SP score 0.81 0.73 0.76 0.73 0.77 0.82
EFIN HD neutral neutral neutral neutral neutral neutral
EFIN HD score 0.67 0.94 0.63 0.46 0.44 0.73
CADD neutral neutral deleterious deleterious deleterious neutral
CADD score -0.55 -0.86 1.95 2.01 2.67 0.56
CADD phred 0.16 0.03 15.88 16.27 20.6 7.9
VEST pvalue 0.22 0.35 0.06 0.05 0.02 0.16
VEST FDR 0.45 0.5 0.35 0.35 0.35 0.45
PANTHER neutral neutral neutral neutral neutral neutral
PANTHER score 0.14 0.11 0.27 0.28 0.44 0.13
PhD-SNP neutral neutral disease disease disease neutral
PhD-SNP score 0.23 0.1 0.63 0.53 0.73 0.27
SNAP neutral neutral neutral neutral disease neutral
SNAP score 0.2 0.17 0.25 0.42 0.6 0.39
Meta-SNP neutral neutral neutral neutral disease neutral
Meta-SNP score 0.4 0.26 0.43 0.5 0.73 0.42
Meta-SNP RI 2 5 1 0 5 2
CAROL neutral neutral neutral neutral neutral neutral
CAROL score 0.0 0.52 0.49 0.82 0.93 0.49
Condel deleterious deleterious deleterious deleterious neutral deleterious
Condel score 1.0 0.74 0.64 0.53 0.43 0.76
COVEC WMV neutral neutral neutral neutral neutral neutral
COVEC WMV score -6 -6 -6 -6 -3 -6
MtoolBox neutral neutral neutral neutral neutral neutral
MtoolBox DS 0.08 0.08 0.16 0.15 0.24 0.08
PolyPhen2 transf high impact high impact medium impact medium impact medium impact high impact
PolyPhen2 transf score 2.07 2.07 -0.08 0.15 -0.21 2.07
SIFT_transf high impact medium impact medium impact medium impact medium impact medium impact
SIFT transf score 1.96 0.26 0.21 -0.13 -0.4 0.29
MutationAssessor transf medium impact low impact medium impact low impact medium impact low impact
MutationAssessor transf score -0.86 -2.08 -0.62 -1.07 0.74 -1.45
CHASM pvalue 0.52 0.77 0.36 0.24 0.1 0.31
CHASM FDR 0.8 0.85 0.8 0.8 0.8 0.8
APOGEE1 Neutral Neutral Neutral Neutral Neutral Neutral
APOGEE1 score 0.3 0.42 0.36 0.38 0.34 0.3
APOGEE2 Likely-benign Benign Likely-benign VUS- VUS Benign
APOGEE2 score 0.0829289572330553 0.0178600066502164 0.247953448807371 0.303199788064632 0.474070204093719 0.0614121678783302
SNPDryad score 0.39 0.03 0.65 0.86 0.84 0.49
MutationTaster polymorphism polymorphism polymorphism polymorphism polymorphism polymorphism
MutationTaster score 1 1 1 1 1 1
DEOGEN2 score 0.01 0.01 0.04 0.11 0.22 0.04
Mitoclass.1 neutral neutral neutral neutral damaging neutral
dbSNP 155 id . rs878853008 . . . .
ClinVar July2022 Variation id . . . . . .
ClinVar July2022 CLNSIG . . . . . .
ClinVar July2022 CLNDN . . . . . .
ClinVar July2022 CLNDISDB . . . . . .
COSMIC 90 . . . . . .
MITOMAP Allele . . . . . .
MITOMAP Disease Het/Hom . . . . . .
MITOMAP Disease Clinical info . . . . . .
MITOMAP Disease Status . . . . . .
MITOMAP Disease GenBank Freq . . . . . .
MITOMAP Disease GenBank Seqs . . . . . .
MITOMAP Disease GenBank Curated refs . . . . . .
MITOMAP General GenBank Freq 0 0.00081 . . . .
MITOMAP General GenBank Seqs 0 48 . . . .
MITOMAP General Curated refs 1 3 . . . .
gnomAD 3.1 filter npg PASS . . . PASS
gnomAD 3.1 AC Homo 0 57 . . . 0
gnomAD 3.1 AC Het 0 3 . . . 2
gnomAD 3.1 AF Hom 0 0.0010103517 . . . 0
gnomAD 3.1 AF Het 0 0.000053176405 . . . 0.000035440884
gnomAD 3.1 AN 56431 56416 . . . 56432
HelixMTdb AC Hom 0.0 59.0 . . . .
HelixMTdb AF Hom 0.0 0.00030104653 . . . .
HelixMTdb AC Het 2.0 16.0 . . . .
HelixMTdb AF Het 1.0204967e-05 8.163974e-05 . . . .
HelixMTdb mean ARF 0.23311 0.40884 . . . .
HelixMTdb max ARF 0.3375 0.97368 . . . .
EVmutation MT-ND1_305V|306S:0.080671 MT-ND1_305V|306S:0.080671 MT-ND1_305V|306S:0.080671 MT-ND1_305V|306S:0.080671 MT-ND1_305V|306S:0.080671 MT-ND1_305V|306S:0.080671
Site A InterP ND1_305 ND1_305 ND1_305 ND1_305 ND1_305 ND1_305
Site B InterP ND3_10;ND4_51;ND4_367;ND4_350;ND4_416;ND4L_61;ND4L_44;ND6_109;ND4L_73 ND3_10;ND4_51;ND4_367;ND4_350;ND4_416;ND4L_61;ND4L_44;ND6_109;ND4L_73 ND3_10;ND4_51;ND4_367;ND4_350;ND4_416;ND4L_61;ND4L_44;ND6_109;ND4L_73 ND3_10;ND4_51;ND4_367;ND4_350;ND4_416;ND4L_61;ND4L_44;ND6_109;ND4L_73 ND3_10;ND4_51;ND4_367;ND4_350;ND4_416;ND4L_61;ND4L_44;ND6_109;ND4L_73 ND3_10;ND4_51;ND4_367;ND4_350;ND4_416;ND4L_61;ND4L_44;ND6_109;ND4L_73
Covariation Score InterP mfDCA_37.05;mfDCA_41.56;mfDCA_32.89;mfDCA_25.86;mfDCA_24.64;mfDCA_21.86;mfDCA_20.68;mfDCA_21.68;cMI_51.87176 mfDCA_37.05;mfDCA_41.56;mfDCA_32.89;mfDCA_25.86;mfDCA_24.64;mfDCA_21.86;mfDCA_20.68;mfDCA_21.68;cMI_51.87176 mfDCA_37.05;mfDCA_41.56;mfDCA_32.89;mfDCA_25.86;mfDCA_24.64;mfDCA_21.86;mfDCA_20.68;mfDCA_21.68;cMI_51.87176 mfDCA_37.05;mfDCA_41.56;mfDCA_32.89;mfDCA_25.86;mfDCA_24.64;mfDCA_21.86;mfDCA_20.68;mfDCA_21.68;cMI_51.87176 mfDCA_37.05;mfDCA_41.56;mfDCA_32.89;mfDCA_25.86;mfDCA_24.64;mfDCA_21.86;mfDCA_20.68;mfDCA_21.68;cMI_51.87176 mfDCA_37.05;mfDCA_41.56;mfDCA_32.89;mfDCA_25.86;mfDCA_24.64;mfDCA_21.86;mfDCA_20.68;mfDCA_21.68;cMI_51.87176
Site A IntraP ND1_305 ND1_305 ND1_305 ND1_305 ND1_305 ND1_305
Site B IntraP ND1_250;ND1_309;ND1_64;ND1_178;ND1_229;ND1_248;ND1_72 ND1_250;ND1_309;ND1_64;ND1_178;ND1_229;ND1_248;ND1_72 ND1_250;ND1_309;ND1_64;ND1_178;ND1_229;ND1_248;ND1_72 ND1_250;ND1_309;ND1_64;ND1_178;ND1_229;ND1_248;ND1_72 ND1_250;ND1_309;ND1_64;ND1_178;ND1_229;ND1_248;ND1_72 ND1_250;ND1_309;ND1_64;ND1_178;ND1_229;ND1_248;ND1_72
Covariation Score IntraP mfDCA_24.0795;mfDCA_22.4663;mfDCA_21.8998;mfDCA_18.6721;mfDCA_17.7758;mfDCA_15.9008;mfDCA_15.7482 mfDCA_24.0795;mfDCA_22.4663;mfDCA_21.8998;mfDCA_18.6721;mfDCA_17.7758;mfDCA_15.9008;mfDCA_15.7482 mfDCA_24.0795;mfDCA_22.4663;mfDCA_21.8998;mfDCA_18.6721;mfDCA_17.7758;mfDCA_15.9008;mfDCA_15.7482 mfDCA_24.0795;mfDCA_22.4663;mfDCA_21.8998;mfDCA_18.6721;mfDCA_17.7758;mfDCA_15.9008;mfDCA_15.7482 mfDCA_24.0795;mfDCA_22.4663;mfDCA_21.8998;mfDCA_18.6721;mfDCA_17.7758;mfDCA_15.9008;mfDCA_15.7482 mfDCA_24.0795;mfDCA_22.4663;mfDCA_21.8998;mfDCA_18.6721;mfDCA_17.7758;mfDCA_15.9008;mfDCA_15.7482
CPD AA ref . . . . . .
CPD AA alt . . . . . .
CPD Aln pos . . . . . .
CPD Frequency . . . . . .
CPD Species name . . . . . .
CPD RefSeq Protein ID . . . . . .
CPD Ncbi Taxon id . . . . . .
DDG intra MT-ND1:V305L:I309M:-1.4981:-1.22193:-0.249539;MT-ND1:V305L:I309L:-1.40451:-1.22193:-0.294795;MT-ND1:V305L:I309S:-1.23236:-1.22193:0.0335882;MT-ND1:V305L:I309F:-1.43827:-1.22193:-0.269124;MT-ND1:V305L:I309T:-1.42389:-1.22193:-0.218062;MT-ND1:V305L:I309V:-0.746552:-1.22193:0.472429;MT-ND1:V305L:I309N:-0.867703:-1.22193:0.437388;MT-ND1:V305L:S178W:20.5661:-1.22193:20.7782;MT-ND1:V305L:S178T:-1.79412:-1.22193:1.24813;MT-ND1:V305L:S178A:-0.944899:-1.22193:0.272896;MT-ND1:V305L:S178L:0.808509:-1.22193:2.01303;MT-ND1:V305L:S178P:3.80303:-1.22193:4.74959;MT-ND1:V305L:T229K:-0.324422:-1.22193:0.836345;MT-ND1:V305L:T229P:1.05585:-1.22193:2.27594;MT-ND1:V305L:T229M:-4.84554:-1.22193:-3.75864;MT-ND1:V305L:T229A:-1.80279:-1.22193:-0.589902;MT-ND1:V305L:T229S:-1.45318:-1.22193:-0.208557;MT-ND1:V305L:I72N:-0.719648:-1.22193:0.500478;MT-ND1:V305L:I72F:-1.11272:-1.22193:0.0882582;MT-ND1:V305L:I72M:-1.46513:-1.22193:-0.242564;MT-ND1:V305L:I72S:-0.913356:-1.22193:0.259938;MT-ND1:V305L:I72L:-1.34198:-1.22193:-0.0699018;MT-ND1:V305L:I72T:-0.405893:-1.22193:0.813886;MT-ND1:V305L:I72V:-0.798:-1.22193:0.418455 MT-ND1:V305I:I309F:-1.13619:-0.869:-0.269124;MT-ND1:V305I:I309S:-0.806121:-0.869:0.0335882;MT-ND1:V305I:I309L:-1.20354:-0.869:-0.294795;MT-ND1:V305I:I309M:-1.15083:-0.869:-0.249539;MT-ND1:V305I:I309N:-0.435544:-0.869:0.437388;MT-ND1:V305I:I309V:-0.400428:-0.869:0.472429;MT-ND1:V305I:I309T:-1.09017:-0.869:-0.218062;MT-ND1:V305I:S178L:1.25445:-0.869:2.01303;MT-ND1:V305I:S178W:22.3166:-0.869:20.7782;MT-ND1:V305I:S178A:-0.611986:-0.869:0.272896;MT-ND1:V305I:S178P:4.18659:-0.869:4.74959;MT-ND1:V305I:S178T:0.671172:-0.869:1.24813;MT-ND1:V305I:T229S:-1.07859:-0.869:-0.208557;MT-ND1:V305I:T229A:-1.46389:-0.869:-0.589902;MT-ND1:V305I:T229M:-4.53373:-0.869:-3.75864;MT-ND1:V305I:T229P:1.40874:-0.869:2.27594;MT-ND1:V305I:T229K:0.235581:-0.869:0.836345;MT-ND1:V305I:I72L:-0.962317:-0.869:-0.0699018;MT-ND1:V305I:I72M:-1.11274:-0.869:-0.242564;MT-ND1:V305I:I72F:-0.754768:-0.869:0.0882582;MT-ND1:V305I:I72T:-0.0606689:-0.869:0.813886;MT-ND1:V305I:I72S:-0.611827:-0.869:0.259938;MT-ND1:V305I:I72V:-0.447626:-0.869:0.418455;MT-ND1:V305I:I72N:-0.381318:-0.869:0.500478 MT-ND1:V305F:I309V:0.119928:-0.223954:0.472429;MT-ND1:V305F:I309T:-0.390035:-0.223954:-0.218062;MT-ND1:V305F:I309M:-0.672362:-0.223954:-0.249539;MT-ND1:V305F:I309N:-0.195582:-0.223954:0.437388;MT-ND1:V305F:I309F:-0.727529:-0.223954:-0.269124;MT-ND1:V305F:I309L:-0.531359:-0.223954:-0.294795;MT-ND1:V305F:I309S:-0.0641067:-0.223954:0.0335882;MT-ND1:V305F:S178T:1.00545:-0.223954:1.24813;MT-ND1:V305F:S178P:4.60225:-0.223954:4.74959;MT-ND1:V305F:S178L:1.85669:-0.223954:2.01303;MT-ND1:V305F:S178A:0.058249:-0.223954:0.272896;MT-ND1:V305F:S178W:27.5743:-0.223954:20.7782;MT-ND1:V305F:T229K:1.29552:-0.223954:0.836345;MT-ND1:V305F:T229P:1.76011:-0.223954:2.27594;MT-ND1:V305F:T229S:-0.601209:-0.223954:-0.208557;MT-ND1:V305F:T229M:-3.85859:-0.223954:-3.75864;MT-ND1:V305F:T229A:-1.05683:-0.223954:-0.589902;MT-ND1:V305F:I72N:0.228661:-0.223954:0.500478;MT-ND1:V305F:I72V:0.0375724:-0.223954:0.418455;MT-ND1:V305F:I72F:-0.232201:-0.223954:0.0882582;MT-ND1:V305F:I72T:0.569138:-0.223954:0.813886;MT-ND1:V305F:I72L:-0.295815:-0.223954:-0.0699018;MT-ND1:V305F:I72M:-0.721317:-0.223954:-0.242564;MT-ND1:V305F:I72S:-0.0228275:-0.223954:0.259938 MT-ND1:V305G:I309V:1.82302:1.41586:0.472429;MT-ND1:V305G:I309M:1.07375:1.41586:-0.249539;MT-ND1:V305G:I309T:1.14112:1.41586:-0.218062;MT-ND1:V305G:I309S:1.36991:1.41586:0.0335882;MT-ND1:V305G:I309L:1.20097:1.41586:-0.294795;MT-ND1:V305G:I309N:1.75321:1.41586:0.437388;MT-ND1:V305G:I309F:1.13218:1.41586:-0.269124;MT-ND1:V305G:S178L:3.3864:1.41586:2.01303;MT-ND1:V305G:S178A:1.68183:1.41586:0.272896;MT-ND1:V305G:S178W:26.7478:1.41586:20.7782;MT-ND1:V305G:S178P:6.28073:1.41586:4.74959;MT-ND1:V305G:S178T:1.45186:1.41586:1.24813;MT-ND1:V305G:T229M:-2.22458:1.41586:-3.75864;MT-ND1:V305G:T229A:0.831399:1.41586:-0.589902;MT-ND1:V305G:T229P:3.68762:1.41586:2.27594;MT-ND1:V305G:T229K:2.77805:1.41586:0.836345;MT-ND1:V305G:T229S:1.17688:1.41586:-0.208557;MT-ND1:V305G:I72F:1.46324:1.41586:0.0882582;MT-ND1:V305G:I72T:2.21894:1.41586:0.813886;MT-ND1:V305G:I72L:1.31145:1.41586:-0.0699018;MT-ND1:V305G:I72M:1.17271:1.41586:-0.242564;MT-ND1:V305G:I72S:1.67227:1.41586:0.259938;MT-ND1:V305G:I72N:1.91646:1.41586:0.500478;MT-ND1:V305G:I72V:1.82411:1.41586:0.418455 MT-ND1:V305D:I309S:2.36513:2.34959:0.0335882;MT-ND1:V305D:I309M:2.147:2.34959:-0.249539;MT-ND1:V305D:I309L:2.15026:2.34959:-0.294795;MT-ND1:V305D:I309N:2.76734:2.34959:0.437388;MT-ND1:V305D:I309F:2.11333:2.34959:-0.269124;MT-ND1:V305D:I309V:2.82438:2.34959:0.472429;MT-ND1:V305D:I309T:2.12524:2.34959:-0.218062;MT-ND1:V305D:S178P:7.44778:2.34959:4.74959;MT-ND1:V305D:S178A:2.63589:2.34959:0.272896;MT-ND1:V305D:S178T:2.656:2.34959:1.24813;MT-ND1:V305D:S178W:26.2012:2.34959:20.7782;MT-ND1:V305D:T229K:3.00189:2.34959:0.836345;MT-ND1:V305D:T229A:1.78085:2.34959:-0.589902;MT-ND1:V305D:T229M:-1.1674:2.34959:-3.75864;MT-ND1:V305D:T229P:4.65877:2.34959:2.27594;MT-ND1:V305D:I72N:2.87335:2.34959:0.500478;MT-ND1:V305D:I72V:2.79349:2.34959:0.418455;MT-ND1:V305D:I72T:3.18546:2.34959:0.813886;MT-ND1:V305D:I72F:2.48884:2.34959:0.0882582;MT-ND1:V305D:I72L:2.28466:2.34959:-0.0699018;MT-ND1:V305D:I72M:2.14511:2.34959:-0.242564;MT-ND1:V305D:S178L:4.60319:2.34959:2.01303;MT-ND1:V305D:T229S:2.14889:2.34959:-0.208557;MT-ND1:V305D:I72S:2.58868:2.34959:0.259938 MT-ND1:V305A:I309V:1.28565:0.793804:0.472429;MT-ND1:V305A:I309N:1.20168:0.793804:0.437388;MT-ND1:V305A:I309L:0.550233:0.793804:-0.294795;MT-ND1:V305A:I309T:0.617013:0.793804:-0.218062;MT-ND1:V305A:I309S:0.808097:0.793804:0.0335882;MT-ND1:V305A:I309M:0.636913:0.793804:-0.249539;MT-ND1:V305A:I309F:0.555773:0.793804:-0.269124;MT-ND1:V305A:S178A:1.05109:0.793804:0.272896;MT-ND1:V305A:S178W:24.6175:0.793804:20.7782;MT-ND1:V305A:S178L:2.92605:0.793804:2.01303;MT-ND1:V305A:S178T:0.87021:0.793804:1.24813;MT-ND1:V305A:S178P:5.78176:0.793804:4.74959;MT-ND1:V305A:T229M:-2.61731:0.793804:-3.75864;MT-ND1:V305A:T229A:0.188347:0.793804:-0.589902;MT-ND1:V305A:T229K:2.10378:0.793804:0.836345;MT-ND1:V305A:T229S:0.575211:0.793804:-0.208557;MT-ND1:V305A:T229P:3.07922:0.793804:2.27594;MT-ND1:V305A:I72F:0.920478:0.793804:0.0882582;MT-ND1:V305A:I72M:0.549126:0.793804:-0.242564;MT-ND1:V305A:I72S:1.06371:0.793804:0.259938;MT-ND1:V305A:I72T:1.60702:0.793804:0.813886;MT-ND1:V305A:I72L:0.692854:0.793804:-0.0699018;MT-ND1:V305A:I72N:1.26405:0.793804:0.500478;MT-ND1:V305A:I72V:1.21995:0.793804:0.418455
DDG intra interface MT-ND1:MT-ND3:5lc5:H:A:V305L:I309F:-0.27973:-1.43269:0.55258;MT-ND1:MT-ND3:5lc5:H:A:V305L:I309L:-1.40093:-1.43269:-0.19955;MT-ND1:MT-ND3:5lc5:H:A:V305L:I309M:-1.20798:-1.43269:-0.1133;MT-ND1:MT-ND3:5lc5:H:A:V305L:I309N:1.49436:-1.43269:2.70746;MT-ND1:MT-ND3:5lc5:H:A:V305L:I309S:1.90057:-1.43269:3.17307;MT-ND1:MT-ND3:5lc5:H:A:V305L:I309T:0.62335:-1.43269:1.90168;MT-ND1:MT-ND3:5lc5:H:A:V305L:I309V:-0.71235:-1.43269:0.61358;MT-ND1:MT-ND3:5ldw:H:A:V305L:I309F:-0.19235:-1.1471:0.8733;MT-ND1:MT-ND3:5ldw:H:A:V305L:I309L:-0.7551:-1.1471:-0.00810000000001;MT-ND1:MT-ND3:5ldw:H:A:V305L:I309M:-0.53636:-1.1471:0.6466;MT-ND1:MT-ND3:5ldw:H:A:V305L:I309N:1.76922:-1.1471:2.99749;MT-ND1:MT-ND3:5ldw:H:A:V305L:I309S:2.13239:-1.1471:3.33174;MT-ND1:MT-ND3:5ldw:H:A:V305L:I309T:0.85182:-1.1471:1.96406;MT-ND1:MT-ND3:5ldw:H:A:V305L:I309V:-0.16983:-1.1471:1.19179;MT-ND1:MT-ND3:5ldx:H:A:V305L:I309F:-0.22833:-1.41629:1.09811;MT-ND1:MT-ND3:5ldx:H:A:V305L:I309L:-1.38081:-1.41629:-0.31791;MT-ND1:MT-ND3:5ldx:H:A:V305L:I309M:-0.5685:-1.41629:0.64263;MT-ND1:MT-ND3:5ldx:H:A:V305L:I309N:1.62802:-1.41629:3.0722;MT-ND1:MT-ND3:5ldx:H:A:V305L:I309S:1.70886:-1.41629:3.39694;MT-ND1:MT-ND3:5ldx:H:A:V305L:I309T:0.66863:-1.41629:2.01322;MT-ND1:MT-ND3:5ldx:H:A:V305L:I309V:-0.23859:-1.41629:1.22919 MT-ND1:MT-ND3:5lc5:H:A:V305I:I309F:1.34162:0.56232:0.55258;MT-ND1:MT-ND3:5lc5:H:A:V305I:I309L:-0.10422:0.56232:-0.19955;MT-ND1:MT-ND3:5lc5:H:A:V305I:I309M:0.11297:0.56232:-0.1133;MT-ND1:MT-ND3:5lc5:H:A:V305I:I309N:3.21341:0.56232:2.70746;MT-ND1:MT-ND3:5lc5:H:A:V305I:I309S:3.3232:0.56232:3.17307;MT-ND1:MT-ND3:5lc5:H:A:V305I:I309T:2.19797:0.56232:1.90168;MT-ND1:MT-ND3:5lc5:H:A:V305I:I309V:1.21239:0.56232:0.61358;MT-ND1:MT-ND3:5ldw:H:A:V305I:I309F:2.14223:1.42111:0.8733;MT-ND1:MT-ND3:5ldw:H:A:V305I:I309L:1.29243:1.42111:-0.00810000000001;MT-ND1:MT-ND3:5ldw:H:A:V305I:I309M:2.39137:1.42111:0.6466;MT-ND1:MT-ND3:5ldw:H:A:V305I:I309N:4.3981:1.42111:2.99749;MT-ND1:MT-ND3:5ldw:H:A:V305I:I309S:4.71863:1.42111:3.33174;MT-ND1:MT-ND3:5ldw:H:A:V305I:I309T:3.49537:1.42111:1.96406;MT-ND1:MT-ND3:5ldw:H:A:V305I:I309V:2.52002:1.42111:1.19179;MT-ND1:MT-ND3:5ldx:H:A:V305I:I309F:1.96097:0.12686:1.09811;MT-ND1:MT-ND3:5ldx:H:A:V305I:I309L:-0.05395:0.12686:-0.31791;MT-ND1:MT-ND3:5ldx:H:A:V305I:I309M:1.23777:0.12686:0.64263;MT-ND1:MT-ND3:5ldx:H:A:V305I:I309N:3.07261:0.12686:3.0722;MT-ND1:MT-ND3:5ldx:H:A:V305I:I309S:3.39299:0.12686:3.39694;MT-ND1:MT-ND3:5ldx:H:A:V305I:I309T:2.04241:0.12686:2.01322;MT-ND1:MT-ND3:5ldx:H:A:V305I:I309V:1.76228:0.12686:1.22919 MT-ND1:MT-ND3:5lc5:H:A:V305F:I309F:-0.56578:-2.16007:0.55258;MT-ND1:MT-ND3:5lc5:H:A:V305F:I309L:-2.14208:-2.16007:-0.19955;MT-ND1:MT-ND3:5lc5:H:A:V305F:I309M:-1.83163:-2.16007:-0.1133;MT-ND1:MT-ND3:5lc5:H:A:V305F:I309N:0.32477:-2.16007:2.70746;MT-ND1:MT-ND3:5lc5:H:A:V305F:I309S:0.45502:-2.16007:3.17307;MT-ND1:MT-ND3:5lc5:H:A:V305F:I309T:-0.65755:-2.16007:1.90168;MT-ND1:MT-ND3:5lc5:H:A:V305F:I309V:-1.47791:-2.16007:0.61358;MT-ND1:MT-ND3:5ldw:H:A:V305F:I309F:-1.01752:-1.55959:0.8733;MT-ND1:MT-ND3:5ldw:H:A:V305F:I309L:-1.24375:-1.55959:-0.00810000000001;MT-ND1:MT-ND3:5ldw:H:A:V305F:I309M:-0.83015:-1.55959:0.6466;MT-ND1:MT-ND3:5ldw:H:A:V305F:I309N:1.18155:-1.55959:2.99749;MT-ND1:MT-ND3:5ldw:H:A:V305F:I309S:0.78329:-1.55959:3.33174;MT-ND1:MT-ND3:5ldw:H:A:V305F:I309T:0.34621:-1.55959:1.96406;MT-ND1:MT-ND3:5ldw:H:A:V305F:I309V:-0.86491:-1.55959:1.19179;MT-ND1:MT-ND3:5ldx:H:A:V305F:I309F:-1.31194:-1.1139:1.09811;MT-ND1:MT-ND3:5ldx:H:A:V305F:I309L:-1.96866:-1.1139:-0.31791;MT-ND1:MT-ND3:5ldx:H:A:V305F:I309M:-1.75434:-1.1139:0.64263;MT-ND1:MT-ND3:5ldx:H:A:V305F:I309N:0.74815:-1.1139:3.0722;MT-ND1:MT-ND3:5ldx:H:A:V305F:I309S:0.6016:-1.1139:3.39694;MT-ND1:MT-ND3:5ldx:H:A:V305F:I309T:0.13529:-1.1139:2.01322;MT-ND1:MT-ND3:5ldx:H:A:V305F:I309V:-0.83147:-1.1139:1.22919 MT-ND1:MT-ND3:5lc5:H:A:V305G:I309F:3.75618:2.64266:0.55258;MT-ND1:MT-ND3:5lc5:H:A:V305G:I309L:2.433:2.64266:-0.19955;MT-ND1:MT-ND3:5lc5:H:A:V305G:I309M:2.42469:2.64266:-0.1133;MT-ND1:MT-ND3:5lc5:H:A:V305G:I309N:5.50831:2.64266:2.70746;MT-ND1:MT-ND3:5lc5:H:A:V305G:I309S:5.84297:2.64266:3.17307;MT-ND1:MT-ND3:5lc5:H:A:V305G:I309T:4.55828:2.64266:1.90168;MT-ND1:MT-ND3:5lc5:H:A:V305G:I309V:3.27329:2.64266:0.61358;MT-ND1:MT-ND3:5ldw:H:A:V305G:I309F:4.09994:3.07753:0.8733;MT-ND1:MT-ND3:5ldw:H:A:V305G:I309L:3.14811:3.07753:-0.00810000000001;MT-ND1:MT-ND3:5ldw:H:A:V305G:I309M:4.11169:3.07753:0.6466;MT-ND1:MT-ND3:5ldw:H:A:V305G:I309N:6.1782:3.07753:2.99749;MT-ND1:MT-ND3:5ldw:H:A:V305G:I309S:6.41259:3.07753:3.33174;MT-ND1:MT-ND3:5ldw:H:A:V305G:I309T:5.1288:3.07753:1.96406;MT-ND1:MT-ND3:5ldw:H:A:V305G:I309V:4.21568:3.07753:1.19179;MT-ND1:MT-ND3:5ldx:H:A:V305G:I309F:4.11492:2.67583:1.09811;MT-ND1:MT-ND3:5ldx:H:A:V305G:I309L:2.32373:2.67583:-0.31791;MT-ND1:MT-ND3:5ldx:H:A:V305G:I309M:3.68638:2.67583:0.64263;MT-ND1:MT-ND3:5ldx:H:A:V305G:I309N:5.72403:2.67583:3.0722;MT-ND1:MT-ND3:5ldx:H:A:V305G:I309S:5.80913:2.67583:3.39694;MT-ND1:MT-ND3:5ldx:H:A:V305G:I309T:4.7341:2.67583:2.01322;MT-ND1:MT-ND3:5ldx:H:A:V305G:I309V:3.80264:2.67583:1.22919 MT-ND1:MT-ND3:5lc5:H:A:V305D:I309F:3.61662:3.12026:0.55258;MT-ND1:MT-ND3:5lc5:H:A:V305D:I309L:2.82956:3.12026:-0.19955;MT-ND1:MT-ND3:5lc5:H:A:V305D:I309M:3.45423:3.12026:-0.1133;MT-ND1:MT-ND3:5lc5:H:A:V305D:I309N:5.9234:3.12026:2.70746;MT-ND1:MT-ND3:5lc5:H:A:V305D:I309S:6.31912:3.12026:3.17307;MT-ND1:MT-ND3:5lc5:H:A:V305D:I309T:5.02859:3.12026:1.90168;MT-ND1:MT-ND3:5lc5:H:A:V305D:I309V:3.70596:3.12026:0.61358;MT-ND1:MT-ND3:5ldw:H:A:V305D:I309F:4.55987:3.81919:0.8733;MT-ND1:MT-ND3:5ldw:H:A:V305D:I309L:3.79292:3.81919:-0.00810000000001;MT-ND1:MT-ND3:5ldw:H:A:V305D:I309M:4.69843:3.81919:0.6466;MT-ND1:MT-ND3:5ldw:H:A:V305D:I309N:6.8996:3.81919:2.99749;MT-ND1:MT-ND3:5ldw:H:A:V305D:I309S:7.17469:3.81919:3.33174;MT-ND1:MT-ND3:5ldw:H:A:V305D:I309T:5.92721:3.81919:1.96406;MT-ND1:MT-ND3:5ldw:H:A:V305D:I309V:4.97216:3.81919:1.19179;MT-ND1:MT-ND3:5ldx:H:A:V305D:I309F:4.46816:3.3723:1.09811;MT-ND1:MT-ND3:5ldx:H:A:V305D:I309L:3.03283:3.3723:-0.31791;MT-ND1:MT-ND3:5ldx:H:A:V305D:I309M:4.289:3.3723:0.64263;MT-ND1:MT-ND3:5ldx:H:A:V305D:I309N:6.41703:3.3723:3.0722;MT-ND1:MT-ND3:5ldx:H:A:V305D:I309S:6.48901:3.3723:3.39694;MT-ND1:MT-ND3:5ldx:H:A:V305D:I309T:5.46549:3.3723:2.01322;MT-ND1:MT-ND3:5ldx:H:A:V305D:I309V:4.50528:3.3723:1.22919 MT-ND1:MT-ND3:5lc5:H:A:V305A:I309F:2.88306:1.92952:0.55258;MT-ND1:MT-ND3:5lc5:H:A:V305A:I309L:1.61336:1.92952:-0.19955;MT-ND1:MT-ND3:5lc5:H:A:V305A:I309M:1.91596:1.92952:-0.1133;MT-ND1:MT-ND3:5lc5:H:A:V305A:I309N:4.74451:1.92952:2.70746;MT-ND1:MT-ND3:5lc5:H:A:V305A:I309S:5.06966:1.92952:3.17307;MT-ND1:MT-ND3:5lc5:H:A:V305A:I309T:3.78578:1.92952:1.90168;MT-ND1:MT-ND3:5lc5:H:A:V305A:I309V:2.50214:1.92952:0.61358;MT-ND1:MT-ND3:5ldw:H:A:V305A:I309F:3.34976:2.20052:0.8733;MT-ND1:MT-ND3:5ldw:H:A:V305A:I309L:2.70407:2.20052:-0.00810000000001;MT-ND1:MT-ND3:5ldw:H:A:V305A:I309M:3.03172:2.20052:0.6466;MT-ND1:MT-ND3:5ldw:H:A:V305A:I309N:5.20012:2.20052:2.99749;MT-ND1:MT-ND3:5ldw:H:A:V305A:I309S:5.49733:2.20052:3.33174;MT-ND1:MT-ND3:5ldw:H:A:V305A:I309T:4.2463:2.20052:1.96406;MT-ND1:MT-ND3:5ldw:H:A:V305A:I309V:3.31589:2.20052:1.19179;MT-ND1:MT-ND3:5ldx:H:A:V305A:I309F:3.26489:1.99239:1.09811;MT-ND1:MT-ND3:5ldx:H:A:V305A:I309L:1.70756:1.99239:-0.31791;MT-ND1:MT-ND3:5ldx:H:A:V305A:I309M:3.11838:1.99239:0.64263;MT-ND1:MT-ND3:5ldx:H:A:V305A:I309N:5.04517:1.99239:3.0722;MT-ND1:MT-ND3:5ldx:H:A:V305A:I309S:5.11491:1.99239:3.39694;MT-ND1:MT-ND3:5ldx:H:A:V305A:I309T:4.07485:1.99239:2.01322;MT-ND1:MT-ND3:5ldx:H:A:V305A:I309V:3.133:1.99239:1.22919
DDG inter MT-ND1:MT-ND3:5lc5:H:A:V305L:N10T:-2.19796:-1.39616168:-0.845690131;MT-ND1:MT-ND3:5lc5:H:A:V305L:N10K:-0.77525:-1.39616168:0.559670269;MT-ND1:MT-ND3:5lc5:H:A:V305L:N10H:-1.96435:-1.39616168:-0.468639374;MT-ND1:MT-ND3:5lc5:H:A:V305L:N10D:0.57164:-1.39616168:1.9348892;MT-ND1:MT-ND3:5lc5:H:A:V305L:N10Y:-2.58335:-1.39616168:-1.04049873;MT-ND1:MT-ND3:5lc5:H:A:V305L:N10I:-2.04876:-1.39616168:-0.200120538;MT-ND1:MT-ND3:5lc5:H:A:V305L:N10S:-0.29366:-1.39616168:1.00994909;MT-ND1:MT-ND3:5ldw:H:A:V305L:N10T:-2.05459:-1.10788035:-0.944197059;MT-ND1:MT-ND3:5ldw:H:A:V305L:N10K:-1.71841:-1.10788035:-0.557247937;MT-ND1:MT-ND3:5ldw:H:A:V305L:N10H:-2.46713:-1.10788035:-1.41110837;MT-ND1:MT-ND3:5ldw:H:A:V305L:N10D:0.38127:-1.10788035:1.56138194;MT-ND1:MT-ND3:5ldw:H:A:V305L:N10Y:-3.04744:-1.10788035:-1.868029;MT-ND1:MT-ND3:5ldw:H:A:V305L:N10I:-3.19333:-1.10788035:-1.98465884;MT-ND1:MT-ND3:5ldw:H:A:V305L:N10S:-0.38243:-1.10788035:0.722851157;MT-ND1:MT-ND3:5ldx:H:A:V305L:N10T:-2.0752:-1.41837955:-0.727460086;MT-ND1:MT-ND3:5ldx:H:A:V305L:N10K:-2.39057:-1.41837955:-0.983650565;MT-ND1:MT-ND3:5ldx:H:A:V305L:N10H:-2.71028:-1.41837955:-1.23474002;MT-ND1:MT-ND3:5ldx:H:A:V305L:N10D:0.40676:-1.41837955:1.77093887;MT-ND1:MT-ND3:5ldx:H:A:V305L:N10Y:-3.69892:-1.41837955:-1.7146492;MT-ND1:MT-ND3:5ldx:H:A:V305L:N10I:-3.15255:-1.41837955:-1.75487101;MT-ND1:MT-ND3:5ldx:H:A:V305L:N10S:-0.52073:-1.41837955:0.834559619 MT-ND1:MT-ND3:5lc5:H:A:V305I:N10S:1.66165:0.511240363:1.00994909;MT-ND1:MT-ND3:5lc5:H:A:V305I:N10D:2.25623:0.511240363:1.9348892;MT-ND1:MT-ND3:5lc5:H:A:V305I:N10T:0.23766:0.511240363:-0.845690131;MT-ND1:MT-ND3:5lc5:H:A:V305I:N10I:-0.58641:0.511240363:-0.200120538;MT-ND1:MT-ND3:5lc5:H:A:V305I:N10H:-0.33634:0.511240363:-0.468639374;MT-ND1:MT-ND3:5lc5:H:A:V305I:N10K:1.14103:0.511240363:0.559670269;MT-ND1:MT-ND3:5lc5:H:A:V305I:N10Y:-0.93517:0.511240363:-1.04049873;MT-ND1:MT-ND3:5ldw:H:A:V305I:N10S:2.22336:1.48407102:0.722851157;MT-ND1:MT-ND3:5ldw:H:A:V305I:N10D:2.95007:1.48407102:1.56138194;MT-ND1:MT-ND3:5ldw:H:A:V305I:N10T:0.38335:1.48407102:-0.944197059;MT-ND1:MT-ND3:5ldw:H:A:V305I:N10I:-0.4788:1.48407102:-1.98465884;MT-ND1:MT-ND3:5ldw:H:A:V305I:N10H:0.06164:1.48407102:-1.41110837;MT-ND1:MT-ND3:5ldw:H:A:V305I:N10K:0.75026:1.48407102:-0.557247937;MT-ND1:MT-ND3:5ldw:H:A:V305I:N10Y:-0.28157:1.48407102:-1.868029;MT-ND1:MT-ND3:5ldx:H:A:V305I:N10S:0.83923:0.10269966:0.834559619;MT-ND1:MT-ND3:5ldx:H:A:V305I:N10D:1.99761:0.10269966:1.77093887;MT-ND1:MT-ND3:5ldx:H:A:V305I:N10T:-0.4218:0.10269966:-0.727460086;MT-ND1:MT-ND3:5ldx:H:A:V305I:N10I:-1.56658:0.10269966:-1.75487101;MT-ND1:MT-ND3:5ldx:H:A:V305I:N10H:-1.02777:0.10269966:-1.23474002;MT-ND1:MT-ND3:5ldx:H:A:V305I:N10K:-0.57668:0.10269966:-0.983650565;MT-ND1:MT-ND3:5ldx:H:A:V305I:N10Y:-1.60254:0.10269966:-1.7146492 MT-ND1:MT-ND3:5lc5:H:A:V305F:N10T:-2.92942:-2.1739502:-0.845690131;MT-ND1:MT-ND3:5lc5:H:A:V305F:N10I:-2.9242:-2.1739502:-0.200120538;MT-ND1:MT-ND3:5lc5:H:A:V305F:N10D:-0.18911:-2.1739502:1.9348892;MT-ND1:MT-ND3:5lc5:H:A:V305F:N10S:-1.04288:-2.1739502:1.00994909;MT-ND1:MT-ND3:5lc5:H:A:V305F:N10H:-2.74569:-2.1739502:-0.468639374;MT-ND1:MT-ND3:5lc5:H:A:V305F:N10Y:-3.08428:-2.1739502:-1.04049873;MT-ND1:MT-ND3:5lc5:H:A:V305F:N10K:-1.5455:-2.1739502:0.559670269;MT-ND1:MT-ND3:5ldw:H:A:V305F:N10T:-1.60022:-0.851601005:-0.944197059;MT-ND1:MT-ND3:5ldw:H:A:V305F:N10I:-2.77025:-0.851601005:-1.98465884;MT-ND1:MT-ND3:5ldw:H:A:V305F:N10D:0.96043:-0.851601005:1.56138194;MT-ND1:MT-ND3:5ldw:H:A:V305F:N10S:0.11619:-0.851601005:0.722851157;MT-ND1:MT-ND3:5ldw:H:A:V305F:N10H:-2.30228:-0.851601005:-1.41110837;MT-ND1:MT-ND3:5ldw:H:A:V305F:N10Y:-2.33086:-0.851601005:-1.868029;MT-ND1:MT-ND3:5ldw:H:A:V305F:N10K:-2.25776:-0.851601005:-0.557247937;MT-ND1:MT-ND3:5ldx:H:A:V305F:N10T:-1.88928:-1.10611987:-0.727460086;MT-ND1:MT-ND3:5ldx:H:A:V305F:N10I:-2.6484:-1.10611987:-1.75487101;MT-ND1:MT-ND3:5ldx:H:A:V305F:N10D:0.46146:-1.10611987:1.77093887;MT-ND1:MT-ND3:5ldx:H:A:V305F:N10S:0.21132:-1.10611987:0.834559619;MT-ND1:MT-ND3:5ldx:H:A:V305F:N10H:-2.12036:-1.10611987:-1.23474002;MT-ND1:MT-ND3:5ldx:H:A:V305F:N10Y:-2.90224:-1.10611987:-1.7146492;MT-ND1:MT-ND3:5ldx:H:A:V305F:N10K:-1.65306:-1.10611987:-0.983650565 MT-ND1:MT-ND3:5lc5:H:A:V305G:N10S:3.78371:2.66267157:1.00994909;MT-ND1:MT-ND3:5lc5:H:A:V305G:N10Y:0.92958:2.66267157:-1.04049873;MT-ND1:MT-ND3:5lc5:H:A:V305G:N10T:1.92566:2.66267157:-0.845690131;MT-ND1:MT-ND3:5lc5:H:A:V305G:N10K:3.00747:2.66267157:0.559670269;MT-ND1:MT-ND3:5lc5:H:A:V305G:N10D:4.59602:2.66267157:1.9348892;MT-ND1:MT-ND3:5lc5:H:A:V305G:N10H:2.00185:2.66267157:-0.468639374;MT-ND1:MT-ND3:5lc5:H:A:V305G:N10I:2.53533:2.66267157:-0.200120538;MT-ND1:MT-ND3:5ldw:H:A:V305G:N10S:3.85865:3.10235167:0.722851157;MT-ND1:MT-ND3:5ldw:H:A:V305G:N10Y:1.34165:3.10235167:-1.868029;MT-ND1:MT-ND3:5ldw:H:A:V305G:N10T:2.1546:3.10235167:-0.944197059;MT-ND1:MT-ND3:5ldw:H:A:V305G:N10K:2.54434:3.10235167:-0.557247937;MT-ND1:MT-ND3:5ldw:H:A:V305G:N10D:4.65965:3.10235167:1.56138194;MT-ND1:MT-ND3:5ldw:H:A:V305G:N10H:1.74869:3.10235167:-1.41110837;MT-ND1:MT-ND3:5ldw:H:A:V305G:N10I:1.06377:3.10235167:-1.98465884;MT-ND1:MT-ND3:5ldx:H:A:V305G:N10S:3.58979:2.67550015:0.834559619;MT-ND1:MT-ND3:5ldx:H:A:V305G:N10Y:0.32186:2.67550015:-1.7146492;MT-ND1:MT-ND3:5ldx:H:A:V305G:N10T:1.98526:2.67550015:-0.727460086;MT-ND1:MT-ND3:5ldx:H:A:V305G:N10K:1.71797:2.67550015:-0.983650565;MT-ND1:MT-ND3:5ldx:H:A:V305G:N10D:4.46936:2.67550015:1.77093887;MT-ND1:MT-ND3:5ldx:H:A:V305G:N10H:1.46993:2.67550015:-1.23474002;MT-ND1:MT-ND3:5ldx:H:A:V305G:N10I:0.9032:2.67550015:-1.75487101 MT-ND1:MT-ND3:5lc5:H:A:V305D:N10H:2.92028:3.12862015:-0.468639374;MT-ND1:MT-ND3:5lc5:H:A:V305D:N10T:2.30751:3.12862015:-0.845690131;MT-ND1:MT-ND3:5lc5:H:A:V305D:N10S:4.25916:3.12862015:1.00994909;MT-ND1:MT-ND3:5lc5:H:A:V305D:N10K:3.61004:3.12862015:0.559670269;MT-ND1:MT-ND3:5lc5:H:A:V305D:N10I:2.89514:3.12862015:-0.200120538;MT-ND1:MT-ND3:5lc5:H:A:V305D:N10Y:2.1728:3.12862015:-1.04049873;MT-ND1:MT-ND3:5lc5:H:A:V305D:N10D:5.13175:3.12862015:1.9348892;MT-ND1:MT-ND3:5ldw:H:A:V305D:N10H:2.45739:3.81080866:-1.41110837;MT-ND1:MT-ND3:5ldw:H:A:V305D:N10T:2.92836:3.81080866:-0.944197059;MT-ND1:MT-ND3:5ldw:H:A:V305D:N10S:4.61387:3.81080866:0.722851157;MT-ND1:MT-ND3:5ldw:H:A:V305D:N10K:3.1055:3.81080866:-0.557247937;MT-ND1:MT-ND3:5ldw:H:A:V305D:N10I:1.78167:3.81080866:-1.98465884;MT-ND1:MT-ND3:5ldw:H:A:V305D:N10Y:2.0629:3.81080866:-1.868029;MT-ND1:MT-ND3:5ldw:H:A:V305D:N10D:5.34692:3.81080866:1.56138194;MT-ND1:MT-ND3:5ldx:H:A:V305D:N10H:2.11344:3.37083101:-1.23474002;MT-ND1:MT-ND3:5ldx:H:A:V305D:N10T:2.76616:3.37083101:-0.727460086;MT-ND1:MT-ND3:5ldx:H:A:V305D:N10S:4.32932:3.37083101:0.834559619;MT-ND1:MT-ND3:5ldx:H:A:V305D:N10K:2.43713:3.37083101:-0.983650565;MT-ND1:MT-ND3:5ldx:H:A:V305D:N10I:1.67832:3.37083101:-1.75487101;MT-ND1:MT-ND3:5ldx:H:A:V305D:N10Y:1.70452:3.37083101:-1.7146492;MT-ND1:MT-ND3:5ldx:H:A:V305D:N10D:5.1231:3.37083101:1.77093887 MT-ND1:MT-ND3:5lc5:H:A:V305A:N10Y:0.84752:1.90028071:-1.04049873;MT-ND1:MT-ND3:5lc5:H:A:V305A:N10D:3.81584:1.90028071:1.9348892;MT-ND1:MT-ND3:5lc5:H:A:V305A:N10S:2.8869:1.90028071:1.00994909;MT-ND1:MT-ND3:5lc5:H:A:V305A:N10K:2.45861:1.90028071:0.559670269;MT-ND1:MT-ND3:5lc5:H:A:V305A:N10T:1.1108:1.90028071:-0.845690131;MT-ND1:MT-ND3:5lc5:H:A:V305A:N10I:1.70858:1.90028071:-0.200120538;MT-ND1:MT-ND3:5lc5:H:A:V305A:N10H:1.4533:1.90028071:-0.468639374;MT-ND1:MT-ND3:5ldw:H:A:V305A:N10Y:0.45695:2.19327092:-1.868029;MT-ND1:MT-ND3:5ldw:H:A:V305A:N10D:3.76108:2.19327092:1.56138194;MT-ND1:MT-ND3:5ldw:H:A:V305A:N10S:2.92739:2.19327092:0.722851157;MT-ND1:MT-ND3:5ldw:H:A:V305A:N10K:1.65691:2.19327092:-0.557247937;MT-ND1:MT-ND3:5ldw:H:A:V305A:N10T:1.26292:2.19327092:-0.944197059;MT-ND1:MT-ND3:5ldw:H:A:V305A:N10I:0.21075:2.19327092:-1.98465884;MT-ND1:MT-ND3:5ldw:H:A:V305A:N10H:0.78828:2.19327092:-1.41110837;MT-ND1:MT-ND3:5ldx:H:A:V305A:N10Y:0.56894:1.99108887:-1.7146492;MT-ND1:MT-ND3:5ldx:H:A:V305A:N10D:3.75961:1.99108887:1.77093887;MT-ND1:MT-ND3:5ldx:H:A:V305A:N10S:2.8233:1.99108887:0.834559619;MT-ND1:MT-ND3:5ldx:H:A:V305A:N10K:1.00447:1.99108887:-0.983650565;MT-ND1:MT-ND3:5ldx:H:A:V305A:N10T:1.26393:1.99108887:-0.727460086;MT-ND1:MT-ND3:5ldx:H:A:V305A:N10I:0.23609:1.99108887:-1.75487101;MT-ND1:MT-ND3:5ldx:H:A:V305A:N10H:0.7544:1.99108887:-1.23474002
For more info, please check the output legend.
ΔΔG values >±0.61 Kcal/mol are indicative of disrupting variants.
ΔΔG values close to zero (<±0.1 Kcal/mol) are indicative of possibly
compensating double mutants.
For more info, please check the output legend.
ΔΔG values >±0.61 Kcal/mol are indicative of disrupting variants.
ΔΔG values close to zero (<±0.1 Kcal/mol) are indicative of possibly
compensating double mutants.
For more info, please check the output legend.
ΔΔG values >±0.61 Kcal/mol are indicative of disrupting variants.
ΔΔG values close to zero (<±0.1 Kcal/mol) are indicative of possibly
compensating double mutants.
For more info, please check the output legend.
For more info, please check the output legend.
Score:  
0
  [min -20, max 10]
  • Predicted accelerated evolution:  score <= 0
  • Conserved:  score > 0
Score:  
0
  [min 0, max 1]
  • Non-conserved:  score <= 0.7
  • Conserved:  score > 0.7 (soft threshold)
Score:  
0
  [min 0, max 1]
  • Neutral:  score <= 0.15
  • Possibly damaging:  0.15 < score <= 0.85
  • Probably damaging:  score > 0.85
Score:  
0
  [min 0, max 1]
  • Neutral:  score > 0.05
  • Deleterious:  score <= 0.05
Score:  
0
  [min 0, max 1]
  • Neutral:  score > 0.05
  • Deleterious:  score <= 0.05
Score:  
0
  [min -15, max 10]
  • Neutral:  score > -3
  • Deleterious:  score <= -3
Score:  
0
  [min -3, max 6]
  • Neutral:  score > -1.5
  • Deleterious:  score <= -1.5
Score:  
0
  [min -14, max 14]
  • Neutral:  score > -2.5
  • Deleterious:  score <= -2.5 (soft threshold)
Score:  
0
  [min -6, max 6]
  • Neutral:  score <= 0.8
  • Low impact:  0.8 < score <= 1.9
  • Medium impact:  1.9 < score <= 3.5
  • High impact:  score > 3.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score > 0.6
  • Damaging:  score <= 0.6
Score:  
0
  [min 0, max 1]
  • Neutral:  score > 0.28
  • Damaging:  score <= 0.28
Phred score:  
0
  [min 0, max 35]
  • Neutral:  score < 20 (soft threshold)
  • Deleterious:  score >= 20
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Polymorphism:  score < 0.5
  • Disease causing:  score >= 0.5
P-value:  
0
  [min 0, max 1]
  • Neutral:  p-value > 0.05
  • Pathogenic:  p-value <= 0.05
Score:  
0
  [min 0, max 1]
No hard-thresholds were indicated by authors (ref). Indicatively:
  • Neutral:  score < 0.9
  • Pathogenic:  score >= 0.9
No score. Categorical only
Please refer to Additional File 14: Table S10 for further details.
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.98
  • Deleterious:  score >= 0.98
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Deleterious:  score >= 0.5
Score:  
0
  [min -6, max 6]
  • Neutral:  score < 0
  • Deleterious:  score > 0
  • Inaccurate prediction:  score = 0
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Deleterious:  score >= 0.5
DS score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.43
  • Deleterious:  score >= 0.43
Pathogenicity score:  
0
  [min 0, max 1]
  • Neutral:  score ≤ 0.5
  • Pathogenic:  score > 0.5


Pathogenicity score for this variant:  
0
  [min 0, max 1]
ACMG-AMP curations for mitochondrial variants should use the raw scores. Standalone probabilities are shown below:
  • Benign:  score ≤ 0.062 (prob. ≤ 0.001)
  • Likely-benign:  0.062 < score ≤ 0.265 (0.001 < prob. ≤ 0.1)
  • Low-scoring VUS (VUS-):  0.265 < score ≤ 0.396 (0.1 < prob. ≤ 0.33)
  • VUS:  0.396 < score ≤ 0.544 (0.33 < prob. ≤ 0.66)
  • High-scoring VUS (VUS+):  0.544 < score < 0.716 (0.66 < prob. < 0.9)
  • Likely-pathogenic:  0.716 ≤ score < 0.907 (0.9 ≤ prob. < 0.99)
  • Pathogenic:  score ≥ 0.907 (prob. ≥ 0.99)
Score:  
0
  [min -5, max 5]
  • Low impact:  score <= -1 (soft threshold)
  • Medium impact:  -1 < score < 1.5 (soft threshold)
  • High impact:  score >= 1.5 (soft threshold)
Score:  
0
  [min -5, max 5]
  • Low impact:  score <= -1
  • Medium impact:  -1 < score < 2 (soft threshold)
  • High impact:  score >= 2 (soft threshold)
Score:  
0
  [min -5, max 5]
  • Low impact:  score <= -1
  • Medium impact:  -1 < score < 2 (soft threshold)
  • High impact:  score >= 2 (soft threshold)
P-value:  
0
  [min 0, max 1]
  • Neutral:  FDR > 0.2
  • Driver:  FDR <= 0.2
The frequency of a CPD variant is proportional to the
number of aligned orthologous sequences that
carry a specific human pathogenic variant as
wild-type amino acid on the total number of aligned
sequences.

For more info, please check the output legend