3682 (A > G)

General info

Chr
chrM
Start
3682
End
3682
Ref
A
Alt
G
Mitimpact ID
MI.11533
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
376
AA pos
126
AA ref
N
AA alt
D
Codon substitution
Aac/Gac
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Powered by MitoWheel

Conservation

PhyloP 100v
-1.62
PhastCons 100v
0

Pathogenicity predictors

PolyPhen2
Possibly damaging
PolyPhen2 score
0.72
SIFT
Neutral
SIFT score
0.2
FatHmm
Neutral
FatHmm score
-1
FatHMMW
Neutral
FatHMMW score
2.74
PROVEAN
Neutral
PROVEAN score
-1.03
Mutation Assessor
Medium impact
Mutation Assessor score
2.94
EFIN SP
Neutral
EFIN SP score
0.66
EFIN HD
Damaging
EFIN HD score
0.25
VEST p-value
0.64
VEST FDR
0.7
PANTHER
Neutral
PANTHER score
0.22
PhD-SNP
Disease
PhD-SNP score
0.61
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Deleterious
CADD score
3.84
CADD phred
23.4
SNAP
Disease
SNAP score
0.62
MitoClass 1
Neutral
SNPDryad score
0.68

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.85
Condel
Neutral
Condel score
0.24
COVEC WMV
.
COVEC WMV score
0
Meta SNP
Disease
Meta SNP score
0.7
Meta SNP RI
4
MtoolBox
Deleterious
MtoolBox DS
0.57
APOGEE
N
APOGEE score
0.42
DEOGEN2 score
0.12

Cancer-specific predictors

PolyPhen2 transf
Low impact
PolyPhen2 transf score
-1.14
SIFT transf
Medium impact
SIFT transf score
-0.06
MutationAssessor transf
Medium impact
MutationAssessor transf score
1.38
CHASM p-value
0.29
CHASM FDR
0.8

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Databases of Allelic frequency & Phenotype

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153
.

Pathogenic variants, CPD

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

3682 (A > T)

General info

Chr
chrM
Start
3682
End
3682
Ref
A
Alt
T
Mitimpact ID
MI.11534
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
376
AA pos
126
AA ref
N
AA alt
Y
Codon substitution
Aac/Tac
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Powered by MitoWheel

Conservation

PhyloP 100v
-1.62
PhastCons 100v
0

Pathogenicity predictors

PolyPhen2
Probably damaging
PolyPhen2 score
0.96
SIFT
Neutral
SIFT score
1
FatHmm
Deleterious
FatHmm score
-3.02
FatHMMW
Neutral
FatHMMW score
2.68
PROVEAN
Neutral
PROVEAN score
-1.98
Mutation Assessor
Medium impact
Mutation Assessor score
2.04
EFIN SP
Neutral
EFIN SP score
0.68
EFIN HD
Neutral
EFIN HD score
0.3
VEST p-value
0.08
VEST FDR
0.35
PANTHER
Neutral
PANTHER score
0.44
PhD-SNP
Disease
PhD-SNP score
0.7
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Deleterious
CADD score
3.75
CADD phred
23.3
SNAP
Disease
SNAP score
0.62
MitoClass 1
Neutral
SNPDryad score
0.93

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.96
Condel
Deleterious
Condel score
0.52
COVEC WMV
Deleterious
COVEC WMV score
1
Meta SNP
Disease
Meta SNP score
0.7
Meta SNP RI
4
MtoolBox
Deleterious
MtoolBox DS
0.75
APOGEE
N
APOGEE score
0.23
DEOGEN2 score
0.05

Cancer-specific predictors

PolyPhen2 transf
Low impact
PolyPhen2 transf score
-2.05
SIFT transf
High impact
SIFT transf score
1.96
MutationAssessor transf
Medium impact
MutationAssessor transf score
0.59
CHASM p-value
0.17
CHASM FDR
0.8

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Databases of Allelic frequency & Phenotype

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153
.

Pathogenic variants, CPD

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

3682 (A > C)

General info

Chr
chrM
Start
3682
End
3682
Ref
A
Alt
C
Mitimpact ID
MI.11535
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
376
AA pos
126
AA ref
N
AA alt
H
Codon substitution
Aac/Cac
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Powered by MitoWheel

Conservation

PhyloP 100v
-1.62
PhastCons 100v
0

Pathogenicity predictors

PolyPhen2
Probably damaging
PolyPhen2 score
0.95
SIFT
Neutral
SIFT score
0.52
FatHmm
Neutral
FatHmm score
-2.13
FatHMMW
Neutral
FatHMMW score
2.7
PROVEAN
Neutral
PROVEAN score
-1.04
Mutation Assessor
Medium impact
Mutation Assessor score
2.59
EFIN SP
Neutral
EFIN SP score
0.64
EFIN HD
Neutral
EFIN HD score
0.28
VEST p-value
0.4
VEST FDR
0.5
PANTHER
Neutral
PANTHER score
0.34
PhD-SNP
Neutral
PhD-SNP score
0.47
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Deleterious
CADD score
3.08
CADD phred
22.5
SNAP
Disease
SNAP score
0.63
MitoClass 1
Neutral
SNPDryad score
0.38

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.94
Condel
Neutral
Condel score
0.29
COVEC WMV
Deleterious
COVEC WMV score
1
Meta SNP
Disease
Meta SNP score
0.53
Meta SNP RI
1
MtoolBox
Deleterious
MtoolBox DS
0.68
APOGEE
N
APOGEE score
0.34
DEOGEN2 score
0.05

Cancer-specific predictors

PolyPhen2 transf
Low impact
PolyPhen2 transf score
-1.95
SIFT transf
Medium impact
SIFT transf score
0.29
MutationAssessor transf
Medium impact
MutationAssessor transf score
1.07
CHASM p-value
0.14
CHASM FDR
0.8

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Databases of Allelic frequency & Phenotype

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153
.

Pathogenic variants, CPD

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

3683 (A > T)

General info

Chr
chrM
Start
3683
End
3683
Ref
A
Alt
T
Mitimpact ID
MI.11536
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
377
AA pos
126
AA ref
N
AA alt
I
Codon substitution
aAc/aTc
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Powered by MitoWheel

Conservation

PhyloP 100v
8.49
PhastCons 100v
1

Pathogenicity predictors

PolyPhen2
Probably damaging
PolyPhen2 score
0.95
SIFT
Neutral
SIFT score
0.4
FatHmm
Neutral
FatHmm score
-2.63
FatHMMW
Neutral
FatHMMW score
2.69
PROVEAN
Deleterious
PROVEAN score
-2.91
Mutation Assessor
Low impact
Mutation Assessor score
1.47
EFIN SP
Neutral
EFIN SP score
0.67
EFIN HD
Neutral
EFIN HD score
0.28
VEST p-value
0.12
VEST FDR
0.4
PANTHER
Neutral
PANTHER score
0.37
PhD-SNP
Disease
PhD-SNP score
0.78
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Deleterious
CADD score
3.75
CADD phred
23.3
SNAP
Disease
SNAP score
0.58
MitoClass 1
Neutral
SNPDryad score
0.92

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.95
Condel
Neutral
Condel score
0.23
COVEC WMV
Neutral
COVEC WMV score
-2
Meta SNP
Disease
Meta SNP score
0.72
Meta SNP RI
4
MtoolBox
Deleterious
MtoolBox DS
0.75
APOGEE
N
APOGEE score
0.5
DEOGEN2 score
0.11

Cancer-specific predictors

PolyPhen2 transf
Low impact
PolyPhen2 transf score
-1.95
SIFT transf
Medium impact
SIFT transf score
0.18
MutationAssessor transf
Medium impact
MutationAssessor transf score
0.1
CHASM p-value
0.14
CHASM FDR
0.8

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Databases of Allelic frequency & Phenotype

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153
.

Pathogenic variants, CPD

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

3683 (A > G)

General info

Chr
chrM
Start
3683
End
3683
Ref
A
Alt
G
Mitimpact ID
MI.11537
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
377
AA pos
126
AA ref
N
AA alt
S
Codon substitution
aAc/aGc
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Powered by MitoWheel

Conservation

PhyloP 100v
8.49
PhastCons 100v
1

Pathogenicity predictors

PolyPhen2
Possibly damaging
PolyPhen2 score
0.53
SIFT
Neutral
SIFT score
0.64
FatHmm
Neutral
FatHmm score
-0.97
FatHMMW
Neutral
FatHMMW score
2.74
PROVEAN
Neutral
PROVEAN score
-0.15
Mutation Assessor
Low impact
Mutation Assessor score
1.24
EFIN SP
Neutral
EFIN SP score
0.78
EFIN HD
Neutral
EFIN HD score
0.28
VEST p-value
0.55
VEST FDR
0.6
PANTHER
Neutral
PANTHER score
0.14
PhD-SNP
Neutral
PhD-SNP score
0.48
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Deleterious
CADD score
2.94
CADD phred
22
SNAP
Neutral
SNAP score
0.49
MitoClass 1
Neutral
SNPDryad score
0.31

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.45
Condel
Deleterious
Condel score
0.56
COVEC WMV
Neutral
COVEC WMV score
-3
Meta SNP
Neutral
Meta SNP score
0.43
Meta SNP RI
1
MtoolBox
Deleterious
MtoolBox DS
0.44
APOGEE
N
APOGEE score
0.53
DEOGEN2 score
0.01

Cancer-specific predictors

PolyPhen2 transf
Medium impact
PolyPhen2 transf score
-0.8
SIFT transf
Medium impact
SIFT transf score
0.42
MutationAssessor transf
Medium impact
MutationAssessor transf score
-0.11
CHASM p-value
0.15
CHASM FDR
0.8

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Databases of Allelic frequency & Phenotype

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153
.

Pathogenic variants, CPD

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

3683 (A > C)

General info

Chr
chrM
Start
3683
End
3683
Ref
A
Alt
C
Mitimpact ID
MI.11538
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
377
AA pos
126
AA ref
N
AA alt
T
Codon substitution
aAc/aCc
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Powered by MitoWheel

Conservation

PhyloP 100v
8.49
PhastCons 100v
1

Pathogenicity predictors

PolyPhen2
Possibly damaging
PolyPhen2 score
0.72
SIFT
Neutral
SIFT score
0.38
FatHmm
Neutral
FatHmm score
-1.35
FatHMMW
Neutral
FatHMMW score
2.72
PROVEAN
Neutral
PROVEAN score
-1.05
Mutation Assessor
Medium impact
Mutation Assessor score
2.24
EFIN SP
Neutral
EFIN SP score
0.63
EFIN HD
Neutral
EFIN HD score
0.3
VEST p-value
0.38
VEST FDR
0.5
PANTHER
Neutral
PANTHER score
0.18
PhD-SNP
Neutral
PhD-SNP score
0.49
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Deleterious
CADD score
3.26
CADD phred
22.8
SNAP
Disease
SNAP score
0.57
MitoClass 1
Neutral
SNPDryad score
0.43

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.74
Condel
Neutral
Condel score
0.33
COVEC WMV
.
COVEC WMV score
0
Meta SNP
Disease
Meta SNP score
0.56
Meta SNP RI
1
MtoolBox
Deleterious
MtoolBox DS
0.54
APOGEE
P
APOGEE score
0.67
DEOGEN2 score
0.03

Cancer-specific predictors

PolyPhen2 transf
Low impact
PolyPhen2 transf score
-1.14
SIFT transf
Medium impact
SIFT transf score
0.16
MutationAssessor transf
Medium impact
MutationAssessor transf score
0.77
CHASM p-value
0.2
CHASM FDR
0.8

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Databases of Allelic frequency & Phenotype

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153
.

Pathogenic variants, CPD

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

General info

Chr
chrM
Start
3684
End
3684
Ref
C
Alt
G
Mitimpact ID
MI.11539
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
378
AA pos
126
AA ref
N
AA alt
K
Codon substitution
aaC/aaG
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Powered by MitoWheel

Conservation

PhyloP 100v
6.65
PhastCons 100v
1

Pathogenicity predictors

PolyPhen2
Benign
PolyPhen2 score
0.03
SIFT
Neutral
SIFT score
0.37
FatHmm
Neutral
FatHmm score
2.2
FatHMMW
Neutral
FatHMMW score
3.23
PROVEAN
Neutral
PROVEAN score
4.14
Mutation Assessor
Neutral impact
Mutation Assessor score
-1.8
EFIN SP
Neutral
EFIN SP score
0.7
EFIN HD
Neutral
EFIN HD score
0.81
VEST p-value
0.49
VEST FDR
0.55
PANTHER
Neutral
PANTHER score
0.23
PhD-SNP
Neutral
PhD-SNP score
0.05
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Neutral
CADD score
1.27
CADD phred
12.09
SNAP
Neutral
SNAP score
0.26
MitoClass 1
Neutral
SNPDryad score
0.11

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.61
Condel
Deleterious
Condel score
0.67
COVEC WMV
Neutral
COVEC WMV score
-6
Meta SNP
Neutral
Meta SNP score
0.18
Meta SNP RI
6
MtoolBox
Neutral
MtoolBox DS
0.12
APOGEE
P
APOGEE score
0.62
DEOGEN2 score
0.01

Cancer-specific predictors

PolyPhen2 transf
Medium impact
PolyPhen2 transf score
0.67
SIFT transf
Medium impact
SIFT transf score
0.15
MutationAssessor transf
Low impact
MutationAssessor transf score
-2.76
CHASM p-value
0.41
CHASM FDR
0.8

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Databases of Allelic frequency & Phenotype

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153
.

Pathogenic variants, CPD

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
.
Species name
.
Ncbi taxon ID
.

General info

Chr
chrM
Start
3684
End
3684
Ref
C
Alt
A
Mitimpact ID
MI.11540
Gene symbol
MT-ND1
RC complex
I
Ensembl gene ID
Ensembl protein ID
Ensembl transcript ID
Uniprot name
Uniprot ID
Ncbi gene ID
Ncbi protein ID
Gene position
378
AA pos
126
AA ref
N
AA alt
K
Codon substitution
aaC/aaA
Powered by NGL Viewer
Powered by MitoWheel

Conservation

PhyloP 100v
6.65
PhastCons 100v
1

Pathogenicity predictors

PolyPhen2
Benign
PolyPhen2 score
0.03
SIFT
Neutral
SIFT score
0.37
FatHmm
Neutral
FatHmm score
2.2
FatHMMW
Neutral
FatHMMW score
3.23
PROVEAN
Neutral
PROVEAN score
4.14
Mutation Assessor
Neutral impact
Mutation Assessor score
-1.8
EFIN SP
Neutral
EFIN SP score
0.7
EFIN HD
Neutral
EFIN HD score
0.81
VEST p-value
0.49
VEST FDR
0.55
PANTHER
Neutral
PANTHER score
0.23
PhD-SNP
Neutral
PhD-SNP score
0.05
MutationTaster
Polymorphism
MutationTaster score
1
CADD
Neutral
CADD score
1.69
CADD phred
14.36
SNAP
Neutral
SNAP score
0.26
MitoClass 1
Neutral
SNPDryad score
0.11

Pathogenicity meta-predictors

CAROL
Neutral
CAROL score
0.61
Condel
Deleterious
Condel score
0.67
COVEC WMV
Neutral
COVEC WMV score
-6
Meta SNP
Neutral
Meta SNP score
0.18
Meta SNP RI
6
MtoolBox
Neutral
MtoolBox DS
0.12
APOGEE
P
APOGEE score
0.63
DEOGEN2 score
0.01

Cancer-specific predictors

PolyPhen2 transf
Medium impact
PolyPhen2 transf score
0.67
SIFT transf
Medium impact
SIFT transf score
0.15
MutationAssessor transf
Low impact
MutationAssessor transf score
-2.76
CHASM p-value
0.41
CHASM FDR
0.8

Residue interaction

EVmutation
Site A-B InterP
Site A-B IntraP
ΔΔG intra
ΔΔG intra interface
ΔΔG inter

Databases of Allelic frequency & Phenotype

ClinVar March2020 ClinSig
.
ClinVar March2020 ClnDBN
.
ClinVar March2020 ClnAllele ID
.
ClinVar March2020 ClnDSDB
.
MITOMAP Allele
.
MITOMAP Phenotype
.
MITOMAP Homoplasmy
.
MITOMAP Heteroplasmy
.
MITOMAP Status
.
MITOMAP NRef
.
COSMIC 90
.
dbSNP 153
.

Pathogenic variants, CPD

Frequency
.
AA ref
.
CPD AA alt
.
Aln pos
.
RefSeq protein ID
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Species name
.
Ncbi taxon ID
.
~ 3682 (A/G) 3682 (A/T) 3682 (A/C) 3683 (A/T) 3683 (A/G) 3683 (A/C) 3684 (C/G) 3684 (C/A)
~ 3682 (Aac/Gac) 3682 (Aac/Tac) 3682 (Aac/Cac) 3683 (aAc/aTc) 3683 (aAc/aGc) 3683 (aAc/aCc) 3684 (aaC/aaG) 3684 (aaC/aaA)
Chr chrM chrM chrM chrM chrM chrM chrM chrM
Start 3682 3682 3682 3683 3683 3683 3684 3684
End 3682 3682 3682 3683 3683 3683 3684 3684
Ref A A A A A A C C
Alt G T C T G C G A
MitImpact id MI.11533 MI.11534 MI.11535 MI.11536 MI.11537 MI.11538 MI.11539 MI.11540
Gene symbol MT-ND1 MT-ND1 MT-ND1 MT-ND1 MT-ND1 MT-ND1 MT-ND1 MT-ND1
Respiratory Chain complex I I I I I I I I
Ensembl gene id ENSG00000198888 ENSG00000198888 ENSG00000198888 ENSG00000198888 ENSG00000198888 ENSG00000198888 ENSG00000198888 ENSG00000198888
Ensembl protein id ENSP00000354687 ENSP00000354687 ENSP00000354687 ENSP00000354687 ENSP00000354687 ENSP00000354687 ENSP00000354687 ENSP00000354687
Ensembl transcript id ENST00000361390 ENST00000361390 ENST00000361390 ENST00000361390 ENST00000361390 ENST00000361390 ENST00000361390 ENST00000361390
Uniprot name NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN NU1M_HUMAN
Uniprot id P03886 P03886 P03886 P03886 P03886 P03886 P03886 P03886
Ncbi gene id 4535 4535 4535 4535 4535 4535 4535 4535
Ncbi protein id YP_003024026.1 YP_003024026.1 YP_003024026.1 YP_003024026.1 YP_003024026.1 YP_003024026.1 YP_003024026.1 YP_003024026.1
Gene position 376 376 376 377 377 377 378 378
AA position 126 126 126 126 126 126 126 126
AA ref N N N N N N N N
AA alt D Y H I S T K K
Codon substitution Aac/Gac Aac/Tac Aac/Cac aAc/aTc aAc/aGc aAc/aCc aaC/aaG aaC/aaA
PhyloP 100V -1.62 -1.62 -1.62 8.49 8.49 8.49 6.65 6.65
PhastCons 100V 0 0 0 1 1 1 1 1
PolyPhen2 possibly_damaging probably_damaging probably_damaging probably_damaging possibly_damaging possibly_damaging benign benign
PolyPhen2 score 0.72 0.96 0.95 0.95 0.53 0.72 0.03 0.03
SIFT neutral neutral neutral neutral neutral neutral neutral neutral
SIFT score 0.2 1 0.52 0.4 0.64 0.38 0.37 0.37
FatHmm neutral deleterious neutral neutral neutral neutral neutral neutral
FatHmm score -1 -3.02 -2.13 -2.63 -0.97 -1.35 2.2 2.2
FatHmmW neutral neutral neutral neutral neutral neutral neutral neutral
FatHmmW score 2.74 2.68 2.7 2.69 2.74 2.72 3.23 3.23
PROVEAN neutral neutral neutral deleterious neutral neutral neutral neutral
PROVEAN score -1.03 -1.98 -1.04 -2.91 -0.15 -1.05 4.14 4.14
MutationAssessor medium impact medium impact medium impact low impact low impact medium impact neutral impact neutral impact
MutationAssessor score 2.94 2.04 2.59 1.47 1.24 2.24 -1.8 -1.8
EFIN SP neutral neutral neutral neutral neutral neutral neutral neutral
EFIN SP score 0.66 0.68 0.64 0.67 0.78 0.63 0.7 0.7
EFIN HD damaging neutral neutral neutral neutral neutral neutral neutral
EFIN HD score 0.25 0.3 0.28 0.28 0.28 0.3 0.81 0.81
CADD deleterious deleterious deleterious deleterious deleterious deleterious neutral neutral
CADD score 3.84 3.75 3.08 3.75 2.94 3.26 1.27 1.69
CADD phred 23.4 23.3 22.5 23.3 22 22.8 12.09 14.36
VEST pvalue 0.64 0.08 0.4 0.12 0.55 0.38 0.49 0.49
VEST FDR 0.7 0.35 0.5 0.4 0.6 0.5 0.55 0.55
PANTHER neutral neutral neutral neutral neutral neutral neutral neutral
PANTHER score 0.22 0.44 0.34 0.37 0.14 0.18 0.23 0.23
PhD-SNP disease disease neutral disease neutral neutral neutral neutral
PhD-SNP score 0.61 0.7 0.47 0.78 0.48 0.49 0.05 0.05
SNAP disease disease disease disease neutral disease neutral neutral
SNAP score 0.62 0.62 0.63 0.58 0.49 0.57 0.26 0.26
Meta-SNP disease disease disease disease neutral disease neutral neutral
Meta-SNP score 0.7 0.7 0.53 0.72 0.43 0.56 0.18 0.18
Meta-SNP RI 4 4 1 4 1 1 6 6
CAROL neutral neutral neutral neutral neutral neutral neutral neutral
CAROL score 0.85 0.96 0.94 0.95 0.45 0.74 0.61 0.61
Condel neutral deleterious neutral neutral deleterious neutral deleterious deleterious
Condel score 0.24 0.52 0.29 0.23 0.56 0.33 0.67 0.67
COVEC WMV . deleterious deleterious neutral neutral . neutral neutral
COVEC WMV score 0 1 1 -2 -3 0 -6 -6
MtoolBox deleterious deleterious deleterious deleterious deleterious deleterious neutral neutral
MtoolBox DS 0.57 0.75 0.68 0.75 0.44 0.54 0.12 0.12
PolyPhen2 transf low impact low impact low impact low impact medium impact low impact medium impact medium impact
PolyPhen2 transf score -1.14 -2.05 -1.95 -1.95 -0.8 -1.14 0.67 0.67
SIFT_transf medium impact high impact medium impact medium impact medium impact medium impact medium impact medium impact
SIFT transf score -0.06 1.96 0.29 0.18 0.42 0.16 0.15 0.15
MutationAssessor transf medium impact medium impact medium impact medium impact medium impact medium impact low impact low impact
MutationAssessor transf score 1.38 0.59 1.07 0.1 -0.11 0.77 -2.76 -2.76
CHASM pvalue 0.29 0.17 0.14 0.14 0.15 0.2 0.41 0.41
CHASM FDR 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8
APOGEE N N N N N P P P
APOGEE score 0.42 0.23 0.34 0.5 0.53 0.67 0.62 0.63
SNPDryad score 0.68 0.93 0.38 0.92 0.31 0.43 0.11 0.11
MutationTaster polymorphism polymorphism polymorphism polymorphism polymorphism polymorphism polymorphism polymorphism
MutationTaster score 1 1 1 1 1 1 1 1
DEOGEN2 score 0.12 0.05 0.05 0.11 0.01 0.03 0.01 0.01
Mitoclass.1 neutral neutral neutral neutral neutral neutral neutral neutral
dbSNP 153 id . . . . . . . .
ClinVar March2020 ClinSig . . . . . . . .
ClinVar March2020 ClnDBN . . . . . . . .
ClinVar March2020 ClnAllele id . . . . . . . .
ClinVar March2020 ClnDSDB . . . . . . . .
COSMIC 90 . . . . . . . .
CPD Frequency . . . . . . . .
MITOMAP Allele . . . . . . . .
MITOMAP Phenotype . . . . . . . .
MITOMAP Homoplasmy . . . . . . . .
MITOMAP Heteroplasmy . . . . . . . .
MITOMAP Status . . . . . . . .
MITOMAP NRef . . . . . . . .
EVmutation MT-ND1_126N|128A:0.161216;129L:0.079319 MT-ND1_126N|128A:0.161216;129L:0.079319 MT-ND1_126N|128A:0.161216;129L:0.079319 MT-ND1_126N|128A:0.161216;129L:0.079319 MT-ND1_126N|128A:0.161216;129L:0.079319 MT-ND1_126N|128A:0.161216;129L:0.079319 MT-ND1_126N|128A:0.161216;129L:0.079319 MT-ND1_126N|128A:0.161216;129L:0.079319
Site A InterP ND1_126 ND1_126 ND1_126 ND1_126 ND1_126 ND1_126 ND1_126 ND1_126
Site B InterP ND2_241;ND2_308;ND2_281;ND3_22;ND4_333;ND4_421;ND5_301;ND5_309;ND5_373;ND5_549;ND5_37;ND6_126;ND2_166;ND2_281;ND2_286;ND3_18;ND3_45;ND3_112;ND3_49;ND3_46;ND3_21;ND4_363;ND4_62;ND4_345;ND4L_87;ND4L_91;ND5_428;ND5_420;ND5_480;ND6_85;ND6_50 ND2_241;ND2_308;ND2_281;ND3_22;ND4_333;ND4_421;ND5_301;ND5_309;ND5_373;ND5_549;ND5_37;ND6_126;ND2_166;ND2_281;ND2_286;ND3_18;ND3_45;ND3_112;ND3_49;ND3_46;ND3_21;ND4_363;ND4_62;ND4_345;ND4L_87;ND4L_91;ND5_428;ND5_420;ND5_480;ND6_85;ND6_50 ND2_241;ND2_308;ND2_281;ND3_22;ND4_333;ND4_421;ND5_301;ND5_309;ND5_373;ND5_549;ND5_37;ND6_126;ND2_166;ND2_281;ND2_286;ND3_18;ND3_45;ND3_112;ND3_49;ND3_46;ND3_21;ND4_363;ND4_62;ND4_345;ND4L_87;ND4L_91;ND5_428;ND5_420;ND5_480;ND6_85;ND6_50 ND2_241;ND2_308;ND2_281;ND3_22;ND4_333;ND4_421;ND5_301;ND5_309;ND5_373;ND5_549;ND5_37;ND6_126;ND2_166;ND2_281;ND2_286;ND3_18;ND3_45;ND3_112;ND3_49;ND3_46;ND3_21;ND4_363;ND4_62;ND4_345;ND4L_87;ND4L_91;ND5_428;ND5_420;ND5_480;ND6_85;ND6_50 ND2_241;ND2_308;ND2_281;ND3_22;ND4_333;ND4_421;ND5_301;ND5_309;ND5_373;ND5_549;ND5_37;ND6_126;ND2_166;ND2_281;ND2_286;ND3_18;ND3_45;ND3_112;ND3_49;ND3_46;ND3_21;ND4_363;ND4_62;ND4_345;ND4L_87;ND4L_91;ND5_428;ND5_420;ND5_480;ND6_85;ND6_50 ND2_241;ND2_308;ND2_281;ND3_22;ND4_333;ND4_421;ND5_301;ND5_309;ND5_373;ND5_549;ND5_37;ND6_126;ND2_166;ND2_281;ND2_286;ND3_18;ND3_45;ND3_112;ND3_49;ND3_46;ND3_21;ND4_363;ND4_62;ND4_345;ND4L_87;ND4L_91;ND5_428;ND5_420;ND5_480;ND6_85;ND6_50 ND2_241;ND2_308;ND2_281;ND3_22;ND4_333;ND4_421;ND5_301;ND5_309;ND5_373;ND5_549;ND5_37;ND6_126;ND2_166;ND2_281;ND2_286;ND3_18;ND3_45;ND3_112;ND3_49;ND3_46;ND3_21;ND4_363;ND4_62;ND4_345;ND4L_87;ND4L_91;ND5_428;ND5_420;ND5_480;ND6_85;ND6_50 ND2_241;ND2_308;ND2_281;ND3_22;ND4_333;ND4_421;ND5_301;ND5_309;ND5_373;ND5_549;ND5_37;ND6_126;ND2_166;ND2_281;ND2_286;ND3_18;ND3_45;ND3_112;ND3_49;ND3_46;ND3_21;ND4_363;ND4_62;ND4_345;ND4L_87;ND4L_91;ND5_428;ND5_420;ND5_480;ND6_85;ND6_50
Covariation Score InterP mfDCA:37.2304;mfDCA:31.6684;mfDCA:28.7427;mfDCA:27.6729;mfDCA:27.9839;mfDCA:24.5377;mfDCA:52.418;mfDCA:50.4615;mfDCA:46.5945;mfDCA:31.4902;mfDCA:29.965;mfDCA:25.4951;cMI:69.344261;cMI:47.778202;cMI:46.966953;cMI:52.283241;cMI:41.725754;cMI:41.227612;cMI:38.786575;cMI:38.561302;cMI:38.196899;cMI:28.745068;cMI:27.119209;cMI:24.457319;cMI:49.410023;cMI:45.503437;cMI:33.707512;cMI:31.031744;cMI:29.24682;cMI:62.307358;cMI:52.770638 mfDCA:37.2304;mfDCA:31.6684;mfDCA:28.7427;mfDCA:27.6729;mfDCA:27.9839;mfDCA:24.5377;mfDCA:52.418;mfDCA:50.4615;mfDCA:46.5945;mfDCA:31.4902;mfDCA:29.965;mfDCA:25.4951;cMI:69.344261;cMI:47.778202;cMI:46.966953;cMI:52.283241;cMI:41.725754;cMI:41.227612;cMI:38.786575;cMI:38.561302;cMI:38.196899;cMI:28.745068;cMI:27.119209;cMI:24.457319;cMI:49.410023;cMI:45.503437;cMI:33.707512;cMI:31.031744;cMI:29.24682;cMI:62.307358;cMI:52.770638 mfDCA:37.2304;mfDCA:31.6684;mfDCA:28.7427;mfDCA:27.6729;mfDCA:27.9839;mfDCA:24.5377;mfDCA:52.418;mfDCA:50.4615;mfDCA:46.5945;mfDCA:31.4902;mfDCA:29.965;mfDCA:25.4951;cMI:69.344261;cMI:47.778202;cMI:46.966953;cMI:52.283241;cMI:41.725754;cMI:41.227612;cMI:38.786575;cMI:38.561302;cMI:38.196899;cMI:28.745068;cMI:27.119209;cMI:24.457319;cMI:49.410023;cMI:45.503437;cMI:33.707512;cMI:31.031744;cMI:29.24682;cMI:62.307358;cMI:52.770638 mfDCA:37.2304;mfDCA:31.6684;mfDCA:28.7427;mfDCA:27.6729;mfDCA:27.9839;mfDCA:24.5377;mfDCA:52.418;mfDCA:50.4615;mfDCA:46.5945;mfDCA:31.4902;mfDCA:29.965;mfDCA:25.4951;cMI:69.344261;cMI:47.778202;cMI:46.966953;cMI:52.283241;cMI:41.725754;cMI:41.227612;cMI:38.786575;cMI:38.561302;cMI:38.196899;cMI:28.745068;cMI:27.119209;cMI:24.457319;cMI:49.410023;cMI:45.503437;cMI:33.707512;cMI:31.031744;cMI:29.24682;cMI:62.307358;cMI:52.770638 mfDCA:37.2304;mfDCA:31.6684;mfDCA:28.7427;mfDCA:27.6729;mfDCA:27.9839;mfDCA:24.5377;mfDCA:52.418;mfDCA:50.4615;mfDCA:46.5945;mfDCA:31.4902;mfDCA:29.965;mfDCA:25.4951;cMI:69.344261;cMI:47.778202;cMI:46.966953;cMI:52.283241;cMI:41.725754;cMI:41.227612;cMI:38.786575;cMI:38.561302;cMI:38.196899;cMI:28.745068;cMI:27.119209;cMI:24.457319;cMI:49.410023;cMI:45.503437;cMI:33.707512;cMI:31.031744;cMI:29.24682;cMI:62.307358;cMI:52.770638 mfDCA:37.2304;mfDCA:31.6684;mfDCA:28.7427;mfDCA:27.6729;mfDCA:27.9839;mfDCA:24.5377;mfDCA:52.418;mfDCA:50.4615;mfDCA:46.5945;mfDCA:31.4902;mfDCA:29.965;mfDCA:25.4951;cMI:69.344261;cMI:47.778202;cMI:46.966953;cMI:52.283241;cMI:41.725754;cMI:41.227612;cMI:38.786575;cMI:38.561302;cMI:38.196899;cMI:28.745068;cMI:27.119209;cMI:24.457319;cMI:49.410023;cMI:45.503437;cMI:33.707512;cMI:31.031744;cMI:29.24682;cMI:62.307358;cMI:52.770638 mfDCA:37.2304;mfDCA:31.6684;mfDCA:28.7427;mfDCA:27.6729;mfDCA:27.9839;mfDCA:24.5377;mfDCA:52.418;mfDCA:50.4615;mfDCA:46.5945;mfDCA:31.4902;mfDCA:29.965;mfDCA:25.4951;cMI:69.344261;cMI:47.778202;cMI:46.966953;cMI:52.283241;cMI:41.725754;cMI:41.227612;cMI:38.786575;cMI:38.561302;cMI:38.196899;cMI:28.745068;cMI:27.119209;cMI:24.457319;cMI:49.410023;cMI:45.503437;cMI:33.707512;cMI:31.031744;cMI:29.24682;cMI:62.307358;cMI:52.770638 mfDCA:37.2304;mfDCA:31.6684;mfDCA:28.7427;mfDCA:27.6729;mfDCA:27.9839;mfDCA:24.5377;mfDCA:52.418;mfDCA:50.4615;mfDCA:46.5945;mfDCA:31.4902;mfDCA:29.965;mfDCA:25.4951;cMI:69.344261;cMI:47.778202;cMI:46.966953;cMI:52.283241;cMI:41.725754;cMI:41.227612;cMI:38.786575;cMI:38.561302;cMI:38.196899;cMI:28.745068;cMI:27.119209;cMI:24.457319;cMI:49.410023;cMI:45.503437;cMI:33.707512;cMI:31.031744;cMI:29.24682;cMI:62.307358;cMI:52.770638
Site A IntraP ND1_126 ND1_126 ND1_126 ND1_126 ND1_126 ND1_126 ND1_126 ND1_126
Site B IntraP ND1_161;ND1_276;ND1_249;ND1_213;ND1_240 ND1_161;ND1_276;ND1_249;ND1_213;ND1_240 ND1_161;ND1_276;ND1_249;ND1_213;ND1_240 ND1_161;ND1_276;ND1_249;ND1_213;ND1_240 ND1_161;ND1_276;ND1_249;ND1_213;ND1_240 ND1_161;ND1_276;ND1_249;ND1_213;ND1_240 ND1_161;ND1_276;ND1_249;ND1_213;ND1_240 ND1_161;ND1_276;ND1_249;ND1_213;ND1_240
Covariation Score IntraP cMI:17.751915;cMI:15.33259;cMI:14.414145;cMI:14.05986;cMI:13.257043 cMI:17.751915;cMI:15.33259;cMI:14.414145;cMI:14.05986;cMI:13.257043 cMI:17.751915;cMI:15.33259;cMI:14.414145;cMI:14.05986;cMI:13.257043 cMI:17.751915;cMI:15.33259;cMI:14.414145;cMI:14.05986;cMI:13.257043 cMI:17.751915;cMI:15.33259;cMI:14.414145;cMI:14.05986;cMI:13.257043 cMI:17.751915;cMI:15.33259;cMI:14.414145;cMI:14.05986;cMI:13.257043 cMI:17.751915;cMI:15.33259;cMI:14.414145;cMI:14.05986;cMI:13.257043 cMI:17.751915;cMI:15.33259;cMI:14.414145;cMI:14.05986;cMI:13.257043
CPD AA ref . . . . . . . .
CPD AA alt . . . . . . . .
CPD Aln pos . . . . . . . .
CPD Species name . . . . . . . .
CPD RefSeq Protein ID . . . . . . . .
CPD Ncbi Taxon id . . . . . . . .
DDG intra MT-ND1:N126D:I213N:-0.80312:-1.35328:0.570276;MT-ND1:N126D:I213S:-0.715128:-1.35328:0.54308;MT-ND1:N126D:I213F:-1.56103:-1.35328:-0.142791;MT-ND1:N126D:I213V:-1.34912:-1.35328:-0.133635;MT-ND1:N126D:I213T:-1.36419:-1.35328:-0.123203;MT-ND1:N126D:I213L:-2.06085:-1.35328:-0.717595;MT-ND1:N126D:I213M:-1.88268:-1.35328:-0.483465;MT-ND1:N126D:A249P:-2.33383:-1.35328:-0.969457;MT-ND1:N126D:A249T:-0.73683:-1.35328:0.585672;MT-ND1:N126D:A249V:-0.941099:-1.35328:0.387706;MT-ND1:N126D:A249S:-0.947884:-1.35328:0.416877;MT-ND1:N126D:A249E:-1.38265:-1.35328:-0.081467;MT-ND1:N126D:A249G:-1.0733:-1.35328:0.24999;MT-ND1:N126D:A276S:-1.51652:-1.35328:-0.200186;MT-ND1:N126D:A276G:-0.980347:-1.35328:0.386782;MT-ND1:N126D:A276E:-1.26429:-1.35328:0.0557187;MT-ND1:N126D:A276P:-0.238444:-1.35328:1.16054;MT-ND1:N126D:A276V:-0.724091:-1.35328:0.62968;MT-ND1:N126D:A276T:-0.688079:-1.35328:0.683193 MT-ND1:N126Y:I213L:-2.03197:-1.04055:-0.717595;MT-ND1:N126Y:I213S:-0.647457:-1.04055:0.54308;MT-ND1:N126Y:I213F:-1.38274:-1.04055:-0.142791;MT-ND1:N126Y:I213T:-1.2891:-1.04055:-0.123203;MT-ND1:N126Y:I213V:-1.38109:-1.04055:-0.133635;MT-ND1:N126Y:I213N:-0.777702:-1.04055:0.570276;MT-ND1:N126Y:I213M:-1.61687:-1.04055:-0.483465;MT-ND1:N126Y:A249S:-0.723282:-1.04055:0.416877;MT-ND1:N126Y:A249P:-2.1532:-1.04055:-0.969457;MT-ND1:N126Y:A249V:-0.840571:-1.04055:0.387706;MT-ND1:N126Y:A249G:-0.773844:-1.04055:0.24999;MT-ND1:N126Y:A249E:-1.3226:-1.04055:-0.081467;MT-ND1:N126Y:A249T:-0.634344:-1.04055:0.585672;MT-ND1:N126Y:A276E:-0.963784:-1.04055:0.0557187;MT-ND1:N126Y:A276G:-0.878653:-1.04055:0.386782;MT-ND1:N126Y:A276V:-0.517871:-1.04055:0.62968;MT-ND1:N126Y:A276S:-1.38693:-1.04055:-0.200186;MT-ND1:N126Y:A276P:-0.0305314:-1.04055:1.16054;MT-ND1:N126Y:A276T:-0.494543:-1.04055:0.683193 MT-ND1:N126H:I213M:-1.09881:-0.611863:-0.483465;MT-ND1:N126H:I213F:-0.87268:-0.611863:-0.142791;MT-ND1:N126H:I213V:-0.637399:-0.611863:-0.133635;MT-ND1:N126H:I213N:-0.0260564:-0.611863:0.570276;MT-ND1:N126H:I213S:0.0570077:-0.611863:0.54308;MT-ND1:N126H:I213L:-1.34997:-0.611863:-0.717595;MT-ND1:N126H:I213T:-0.65633:-0.611863:-0.123203;MT-ND1:N126H:A249S:-0.198075:-0.611863:0.416877;MT-ND1:N126H:A249T:0.0464597:-0.611863:0.585672;MT-ND1:N126H:A249V:-0.214322:-0.611863:0.387706;MT-ND1:N126H:A249P:-1.57716:-0.611863:-0.969457;MT-ND1:N126H:A249E:-0.717267:-0.611863:-0.081467;MT-ND1:N126H:A249G:-0.327082:-0.611863:0.24999;MT-ND1:N126H:A276S:-0.780954:-0.611863:-0.200186;MT-ND1:N126H:A276G:-0.211246:-0.611863:0.386782;MT-ND1:N126H:A276E:-0.529948:-0.611863:0.0557187;MT-ND1:N126H:A276P:0.617763:-0.611863:1.16054;MT-ND1:N126H:A276V:0.0245213:-0.611863:0.62968;MT-ND1:N126H:A276T:0.0825789:-0.611863:0.683193 MT-ND1:N126I:I213N:-0.568668:-1.02185:0.570276;MT-ND1:N126I:I213S:-0.429043:-1.02185:0.54308;MT-ND1:N126I:I213L:-1.8485:-1.02185:-0.717595;MT-ND1:N126I:I213T:-1.10267:-1.02185:-0.123203;MT-ND1:N126I:I213V:-1.18064:-1.02185:-0.133635;MT-ND1:N126I:I213F:-1.19071:-1.02185:-0.142791;MT-ND1:N126I:A249G:-0.776523:-1.02185:0.24999;MT-ND1:N126I:A249V:-0.670835:-1.02185:0.387706;MT-ND1:N126I:A249E:-0.916627:-1.02185:-0.081467;MT-ND1:N126I:A249T:-0.41351:-1.02185:0.585672;MT-ND1:N126I:A249P:-1.9954:-1.02185:-0.969457;MT-ND1:N126I:A276V:-0.395256:-1.02185:0.62968;MT-ND1:N126I:A276E:-0.975685:-1.02185:0.0557187;MT-ND1:N126I:A276P:0.183424:-1.02185:1.16054;MT-ND1:N126I:A276G:-0.613625:-1.02185:0.386782;MT-ND1:N126I:A276S:-1.21579:-1.02185:-0.200186;MT-ND1:N126I:A276T:-0.310528:-1.02185:0.683193;MT-ND1:N126I:A249S:-0.624187:-1.02185:0.416877;MT-ND1:N126I:I213M:-1.49176:-1.02185:-0.483465 MT-ND1:N126S:I213S:0.773977:0.210032:0.54308;MT-ND1:N126S:I213F:0.00909783:0.210032:-0.142791;MT-ND1:N126S:I213N:0.585099:0.210032:0.570276;MT-ND1:N126S:I213L:-0.515264:0.210032:-0.717595;MT-ND1:N126S:I213T:0.103584:0.210032:-0.123203;MT-ND1:N126S:I213M:-0.25648:0.210032:-0.483465;MT-ND1:N126S:I213V:0.177965:0.210032:-0.133635;MT-ND1:N126S:A249E:0.242351:0.210032:-0.081467;MT-ND1:N126S:A249G:0.496239:0.210032:0.24999;MT-ND1:N126S:A249S:0.616427:0.210032:0.416877;MT-ND1:N126S:A249T:0.814568:0.210032:0.585672;MT-ND1:N126S:A249V:0.608905:0.210032:0.387706;MT-ND1:N126S:A249P:-0.743712:0.210032:-0.969457;MT-ND1:N126S:A276T:0.871773:0.210032:0.683193;MT-ND1:N126S:A276G:0.586774:0.210032:0.386782;MT-ND1:N126S:A276P:1.49278:0.210032:1.16054;MT-ND1:N126S:A276V:0.852967:0.210032:0.62968;MT-ND1:N126S:A276E:0.283738:0.210032:0.0557187;MT-ND1:N126S:A276S:0.0186631:0.210032:-0.200186 MT-ND1:N126T:I213F:-0.161443:0.0249942:-0.142791;MT-ND1:N126T:I213S:0.563877:0.0249942:0.54308;MT-ND1:N126T:I213L:-0.714951:0.0249942:-0.717595;MT-ND1:N126T:I213N:0.518234:0.0249942:0.570276;MT-ND1:N126T:I213T:-0.0862825:0.0249942:-0.123203;MT-ND1:N126T:I213M:-0.484902:0.0249942:-0.483465;MT-ND1:N126T:I213V:-0.0450998:0.0249942:-0.133635;MT-ND1:N126T:A249P:-0.962049:0.0249942:-0.969457;MT-ND1:N126T:A249E:0.0931174:0.0249942:-0.081467;MT-ND1:N126T:A249G:0.296433:0.0249942:0.24999;MT-ND1:N126T:A249S:0.435213:0.0249942:0.416877;MT-ND1:N126T:A249T:0.593129:0.0249942:0.585672;MT-ND1:N126T:A249V:0.425138:0.0249942:0.387706;MT-ND1:N126T:A276S:-0.206018:0.0249942:-0.200186;MT-ND1:N126T:A276P:1.1948:0.0249942:1.16054;MT-ND1:N126T:A276V:0.678573:0.0249942:0.62968;MT-ND1:N126T:A276T:0.727631:0.0249942:0.683193;MT-ND1:N126T:A276G:0.421614:0.0249942:0.386782;MT-ND1:N126T:A276E:0.103294:0.0249942:0.0557187 MT-ND1:N126K:I213M:-1.22772:-0.694078:-0.483465;MT-ND1:N126K:I213V:-0.7669:-0.694078:-0.133635;MT-ND1:N126K:I213T:-0.770749:-0.694078:-0.123203;MT-ND1:N126K:I213L:-1.44404:-0.694078:-0.717595;MT-ND1:N126K:I213F:-0.974428:-0.694078:-0.142791;MT-ND1:N126K:I213N:-0.206493:-0.694078:0.570276;MT-ND1:N126K:I213S:-0.124558:-0.694078:0.54308;MT-ND1:N126K:A249S:-0.27373:-0.694078:0.416877;MT-ND1:N126K:A249V:-0.2602:-0.694078:0.387706;MT-ND1:N126K:A249E:-0.699514:-0.694078:-0.081467;MT-ND1:N126K:A249P:-1.68144:-0.694078:-0.969457;MT-ND1:N126K:A249G:-0.448006:-0.694078:0.24999;MT-ND1:N126K:A249T:-0.158863:-0.694078:0.585672;MT-ND1:N126K:A276V:-0.0985182:-0.694078:0.62968;MT-ND1:N126K:A276T:-0.0597012:-0.694078:0.683193;MT-ND1:N126K:A276G:-0.310009:-0.694078:0.386782;MT-ND1:N126K:A276P:0.614259:-0.694078:1.16054;MT-ND1:N126K:A276E:-0.673986:-0.694078:0.0557187;MT-ND1:N126K:A276S:-0.930457:-0.694078:-0.200186 MT-ND1:N126K:I213M:-1.22772:-0.694078:-0.483465;MT-ND1:N126K:I213V:-0.7669:-0.694078:-0.133635;MT-ND1:N126K:I213T:-0.770749:-0.694078:-0.123203;MT-ND1:N126K:I213L:-1.44404:-0.694078:-0.717595;MT-ND1:N126K:I213F:-0.974428:-0.694078:-0.142791;MT-ND1:N126K:I213N:-0.206493:-0.694078:0.570276;MT-ND1:N126K:I213S:-0.124558:-0.694078:0.54308;MT-ND1:N126K:A249S:-0.27373:-0.694078:0.416877;MT-ND1:N126K:A249V:-0.2602:-0.694078:0.387706;MT-ND1:N126K:A249E:-0.699514:-0.694078:-0.081467;MT-ND1:N126K:A249P:-1.68144:-0.694078:-0.969457;MT-ND1:N126K:A249G:-0.448006:-0.694078:0.24999;MT-ND1:N126K:A249T:-0.158863:-0.694078:0.585672;MT-ND1:N126K:A276V:-0.0985182:-0.694078:0.62968;MT-ND1:N126K:A276T:-0.0597012:-0.694078:0.683193;MT-ND1:N126K:A276G:-0.310009:-0.694078:0.386782;MT-ND1:N126K:A276P:0.614259:-0.694078:1.16054;MT-ND1:N126K:A276E:-0.673986:-0.694078:0.0557187;MT-ND1:N126K:A276S:-0.930457:-0.694078:-0.200186
DDG intra interface 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MT-ND1:MT-ND3:5lc5:H:A:N126K:I213F:0.49754:0.39067:0.26227;MT-ND1:MT-ND3:5lc5:H:A:N126K:I213L:0.50516:0.39067:0.02712;MT-ND1:MT-ND3:5lc5:H:A:N126K:I213M:0.65707:0.39067:0.09873;MT-ND1:MT-ND3:5lc5:H:A:N126K:I213N:-0.23573:0.39067:-0.64295;MT-ND1:MT-ND3:5lc5:H:A:N126K:I213S:0.58293:0.39067:-0.01554;MT-ND1:MT-ND3:5lc5:H:A:N126K:I213T:0.29141:0.39067:0.0437;MT-ND1:MT-ND3:5lc5:H:A:N126K:I213V:0.16195:0.39067:-0.24876;MT-ND1:MT-ND3:5ldw:H:A:N126K:I213F:0.0437:-0.13726:0.18591;MT-ND1:MT-ND3:5ldw:H:A:N126K:I213L:-0.04437:-0.13726:0.01373;MT-ND1:MT-ND3:5ldw:H:A:N126K:I213M:0.02401:-0.13726:0.02308;MT-ND1:MT-ND3:5ldw:H:A:N126K:I213N:-0.27174:-0.13726:-0.48608;MT-ND1:MT-ND3:5ldw:H:A:N126K:I213S:-0.13648:-0.13726:-0.02555;MT-ND1:MT-ND3:5ldw:H:A:N126K:I213T:-0.12464:-0.13726:-0.05294;MT-ND1:MT-ND3:5ldw:H:A:N126K:I213V:-0.03989:-0.13726:-0.05191;MT-ND1:MT-ND3:5ldx:H:A:N126K:I213F:0.04482:0.22525:0.10641;MT-ND1:MT-ND3:5ldx:H:A:N126K:I213L:0.38613:0.22525:0.03409;MT-ND1:MT-ND3:5ldx:H:A:N126K:I213M:0.40779:0.22525:0.03281;MT-ND1:MT-ND3:5ldx:H:A:N126K:I213N:0.10833:0.22525:-0.31828;MT-ND1:MT-ND3:5ldx:H:A:N126K:I213S:0.31437:0.22525:-0.03982;MT-ND1:MT-ND3:5ldx:H:A:N126K:I213T:0.37564:0.22525:-0.06167;MT-ND1:MT-ND3:5ldx:H:A:N126K:I213V:0.35195:0.22525:-0.01765;MT-ND1:NDUFS2:5lc5:H:D:N126K:A276E:-0.98124:-1.13044:-0.00958;MT-ND1:NDUFS2:5lc5:H:D:N126K:A276G:-0.66335:-1.13044:0.45938;MT-ND1:NDUFS2:5lc5:H:D:N126K:A276P:-0.47804:-1.13044:0.4897;MT-ND1:NDUFS2:5lc5:H:D:N126K:A276S:-0.86646:-1.13044:0.22672;MT-ND1:NDUFS2:5lc5:H:D:N126K:A276T:-1.36649:-1.13044:-0.30414;MT-ND1:NDUFS2:5lc5:H:D:N126K:A276V:-1.55567:-1.13044:-0.40074;MT-ND1:NDUFS2:5ldw:H:D:N126K:A276E:0.2681222:-0.189033:0.4444985;MT-ND1:NDUFS2:5ldw:H:D:N126K:A276G:0.0695735:-0.189033:0.5169461;MT-ND1:NDUFS2:5ldw:H:D:N126K:A276P:0.059423236:-0.189033:0.1625805;MT-ND1:NDUFS2:5ldw:H:D:N126K:A276S:-0.6524438:-0.189033:-0.3965543;MT-ND1:NDUFS2:5ldw:H:D:N126K:A276T:-0.5528349:-0.189033:-0.2743957;MT-ND1:NDUFS2:5ldw:H:D:N126K:A276V:-0.17823476:-0.189033:-0.0879116;MT-ND1:NDUFS2:5ldx:H:D:N126K:A276E:-0.31812917:-0.4004477:0.21912504;MT-ND1:NDUFS2:5ldx:H:D:N126K:A276G:-0.19093913:-0.4004477:0.1624912;MT-ND1:NDUFS2:5ldx:H:D:N126K:A276P:-0.29156192:-0.4004477:0.1954252;MT-ND1:NDUFS2:5ldx:H:D:N126K:A276S:-0.11178995:-0.4004477:0.2913374;MT-ND1:NDUFS2:5ldx:H:D:N126K:A276T:-0.890995874:-0.4004477:-0.6121604;MT-ND1:NDUFS2:5ldx:H:D:N126K:A276V:-0.62977184:-0.4004477:-0.2327356 MT-ND1:MT-ND3:5lc5:H:A:N126K:I213F:0.49754:0.39067:0.26227;MT-ND1:MT-ND3:5lc5:H:A:N126K:I213L:0.50516:0.39067:0.02712;MT-ND1:MT-ND3:5lc5:H:A:N126K:I213M:0.65707:0.39067:0.09873;MT-ND1:MT-ND3:5lc5:H:A:N126K:I213N:-0.23573:0.39067:-0.64295;MT-ND1:MT-ND3:5lc5:H:A:N126K:I213S:0.58293:0.39067:-0.01554;MT-ND1:MT-ND3:5lc5:H:A:N126K:I213T:0.29141:0.39067:0.0437;MT-ND1:MT-ND3:5lc5:H:A:N126K:I213V:0.16195:0.39067:-0.24876;MT-ND1:MT-ND3:5ldw:H:A:N126K:I213F:0.0437:-0.13726:0.18591;MT-ND1:MT-ND3:5ldw:H:A:N126K:I213L:-0.04437:-0.13726:0.01373;MT-ND1:MT-ND3:5ldw:H:A:N126K:I213M:0.02401:-0.13726:0.02308;MT-ND1:MT-ND3:5ldw:H:A:N126K:I213N:-0.27174:-0.13726:-0.48608;MT-ND1:MT-ND3:5ldw:H:A:N126K:I213S:-0.13648:-0.13726:-0.02555;MT-ND1:MT-ND3:5ldw:H:A:N126K:I213T:-0.12464:-0.13726:-0.05294;MT-ND1:MT-ND3:5ldw:H:A:N126K:I213V:-0.03989:-0.13726:-0.05191;MT-ND1:MT-ND3:5ldx:H:A:N126K:I213F:0.04482:0.22525:0.10641;MT-ND1:MT-ND3:5ldx:H:A:N126K:I213L:0.38613:0.22525:0.03409;MT-ND1:MT-ND3:5ldx:H:A:N126K:I213M:0.40779:0.22525:0.03281;MT-ND1:MT-ND3:5ldx:H:A:N126K:I213N:0.10833:0.22525:-0.31828;MT-ND1:MT-ND3:5ldx:H:A:N126K:I213S:0.31437:0.22525:-0.03982;MT-ND1:MT-ND3:5ldx:H:A:N126K:I213T:0.37564:0.22525:-0.06167;MT-ND1:MT-ND3:5ldx:H:A:N126K:I213V:0.35195:0.22525:-0.01765;MT-ND1:NDUFS2:5lc5:H:D:N126K:A276E:-0.98124:-1.13044:-0.00958;MT-ND1:NDUFS2:5lc5:H:D:N126K:A276G:-0.66335:-1.13044:0.45938;MT-ND1:NDUFS2:5lc5:H:D:N126K:A276P:-0.47804:-1.13044:0.4897;MT-ND1:NDUFS2:5lc5:H:D:N126K:A276S:-0.86646:-1.13044:0.22672;MT-ND1:NDUFS2:5lc5:H:D:N126K:A276T:-1.36649:-1.13044:-0.30414;MT-ND1:NDUFS2:5lc5:H:D:N126K:A276V:-1.55567:-1.13044:-0.40074;MT-ND1:NDUFS2:5ldw:H:D:N126K:A276E:0.2681222:-0.189033:0.4444985;MT-ND1:NDUFS2:5ldw:H:D:N126K:A276G:0.0695735:-0.189033:0.5169461;MT-ND1:NDUFS2:5ldw:H:D:N126K:A276P:0.059423236:-0.189033:0.1625805;MT-ND1:NDUFS2:5ldw:H:D:N126K:A276S:-0.6524438:-0.189033:-0.3965543;MT-ND1:NDUFS2:5ldw:H:D:N126K:A276T:-0.5528349:-0.189033:-0.2743957;MT-ND1:NDUFS2:5ldw:H:D:N126K:A276V:-0.17823476:-0.189033:-0.0879116;MT-ND1:NDUFS2:5ldx:H:D:N126K:A276E:-0.31812917:-0.4004477:0.21912504;MT-ND1:NDUFS2:5ldx:H:D:N126K:A276G:-0.19093913:-0.4004477:0.1624912;MT-ND1:NDUFS2:5ldx:H:D:N126K:A276P:-0.29156192:-0.4004477:0.1954252;MT-ND1:NDUFS2:5ldx:H:D:N126K:A276S:-0.11178995:-0.4004477:0.2913374;MT-ND1:NDUFS2:5ldx:H:D:N126K:A276T:-0.890995874:-0.4004477:-0.6121604;MT-ND1:NDUFS2:5ldx:H:D:N126K:A276V:-0.62977184:-0.4004477:-0.2327356
DDG inter 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For more info, please check the output legend.
For more info, please check the output legend.
For more info, please check the output legend.
For more info, please check the output legend.
For more info, please check the output legend.