4219 (G > T)

General info

Chr
chrM
Start
4219
End
4219
Ref
G
Alt
T
Mitimpact ID
MI.12658
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
913
AA pos
305
AA ref
V
AA alt
F
Codon substitution
Gtc/Ttc
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Powered by MitoWheel

Conservation

PhyloP 100v
-5.5 Conservation Score
PhastCons 100v
0 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Deleterious Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Neutral Score and details of the predictor
Mutation Assessor
Neutral impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Disease Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Deleterious Score and details of the predictor
SNAP
Neutral Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Neutral Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Neutral Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Medium impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

4219 (G > C)

General info

Chr
chrM
Start
4219
End
4219
Ref
G
Alt
C
Mitimpact ID
MI.12659
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
913
AA pos
305
AA ref
V
AA alt
L
Codon substitution
Gtc/Ctc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
-5.5 Conservation Score
PhastCons 100v
0 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Neutral Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Neutral Score and details of the predictor
Mutation Assessor
Neutral impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Neutral Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Neutral Score and details of the predictor
SNAP
Neutral Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Neutral Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Neutral Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
High impact Score and details of the cancer-specific predictor
SIFT transf
High impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

4219 (G > A)

General info

Chr
chrM
Start
4219
End
4219
Ref
G
Alt
A
Mitimpact ID
MI.12660
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
913
AA pos
305
AA ref
V
AA alt
I
Codon substitution
Gtc/Atc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
-5.5 Conservation Score
PhastCons 100v
0 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Neutral Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Neutral Score and details of the predictor
Mutation Assessor
Neutral impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Neutral Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Neutral Score and details of the predictor
SNAP
Neutral Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Neutral Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Neutral Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
High impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Low impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar March2020 ClinSig
Benign/likely benign
ClinVar March2020 ClnDBN
Leigh syndrome;

not provided
ClinVar March2020 ClnAllele ID
237002
ClinVar March2020 ClnDSDB
Medgen:c0023264, omim:256000, orphanet:orpha506, snomed ct:29570005;

medgen:cn517202
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

4220 (T > A)

General info

Chr
chrM
Start
4220
End
4220
Ref
T
Alt
A
Mitimpact ID
MI.12661
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
914
AA pos
305
AA ref
V
AA alt
D
Codon substitution
gTc/gAc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
0.03 Conservation Score
PhastCons 100v
0 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Deleterious Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Deleterious Score and details of the predictor
Mutation Assessor
Medium impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Pathogenic Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Disease Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Deleterious Score and details of the predictor
SNAP
Disease Score and details of the predictor
MitoClass 1
Damaging Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Neutral Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Neutral Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Disease Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Medium impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Medium impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

4220 (T > G)

General info

Chr
chrM
Start
4220
End
4220
Ref
T
Alt
G
Mitimpact ID
MI.12662
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
914
AA pos
305
AA ref
V
AA alt
G
Codon substitution
gTc/gGc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
0.03 Conservation Score
PhastCons 100v
0 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Deleterious Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Deleterious Score and details of the predictor
Mutation Assessor
Neutral impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Pathogenic Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Disease Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Deleterious Score and details of the predictor
SNAP
Neutral Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Neutral Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Neutral Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
Medium impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Low impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

4220 (T > C)

General info

Chr
chrM
Start
4220
End
4220
Ref
T
Alt
C
Mitimpact ID
MI.12663
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
914
AA pos
305
AA ref
V
AA alt
A
Codon substitution
gTc/gCc
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
0.03 Conservation Score
PhastCons 100v
0 Conservation Score

Pathogenicity predictors

PolyPhen2
Benign Score and details of the predictor
SIFT
Neutral Score and details of the predictor
FatHmm
Neutral Score and details of the predictor
FatHMMW
Neutral Score and details of the predictor
PROVEAN
Neutral Score and details of the predictor
Mutation Assessor
Neutral impact Score and details of the predictor
EFIN SP
Neutral Score and details of the predictor
EFIN HD
Neutral Score and details of the predictor
VEST
Neutral Score and details of the predictor
PANTHER
Neutral Score and details of the predictor
PhD-SNP
Neutral Score and details of the predictor
MutationTaster
Polymorphism Score and details of the predictor
CADD
Neutral Score and details of the predictor
SNAP
Neutral Score and details of the predictor
MitoClass 1
Neutral Score and details of the predictor
SNPDryad
Neutral Score and details of the predictor

Pathogenicity meta-predictors

APOGEE
Neutral Score and details of the meta-predictor
CAROL
Neutral Score and details of the meta-predictor
Condel
Deleterious Score and details of the meta-predictor
COVEC WMV
Neutral Score and details of the meta-predictor
Meta SNP
Neutral Score and details of the meta-predictor
MtoolBox
Neutral Score and details of the meta-predictor
DEOGEN2
Neutral Score and details of the meta-predictor

Cancer-specific predictors

PolyPhen2 transf
High impact Score and details of the cancer-specific predictor
SIFT transf
Medium impact Score and details of the cancer-specific predictor
MutationAssessor transf
Low impact Score and details of the cancer-specific predictor
CHASM
Neutral Score and details of the cancer-specific predictor

Databases of Phenotypes

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Compensated Pathogenic Deviations

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.
~ 4219 (G/T) 4219 (G/C) 4219 (G/A) 4220 (T/A) 4220 (T/G) 4220 (T/C)
~ 4219 (Gtc/Ttc) 4219 (Gtc/Ctc) 4219 (Gtc/Atc) 4220 (gTc/gAc) 4220 (gTc/gGc) 4220 (gTc/gCc)
Chr chrM chrM chrM chrM chrM chrM
Start 4219 4219 4219 4220 4220 4220
End 4219 4219 4219 4220 4220 4220
Ref G G G T T T
Alt T C A A G C
MitImpact id MI.12658 MI.12659 MI.12660 MI.12661 MI.12662 MI.12663
Gene symbol MT-ND1 MT-ND1 MT-ND1 MT-ND1 MT-ND1 MT-ND1
Respiratory Chain complex I I I I I I
Ensembl gene id ENSG00000198888 ENSG00000198888 ENSG00000198888 ENSG00000198888 ENSG00000198888 ENSG00000198888
Ensembl protein id ENSP00000354687 ENSP00000354687 ENSP00000354687 ENSP00000354687 ENSP00000354687 ENSP00000354687
Ensembl transcript id ENST00000361390 ENST00000361390 ENST00000361390 ENST00000361390 ENST00000361390 ENST00000361390
Uniprot name NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN
Uniprot id P03886 P03886 P03886 P03886 P03886 P03886
Ncbi gene id 4535 4535 4535 4535 4535 4535
Ncbi protein id YP_003024026.1 YP_003024026.1 YP_003024026.1 YP_003024026.1 YP_003024026.1 YP_003024026.1
Gene position 913 913 913 914 914 914
AA position 305 305 305 305 305 305
AA ref V V V V V V
AA alt F L I D G A
Codon substitution Gtc/Ttc Gtc/Ctc Gtc/Atc gTc/gAc gTc/gGc gTc/gCc
PhyloP 100V -5.5 -5.5 -5.5 0.03 0.03 0.03
PhastCons 100V 0 0 0 0 0 0
PolyPhen2 benign benign benign benign benign benign
PolyPhen2 score 0.16 0 0 0.21 0.1 0
SIFT neutral neutral neutral neutral neutral neutral
SIFT score 0.43 1 0.48 0.06 0.16 0.51
FatHmm deleterious neutral neutral deleterious deleterious neutral
FatHmm score -3 -1.49 -0.42 -4.11 -3.26 -1.35
FatHmmW neutral neutral neutral neutral neutral neutral
FatHmmW score 2.7 2.77 2.81 2.7 2.7 2.88
PROVEAN neutral neutral neutral deleterious deleterious neutral
PROVEAN score -1.95 0.01 0.24 -3.92 -4.34 -2.01
MutationAssessor neutral impact neutral impact neutral impact medium impact neutral impact neutral impact
MutationAssessor score 0.65 0.38 -1.02 2.21 0.14 -0.3
EFIN SP neutral neutral neutral neutral neutral neutral
EFIN SP score 0.76 0.81 0.73 0.77 0.73 0.82
EFIN HD neutral neutral neutral neutral neutral neutral
EFIN HD score 0.63 0.67 0.94 0.44 0.46 0.73
CADD deleterious neutral neutral deleterious deleterious neutral
CADD score 1.95 -0.55 -0.86 2.67 2.01 0.56
CADD phred 15.88 0.16 0.03 20.6 16.27 7.9
VEST pvalue 0.06 0.22 0.35 0.02 0.05 0.16
VEST FDR 0.35 0.45 0.5 0.35 0.35 0.45
PANTHER neutral neutral neutral neutral neutral neutral
PANTHER score 0.27 0.14 0.11 0.44 0.28 0.13
PhD-SNP disease neutral neutral disease disease neutral
PhD-SNP score 0.63 0.23 0.1 0.73 0.53 0.27
SNAP neutral neutral neutral disease neutral neutral
SNAP score 0.25 0.2 0.17 0.6 0.42 0.39
Meta-SNP neutral neutral neutral disease neutral neutral
Meta-SNP score 0.43 0.4 0.26 0.73 0.5 0.42
Meta-SNP RI 1 2 5 5 0 2
CAROL neutral neutral neutral neutral neutral neutral
CAROL score 0.49 0 0.52 0.93 0.82 0.49
Condel deleterious deleterious deleterious neutral deleterious deleterious
Condel score 0.64 1 0.74 0.43 0.53 0.76
COVEC WMV neutral neutral neutral neutral neutral neutral
COVEC WMV score -6 -6 -6 -3 -6 -6
MtoolBox neutral neutral neutral neutral neutral neutral
MtoolBox DS 0.16 0.08 0.08 0.24 0.15 0.08
PolyPhen2 transf medium impact high impact high impact medium impact medium impact high impact
PolyPhen2 transf score -0.08 2.07 2.07 -0.21 0.15 2.07
SIFT_transf medium impact high impact medium impact medium impact medium impact medium impact
SIFT transf score 0.21 1.96 0.26 -0.4 -0.13 0.29
MutationAssessor transf medium impact medium impact low impact medium impact low impact low impact
MutationAssessor transf score -0.62 -0.86 -2.08 0.74 -1.07 -1.45
CHASM pvalue 0.36 0.52 0.77 0.1 0.24 0.31
CHASM FDR 0.8 0.8 0.85 0.8 0.8 0.8
APOGEE Neutral Neutral Neutral Neutral Neutral Neutral
APOGEE score 0.36 0.3 0.42 0.34 0.38 0.3
SNPDryad score 0.65 0.39 0.03 0.84 0.86 0.49
MutationTaster polymorphism polymorphism polymorphism polymorphism polymorphism polymorphism
MutationTaster score 1 1 1 1 1 1
DEOGEN2 score 0.04 0.01 0.01 0.22 0.11 0.04
Mitoclass.1 neutral neutral neutral damaging neutral neutral
dbSNP 153 id . . rs878853008 . . .
ClinVar March2020 ClinSig . . Benign/Likely_benign . . .
ClinVar March2020 ClnDBN . . Leigh_syndrome|not_provided . . .
ClinVar March2020 ClnAllele id . . 237002 . . .
ClinVar March2020 ClnDSDB . . MedGen:C0023264,OMIM:256000,Orphanet:ORPHA506,SNOMED_CT:29570005|MedGen:CN517202 . . .
COSMIC 90 . . . . . .
CPD Frequency . . . . . .
MITOMAP Allele . . . . . .
MITOMAP Phenotype . . . . . .
MITOMAP Homoplasmy . . . . . .
MITOMAP Heteroplasmy . . . . . .
MITOMAP Status . . . . . .
MITOMAP NRef . . . . . .
EVmutation MT-ND1_305V|306S:0.080671 MT-ND1_305V|306S:0.080671 MT-ND1_305V|306S:0.080671 MT-ND1_305V|306S:0.080671 MT-ND1_305V|306S:0.080671 MT-ND1_305V|306S:0.080671
Site A InterP ND1_305 ND1_305 ND1_305 ND1_305 ND1_305 ND1_305
Site B InterP ND3_10;ND4_51;ND4_367;ND4_350;ND4_416;ND4L_61;ND4L_44;ND6_109;ND4L_73 ND3_10;ND4_51;ND4_367;ND4_350;ND4_416;ND4L_61;ND4L_44;ND6_109;ND4L_73 ND3_10;ND4_51;ND4_367;ND4_350;ND4_416;ND4L_61;ND4L_44;ND6_109;ND4L_73 ND3_10;ND4_51;ND4_367;ND4_350;ND4_416;ND4L_61;ND4L_44;ND6_109;ND4L_73 ND3_10;ND4_51;ND4_367;ND4_350;ND4_416;ND4L_61;ND4L_44;ND6_109;ND4L_73 ND3_10;ND4_51;ND4_367;ND4_350;ND4_416;ND4L_61;ND4L_44;ND6_109;ND4L_73
Covariation Score InterP mfDCA_37.05;mfDCA_41.56;mfDCA_32.89;mfDCA_25.86;mfDCA_24.64;mfDCA_21.86;mfDCA_20.68;mfDCA_21.68;cMI_51.87176 mfDCA_37.05;mfDCA_41.56;mfDCA_32.89;mfDCA_25.86;mfDCA_24.64;mfDCA_21.86;mfDCA_20.68;mfDCA_21.68;cMI_51.87176 mfDCA_37.05;mfDCA_41.56;mfDCA_32.89;mfDCA_25.86;mfDCA_24.64;mfDCA_21.86;mfDCA_20.68;mfDCA_21.68;cMI_51.87176 mfDCA_37.05;mfDCA_41.56;mfDCA_32.89;mfDCA_25.86;mfDCA_24.64;mfDCA_21.86;mfDCA_20.68;mfDCA_21.68;cMI_51.87176 mfDCA_37.05;mfDCA_41.56;mfDCA_32.89;mfDCA_25.86;mfDCA_24.64;mfDCA_21.86;mfDCA_20.68;mfDCA_21.68;cMI_51.87176 mfDCA_37.05;mfDCA_41.56;mfDCA_32.89;mfDCA_25.86;mfDCA_24.64;mfDCA_21.86;mfDCA_20.68;mfDCA_21.68;cMI_51.87176
Site A IntraP ND1_305 ND1_305 ND1_305 ND1_305 ND1_305 ND1_305
Site B IntraP ND1_250;ND1_309;ND1_64;ND1_178;ND1_229;ND1_248;ND1_72 ND1_250;ND1_309;ND1_64;ND1_178;ND1_229;ND1_248;ND1_72 ND1_250;ND1_309;ND1_64;ND1_178;ND1_229;ND1_248;ND1_72 ND1_250;ND1_309;ND1_64;ND1_178;ND1_229;ND1_248;ND1_72 ND1_250;ND1_309;ND1_64;ND1_178;ND1_229;ND1_248;ND1_72 ND1_250;ND1_309;ND1_64;ND1_178;ND1_229;ND1_248;ND1_72
Covariation Score IntraP mfDCA_24.0795;mfDCA_22.4663;mfDCA_21.8998;mfDCA_18.6721;mfDCA_17.7758;mfDCA_15.9008;mfDCA_15.7482 mfDCA_24.0795;mfDCA_22.4663;mfDCA_21.8998;mfDCA_18.6721;mfDCA_17.7758;mfDCA_15.9008;mfDCA_15.7482 mfDCA_24.0795;mfDCA_22.4663;mfDCA_21.8998;mfDCA_18.6721;mfDCA_17.7758;mfDCA_15.9008;mfDCA_15.7482 mfDCA_24.0795;mfDCA_22.4663;mfDCA_21.8998;mfDCA_18.6721;mfDCA_17.7758;mfDCA_15.9008;mfDCA_15.7482 mfDCA_24.0795;mfDCA_22.4663;mfDCA_21.8998;mfDCA_18.6721;mfDCA_17.7758;mfDCA_15.9008;mfDCA_15.7482 mfDCA_24.0795;mfDCA_22.4663;mfDCA_21.8998;mfDCA_18.6721;mfDCA_17.7758;mfDCA_15.9008;mfDCA_15.7482
CPD AA ref . . . . . .
CPD AA alt . . . . . .
CPD Aln pos . . . . . .
CPD Species name . . . . . .
CPD RefSeq Protein ID . . . . . .
CPD Ncbi Taxon id . . . . . .
DDG intra MT-ND1:V305F:I309V:0.119928:-0.223954:0.472429;MT-ND1:V305F:I309T:-0.390035:-0.223954:-0.218062;MT-ND1:V305F:I309M:-0.672362:-0.223954:-0.249539;MT-ND1:V305F:I309N:-0.195582:-0.223954:0.437388;MT-ND1:V305F:I309F:-0.727529:-0.223954:-0.269124;MT-ND1:V305F:I309L:-0.531359:-0.223954:-0.294795;MT-ND1:V305F:I309S:-0.0641067:-0.223954:0.0335882;MT-ND1:V305F:S178T:1.00545:-0.223954:1.24813;MT-ND1:V305F:S178P:4.60225:-0.223954:4.74959;MT-ND1:V305F:S178L:1.85669:-0.223954:2.01303;MT-ND1:V305F:S178A:0.058249:-0.223954:0.272896;MT-ND1:V305F:S178W:27.5743:-0.223954:20.7782;MT-ND1:V305F:T229K:1.29552:-0.223954:0.836345;MT-ND1:V305F:T229P:1.76011:-0.223954:2.27594;MT-ND1:V305F:T229S:-0.601209:-0.223954:-0.208557;MT-ND1:V305F:T229M:-3.85859:-0.223954:-3.75864;MT-ND1:V305F:T229A:-1.05683:-0.223954:-0.589902;MT-ND1:V305F:I72N:0.228661:-0.223954:0.500478;MT-ND1:V305F:I72V:0.0375724:-0.223954:0.418455;MT-ND1:V305F:I72F:-0.232201:-0.223954:0.0882582;MT-ND1:V305F:I72T:0.569138:-0.223954:0.813886;MT-ND1:V305F:I72L:-0.295815:-0.223954:-0.0699018;MT-ND1:V305F:I72M:-0.721317:-0.223954:-0.242564;MT-ND1:V305F:I72S:-0.0228275:-0.223954:0.259938 MT-ND1:V305L:I309M:-1.4981:-1.22193:-0.249539;MT-ND1:V305L:I309L:-1.40451:-1.22193:-0.294795;MT-ND1:V305L:I309S:-1.23236:-1.22193:0.0335882;MT-ND1:V305L:I309F:-1.43827:-1.22193:-0.269124;MT-ND1:V305L:I309T:-1.42389:-1.22193:-0.218062;MT-ND1:V305L:I309V:-0.746552:-1.22193:0.472429;MT-ND1:V305L:I309N:-0.867703:-1.22193:0.437388;MT-ND1:V305L:S178W:20.5661:-1.22193:20.7782;MT-ND1:V305L:S178T:-1.79412:-1.22193:1.24813;MT-ND1:V305L:S178A:-0.944899:-1.22193:0.272896;MT-ND1:V305L:S178L:0.808509:-1.22193:2.01303;MT-ND1:V305L:S178P:3.80303:-1.22193:4.74959;MT-ND1:V305L:T229K:-0.324422:-1.22193:0.836345;MT-ND1:V305L:T229P:1.05585:-1.22193:2.27594;MT-ND1:V305L:T229M:-4.84554:-1.22193:-3.75864;MT-ND1:V305L:T229A:-1.80279:-1.22193:-0.589902;MT-ND1:V305L:T229S:-1.45318:-1.22193:-0.208557;MT-ND1:V305L:I72N:-0.719648:-1.22193:0.500478;MT-ND1:V305L:I72F:-1.11272:-1.22193:0.0882582;MT-ND1:V305L:I72M:-1.46513:-1.22193:-0.242564;MT-ND1:V305L:I72S:-0.913356:-1.22193:0.259938;MT-ND1:V305L:I72L:-1.34198:-1.22193:-0.0699018;MT-ND1:V305L:I72T:-0.405893:-1.22193:0.813886;MT-ND1:V305L:I72V:-0.798:-1.22193:0.418455 MT-ND1:V305I:I309F:-1.13619:-0.869:-0.269124;MT-ND1:V305I:I309S:-0.806121:-0.869:0.0335882;MT-ND1:V305I:I309L:-1.20354:-0.869:-0.294795;MT-ND1:V305I:I309M:-1.15083:-0.869:-0.249539;MT-ND1:V305I:I309N:-0.435544:-0.869:0.437388;MT-ND1:V305I:I309V:-0.400428:-0.869:0.472429;MT-ND1:V305I:I309T:-1.09017:-0.869:-0.218062;MT-ND1:V305I:S178L:1.25445:-0.869:2.01303;MT-ND1:V305I:S178W:22.3166:-0.869:20.7782;MT-ND1:V305I:S178A:-0.611986:-0.869:0.272896;MT-ND1:V305I:S178P:4.18659:-0.869:4.74959;MT-ND1:V305I:S178T:0.671172:-0.869:1.24813;MT-ND1:V305I:T229S:-1.07859:-0.869:-0.208557;MT-ND1:V305I:T229A:-1.46389:-0.869:-0.589902;MT-ND1:V305I:T229M:-4.53373:-0.869:-3.75864;MT-ND1:V305I:T229P:1.40874:-0.869:2.27594;MT-ND1:V305I:T229K:0.235581:-0.869:0.836345;MT-ND1:V305I:I72L:-0.962317:-0.869:-0.0699018;MT-ND1:V305I:I72M:-1.11274:-0.869:-0.242564;MT-ND1:V305I:I72F:-0.754768:-0.869:0.0882582;MT-ND1:V305I:I72T:-0.0606689:-0.869:0.813886;MT-ND1:V305I:I72S:-0.611827:-0.869:0.259938;MT-ND1:V305I:I72V:-0.447626:-0.869:0.418455;MT-ND1:V305I:I72N:-0.381318:-0.869:0.500478 MT-ND1:V305D:I309S:2.36513:2.34959:0.0335882;MT-ND1:V305D:I309M:2.147:2.34959:-0.249539;MT-ND1:V305D:I309L:2.15026:2.34959:-0.294795;MT-ND1:V305D:I309N:2.76734:2.34959:0.437388;MT-ND1:V305D:I309F:2.11333:2.34959:-0.269124;MT-ND1:V305D:I309V:2.82438:2.34959:0.472429;MT-ND1:V305D:I309T:2.12524:2.34959:-0.218062;MT-ND1:V305D:S178P:7.44778:2.34959:4.74959;MT-ND1:V305D:S178A:2.63589:2.34959:0.272896;MT-ND1:V305D:S178T:2.656:2.34959:1.24813;MT-ND1:V305D:S178W:26.2012:2.34959:20.7782;MT-ND1:V305D:T229K:3.00189:2.34959:0.836345;MT-ND1:V305D:T229A:1.78085:2.34959:-0.589902;MT-ND1:V305D:T229M:-1.1674:2.34959:-3.75864;MT-ND1:V305D:T229P:4.65877:2.34959:2.27594;MT-ND1:V305D:I72N:2.87335:2.34959:0.500478;MT-ND1:V305D:I72V:2.79349:2.34959:0.418455;MT-ND1:V305D:I72T:3.18546:2.34959:0.813886;MT-ND1:V305D:I72F:2.48884:2.34959:0.0882582;MT-ND1:V305D:I72L:2.28466:2.34959:-0.0699018;MT-ND1:V305D:I72M:2.14511:2.34959:-0.242564;MT-ND1:V305D:S178L:4.60319:2.34959:2.01303;MT-ND1:V305D:T229S:2.14889:2.34959:-0.208557;MT-ND1:V305D:I72S:2.58868:2.34959:0.259938 MT-ND1:V305G:I309V:1.82302:1.41586:0.472429;MT-ND1:V305G:I309M:1.07375:1.41586:-0.249539;MT-ND1:V305G:I309T:1.14112:1.41586:-0.218062;MT-ND1:V305G:I309S:1.36991:1.41586:0.0335882;MT-ND1:V305G:I309L:1.20097:1.41586:-0.294795;MT-ND1:V305G:I309N:1.75321:1.41586:0.437388;MT-ND1:V305G:I309F:1.13218:1.41586:-0.269124;MT-ND1:V305G:S178L:3.3864:1.41586:2.01303;MT-ND1:V305G:S178A:1.68183:1.41586:0.272896;MT-ND1:V305G:S178W:26.7478:1.41586:20.7782;MT-ND1:V305G:S178P:6.28073:1.41586:4.74959;MT-ND1:V305G:S178T:1.45186:1.41586:1.24813;MT-ND1:V305G:T229M:-2.22458:1.41586:-3.75864;MT-ND1:V305G:T229A:0.831399:1.41586:-0.589902;MT-ND1:V305G:T229P:3.68762:1.41586:2.27594;MT-ND1:V305G:T229K:2.77805:1.41586:0.836345;MT-ND1:V305G:T229S:1.17688:1.41586:-0.208557;MT-ND1:V305G:I72F:1.46324:1.41586:0.0882582;MT-ND1:V305G:I72T:2.21894:1.41586:0.813886;MT-ND1:V305G:I72L:1.31145:1.41586:-0.0699018;MT-ND1:V305G:I72M:1.17271:1.41586:-0.242564;MT-ND1:V305G:I72S:1.67227:1.41586:0.259938;MT-ND1:V305G:I72N:1.91646:1.41586:0.500478;MT-ND1:V305G:I72V:1.82411:1.41586:0.418455 MT-ND1:V305A:I309V:1.28565:0.793804:0.472429;MT-ND1:V305A:I309N:1.20168:0.793804:0.437388;MT-ND1:V305A:I309L:0.550233:0.793804:-0.294795;MT-ND1:V305A:I309T:0.617013:0.793804:-0.218062;MT-ND1:V305A:I309S:0.808097:0.793804:0.0335882;MT-ND1:V305A:I309M:0.636913:0.793804:-0.249539;MT-ND1:V305A:I309F:0.555773:0.793804:-0.269124;MT-ND1:V305A:S178A:1.05109:0.793804:0.272896;MT-ND1:V305A:S178W:24.6175:0.793804:20.7782;MT-ND1:V305A:S178L:2.92605:0.793804:2.01303;MT-ND1:V305A:S178T:0.87021:0.793804:1.24813;MT-ND1:V305A:S178P:5.78176:0.793804:4.74959;MT-ND1:V305A:T229M:-2.61731:0.793804:-3.75864;MT-ND1:V305A:T229A:0.188347:0.793804:-0.589902;MT-ND1:V305A:T229K:2.10378:0.793804:0.836345;MT-ND1:V305A:T229S:0.575211:0.793804:-0.208557;MT-ND1:V305A:T229P:3.07922:0.793804:2.27594;MT-ND1:V305A:I72F:0.920478:0.793804:0.0882582;MT-ND1:V305A:I72M:0.549126:0.793804:-0.242564;MT-ND1:V305A:I72S:1.06371:0.793804:0.259938;MT-ND1:V305A:I72T:1.60702:0.793804:0.813886;MT-ND1:V305A:I72L:0.692854:0.793804:-0.0699018;MT-ND1:V305A:I72N:1.26405:0.793804:0.500478;MT-ND1:V305A:I72V:1.21995:0.793804:0.418455
DDG intra interface MT-ND1:MT-ND3:5lc5:H:A:V305F:I309F:-0.56578:-2.16007:0.55258;MT-ND1:MT-ND3:5lc5:H:A:V305F:I309L:-2.14208:-2.16007:-0.19955;MT-ND1:MT-ND3:5lc5:H:A:V305F:I309M:-1.83163:-2.16007:-0.1133;MT-ND1:MT-ND3:5lc5:H:A:V305F:I309N:0.32477:-2.16007:2.70746;MT-ND1:MT-ND3:5lc5:H:A:V305F:I309S:0.45502:-2.16007:3.17307;MT-ND1:MT-ND3:5lc5:H:A:V305F:I309T:-0.65755:-2.16007:1.90168;MT-ND1:MT-ND3:5lc5:H:A:V305F:I309V:-1.47791:-2.16007:0.61358;MT-ND1:MT-ND3:5ldw:H:A:V305F:I309F:-1.01752:-1.55959:0.8733;MT-ND1:MT-ND3:5ldw:H:A:V305F:I309L:-1.24375:-1.55959:-0.00810000000001;MT-ND1:MT-ND3:5ldw:H:A:V305F:I309M:-0.83015:-1.55959:0.6466;MT-ND1:MT-ND3:5ldw:H:A:V305F:I309N:1.18155:-1.55959:2.99749;MT-ND1:MT-ND3:5ldw:H:A:V305F:I309S:0.78329:-1.55959:3.33174;MT-ND1:MT-ND3:5ldw:H:A:V305F:I309T:0.34621:-1.55959:1.96406;MT-ND1:MT-ND3:5ldw:H:A:V305F:I309V:-0.86491:-1.55959:1.19179;MT-ND1:MT-ND3:5ldx:H:A:V305F:I309F:-1.31194:-1.1139:1.09811;MT-ND1:MT-ND3:5ldx:H:A:V305F:I309L:-1.96866:-1.1139:-0.31791;MT-ND1:MT-ND3:5ldx:H:A:V305F:I309M:-1.75434:-1.1139:0.64263;MT-ND1:MT-ND3:5ldx:H:A:V305F:I309N:0.74815:-1.1139:3.0722;MT-ND1:MT-ND3:5ldx:H:A:V305F:I309S:0.6016:-1.1139:3.39694;MT-ND1:MT-ND3:5ldx:H:A:V305F:I309T:0.13529:-1.1139:2.01322;MT-ND1:MT-ND3:5ldx:H:A:V305F:I309V:-0.83147:-1.1139:1.22919 MT-ND1:MT-ND3:5lc5:H:A:V305L:I309F:-0.27973:-1.43269:0.55258;MT-ND1:MT-ND3:5lc5:H:A:V305L:I309L:-1.40093:-1.43269:-0.19955;MT-ND1:MT-ND3:5lc5:H:A:V305L:I309M:-1.20798:-1.43269:-0.1133;MT-ND1:MT-ND3:5lc5:H:A:V305L:I309N:1.49436:-1.43269:2.70746;MT-ND1:MT-ND3:5lc5:H:A:V305L:I309S:1.90057:-1.43269:3.17307;MT-ND1:MT-ND3:5lc5:H:A:V305L:I309T:0.62335:-1.43269:1.90168;MT-ND1:MT-ND3:5lc5:H:A:V305L:I309V:-0.71235:-1.43269:0.61358;MT-ND1:MT-ND3:5ldw:H:A:V305L:I309F:-0.19235:-1.1471:0.8733;MT-ND1:MT-ND3:5ldw:H:A:V305L:I309L:-0.7551:-1.1471:-0.00810000000001;MT-ND1:MT-ND3:5ldw:H:A:V305L:I309M:-0.53636:-1.1471:0.6466;MT-ND1:MT-ND3:5ldw:H:A:V305L:I309N:1.76922:-1.1471:2.99749;MT-ND1:MT-ND3:5ldw:H:A:V305L:I309S:2.13239:-1.1471:3.33174;MT-ND1:MT-ND3:5ldw:H:A:V305L:I309T:0.85182:-1.1471:1.96406;MT-ND1:MT-ND3:5ldw:H:A:V305L:I309V:-0.16983:-1.1471:1.19179;MT-ND1:MT-ND3:5ldx:H:A:V305L:I309F:-0.22833:-1.41629:1.09811;MT-ND1:MT-ND3:5ldx:H:A:V305L:I309L:-1.38081:-1.41629:-0.31791;MT-ND1:MT-ND3:5ldx:H:A:V305L:I309M:-0.5685:-1.41629:0.64263;MT-ND1:MT-ND3:5ldx:H:A:V305L:I309N:1.62802:-1.41629:3.0722;MT-ND1:MT-ND3:5ldx:H:A:V305L:I309S:1.70886:-1.41629:3.39694;MT-ND1:MT-ND3:5ldx:H:A:V305L:I309T:0.66863:-1.41629:2.01322;MT-ND1:MT-ND3:5ldx:H:A:V305L:I309V:-0.23859:-1.41629:1.22919 MT-ND1:MT-ND3:5lc5:H:A:V305I:I309F:1.34162:0.56232:0.55258;MT-ND1:MT-ND3:5lc5:H:A:V305I:I309L:-0.10422:0.56232:-0.19955;MT-ND1:MT-ND3:5lc5:H:A:V305I:I309M:0.11297:0.56232:-0.1133;MT-ND1:MT-ND3:5lc5:H:A:V305I:I309N:3.21341:0.56232:2.70746;MT-ND1:MT-ND3:5lc5:H:A:V305I:I309S:3.3232:0.56232:3.17307;MT-ND1:MT-ND3:5lc5:H:A:V305I:I309T:2.19797:0.56232:1.90168;MT-ND1:MT-ND3:5lc5:H:A:V305I:I309V:1.21239:0.56232:0.61358;MT-ND1:MT-ND3:5ldw:H:A:V305I:I309F:2.14223:1.42111:0.8733;MT-ND1:MT-ND3:5ldw:H:A:V305I:I309L:1.29243:1.42111:-0.00810000000001;MT-ND1:MT-ND3:5ldw:H:A:V305I:I309M:2.39137:1.42111:0.6466;MT-ND1:MT-ND3:5ldw:H:A:V305I:I309N:4.3981:1.42111:2.99749;MT-ND1:MT-ND3:5ldw:H:A:V305I:I309S:4.71863:1.42111:3.33174;MT-ND1:MT-ND3:5ldw:H:A:V305I:I309T:3.49537:1.42111:1.96406;MT-ND1:MT-ND3:5ldw:H:A:V305I:I309V:2.52002:1.42111:1.19179;MT-ND1:MT-ND3:5ldx:H:A:V305I:I309F:1.96097:0.12686:1.09811;MT-ND1:MT-ND3:5ldx:H:A:V305I:I309L:-0.05395:0.12686:-0.31791;MT-ND1:MT-ND3:5ldx:H:A:V305I:I309M:1.23777:0.12686:0.64263;MT-ND1:MT-ND3:5ldx:H:A:V305I:I309N:3.07261:0.12686:3.0722;MT-ND1:MT-ND3:5ldx:H:A:V305I:I309S:3.39299:0.12686:3.39694;MT-ND1:MT-ND3:5ldx:H:A:V305I:I309T:2.04241:0.12686:2.01322;MT-ND1:MT-ND3:5ldx:H:A:V305I:I309V:1.76228:0.12686:1.22919 MT-ND1:MT-ND3:5lc5:H:A:V305D:I309F:3.61662:3.12026:0.55258;MT-ND1:MT-ND3:5lc5:H:A:V305D:I309L:2.82956:3.12026:-0.19955;MT-ND1:MT-ND3:5lc5:H:A:V305D:I309M:3.45423:3.12026:-0.1133;MT-ND1:MT-ND3:5lc5:H:A:V305D:I309N:5.9234:3.12026:2.70746;MT-ND1:MT-ND3:5lc5:H:A:V305D:I309S:6.31912:3.12026:3.17307;MT-ND1:MT-ND3:5lc5:H:A:V305D:I309T:5.02859:3.12026:1.90168;MT-ND1:MT-ND3:5lc5:H:A:V305D:I309V:3.70596:3.12026:0.61358;MT-ND1:MT-ND3:5ldw:H:A:V305D:I309F:4.55987:3.81919:0.8733;MT-ND1:MT-ND3:5ldw:H:A:V305D:I309L:3.79292:3.81919:-0.00810000000001;MT-ND1:MT-ND3:5ldw:H:A:V305D:I309M:4.69843:3.81919:0.6466;MT-ND1:MT-ND3:5ldw:H:A:V305D:I309N:6.8996:3.81919:2.99749;MT-ND1:MT-ND3:5ldw:H:A:V305D:I309S:7.17469:3.81919:3.33174;MT-ND1:MT-ND3:5ldw:H:A:V305D:I309T:5.92721:3.81919:1.96406;MT-ND1:MT-ND3:5ldw:H:A:V305D:I309V:4.97216:3.81919:1.19179;MT-ND1:MT-ND3:5ldx:H:A:V305D:I309F:4.46816:3.3723:1.09811;MT-ND1:MT-ND3:5ldx:H:A:V305D:I309L:3.03283:3.3723:-0.31791;MT-ND1:MT-ND3:5ldx:H:A:V305D:I309M:4.289:3.3723:0.64263;MT-ND1:MT-ND3:5ldx:H:A:V305D:I309N:6.41703:3.3723:3.0722;MT-ND1:MT-ND3:5ldx:H:A:V305D:I309S:6.48901:3.3723:3.39694;MT-ND1:MT-ND3:5ldx:H:A:V305D:I309T:5.46549:3.3723:2.01322;MT-ND1:MT-ND3:5ldx:H:A:V305D:I309V:4.50528:3.3723:1.22919 MT-ND1:MT-ND3:5lc5:H:A:V305G:I309F:3.75618:2.64266:0.55258;MT-ND1:MT-ND3:5lc5:H:A:V305G:I309L:2.433:2.64266:-0.19955;MT-ND1:MT-ND3:5lc5:H:A:V305G:I309M:2.42469:2.64266:-0.1133;MT-ND1:MT-ND3:5lc5:H:A:V305G:I309N:5.50831:2.64266:2.70746;MT-ND1:MT-ND3:5lc5:H:A:V305G:I309S:5.84297:2.64266:3.17307;MT-ND1:MT-ND3:5lc5:H:A:V305G:I309T:4.55828:2.64266:1.90168;MT-ND1:MT-ND3:5lc5:H:A:V305G:I309V:3.27329:2.64266:0.61358;MT-ND1:MT-ND3:5ldw:H:A:V305G:I309F:4.09994:3.07753:0.8733;MT-ND1:MT-ND3:5ldw:H:A:V305G:I309L:3.14811:3.07753:-0.00810000000001;MT-ND1:MT-ND3:5ldw:H:A:V305G:I309M:4.11169:3.07753:0.6466;MT-ND1:MT-ND3:5ldw:H:A:V305G:I309N:6.1782:3.07753:2.99749;MT-ND1:MT-ND3:5ldw:H:A:V305G:I309S:6.41259:3.07753:3.33174;MT-ND1:MT-ND3:5ldw:H:A:V305G:I309T:5.1288:3.07753:1.96406;MT-ND1:MT-ND3:5ldw:H:A:V305G:I309V:4.21568:3.07753:1.19179;MT-ND1:MT-ND3:5ldx:H:A:V305G:I309F:4.11492:2.67583:1.09811;MT-ND1:MT-ND3:5ldx:H:A:V305G:I309L:2.32373:2.67583:-0.31791;MT-ND1:MT-ND3:5ldx:H:A:V305G:I309M:3.68638:2.67583:0.64263;MT-ND1:MT-ND3:5ldx:H:A:V305G:I309N:5.72403:2.67583:3.0722;MT-ND1:MT-ND3:5ldx:H:A:V305G:I309S:5.80913:2.67583:3.39694;MT-ND1:MT-ND3:5ldx:H:A:V305G:I309T:4.7341:2.67583:2.01322;MT-ND1:MT-ND3:5ldx:H:A:V305G:I309V:3.80264:2.67583:1.22919 MT-ND1:MT-ND3:5lc5:H:A:V305A:I309F:2.88306:1.92952:0.55258;MT-ND1:MT-ND3:5lc5:H:A:V305A:I309L:1.61336:1.92952:-0.19955;MT-ND1:MT-ND3:5lc5:H:A:V305A:I309M:1.91596:1.92952:-0.1133;MT-ND1:MT-ND3:5lc5:H:A:V305A:I309N:4.74451:1.92952:2.70746;MT-ND1:MT-ND3:5lc5:H:A:V305A:I309S:5.06966:1.92952:3.17307;MT-ND1:MT-ND3:5lc5:H:A:V305A:I309T:3.78578:1.92952:1.90168;MT-ND1:MT-ND3:5lc5:H:A:V305A:I309V:2.50214:1.92952:0.61358;MT-ND1:MT-ND3:5ldw:H:A:V305A:I309F:3.34976:2.20052:0.8733;MT-ND1:MT-ND3:5ldw:H:A:V305A:I309L:2.70407:2.20052:-0.00810000000001;MT-ND1:MT-ND3:5ldw:H:A:V305A:I309M:3.03172:2.20052:0.6466;MT-ND1:MT-ND3:5ldw:H:A:V305A:I309N:5.20012:2.20052:2.99749;MT-ND1:MT-ND3:5ldw:H:A:V305A:I309S:5.49733:2.20052:3.33174;MT-ND1:MT-ND3:5ldw:H:A:V305A:I309T:4.2463:2.20052:1.96406;MT-ND1:MT-ND3:5ldw:H:A:V305A:I309V:3.31589:2.20052:1.19179;MT-ND1:MT-ND3:5ldx:H:A:V305A:I309F:3.26489:1.99239:1.09811;MT-ND1:MT-ND3:5ldx:H:A:V305A:I309L:1.70756:1.99239:-0.31791;MT-ND1:MT-ND3:5ldx:H:A:V305A:I309M:3.11838:1.99239:0.64263;MT-ND1:MT-ND3:5ldx:H:A:V305A:I309N:5.04517:1.99239:3.0722;MT-ND1:MT-ND3:5ldx:H:A:V305A:I309S:5.11491:1.99239:3.39694;MT-ND1:MT-ND3:5ldx:H:A:V305A:I309T:4.07485:1.99239:2.01322;MT-ND1:MT-ND3:5ldx:H:A:V305A:I309V:3.133:1.99239:1.22919
DDG inter MT-ND1:MT-ND3:5lc5:H:A:V305F:N10T:-2.92942:-2.1739502:-0.845690131;MT-ND1:MT-ND3:5lc5:H:A:V305F:N10I:-2.9242:-2.1739502:-0.200120538;MT-ND1:MT-ND3:5lc5:H:A:V305F:N10D:-0.18911:-2.1739502:1.9348892;MT-ND1:MT-ND3:5lc5:H:A:V305F:N10S:-1.04288:-2.1739502:1.00994909;MT-ND1:MT-ND3:5lc5:H:A:V305F:N10H:-2.74569:-2.1739502:-0.468639374;MT-ND1:MT-ND3:5lc5:H:A:V305F:N10Y:-3.08428:-2.1739502:-1.04049873;MT-ND1:MT-ND3:5lc5:H:A:V305F:N10K:-1.5455:-2.1739502:0.559670269;MT-ND1:MT-ND3:5ldw:H:A:V305F:N10T:-1.60022:-0.851601005:-0.944197059;MT-ND1:MT-ND3:5ldw:H:A:V305F:N10I:-2.77025:-0.851601005:-1.98465884;MT-ND1:MT-ND3:5ldw:H:A:V305F:N10D:0.96043:-0.851601005:1.56138194;MT-ND1:MT-ND3:5ldw:H:A:V305F:N10S:0.11619:-0.851601005:0.722851157;MT-ND1:MT-ND3:5ldw:H:A:V305F:N10H:-2.30228:-0.851601005:-1.41110837;MT-ND1:MT-ND3:5ldw:H:A:V305F:N10Y:-2.33086:-0.851601005:-1.868029;MT-ND1:MT-ND3:5ldw:H:A:V305F:N10K:-2.25776:-0.851601005:-0.557247937;MT-ND1:MT-ND3:5ldx:H:A:V305F:N10T:-1.88928:-1.10611987:-0.727460086;MT-ND1:MT-ND3:5ldx:H:A:V305F:N10I:-2.6484:-1.10611987:-1.75487101;MT-ND1:MT-ND3:5ldx:H:A:V305F:N10D:0.46146:-1.10611987:1.77093887;MT-ND1:MT-ND3:5ldx:H:A:V305F:N10S:0.21132:-1.10611987:0.834559619;MT-ND1:MT-ND3:5ldx:H:A:V305F:N10H:-2.12036:-1.10611987:-1.23474002;MT-ND1:MT-ND3:5ldx:H:A:V305F:N10Y:-2.90224:-1.10611987:-1.7146492;MT-ND1:MT-ND3:5ldx:H:A:V305F:N10K:-1.65306:-1.10611987:-0.983650565 MT-ND1:MT-ND3:5lc5:H:A:V305L:N10T:-2.19796:-1.39616168:-0.845690131;MT-ND1:MT-ND3:5lc5:H:A:V305L:N10K:-0.77525:-1.39616168:0.559670269;MT-ND1:MT-ND3:5lc5:H:A:V305L:N10H:-1.96435:-1.39616168:-0.468639374;MT-ND1:MT-ND3:5lc5:H:A:V305L:N10D:0.57164:-1.39616168:1.9348892;MT-ND1:MT-ND3:5lc5:H:A:V305L:N10Y:-2.58335:-1.39616168:-1.04049873;MT-ND1:MT-ND3:5lc5:H:A:V305L:N10I:-2.04876:-1.39616168:-0.200120538;MT-ND1:MT-ND3:5lc5:H:A:V305L:N10S:-0.29366:-1.39616168:1.00994909;MT-ND1:MT-ND3:5ldw:H:A:V305L:N10T:-2.05459:-1.10788035:-0.944197059;MT-ND1:MT-ND3:5ldw:H:A:V305L:N10K:-1.71841:-1.10788035:-0.557247937;MT-ND1:MT-ND3:5ldw:H:A:V305L:N10H:-2.46713:-1.10788035:-1.41110837;MT-ND1:MT-ND3:5ldw:H:A:V305L:N10D:0.38127:-1.10788035:1.56138194;MT-ND1:MT-ND3:5ldw:H:A:V305L:N10Y:-3.04744:-1.10788035:-1.868029;MT-ND1:MT-ND3:5ldw:H:A:V305L:N10I:-3.19333:-1.10788035:-1.98465884;MT-ND1:MT-ND3:5ldw:H:A:V305L:N10S:-0.38243:-1.10788035:0.722851157;MT-ND1:MT-ND3:5ldx:H:A:V305L:N10T:-2.0752:-1.41837955:-0.727460086;MT-ND1:MT-ND3:5ldx:H:A:V305L:N10K:-2.39057:-1.41837955:-0.983650565;MT-ND1:MT-ND3:5ldx:H:A:V305L:N10H:-2.71028:-1.41837955:-1.23474002;MT-ND1:MT-ND3:5ldx:H:A:V305L:N10D:0.40676:-1.41837955:1.77093887;MT-ND1:MT-ND3:5ldx:H:A:V305L:N10Y:-3.69892:-1.41837955:-1.7146492;MT-ND1:MT-ND3:5ldx:H:A:V305L:N10I:-3.15255:-1.41837955:-1.75487101;MT-ND1:MT-ND3:5ldx:H:A:V305L:N10S:-0.52073:-1.41837955:0.834559619 MT-ND1:MT-ND3:5lc5:H:A:V305I:N10S:1.66165:0.511240363:1.00994909;MT-ND1:MT-ND3:5lc5:H:A:V305I:N10D:2.25623:0.511240363:1.9348892;MT-ND1:MT-ND3:5lc5:H:A:V305I:N10T:0.23766:0.511240363:-0.845690131;MT-ND1:MT-ND3:5lc5:H:A:V305I:N10I:-0.58641:0.511240363:-0.200120538;MT-ND1:MT-ND3:5lc5:H:A:V305I:N10H:-0.33634:0.511240363:-0.468639374;MT-ND1:MT-ND3:5lc5:H:A:V305I:N10K:1.14103:0.511240363:0.559670269;MT-ND1:MT-ND3:5lc5:H:A:V305I:N10Y:-0.93517:0.511240363:-1.04049873;MT-ND1:MT-ND3:5ldw:H:A:V305I:N10S:2.22336:1.48407102:0.722851157;MT-ND1:MT-ND3:5ldw:H:A:V305I:N10D:2.95007:1.48407102:1.56138194;MT-ND1:MT-ND3:5ldw:H:A:V305I:N10T:0.38335:1.48407102:-0.944197059;MT-ND1:MT-ND3:5ldw:H:A:V305I:N10I:-0.4788:1.48407102:-1.98465884;MT-ND1:MT-ND3:5ldw:H:A:V305I:N10H:0.06164:1.48407102:-1.41110837;MT-ND1:MT-ND3:5ldw:H:A:V305I:N10K:0.75026:1.48407102:-0.557247937;MT-ND1:MT-ND3:5ldw:H:A:V305I:N10Y:-0.28157:1.48407102:-1.868029;MT-ND1:MT-ND3:5ldx:H:A:V305I:N10S:0.83923:0.10269966:0.834559619;MT-ND1:MT-ND3:5ldx:H:A:V305I:N10D:1.99761:0.10269966:1.77093887;MT-ND1:MT-ND3:5ldx:H:A:V305I:N10T:-0.4218:0.10269966:-0.727460086;MT-ND1:MT-ND3:5ldx:H:A:V305I:N10I:-1.56658:0.10269966:-1.75487101;MT-ND1:MT-ND3:5ldx:H:A:V305I:N10H:-1.02777:0.10269966:-1.23474002;MT-ND1:MT-ND3:5ldx:H:A:V305I:N10K:-0.57668:0.10269966:-0.983650565;MT-ND1:MT-ND3:5ldx:H:A:V305I:N10Y:-1.60254:0.10269966:-1.7146492 MT-ND1:MT-ND3:5lc5:H:A:V305D:N10H:2.92028:3.12862015:-0.468639374;MT-ND1:MT-ND3:5lc5:H:A:V305D:N10T:2.30751:3.12862015:-0.845690131;MT-ND1:MT-ND3:5lc5:H:A:V305D:N10S:4.25916:3.12862015:1.00994909;MT-ND1:MT-ND3:5lc5:H:A:V305D:N10K:3.61004:3.12862015:0.559670269;MT-ND1:MT-ND3:5lc5:H:A:V305D:N10I:2.89514:3.12862015:-0.200120538;MT-ND1:MT-ND3:5lc5:H:A:V305D:N10Y:2.1728:3.12862015:-1.04049873;MT-ND1:MT-ND3:5lc5:H:A:V305D:N10D:5.13175:3.12862015:1.9348892;MT-ND1:MT-ND3:5ldw:H:A:V305D:N10H:2.45739:3.81080866:-1.41110837;MT-ND1:MT-ND3:5ldw:H:A:V305D:N10T:2.92836:3.81080866:-0.944197059;MT-ND1:MT-ND3:5ldw:H:A:V305D:N10S:4.61387:3.81080866:0.722851157;MT-ND1:MT-ND3:5ldw:H:A:V305D:N10K:3.1055:3.81080866:-0.557247937;MT-ND1:MT-ND3:5ldw:H:A:V305D:N10I:1.78167:3.81080866:-1.98465884;MT-ND1:MT-ND3:5ldw:H:A:V305D:N10Y:2.0629:3.81080866:-1.868029;MT-ND1:MT-ND3:5ldw:H:A:V305D:N10D:5.34692:3.81080866:1.56138194;MT-ND1:MT-ND3:5ldx:H:A:V305D:N10H:2.11344:3.37083101:-1.23474002;MT-ND1:MT-ND3:5ldx:H:A:V305D:N10T:2.76616:3.37083101:-0.727460086;MT-ND1:MT-ND3:5ldx:H:A:V305D:N10S:4.32932:3.37083101:0.834559619;MT-ND1:MT-ND3:5ldx:H:A:V305D:N10K:2.43713:3.37083101:-0.983650565;MT-ND1:MT-ND3:5ldx:H:A:V305D:N10I:1.67832:3.37083101:-1.75487101;MT-ND1:MT-ND3:5ldx:H:A:V305D:N10Y:1.70452:3.37083101:-1.7146492;MT-ND1:MT-ND3:5ldx:H:A:V305D:N10D:5.1231:3.37083101:1.77093887 MT-ND1:MT-ND3:5lc5:H:A:V305G:N10S:3.78371:2.66267157:1.00994909;MT-ND1:MT-ND3:5lc5:H:A:V305G:N10Y:0.92958:2.66267157:-1.04049873;MT-ND1:MT-ND3:5lc5:H:A:V305G:N10T:1.92566:2.66267157:-0.845690131;MT-ND1:MT-ND3:5lc5:H:A:V305G:N10K:3.00747:2.66267157:0.559670269;MT-ND1:MT-ND3:5lc5:H:A:V305G:N10D:4.59602:2.66267157:1.9348892;MT-ND1:MT-ND3:5lc5:H:A:V305G:N10H:2.00185:2.66267157:-0.468639374;MT-ND1:MT-ND3:5lc5:H:A:V305G:N10I:2.53533:2.66267157:-0.200120538;MT-ND1:MT-ND3:5ldw:H:A:V305G:N10S:3.85865:3.10235167:0.722851157;MT-ND1:MT-ND3:5ldw:H:A:V305G:N10Y:1.34165:3.10235167:-1.868029;MT-ND1:MT-ND3:5ldw:H:A:V305G:N10T:2.1546:3.10235167:-0.944197059;MT-ND1:MT-ND3:5ldw:H:A:V305G:N10K:2.54434:3.10235167:-0.557247937;MT-ND1:MT-ND3:5ldw:H:A:V305G:N10D:4.65965:3.10235167:1.56138194;MT-ND1:MT-ND3:5ldw:H:A:V305G:N10H:1.74869:3.10235167:-1.41110837;MT-ND1:MT-ND3:5ldw:H:A:V305G:N10I:1.06377:3.10235167:-1.98465884;MT-ND1:MT-ND3:5ldx:H:A:V305G:N10S:3.58979:2.67550015:0.834559619;MT-ND1:MT-ND3:5ldx:H:A:V305G:N10Y:0.32186:2.67550015:-1.7146492;MT-ND1:MT-ND3:5ldx:H:A:V305G:N10T:1.98526:2.67550015:-0.727460086;MT-ND1:MT-ND3:5ldx:H:A:V305G:N10K:1.71797:2.67550015:-0.983650565;MT-ND1:MT-ND3:5ldx:H:A:V305G:N10D:4.46936:2.67550015:1.77093887;MT-ND1:MT-ND3:5ldx:H:A:V305G:N10H:1.46993:2.67550015:-1.23474002;MT-ND1:MT-ND3:5ldx:H:A:V305G:N10I:0.9032:2.67550015:-1.75487101 MT-ND1:MT-ND3:5lc5:H:A:V305A:N10Y:0.84752:1.90028071:-1.04049873;MT-ND1:MT-ND3:5lc5:H:A:V305A:N10D:3.81584:1.90028071:1.9348892;MT-ND1:MT-ND3:5lc5:H:A:V305A:N10S:2.8869:1.90028071:1.00994909;MT-ND1:MT-ND3:5lc5:H:A:V305A:N10K:2.45861:1.90028071:0.559670269;MT-ND1:MT-ND3:5lc5:H:A:V305A:N10T:1.1108:1.90028071:-0.845690131;MT-ND1:MT-ND3:5lc5:H:A:V305A:N10I:1.70858:1.90028071:-0.200120538;MT-ND1:MT-ND3:5lc5:H:A:V305A:N10H:1.4533:1.90028071:-0.468639374;MT-ND1:MT-ND3:5ldw:H:A:V305A:N10Y:0.45695:2.19327092:-1.868029;MT-ND1:MT-ND3:5ldw:H:A:V305A:N10D:3.76108:2.19327092:1.56138194;MT-ND1:MT-ND3:5ldw:H:A:V305A:N10S:2.92739:2.19327092:0.722851157;MT-ND1:MT-ND3:5ldw:H:A:V305A:N10K:1.65691:2.19327092:-0.557247937;MT-ND1:MT-ND3:5ldw:H:A:V305A:N10T:1.26292:2.19327092:-0.944197059;MT-ND1:MT-ND3:5ldw:H:A:V305A:N10I:0.21075:2.19327092:-1.98465884;MT-ND1:MT-ND3:5ldw:H:A:V305A:N10H:0.78828:2.19327092:-1.41110837;MT-ND1:MT-ND3:5ldx:H:A:V305A:N10Y:0.56894:1.99108887:-1.7146492;MT-ND1:MT-ND3:5ldx:H:A:V305A:N10D:3.75961:1.99108887:1.77093887;MT-ND1:MT-ND3:5ldx:H:A:V305A:N10S:2.8233:1.99108887:0.834559619;MT-ND1:MT-ND3:5ldx:H:A:V305A:N10K:1.00447:1.99108887:-0.983650565;MT-ND1:MT-ND3:5ldx:H:A:V305A:N10T:1.26393:1.99108887:-0.727460086;MT-ND1:MT-ND3:5ldx:H:A:V305A:N10I:0.23609:1.99108887:-1.75487101;MT-ND1:MT-ND3:5ldx:H:A:V305A:N10H:0.7544:1.99108887:-1.23474002
For more info, please check the output legend.
ΔΔG values >±0.61 Kcal/mol are indicative of disrupting variants.
ΔΔG values close to zero (<±0.1 Kcal/mol) are indicative of possibly
compensating double mutants.
For more info, please check the output legend.
ΔΔG values >±0.61 Kcal/mol are indicative of disrupting variants.
ΔΔG values close to zero (<±0.1 Kcal/mol) are indicative of possibly
compensating double mutants.
For more info, please check the output legend.
ΔΔG values >±0.61 Kcal/mol are indicative of disrupting variants.
ΔΔG values close to zero (<±0.1 Kcal/mol) are indicative of possibly
compensating double mutants.
For more info, please check the output legend.
For more info, please check the output legend.
Score:  
0
  [min -20, max 10]
  • Predicted accelerated evolution:  score <= 0
  • Conserved:  score > 0
Score:  
0
  [min 0, max 1]
  • Non-conserved:  score <= 0.9
  • Conserved:  score > 0.9 (soft threshold)
Score:  
0
  [min 0, max 1]
  • Neutral:  score <= 0.15
  • Possibly damaging:  0.15 < score <= 0.85
  • Probably damaging:  score > 0.85
Score:  
0
  [min 0, max 1]
  • Neutral:  score > 0.05
  • Deleterious:  score <= 0.05
Score:  
0
  [min -15, max 10]
  • Neutral:  score > -3
  • Deleterious:  score <= -3
Score:  
0
  [min -3, max 6]
  • Neutral:  score > -1.5
  • Deleterious:  score <= -1.5
Score:  
0
  [min -14, max 14]
  • Neutral:  score > -2.5
  • Deleterious:  score <= -2.5 (soft threshold)
Score:  
0
  [min -6, max 6]
  • Neutral:  score <= 0.8
  • Low impact:  0.8 < score <= 1.9
  • Medium impact:  1.9 < score <= 3.5
  • High impact:  score > 3.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score > 0.6
  • Damaging:  score <= 0.6
Score:  
0
  [min 0, max 1]
  • Neutral:  score > 0.28
  • Damaging:  score <= 0.28
Phred score:  
0
  [min 0, max 35]
  • Neutral:  score < 20 (soft threshold)
  • Deleterious:  score >= 20
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Polymorphism:  score < 0.5
  • Disease causing:  score >= 0.5
P-value:  
0
  [min 0, max 1]
  • Neutral:  p-value > 0.05
  • Pathogenic:  p-value <= 0.05
Score:  
0
  [min 0, max 1]
No hard-thresholds were indicated by authors (ref). Indicatively:
  • Neutral:  score < 0.9
  • Pathogenic:  score >= 0.9
No score. Categorical only
Please refer to Additional File 14: Table S10 for further details.
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.98
  • Deleterious:  score >= 0.98
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Disease:  score >= 0.5
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Deleterious:  score >= 0.5
Score:  
0
  [min -6, max 6]
  • Neutral:  score < 0
  • Deleterious:  score > 0
  • Inaccurate prediction:  score = 0
Score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.5
  • Deleterious:  score >= 0.5
DS score:  
0
  [min 0, max 1]
  • Neutral:  score < 0.43
  • Deleterious:  score >= 0.43
Score:  
0
  [min 0, max 1]
  • Neutral:  score <= 0.5
  • Pathogenic:  score > 0.5
Score:  
0
  [min -5, max 5]
  • Low impact:  score <= -1 (soft threshold)
  • Medium impact:  -1 < score < 1.5 (soft threshold)
  • High impact:  score >= 1.5 (soft threshold)
Score:  
0
  [min -5, max 5]
  • Low impact:  score <= -1
  • Medium impact:  -1 < score < 2 (soft threshold)
  • High impact:  score >= 2 (soft threshold)
Score:  
0
  [min -5, max 5]
  • Low impact:  score <= -1
  • Medium impact:  -1 < score < 2 (soft threshold)
  • High impact:  score >= 2 (soft threshold)
P-value:  
0
  [min 0, max 1]
  • Neutral:  FDR > 0.2
  • Driver:  FDR <= 0.2
The frequency of a CPD variant is proportional to the
number of aligned orthologous sequences that
carry a specific human pathogenic variant as
wild-type amino acid on the total number of aligned
sequences.

For more info, please check the output legend